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Discovery and structure-activity relationship studies of novel tetrahydro-β-carboline derivatives as apoptosis initiators for treating bacterial infections

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Journal of Integrative Agriculture 2024年第4期23卷 1259-1273页

作者： Shanshan Su Hongwu Liu Junrong Zhang Puying Qi Yue Ding Ling Zhang linli Yang Liwei Liu Xiang Zhou Song Yang National Key Laboratory of Green Pesticide/Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education/Center for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China

Developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food *** this paper,to discover the new bactericide candidates,we designed,prepared a new type of1,2,3,4-tetrahydro-β-carboline(THC)derivatives and evaluated the in vitro and in vivo bioactivities against the Xanthomonas oryzae ***(Xoo),Xanthomonas axonopodis ***(Xac),and Pseudomonas syringae ***(Psa).The in vitro bioassay results exhibited that most title molecules possessed good activity toward the three plant pathogenic bacteria,the compound A17 showed the most active against Xoo and Xac with EC50 values of 7.27 and 4.89 mg mL^(-1)respectively,and compound A8 exhibited the best inhibitory activity against Psa with EC50value of 4.87 mg mL^(-1).Pot experiments showed that compound A17 exhibited excellent in vivo antibacterial activities to manage rice bacterial leaf blight and citrus bacterial canker,with protective efficiencies of 52.67 and 79.79%at 200 mgmL^(-1),***,compound A8 showed good control efficiency(84.31%)against kiwifruit bacterial canker at 200 mg mL^(-1).Antibacterial mechanism suggested that these compounds could interfere with the balance of the redox system,damage the cell membrane,and induce the apoptosis of Xoo *** together,our study revealed that tetrahydro-β-carboline derivatives could be a promising candidate model for novel broadspectrum bactericides.

关键词： tetrahydro-β-carboline derivatives antibacterial activity ROS cell apoptosis

3D bioprinting of collagen-based materials for oral medicine

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Collagen and Leather 2024年第1期5卷 28-46页

作者： Bosen Yang Hai Liu linli Jiang Yiwei Zeng Yiyuan Han Chuanlu Sha Xin Xie Hui Li Jiajing Zhou Wei Lin College of Biomass Science and Engineering Key Laboratory of Leather Chemistry and Engineering of Ministry of EducationNational Engineering Laboratory for Clean Technology of Leather ManufactureSichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengdu 610065China Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA

Oral diseases have emerged as one of the leading public health challenges *** the existing clinical modalities for restoration of dental tissue loss and craniomaxillofacial injuries can achieve satisfactory therapeutic results,they cannot fully restore the original complex anatomical structure and physiological function of the tissue.3D printing of biological tissues has gained growing interest in the field of oral medicine with the ability to control the bioink component and printing structure for spatially heterogeneous repairing constructs,holding enormous promise for the precise treatment of oral ***,collagen-based materials have been recognized as promising biogenic bioinks for the regeneration of several tissues with high cell-activating and biocompatible *** this review,we summarize 3D printing methods for collagen-based biomaterials and their ***,we highlight the animal sources of collagen and their characteristics,as well as the methods of collagen ***,this review provides an overview of the 3D bioprinting technology for the regeneration of the pulpal nerve and blood vessels,cartilage,and periodontal *** envision that this technique opens up immense opportunities over the conventional ones,with high replicability and customized function,which can ultimately promote effective oral tissue regeneration.

关键词： 3D bioprinting Oral medicine Tissue engineering Collagen Scaffold materials Bioink Hydrogel

Gel electrolyte based high-performance fiber battery

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Science Bulletin 2024年第18期69卷 2811-2813页

作者： linli Gan Mengdie Lei Guangming Cai Weilin Xu State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

Batteries have experienced rapid development due to their outstanding energy storage performance and widespread *** progress has driven advancements in electric vehicles,energy storage systems,and portable electronic devices,while also increasing demand for lightweight designs,high energy density,and environmental sustainability[1].However,traditional rigid batteries face significant challenges related to mechanical flexibility,safety,and environmental impact,making them unsuitable for the unique requirements of these emerging applications[2].Consequently,flexible fiber batteries have emerged,leveraging innovations in materials and structural design to offer energy solutions capable of bending,stretching,and adapting to various complex *** batteries hold great potential in applications such as wearable devices[3],flexible electronics[4],smart textiles[5,6],and biomedical devices[7].Traditional lithium-ion batteries are widely used due to their high energy density and long cycle life.

关键词： battery performance fiber

Research on the Path of Cultivating High-Level Technical and Skilled Talents in Vocational Undergraduate Colleges and Universities

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Journal of Contemporary Educational Research 2024年第7期8卷 150-157页

作者： Kan Su Seong Pek Lim linli Yao Faculty of Education and Social Sciences Universiti Selangor40000 Shah AlamSelangorMalaysia School of Communication Chengdu Vocational University of The ArtsChengdu 610000Sichuan ProvinceChina

This paper explores strategies to cultivate high-level technical talents in vocational undergraduate colleges by analyzing their development,the essence of such talents,and proposing several key *** include optimizing professional settings and curricula,enhancing school-enterprise cooperation and the integration of industry-university-research,improving teaching staff quality and educational standards,and expanding international *** importance of policy support and funding and establishing robust quality assurance systems is emphasized for effectively cultivating skilled talents in vocational undergraduate colleges.

关键词： Vocational undergraduate colleges High-level technical talents Professional setting Innovation and entrepreneurship education

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权益极端尾部风险、杠杆率与公司债信用利差

中国管理科学 2024年第5期32卷 47-60页

作者：谢林利凌爱凡华东交通大学经济管理学院江西南昌330013 上海外国语大学国际金融贸易学院上海201620

论文从公司权益极端尾部风险的角度讨论了近年来中国公司债信用利差持续高位的原因。基于Merton违约模型,建立了公司权益极端尾部风险与公司债信用利差的理论联系,公司权益极端尾部风险通过杠杆率渠道,对公司信用利差产生正面影响。基... 详细信息

论文从公司权益极端尾部风险的角度讨论了近年来中国公司债信用利差持续高位的原因。基于Merton违约模型,建立了公司权益极端尾部风险与公司债信用利差的理论联系,公司权益极端尾部风险通过杠杆率渠道,对公司信用利差产生正面影响。基于中国A股市场2009-2020年的827只公司债和匹配股票样本数据,论文发现与理论预期一致,权益极端尾部风险越高的公司,其发行公司债的信用利差也越高。进一步实证发现,权益极端尾部风险对信用利差的影响,随着公司信用评级或长期负债占比升高而逐渐减弱,随着市场行情变坏而逐渐变强。机制分析发现,公司杠杆率是权益极端尾部风险对信用利差产生影响的重要渠道,因为权益极端尾部风险上升,会增加公司的负债杠杆率,从而提高公司违约风险和信用利差。论文研究是对中国公司债信用利差持续高位原因的新解释,同时有助于人们理解“信用利差之谜”产生的原因。

关键词：极端尾部风险信用利差违约模型异质波动率

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Epidemiological analysis of the clinicopathologic characteristics,treatment,and prognosis of 2648 jaw cysts in West China

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Chinese Medical Journal 2024年第9期137卷 1124-1126页

作者： Hui Li Zuoqiang Liu linli Jiang Jiangyu Liang Lei Liu Department of Oral and Maxillofacial Surgery State Key Laboratory of Oral Disease&National Center for Stomatology&National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China Department of Biomaterials Sciences and Prosthodontics School of DentistryUniversity of MichiganAnn ArborMIUnited States

To the Editor:The jaw cyst is one of the most common benign tumors in the oral and maxillofacial region.[1]To date,several studies have reported on jaw cysts in general populations from Italy,Brazil,Greece,and the United States in accordance with the 4th World Health Organization(WHO)classication of head and neck tumors.[2]However,there are no clinicopathological studies of odontogenic and non-odontogenic cysts in a large Chinese population in relation to the latest WHO classi***,few epidemiological studies have analyzed treatment plans and the possible postoperative complications of jaw ***,this study aimed to perform a detailed and extended epidemiological analysis of jaw cysts in a large population in West China.

关键词： clinic treatment pathologic

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股东个人信用量化及其适用

首都师范大学学报(社会科学版) 2024年第4期 93-100页

作者：陈群峰王林丽中央民族大学法学院中央民族大学文化与人权研究中心

公司的信用基础处若仅以财产作为支撑要素,公司的作用就难以得到充分发挥。股东个人信用兼具人格和财产双重属性,现有关于信用的解释限缩了信用本身的内涵,从而导致对股东个人信用价值的忽视。股东个人信用权益商业化是信用时代发展的... 详细信息

公司的信用基础处若仅以财产作为支撑要素,公司的作用就难以得到充分发挥。股东个人信用兼具人格和财产双重属性,现有关于信用的解释限缩了信用本身的内涵,从而导致对股东个人信用价值的忽视。股东个人信用权益商业化是信用时代发展的必然趋势,征信机构将股东个人信用信息化,使得股东的偿债能力和偿债意愿可评估。为了防范股东认而不缴,可增设股东认缴前附加征信平台担保义务制度,或者基于股东个人信用分值,来确定其认缴的资本数额。

关键词：信用股东人格信用个人信用信息认缴资本制度

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纸基食品包装材料的制备及其性能研究

食品科技 2024年第3期49卷 41-47页

作者：葛林丽张钦发华南农业大学食品学院广东广州510642

随着对绿色环保包装的要求,纸基材料在食品包装中的应用越来越多,但纸基材料存在阻气性、防水性差等缺陷,极大限制了其在食品直接包装领域的使用。文章以苯丙乳液为基体,微晶纤维素(Microcrystalline cellulose,MCC)和纳米微晶纤维素(Na... 详细信息

随着对绿色环保包装的要求,纸基材料在食品包装中的应用越来越多,但纸基材料存在阻气性、防水性差等缺陷,极大限制了其在食品直接包装领域的使用。文章以苯丙乳液为基体,微晶纤维素(Microcrystalline cellulose,MCC)和纳米微晶纤维素(Nanocrystalline cellulose,NCC)为增强材料制备复合涂料,将其涂布于牛皮纸上,探讨了复合涂料中MCC和NCC添加量对涂料黏度、涂布纸张氧气和水蒸气阻隔性以及吸水性能的影响。结果表明,随着MCC和NCC的添加比例的增加,涂料黏度均先下降后上升,而涂布纸氧气阻隔性均是先上升后下降,吸水性先下降后上升;对水蒸气的阻隔性是随着MCC添加比例的增加先上升后下降,而随着NCC的增加却呈逐渐下降趋势。当MCC和NCC添加比例分别为5%和1%时,氧气透过量最低分别为1623.45 cm^(3)/(m^(2)·d)和1309.50 cm^(3)/(m^(2)·d),纸张表面吸水量(Cobb值)达到最低分别为1.16 g/m^(2)和1.60 g/m^(2),添加MCC时涂布纸的水蒸气透过量达到最低为450.23 g/(m^(2)·d)。研究结果表明,MCC和NCC可以有效提高复合涂料的黏度,改变涂布纸的阻气性和阻水性,NCC比MCC影响更明显。

关键词：食品包装纸基材料苯丙乳液纤维素阻隔性

高校教师评价制度改革的模式分化与内在逻辑——基于组织视角的分析

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教育发展研究 2024年第9期44卷 21-28页

作者：戴粦利陈先哲华南师范大学中国特色现代大学治理研究中心华南师范大学教育科学学院广州510631

从组织视角出发,基于“激励-约束”的理论分析框架,对国内27所本科高校开展调研,分析我国高校教师评价制度改革的模式分化及内在逻辑。研究发现:所调研的一流大学建设高校主要形成了“强激励-强约束”的身份约束模式,一流学科建设高校... 详细信息

从组织视角出发,基于“激励-约束”的理论分析框架,对国内27所本科高校开展调研,分析我国高校教师评价制度改革的模式分化及内在逻辑。研究发现:所调研的一流大学建设高校主要形成了“强激励-强约束”的身份约束模式,一流学科建设高校主要形成了“强激励-弱约束”的物质约束模式,应用型本科高校主要形成了“弱激励-弱约束”的底线约束模式,个别高水平理工科院校形成了间接“激励-约束”的责任发包模式。高校教师评价制度改革的模式分化主要基于不同类型高校的资源条件、目标定位、历史传统、决策者认知等内部结构性因素,未来应更加重视这些组织内部因素的分析并寻求“激励-约束”的平衡,进一步丰富教育评价改革的实践探索。

关键词：高校教师评价制度模式分化内在逻辑 “激励-约束”