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circPVT1 promotes silica-induced epithelial-mesenchymal transition by modulating the miR-497-5p/TCF3 axis

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Journal of Biomedical Research 2024年第2期38卷 163-174,I0011-I0015页

作者： Siyun Zhou Yan Li wenqing Sun Dongyu Ma Yi liu Demin Cheng Guanru Li Chunhui Ni Department of Occupational Medical and Environmental Health Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Biomedical Publications Center Nanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversityNanjingJiangsu 211166China

Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary ***,whether circRNA is involved in the process remains *** present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying *** found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial *** isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the *** immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to ***,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3(TCF3),an E-cadherin transcriptional repressor,in the silica-treated epithelial ***,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3 axis in the silica-induced EMT process in lung epithelial *** validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.

关键词： silicosis epithelial-mesenchymal transition circPVT1 miR-497-5p TCF3

A Trade-off between Solvation and Collision Activation in Steering Competing E2 and S_(N)2 Dynamics

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Precision Chemistry 2024年第1期2卷 40-48页

作者： Hongyi Wang Xu liu Siwei Zhao Gang Fu wenqing Zhen Li Yang Jiaxu Zhang State Key Laboratory of Urban Water Resource and Environment MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and StorageSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001P.R.China College of Chemistry Liaoning UniversityShenyang 110036P.R.China

The prototypical E2 elimination and SN2 sub-stitution reactions between microsolvated fluoride and ethyl bromide show unexpected dynamic behaviors in mechanistic evolution driven by solvation and collision *** the steric effects,the gas-phase selectivity favors an E2 pathway barely dependent on collision ***,base solvation steers the reaction in an effective way toward substitution at a near-thermal energy,whereas the governing high-energy events retain *** dynamics simulations reproduce exper-imental findings and uncover a crucial solute-solvent coupling in determining such competing ***,collision activation can tune the underlying atomistic dynamics essentially in the reactant entrance channel and cause a mechanism *** features for the ubiquitous competing E2/SN2 dynamics remain quite unknown,providing unique insight into reaction selectivity for complex chemical networks.

关键词： E2/S_(N)2 Competition Atomistic Dynamics Reaction Mechanisms Microsolvation Collision Activation

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三维原子探针对Ni_4Mo合金的研究

稀有金属材料与工程 2008年第10期37卷 1719-1722页

作者：刘文庆刘庆冬周邦新上海大学上海200444

用带场离子显微镜(FIM)功能的三维原子探针(3DAP)对Ni4Mo有序合金进行研究,并测试脉冲分数对试验结果的影响。观察到Ni4Mo有序合金中存在反相畴界。当脉冲分数为20%时,3DAP能比较准确地对纳米空间中的Ni元素和Mo元素进行定量分析,并能... 详细信息

用带场离子显微镜(FIM)功能的三维原子探针(3DAP)对Ni4Mo有序合金进行研究,并测试脉冲分数对试验结果的影响。观察到Ni4Mo有序合金中存在反相畴界。当脉冲分数为20%时,3DAP能比较准确地对纳米空间中的Ni元素和Mo元素进行定量分析,并能给出空间位置分辨率较高的三维分布图形。当脉冲分数小于20%时,脉冲分数越低,3DAP测得的结果与真实成分的偏差越大。脉冲分数对元素同位素丰度和元素电离价态的测量结果没有影响。

关键词：三维原子探针 Ni4Mo有序合金脉冲分数

第四届国际差分吸收光谱环境研究与监测学术研讨会论文摘要集

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大气与环境光学学报 2008年第4期3卷 286-320页

作者： wenqing liu Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences China

由中国科学院安徽光学精密机械研究所承办，中国科学院、德国海德堡大学、大气组分变化欧洲卓越网络TROPOSAT－2（AT－2）项目指导委员会、安徽省光学学会协办的“第四届国际DOAS环境研究与监测学术研讨会”（the Fourth DOAS Internati... 详细信息

由中国科学院安徽光学精密机械研究所承办，中国科学院、德国海德堡大学、大气组分变化欧洲卓越网络TROPOSAT－2（AT－2）项目指导委员会、安徽省光学学会协办的“第四届国际DOAS环境研究与监测学术研讨会”（the Fourth DOAS International Workshop for Environmental Researchand Monitoring）于2008年3月30日－4月3日在合肥召开。

关键词：学术研讨会差分吸收光谱论文摘要监测环境国际 Workshop 中国科学院

Two-dimensional ferromagnetic superlattices

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National Science Review 2020年第4期7卷 745-754页

作者： Shanshan liu Ke Yang wenqing liu Enze Zhang Zihan Li Xiaoqian Zhang Zhiming Liao Wen Zhang Jiabao Sun Yunkun Yang Han Gao Ce Huang Linfeng Ai Ping Kwan Johnny Wong ANDrew Thye Shen Wee Alpha T.N'Diaye Simon A.Morton Xufeng Kou Jin Zou Yongbing Xu Hua Wu Faxian Xiu State Key Laboratory of Surface Physics and Department of Physics Fudan University Institute for Nanoelectronic Devices and Quantum Computing Fudan University Laboratory for Computational Physical Sciences (MOE) Fudan University Department of Electronic Engineering Royal Holloway University of London School of Electronic Science and Engineering Nanjing University Materials Engineering The University of Queensland Department of Physics National University of Singapore Centre for Advanced 2D Materials and Graphene Research Centre National University of Singapore Lawrence Berkeley National Laboratory School of Information Science and Technology Shanghai Tech University Centre for Microscopy and Microanalysis The University of Queensland Collaborative Innovation Center of Advanced Microstructures

Mechanically exfoliated two-dimensional ferromagnetic materials(2 D FMs) possess long-range ferromagnetic order and topologically nontrivial skyrmions in few layers. However, because of the dimensionality effect, such few-layer systems usually exhibit much lower Curie temperature(TC) compared to their bulk counterparts. It is therefore of great interest to explore effective approaches to enhance their TC, particularly in wafer-scale for practical applications. Here, we report an interfacial proximity-induced high-TC2 D FM FeGe Te(FGT) via A-type antiferromagnetic material Cr Sb(CS) which strongly couples to FGT. A superlattice structure of(FGT/CS)n, where n stands for the period of FGT/CS heterostructure, has been successfully produced with sharp interfaces by molecular-beam epitaxy on 2-inch wafers. By performing elemental specific X-ray magnetic circular dichroism(XMCD) measurements, we have unequivocally discovered that TCof 4-layer FeGeTecan be significantly enhanced from 140 K to230 K because of the interfacial ferromagnetic coupling. Meanwhile, an inverse proximity effect occurs in the FGT/CS interface, driving the interfacial antiferromagnetic Cr Sb into a ferrimagnetic state as evidenced by double-switching behavior in hysteresis loops and the XMCD spectra. Density functional theory calculations show that the Fe-Te/Cr-Sb interface is strongly FM coupled and doping of the spin-polarized electrons by the interfacial Cr layer gives rise to the TCenhancement of the FeGeTefilms, in accordance with our XMCD measurements. Strikingly, by introducing rich Fe in a 4-layer FGT/CS superlattice, TCcan be further enhanced to near room temperature. Our results provide a feasible approach for enhancing the magnetic order of few-layer 2 D FMs in wafer-scale and render opportunities for realizing realistic ultra-thin spintronic devices.

关键词： 2D ferromagnetic material room temperature 2-inch Fe3GeTe2 film wafers proximity effect (Fe3GeTe2/CrSb)nsuperlattice

LIQUIDUS OF Ag-Cu-Bi SYSTEM

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Acta Metallurgica Sinica(English Letters) 1989年第8期2卷 151-152页

作者： liu Shuqi SUN wenqing Deptrtment of Chemistry,Peking University,Beijing,China[Originally published in ACTA METALL SIN (CHINESE EDN) 24 (5) 1988 pp B376—B378,received 8 September 1987]

The diagram of Ag-Cu-Bi system was constructed from the investigation of 12 internal sec- tions by DTA heating as well as cooling curves in an atmosphere of dry N_*** composi- tion of ternary eutectic point melting at 258℃ lies in Ag(5.0)-Cu(0.5)-Bi(94.5) at.-%.The liquiduses of Ag-Cu,Ag-Bi and Cu-Bi binaries were reinvestigated.

关键词： Ag-Cu-Bi ternary system liquidus

The issues of prestack reverse time migration and solutions with Graphic Processing Unit implementation

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The issues of prestack reverse time migration and solutions ...

捕食者食饵均染病的入侵反应扩散捕食系统中扩散的作用

中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： Hongwei liu Bo Li Hong liu Xiaolong Tong Qin liu Xiwen Wang wenqing liu Key Laboratory of Petroleum Resources Research Institute of Geology and Geophysics Chinese Academy of Sciences

Prestack reverse time migration(RTM) is a very useful tool for seismic imaging but has mainly three bottlenecks:highly intensive computation cost,low-frequency band imaging noise and massive memory ***,PC-clusters with thousands of computation nodes are used to perform RTM but it is too expensive for small companies and *** this article,we use Graphic Processing Unit(GPU) architecture,which is cheaper and faster to implement RTM and we obtain an order of magnitude higher speedup ratio to solve the problem of intensive computation *** at the massive memory demand,we adopt the pseudo random boundary condition that sacrifices the computation cost but reduces the memory demand. For rugged topography RTM,it is difficult to deal with the rugged free boundary condition with the finite difference *** employ a simplified boundary condition that avoids the abundant logical judgment to make the GPU implementation possible and does not induce any sacrifice on ***,we have also done some tests on multi-GPU implementation for wide azimuth geometries using the latest GPU cards and ***,we discuss the challenges of anisotropy RTM and GPU *** the jobs stated above are based on GPU and the synthetic data examples will show the efficiency of the algorithm and solutions.

关键词： RTM GPU Pseudo random boundary Rugged topography Anisotropy

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应用数学和力学 2019年第3期40卷 321-331页

作者：柳文清陈清婉福建师范大学闽南科技学院福建泉州362300

研究了捕食者食饵均染病的入侵反应扩散捕食系统.利用特征值方法和构造Lyapunov函数,获得了入侵扩散对正常数平衡解的影响,当入侵扩散系数充分大时,导致平衡态失稳.进一步,利用拓扑度方法,证明了在一定条件下入侵扩散系数很大,自扩散充... 详细信息

研究了捕食者食饵均染病的入侵反应扩散捕食系统.利用特征值方法和构造Lyapunov函数,获得了入侵扩散对正常数平衡解的影响,当入侵扩散系数充分大时,导致平衡态失稳.进一步,利用拓扑度方法,证明了在一定条件下入侵扩散系数很大,自扩散充分小时,有非常数正平衡解存在.

关键词：入侵反应扩散稳定性正常数平衡解非常数正平衡解

Raman光谱及DR技术在可移动文物追溯中的实验研究

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陶瓷学报 2022年第6期43卷 1105-1112页

作者：刘文庆王平南京江宁区文化遗产保护中心江苏南京210000 牛首山文化旅游区管委会文宗科江苏南京210000 南京航空航天大学江苏南京210016 高速载运设施的无损检测监控技术工信部重点实验室江苏南京210016

以江宁博物馆中的纸质类、金属类和陶瓷类文物为检测对象,介绍了包括拉曼(Raman)光谱技术和射线数字(Digital Radiography,DR)技术在内的无损检测技术原理。利用便携式拉曼光谱仪、X射线成像仪等现代科学仪器对可移动文物进行了检测。... 详细信息

以江宁博物馆中的纸质类、金属类和陶瓷类文物为检测对象,介绍了包括拉曼(Raman)光谱技术和射线数字(Digital Radiography,DR)技术在内的无损检测技术原理。利用便携式拉曼光谱仪、X射线成像仪等现代科学仪器对可移动文物进行了检测。检测结果分析表明,拉曼光谱技术检测数据的重复性好,同一点测量数据的自相关达0.99以上,可信度高;不同年代陶瓷文物、书法作品的真迹和仿品的拉曼光谱有明显区别,可以将固定点全谱线的保存作为特征存储。X射线技术能够获得金属和陶瓷类文物的内部细节。以拉曼和X射线为代表的无损检测技术可以为文物特征基因库的建立提供特征元素、为已有档案的文物真伪鉴别提供技术支持。

关键词：文物保护基因库拉曼光谱射线数字