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Effects of Deformation on Bainite Transformation During Continuous Cooling of Low Carbon Steels

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Journal of Iron and Steel Research International 2006年第2期13卷 37-39页

作者： DU lin-xiu yi Hai-long DING Hua LIU Xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Hot deformation experiments were carried out on Gleeble 1500 thermo-mechanical simulator. The bainite transformation after deformation was investigated by optical microstructure analysis. The results indicated that the deformation accelerated the bainite transformation when the deformation was carried out at high temperature and no or little ferrite was precipitated before bainite transformation; when the deformation was carried out at low temperature, the deformation hindered the bainite transformation because a lot of ferrite precipitated before bainite transformation.

关键词： deformation bainite continuous cooling low carbon steel

Study on the Application of iTRAQ Technology in Retinal Apoptosis Protein in Diabetic Retinopathy Mice

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Chinese Journal of Biomedical Engineering(English Edition) 2023年第4期32卷 161-169,184页

作者： QUE Li-dan lin yi-long QUE Xiu-ping LIU Bin longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian 364000China Quanzhou Maternal and Child Health Hospital Children's Hospital Quanzhou Fujian 362000China

Objective:Using isobaric tags for relative and absolute quantitation(i TRAQ)technology to study differential protein expression in the retinal tissue of DR mouse models,providing proteomic evidence at the protein level for the pathogenesis of ***:Firstly,establish diabetic mice and DR mice models,use i TRAQ technology to detect the retinal tissue samples of normal control group and DR model group mice,label the total retinal proteins of mice with i TRAQ reagent,and analyze them using mass spectrometry *** the differential proteins of the two groups using BioWorks TM 3.0 software,and conduct interaction feature analysis on the different proteins using the STRING ***:The i TRAQ technology detected a total of 406 different proteins between the diabetes and normal control groups,with 19 of them closely related to retinal cell *** them,significantly different proteins include acyl-CoA dehydrogenase short chain specific(ACADS),ataxin-10(ATXN10),BCL-2-associated X protein(BAX),caspase-3(CASP3),collagen type IIα1 chain(COL4A2),glycyl-tRNA synthetase(GARS),glial fibrillary acidic protein(GFAP),legumain(LGMN),mucin-4(MUC4),N-myc downstream-regulated gene 1 protein(NDRG1),with ratios to internal controls in the normal group of 1.67,2.06,1.76,2.16,1.53,1.87,1.24,1.61,0.42,0.56,respectively;and there is a potential functional association between GFAP,CASP3,and BAX ***:In DR mice retinas,there are abnormal changes in the expression of a large number of apoptosis-related proteins.i TRAQ technology can effectively screen out key apoptosis proteins,among which GFAP,CASP3,and BAX may have adverse effects on the progression of DR by participating in the apoptosis *** application of i TRAQ technology can provide new technical support for proteomic research on apoptosis proteins.

关键词： diabetes retinopathy retinal apoptosis protein relative and absolute quantitation(iTRAQ)technology mice

Improvement of MDA and SOD Expression and Optic Neuroprotection in Glaucoma Mice by Travoprost and β-Blocker

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Chinese Journal of Biomedical Engineering(English Edition) 2023年第2期32卷 73-78页

作者： LIU Hai-hua lin yi-long ZHONG Jun-mu LIU Jian-qiang longyan First Affiliated Hospital of Fujian Medical University Fujian Longyan 364000China

Objective:The goal of this study was to see if travoprost and β-blockers improved MDA and SOD expression as well as neuroprotection in glaucoma ***:One hundred healthy SPF SD rats were randomly allocated into five groups:travoprost and β-blocker group,travoprost group,β-blocker group,model group and blank group,with 20 rats in each *** created a glaucoma mouse model in which the blank group and the model group received the same volume of saline,the β-blocker group received β-blocker,the travoprost group received travoprost,and the travo Prost and β-blocker groups received travo Prost and βreceptor *** cell apoptosis level,intraocular pressure level,MDA and SOD levels were measured after drug ***:The results showed that the levels of intraocular pressure,the apoptosis rate of optic nerve,SOD and MDA of retina in travoprost and β-blocker group,travoprost group,β-blocker group and model group were greater than those in blank group(P<0.05).In comparison to the model group,the intraocular pressure level,optic nerve apoptosis rate,and retinal MDA level in the travoprost and β-blocker group continued to fall,while the retinal SOD level was considerably elevated(P<0.05).The continuous application of travoprost and β-blocker resulted in a constant drop in intraocular pressure,optic nerve apoptosis rate and MDA level in the retina,whereas the SOD level was dramatically elevated(P<0.05).Conclusion:In glaucoma mice,travoprost in combination with a β-blocker can greatly increase MDA expression,SOD and neuroprotection.

关键词： travoprost β-blocker glaucoma optic nerve protection

Correlation of Variables between the Dominant and Non-dominant Eyes in Healthy Young People

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Chinese Journal of Biomedical Engineering(English Edition) 2022年第3期31卷 120-128页

作者： lin yi-long ZHANG Kai-ping LIU Hai-hua ZHONG Jun-mu LIU Jian-qiang Department of Ophthalmology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan Fujian 364000China

Objective:To investigate the correlation of variables between dominant and non-dominant eyes in healthy young ***:300 cases(600 eyes)of healthy young volunteers recruited in our hospital from March 2020 to February 2022were selected as the research *** general data of the volunteers were collected and the dominant eye,diopter,biological parameters and retinal blood flow density were *** compared all the test indexes of volunteers with different dominant eyes,and compared the refractive parameters,biological parameters and retinal blood flow density between the dominant and non-dominant eyes of ***:Among the 300volunteers,62.67%(188/300)had the right eye as the dominant eye and 37.33%(112/300)had the left eye as the dominant *** was no significant difference in gender,BMI and equivalent spherical lens(SE)among the subjects with different dominant eyes(P>0.05).The SE and spherical diopter(S)of dominant eye were higher than that of non-dominant eye(P0.05);There was no significant difference in SE and C between dominant and non-dominant eye in volunteers with SE difference≤0.5 D and 0.51-1.25 D(P>0.05),and spherical diopter(S)of dominant eye was higher than that of non-dominant eye(P2.00 D,the SE and spherical diopter(S)of dominant eye were higher than those of non-dominant eye(P0.05).The levels of RA and CA in the dominant eye of 300 volunteers were lower than those in the non-dominant *** RA and CA levels of the dominant eye were lower than those of the non-dominant eye in volunteers with RA difference≤0.50 D,0.51-1.25 D,1.26-2.00 D,>2.00 D(P<0.05).There was no significant difference in the levels of axial length(AL),central corneal thickness(CCT),anterior chamber depth(ACD)and lens thickn

关键词： young people dominant eye ametropia biological parameters retinal blood flow density

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing long Pengcheng yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Numerical Study of Flow and Heat Transfer Characteristics of Shell-and-Tube Molten Salt Electric Heater with Circularly Perforated Baffles

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Journal of Thermal Science 2025年第1期34卷 24-33页

作者： lin Yongjie ZHANG Cancan WU Yuting ZHANG yi LU Yuanwei Key Laboratory of Heat Transfer and Energy Conversion National User-Side Energy Storage Innovation Research and Development CenterBeijing University of Technology

Numerical simulations of the flow and heat transfer characteristics of four shell-and-tube molten salt electric heaters with different perforation rates was ***-and-tube electric heaters have the same geometry and tube arrangement,and all of them use single segmental baffles,but there exist four different baffle openings（φ）,i.e.,0%,2.52%,4.06%,and 6.31%.The results indicated that the reasonable baffle opening could significantly reduce the shell-side pressure drop,effectively decreasing the shell-side flow dead zone *** can eliminate the local high-temperature phenomenon on the surface of electric heating tubes,but the heat transfer coefficient is slightly *** perforated schemes significantly reduce shell-side pressure drop compared to the baseline solution without open *** particular,the φ=6.31% scheme exhibits the optimal performance among all the schemes,with a maximum reduction of up to 50.50% in shell-side pressure drop relative to the unopened holes *** heat transfer coefficient is the highest for φ=0%,exhibiting a range of5.26% to 5.73%,5.14% to 5.99%,and 7.31% to 8.54% higher than φ=2.52%,4.06%,and 6.31%,respectively,within the calculated *** composite index h/（Δp）1/3was higher for all open-hole solutions than that for the unopened-hole *** best overall performance was for φ=6.31%,which improved the composite index by15.29% to 17.18% over the unopened-hole solution.

关键词： molten salt electric heater perforated baffles heat transfer

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： yi Qi Xueying Chen Bowen Liu Xuliang lin Xueqing Qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

23G微创玻切联合康柏西普眼内注射治疗增殖性糖尿病视网膜病变的临床分析

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赣南医学院学报 2018年第5期38卷 453-455,471页

作者：林毅龙福建医科大学附属龙岩第一医院眼科福建龙岩364000

目的:研究增殖性糖尿病视网膜病变(PDR)应用23G微创玻切联合康柏西普眼内注射治疗的效果。方法:68例增殖性糖尿病视网膜病变患者根据随机数字表分为2组。对照组采用常规23G微创玻切治疗,观察组应用23G微创玻切联合康柏西普眼内注射治疗... 详细信息

目的:研究增殖性糖尿病视网膜病变(PDR)应用23G微创玻切联合康柏西普眼内注射治疗的效果。方法:68例增殖性糖尿病视网膜病变患者根据随机数字表分为2组。对照组采用常规23G微创玻切治疗,观察组应用23G微创玻切联合康柏西普眼内注射治疗。比较两组患者手术实施时间、眼底视网膜新生血管、黄斑水肿消失时间和增殖性糖尿病视网膜病变治疗总有效率、术中出血发生率、术后出血发生率、医源性裂孔发生率,同时比较治疗前后黄斑厚度、最佳矫正视力水平。结果:观察组增殖性糖尿病视网膜病变治疗总有效率明显高于对照组(P<0.05)。观察组术中出血发生率、术后出血发生率、医源性裂孔发生率明显低于对照组(P<0.05)。观察组患者手术实施时间、眼底视网膜新生血管、黄斑水肿消失时间均明显优于对照组(P<0.05)。治疗之前两组患者黄斑厚度、最佳矫正视力水平之间无统计学意义(P<0.05);治疗之后观察组黄斑厚度、最佳矫正视力水平显著优于对照组(P<0.05)。结论:增殖性糖尿病视网膜病变应用23G微创玻切联合康柏西普眼内注射治疗的效果确切,可有效促进眼底视网膜新生血管、水肿消失,改善视力,降低黄斑厚度,缩短疗程。

关键词：增殖性糖尿病视网膜病变 23G微创玻切康柏西普注射眼内

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离心式喷嘴雾化效果的优化研究

装备制造技术 2018年第7期 80-83,96页

作者：林逸龙杭州电子科技大学机械工程学院浙江杭州310018

本文通过数值模拟与实验相结合的方法,对切向槽式离心喷嘴的雾化特性(雾化颗粒尺寸和雾化锥角)进行了研究,按照喷口孔径和切向槽槽宽两个几何参数一共设计了9种喷嘴。综合以上两个几何参数对实际运用的影响作用判断,选择一个最优参数的... 详细信息

本文通过数值模拟与实验相结合的方法,对切向槽式离心喷嘴的雾化特性(雾化颗粒尺寸和雾化锥角)进行了研究,按照喷口孔径和切向槽槽宽两个几何参数一共设计了9种喷嘴。综合以上两个几何参数对实际运用的影响作用判断,选择一个最优参数的喷嘴。

关键词：离心式喷嘴数值模拟孔径切向槽槽宽