检索结果-南通市图书馆

基于网络药理学探讨桑杜防治家禽传染性法氏囊病的作用机制

在线全文

学校读者我要写书评

暂无评论

中国畜牧兽医 2024年第1期51卷 392-406页

作者：荣巧刘进德程永婷王一楠龚柳菲李琳孙菲菲安徽农业大学动物科技学院合肥230036

【目的】本研究运用网络药理学、分子对接和分子动力学模拟方法研究桑叶和杜仲防治传染性法氏囊病(IBD)的作用机制,旨在为防治免疫抑制和传染性法氏囊病的新兽药研发提供思路。【方法】通过中药系统药理学数据库与分析平台(TCMSP)和Swis... 详细信息

【目的】本研究运用网络药理学、分子对接和分子动力学模拟方法研究桑叶和杜仲防治传染性法氏囊病(IBD)的作用机制,旨在为防治免疫抑制和传染性法氏囊病的新兽药研发提供思路。【方法】通过中药系统药理学数据库与分析平台(TCMSP)和SwissTargetPrediction数据库收集桑叶和杜仲的活性成分和靶点,利用GeneCards和GEO数据库获得传染性法氏囊病相关靶点。基于Cytoscape 3.7.2软件构建活性成分-靶点网络图。将药物靶点与疾病靶点取交集后得到共同靶点,基于STRING数据库和Cytoscape 3.7.2软件构建蛋白相互作用(PPI)网络图。使用DAVID数据库对交集靶点进行GO功能和KEGG通路富集分析。利用AutoDock 1.5.6和PyMOL软件进行分子对接,使用Gromacs 2020.6软件进行分子动力学模拟。【结果】筛选得到桑叶和杜仲53个有效活性成分,423个潜在作用靶点,5 949个传染性法氏囊病相关靶点,153个交集靶点。PPI显示,关键靶点主要包括白介素-6(IL6)、连环蛋白-β1(CTNNB1)、原癌基因酪氨酸-蛋白激酶(SRC)、IL1B、血管内皮生长因子(VEGFA)等。GO功能和KEGG信号通路富集分析结果显示,桑叶和杜仲可通过对IL18的反应、干扰素-γ(IFN-γ)受体结合、钙信号通路、神经活性配体-受体相互作用等发挥防治传染性法氏囊病的作用。分子对接和分子动力学模拟结果均表明关键活性成分和关键靶点之间具有良好的亲和力,结合稳定。【结论】桑叶和杜仲可能通过槲皮素、去氢双丁香酚、二十碳-11,14,17-三烯酸甲酯、山柰酚、β-谷甾醇等重要活性成分作用于IL6、CTNNB1、SRC、IL1B、VEGFA等关键靶点,通过对IL18的反应、钙信号通路、神经活性配体-受体相互作用等途径发挥对鸡传染性法氏囊病的防治作用。

关键词：桑叶杜仲传染性法氏囊病网络药理学分子对接分子动力学模拟

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

人工智能在炎症性肠病中的应用进展

胃肠病学和肝病学杂志 2024年第10期33卷 1377-1381页

作者：吴朴仙王红霞林婧任鹏程王祥兰州大学第二临床医学院甘肃兰州730030 兰州大学第二医院消化科

炎症性肠病(inflammatory bowel disease,IBD)是一种具有复杂性和异质性的疾病,以慢性复发和缓解的肠道炎症为特征,目前发病机理尚不明确,临床缺乏特异性的标志物,其精准化诊疗是临床的一大挑战。人工智能(artificial intelligence,AI)... 详细信息

炎症性肠病(inflammatory bowel disease,IBD)是一种具有复杂性和异质性的疾病,以慢性复发和缓解的肠道炎症为特征,目前发病机理尚不明确,临床缺乏特异性的标志物,其精准化诊疗是临床的一大挑战。人工智能(artificial intelligence,AI)具有强大的数据识别和分析能力,结合当前医疗大数据的发展,AI在提高IBD诊断准确性,识别风险个体,评估疾病严重程度,预测治疗反应以及评估预后等方面的应用广泛开展,有巨大的潜力促进IBD精准医疗的发展。本文就AI在IBD诊疗中的应用进展作一综述。

关键词：炎症性肠病人工智能机器学习精准诊疗

The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第12期18卷 2648-2659页

作者： Heng lin Lu Feng Kai-Sa Cui lin-Wen Zeng Deng Gao Long-xiang Zhang Wen-Hua Xu Yu-Hao Sun Hong-Bing Shu Shu Li Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityMedical Research InstituteFrontier Science Center for Immunology and MetabolismResearch Unit of Innate Immune and Inflammatory DiseasesChinese Academy of Medical SciencesWuhan UniversityWuhan430071China Wuxi Cancer Institute Affiliated Hospital of Jiangnan UniversityWuxi214062JiangsuChina

The IL-6-STAT3 axis is critically involved in inflammation-associated carcinogenesis(IAC).How this axis is regulated to modulate IAC remains ***,we show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates STAT3 activation triggered by IL-6,as well as another IL-6 subfamily member,Oncostatin M(OSM).MARCH3 is associated with the IL-6 receptorα-chain(IL-6Rα)and its coreceptor *** experiments indicated that MARCH3 mediates the polyubiquitination of IL-6Rαat K401 and gp130 at K849 following IL-6 stimulation,leading to their translocation to and degradation in ***3 deficiency increases IL-6-and OSM-triggered activation of STAT3 and induction of downstream effector genes in various cell ***3 deficiency enhances dextran sulfate sodium(DSS)-induced STAT3 activation,increases the expression of inflammatory cytokines,and exacerbates colitis,as well as azoxymethane(AOM)/DSS-induced colitis-associated cancer in *** addition,MARCH3 is downregulated in human colorectal cancer tissues and associated with poor survival across different cancer *** findings suggest that MARCH3 is a pivotal negative regulator of IL-6-induced STAT3 activation,inflammation,and inflammation-associated carcinogenesis.

关键词： MARCH3 IL-6 IL-6Ra colitis-associated carcinogenesis polyubiquitination

Initial 12-h Operative Fluid Volume is an Independent Risk Factor for Pleural Effusion after Hepatectomy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 859-864页

作者： xiang cheng Jia-wei WU Ping SUN Zi-fang SONG Qi-chang ZHENG Department of Hepatobiliary Surgery Union Hospital Tongji Medical College Huazhong University of Seienee and Technology Wuhan 430022 China

Pleural effusion after hepatectomy is associated with significant morbidity and prolonged hospital *** studies have addressed the risk factors for postoperative pleural ***,there are no researches concerning the role of the initial 12-h operative fluid *** aim of this study was to evaluate whether the initial 12-h operative fluid volume during liver resection is an independent risk factor for pleural effusion after *** this study,we retrospectively analyzed clinical data of 470 patients consecutively undergoing elective hepatectomy between January 2011 and December *** prospectively collected and retrospectively analyzed baseline and clinical data,including preoperative,intraoperative,and postoperative *** and multivariate analyses were carried out to identify whether the initial 12-h operative fluid volume was an independent risk factor for pleural effusion after *** multivariate analysis identified 2 independent risk factors for pleural effusion：operative time [odds ratio（OR）=10.2] and initial 12-h operative fluid volume（OR=1.0003）.Threshold effect analyses revealed that the initial 12 h operative fluid volume was positively correlated with the incidence of pleural effusion when the initial 12-h operative fluid volume exceeded 4636 m *** conclude that the initial 12-h operative fluid volume during liver resection and operative time are independent risk factors for pleural effusion after *** intravenous fluids should be restricted properly.

关键词： hepatectomy pleural effusion

教育数字化转型背景下包装设计课程教学改革探究——基于OBE+BOPPPS线上线下教学模式

在线全文

学校读者我要写书评

暂无评论

绿色包装 2024年第5期 37-40页

作者：陆培培林洁陈欢马鹏程广西民族大学相思湖学院广西南宁530031 桂林电子科技大学数学与计算科学学院/广西应用数学中心广西桂林541002

教育数字化转型背景下,数字技术加强课程教学设计是推进教学数字化转型发展的重要技术手段之一。本文选取视觉传达设计专业包装设计课程进行教学改革,采用OBE+BOPPPS线上线下混合教学模式,结合学习通平台,以学生为主体,以项目为驱动,搭... 详细信息

教育数字化转型背景下,数字技术加强课程教学设计是推进教学数字化转型发展的重要技术手段之一。本文选取视觉传达设计专业包装设计课程进行教学改革,采用OBE+BOPPPS线上线下混合教学模式,结合学习通平台,以学生为主体,以项目为驱动,搭建包装设计线上线下混合教学。通过借鉴BOPPPS模型,从导入、目标、前测、参与式学习、后测和总结六个环节进行探索。实践证明,OBE+BOPPPS线上线下混合教学模式使学生课程学习目标更清晰、明确,对学习产生浓厚的兴趣与动力,专业能力与职业素养也得到了提高。此模式可促进包装设计课程教学改革发展。

关键词：数字化转型包装设计课程 OBE+BOPPPS 线上线下教学模式

和枢消积丸对H22荷瘤小鼠的抑瘤作用及肿瘤组织VEGF、PDGF蛋白的影响

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中西医结合肝病杂志 2024年第4期34卷 336-340页

作者：陈相霖汪静朱晓宁张玉蓉彭昭宣西南医科大学中西医结合学院四川泸州646000 西南医科大学附属中医医院肝胆病科

目的:探讨和枢消积丸对H22荷瘤小鼠的抑瘤作用和肿瘤血管生成相关因子表达的影响,探索中西医联合有效抗肝细胞癌治疗方案。方法:将H22荷瘤小鼠随机分成空白组、模型组、中药低剂量组(1.37 g/kg和枢消积丸)、中药中剂量组(2.73 g/kg和枢... 详细信息

目的:探讨和枢消积丸对H22荷瘤小鼠的抑瘤作用和肿瘤血管生成相关因子表达的影响,探索中西医联合有效抗肝细胞癌治疗方案。方法:将H22荷瘤小鼠随机分成空白组、模型组、中药低剂量组(1.37 g/kg和枢消积丸)、中药中剂量组(2.73 g/kg和枢消积丸)、中药高剂量组(5.46 g/kg和枢消积丸)、索拉非尼组(0.03 g/kg)和联合组(5.46 g/kg和枢消积丸联合0.03 g/kg索拉非尼),干预14 d。观察各组小鼠生命活动,测量瘤体长短径和体重,灌胃结束后计算肿瘤体积和抑瘤率;检测小鼠肝功能指标AST、ALT;采用HE染色观察肿瘤组织结构和细胞形态;免疫组化及Western Blotting实验检测各组小鼠肿瘤组织中血管内皮生长因子(VEGF)和血小板衍生生长因子(PDGF)蛋白表达水平。结果:和枢消积丸对小鼠体重无明显影响,但可改善H22荷瘤小鼠的精神、活动状态,以及索拉非尼所致腹泻症状;与模型组比,各治疗组荷瘤小鼠皮下肿瘤的体积和质量均降低,联合组抑瘤率达74.8%,效果最明显(P<0.05);和枢消积丸可下调小鼠血清AST、ALT水平,改善肝脏功能(P<0.01);HE染色显示各治疗组小鼠肿瘤组织内部结构紊乱,与和枢消积丸的剂量呈正相关,联合组效果最明显;免疫组化和Western Blotting实验发现,各治疗组小鼠肿瘤组织VEGF、PDGF蛋白表达水平均下降(P<0.01),和枢消积丸联合索拉非尼对VEGF、PDGF的抑制作用比单独使用索拉非尼或和枢消积丸更显著。结论:和枢消积丸可下调肿瘤生成相关因子VEGF和PDGF蛋白表达,对H22荷瘤小鼠具有抑瘤作用,联合索拉非尼的中西医结合治疗最显著。

关键词：和枢消积丸肝细胞癌索拉非尼血管内皮生长因子血小板衍生生长因子

Enhancement of photoacoustic tomography in the tissue with speed-of-sound variance using ultrasound computed tomography

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2015年第11期24卷 63-69页

作者：程任翔陶超刘晓峻 Key Laboratory of Modern Acoustics of Ministry of Education Department of Physics Nanjing University

The speed-of-sound variance will decrease the imaging quality of photoacoustic tomography in acoustically inhomo- geneous tissue. In this study, ultrasound computed tomography is combined with photoacoustic tomography to enhance the photoacoustic tomography in this situation. The speed-of-sound information is recovered by ultrasound computed to- mography. Then, an improved delay-and-sum method is used to reconstruct the image from the photoacoustic signals. The simulation results validate that the proposed method can obtain a better photoacoustic tomography than the conventional method when the speed-of-sound variance is increased. In addition, the influences of the speed-of-sound variance and the fan-angle on the image quality are quantitatively explored to optimize the image scheme. The proposed method has a good performance even when the speed-of-sound variance reaches 14.2%. Furthermore, an optimized fan angle is revealed, which can keep the good image quality with a low cost of hardware. This study has a potential value in extending the biomedical application of photoacoustic tomography.

关键词： photoacoustic tomography speed of sound ultrasound computed tomography

Tuning the electron transport behavior at Li/LATP interface for enhanced cyclability of solid-state Li batteries

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第1期16卷 1634-1641页

作者： linshan Luo Feng Zheng Haowen Gao Chaofei Lan Zhefei Sun Wei Huang xiang Han Ziqi Zhang Pengfei Su Peng Wang Shengshi Guo Guangyang lin Jianfang Xu Jianyuan Wang Jun Li cheng Li Qiaobao Zhang Shunqing Wu Ming-Sheng Wang Songyan Chen Department of Physics Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient DevicesKey Laboratory of Low Dimensional Condensed Matter Physics(Department of Education of Fujian Province)Jiujiang Research InstituteXiamen UniversityXiamen 361005China State Key Lab of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China Western Digital Corporation 951 Sandisk DrMilpitasCA 95035USA

An interlayer is usually employed to tackle the interfacial instability issue between solid electrolytes(SEs)and Li metal caused by the side ***,the failure mechanism of the ionic conductor interlayers,especially the influence from electron penetration,remains largely ***,using Li1.3Al0.3Ti1.7(PO4)3(LATP)as the model SE and LiF as the interlayer,we use metal semiconductor contact barrier theory to reveal the failure origin of Li/LiF@LATP interface based on the calculation results of density functional theory(DFT),in which electrons can easily tunnel through the LiF grain boundary with F vacancies due to its narrow barrier width against electron injection,followed by the reduction of ***,an Al-LiF bilayer between Li/LATP is found to dramatically promote the interfacial stability,due to the highly increased barrier width and homogenized electric field at the ***,the Li symmetric cells with Al-LiF bilayer can exhibit excellent cyclability of more than 2,000 h superior to that interlayered by LiF monolayer(~860 h).Moreover,the Li/Al-LiF@LATP/LiFePO4 solid-state batteries deliver a capacity retention of 83.2%after 350 cycles at 0.5 *** findings emphasize the importance of tuning the electron transport behavior by optimizing the potential barrier for the interface design in high-performance solid-state batteries.

关键词： solid-state electrolyte Li metal LiF Al electron transport interfacial barrier

Natamycin in the treatment of fungal keratitis : a systematic review and Meta-analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2015年第3期8卷 597-602页

作者： Sheng Qiu Gui-Qiu Zhao Jing lin Xue Wang Li-Ting Hu Zhao-Dong Du Qian Wang cheng-cheng Zhu Department of Ophthalmology Medical College Qingdao University Department of Ophthalmology the Affiliated Hospital of Qingdao University

AIM: To review published clinical studies examining the effect of natamycin in the treatment of fungal ***: We selected the publications in CENTRAL,MEDlinE, EMBASE, CNKI, and CBM. This study systematically reviewed published randomized controlled trials(RCTs) that compared natamycin to other antifungal agents, and conducted feasible Meta-analysis of efficacy results using Revman 5.2 ***: We included seven trials which were mainly carried out in developing countries of Asia, with five trials conducted in India, one each in China and Bangladesh. A total of 804 participants were randomized to following comparisons: 2% econazole versus 5%natamycin showed little difference in the effects of treatment of fungal keratitis [RR =0.99, 95% confidence interval(CI), 0.8 to 1.21]; chlorhexidine gluconate versus5% natamycin indicated that the results on healing of the ulcer at 21 d was less conclusive(RR=0.77, 95% CI, 0.55 to 1.08; I2=0%); 1% voriconazole versus 5% natamycin suggested that natamycin treatment appeared to be significantly better outcomes than voriconazole(regression coefficient =-0.18 log MAR; 95% CI,-0.30 to-0.05; P =0.006), especially in Fusarium cases(regression coefficient=-0.41 log MAR; 95% CI,-0.61 to-0.20; P <0.001);natamycin versus fluconazole showed a significant difference in cure rate(χ2=5.048, P <0.05) and natamycin group was more effective than fluconazole in average period of therapy(t =7.94, P <0.01).CONCLUSION: Natamycin was a preferable choice in the treatment of fungal keratitis, especially in the early period of Fusarium cases.

关键词： eye infection fungal natamycin Metaanalysis