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关于ILAE/AES联合报告“重新审视耐药性癫痫概念”的解读

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中风与神经疾病杂志 2024年第6期41卷 486-492,F0002页

作者：张涵瑜林卫红吉林大学第一医院神经内科癫痫中心吉林长春130021

尽管新型抗癫痫药物(ASMs)不断涌现,目前已经发展到第三代,但仍有1/3癫痫患者可发展为耐药性癫痫(DRE)。早在2010年,国际抗癫痫联盟(ILAE)就提出了DRE概念并沿用至今,及早诊断DRE,有助于对ASMs无反应的个体进行术前评估,并从癫痫外科手... 详细信息

尽管新型抗癫痫药物(ASMs)不断涌现,目前已经发展到第三代,但仍有1/3癫痫患者可发展为耐药性癫痫(DRE)。早在2010年,国际抗癫痫联盟(ILAE)就提出了DRE概念并沿用至今,及早诊断DRE,有助于对ASMs无反应的个体进行术前评估,并从癫痫外科手术中受益。由于DRE的发病率仍然很高以及概念一直没有更新,故在2023年8月ILAE/美国癫痫协会(AES)联合工作组从协调临床前和临床研究角度出发,在整个生命周期和跨物种基础上讨论了DRE表现和机制的异质性、复杂性及动态变化。联合工作组建议有必要重新审视DRE的当前定义,以更好地服务DRE临床管理以及指引DRE未来研究方向,为患者筛选更有效、更精准的个体化治疗,以减少DRE发病率,提高患者生活质量。本文旨在就ILAE/AES此份报告做一简要介绍和解读。

关键词：耐药性癫痫发病机制动物模型治疗

维普期刊数据库博看期刊

A novel hyperbranched aromatic polyamide containing bithiazole: Synthesis,metal complexation and magnetic properties

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Science China Chemistry 2011年第2期54卷 320-325页

作者： DING NengWen lin weihong SUN Weilin SHEN ZhiQuan Key Laboratory of Macromolecule Synthesis and Functionalization Ministry of EducationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Based on the polycondensation of bifunctional 2,2′-diamino-4,4′-bithiazole(DABT) and trifunctional 1,3,5-benzenetricarbonyl trichloride (BTC),a novel hyperbranched aromatic polyamide PBD was synthesized with excellent solubility and good thermal *** structure of the polymer was confirmed by FT-IR and 1H NMR *** calculated degree of branching of our product was 52%.By exploring the influence of several different solvent systems,the yield of the polymer increased in the solvent system of DMAc/*** kinds of metal complexes were obtained by chelation of the polyamide with Cu2+ and Ni2+,and the metal contents of the complexes were determined by complexometric *** magnetic behaviors of the complexes were examined as a function of magnetic field strength at 5 K,and as a function of temperature (5–300 K) at a magnetic field strength of 2.4 × 106 A/*** results indicated that the complexes were soft ferromagnetic materials with Curie-Weiss temperature at 102 K and 53 K,respectively.

关键词： hyperbranched aromatic polyamide synthesis magnetic properties

Calcium ion channel and epilepsy

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Neural Regeneration Research 2006年第3期1卷 264-266页

作者： Yudan Lue weihong lin Dihui Ma Department of Neurology First Clinical Hospital of Jilin University. Changchun 130021 Jilin Province China

OBJECTIVE： To review the relationship between calcium ion channel and epilepsy for well investigating the pathogenesis of epilepsy and probing into the new therapeutic pathway of epilepsy. DATA SOURCES： A computer-based online research Calcium ion channel and epilepsy related articles published between January 1994 and December 2006 in the CKNI and Wanfang database with the key words of ＂calcium influxion, epilepsy, calcium-channel blocker＂. The language was limited to Chinese. At the same time, related articles published between January 1993 and December 2006 in Pubmed were searched for on online with the key words of ＂calcium influxion, epilepsy＂ in English. STUDY SELECTION ： The materials were selected firstly. Inclusive criteria： ① Studies related to calcium ion channel and the pathogenesis of epilepsy. ② Studies on the application of calcium ion channel blocker in the treatment of epilepsy. Exclusive criteria： repetitive or irrelated studies. DATA EXTRACTION ： According to the criteria, 123 articles were retrieved and 93 were excluded due to repetirive or irrelated studies. Altogether 30 articles met the inclusive criteria, 11 of them were about the structure and characters of calcium ion channel, 10 about calcium ion channel and the pathogenesis of epilepsy and 9 about calcium blocker and the treatment of epilepsy. DATA SYNTHESIS ： Calcium ion channels mainly consist of voltage dependent calcium channel and receptor operated calcium channel. Depolarization caused by voltage gating channel-induced influxion is the pathological basis of epileptic attack, and it is found in many studies that many anti-epileptic drugs have potential and direct effect to rivalizing voltage-dependent calcium ion channel. CONCLUSION ： Calcium influxion plays an important role in the seizure of epilepsy. Some calcium antagonists seen commonly are being tried in the clinical therapy of epilepsy that is being explored, not applied in clinical practice. If there are enough evidences to j

关键词： ion channels calcium channel clinical significance key words clinical practice

醋酸亮丙瑞林联合孕三烯酮对子宫内膜异位症术后患者的疗效及免疫炎症水平的影响

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中国临床药学杂志 2024年第4期33卷 284-288页

作者：林伟宏李鲁宏朱思远福建医科大学附属第二医院妇产科泉州362000

目的探究醋酸亮丙瑞林联合孕三烯酮对子宫内膜异位症术后患者的疗效及免疫功能影响。方法纳入2020年1月至2022年6月收治的子宫内膜异位症患者共152例,随机分为观察组和对照组,每组76例。所有患者行全麻下经腹腔镜子宫内膜异位症切除术... 详细信息

目的探究醋酸亮丙瑞林联合孕三烯酮对子宫内膜异位症术后患者的疗效及免疫功能影响。方法纳入2020年1月至2022年6月收治的子宫内膜异位症患者共152例,随机分为观察组和对照组,每组76例。所有患者行全麻下经腹腔镜子宫内膜异位症切除术。术后,对照组予醋酸亮丙瑞林治疗,观察组予亮丙瑞林联合孕三烯酮治疗,治疗6个月后随访。检测2组术前及术后血清中雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)、白细胞介素2(IL-2)、白细胞介素6(IL-6)及白细胞介素10(IL-10)水平。评估2组疗效、不良事件总发生率及术后6个月治疗费用。结果术后6个月,2组血清E2、LH及FSH水平比较差异无统计学意义(P>0.05);2组IL-4、IL-6水平较术前均显著降低,IL-2水平较治疗前均显著升高(P0.05)。观察组不良事件总发生率低于对照组(P<0.05)。观察组术后6个月的治疗费用低于对照组(P<0.05)。结论醋酸亮丙瑞林联合孕三烯酮能够改善子宫内膜异位症患者术后的炎症水平,降低不良事件发生率和术后治疗费用,具有较好的临床应用前景。

关键词：醋酸亮丙瑞林孕三烯酮子宫内膜异位症

Brain-derived neurotrophic factor expression is higher in brain tissue from patients with refractory epilepsy than in normal controls

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Neural Regeneration Research 2011年第29期6卷 2262-2266页

作者： Yudan Lv Jiqing Qiu Zan Wang Li Cui Hongmei Meng weihong lin Department of Neurology First Hospital of Jilin University Changchun 130021 Jifin Province China

The role of the brain-derived neurotrophic factor in epilepsy remains controversial. The present study utilized light and electron microscopy to investigate pathological and ultrastructural changes in brain tissue obtained from the seizure foci of 24 patients with temporal epilepsy. We found that epileptic tissue showed neuronal degeneration, glial cell proliferation, nuclear vacuolization, and neural cell tropism. Immunoelectron microscopy and immunohistochemistry showed that brain-derived neurotrophic factor was expressed at significantly higher levels in patients with refractory temporal epilepsy compared with normal controls, demonstrating that the pathological changes within seizure foci in patients with refractory epilepsy are associated with brain-derived neurotrophic factor expression alterations.

关键词： refractory epilepsy brain-derived neurotrophic factor seizure focus brain injury neural regeneration

Extract from Buthus martensii Karsch is associated with potassium channels on glioma cells

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Neural Regeneration Research 2011年第15期6卷 1147-1150页

作者： Mingxian Li Hongmei Meng Shao Wang Min Huang Li Cui weihong lin Department of Respiratory Medicine First Hospital of Jilin University Changchun 130021 Jilin Province China Department of Neurology First Hospital of Jilin University Changchun 130021 Jifin Province China Department of Physiology Basic Medical College of Jilin University Changchun 130020 Jifin Province China

Catilan extracted from Leiurus quinquestriatus is a specific ion channel *** can specifically bind chloride channels of glioma cells and kill these tumor *** questions remain as to whether antigliomatin,the extract from scorpion venom of Buthus martensii Karsch in China,can inhibit glioma growth,and whether this inhibition is correlated with ion channels of tumor *** present study treated rat C6 glioma cells with 0.8,1.2,and 1.6 μg/mL antigliomatin for 20 ***-cell patch clamp technique showed that antigliomatin delayed rectifier potassium channels of C6 glioma *** inhibited tumor growth,which could potentially involve potassium channels of tumor cells.

关键词： scorpion venom antigliomatin brain glioma patch clamp potassium channel Chinese medicine neural regeneration

Effects of glutamate and nimodipine on survival rate of embryonic rat neuronal stem cells cultured in vitro

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Neural Regeneration Research 2008年第12期3卷 1286-1289页

作者： Xiaohong Lu Hailong Fu Qiang Sun Li Cui Dihui Ma weihong lin Department of Neurology First Hospital Jinlin University Changchun 1300021 Jilin Province China

BACKGROUND： At least three types of calcium ion channel （T, N, and L） have been recognized in nerve ceils, but only the L type of channel is sensitive to drugs. Theoretically, nimodipine can lead to L-type channel inactivation and prevent calcium ion inflow, thereby exhibiting protective effects on nerve cells. OBJECTIVE： To observe the protective effects of nimodipine on glutamate-induced injury to embryonic rat neural stem cells, and to make a comparison with MK-801, a nonselective glutamate receptor antagonist. DESIGN, TIME AND SETTING： The present in vitro experiment pertaining to neural stem cells was performed at the Department of Neurology, First Hospital, Jilin University between January 2005 and December 2006. MATERIALS： Glutamate was sourced from the Shanghai Biological Research Institute of the Chinese Academy of Sciences. Nimodipine was provided by Bayer Company, Germany. Brain tissue was taken from Wistar rats on day 15 of gestation for isolation and culture of neural stem cells. METHODS： Passage 2 neural stem cell spheres were taken for preparation of single cell suspension. The prepared single cell suspension was divided into 4 groups：（1） Normal control, normally cultured. （2） Glutamate, cultured with 50, 100, 200, 500, and 1 000 μmol/L glutamate. （3） Nimodipine, received a 30- minute nimodipine [1×（10^-8-10^-2） g/L] culture followed by a glutamate （200 μmol/L） treatment step. （4） MK-801, given as 30- minute MK-801 （100 μmol/L） culture, followed by a glutamate （200 μmol/L） treatment step. MAIN OUTCOME MEASURES： Determination of glutamate-induced cell death by methyl thiazolyl tetrazolium （MTT） assay; calculation of neural stem cell survival rate following addition of nimodipine. RESULTS： The survival rate of neural stem cells was approximately 25.26% following 24 hour 50 μmol/L glutamate culture and gradually decreased as the glutamate dose increased （P 〈 0.05 0.01）. Only 9.27% of neural stem cells survived when the glutamate dose was 1000 μmol/L. Th

关键词： neural stem cells culture glutamate injury nimodipine protective effects

5-hydroxytryptamine-mediated apnea caused by the habenular nucleus

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Neural Regeneration Research 2011年第20期6卷 1554-1558页

作者： Min Wang weihong lin Jinghua Wang Min Huang Chunyong Wang Mingxian Li Shao Wang Department of Pneumology First Hospital of Jilin University Changchun 130021 Jilin Province China Department of Neurology First Hospital of Jilin University Changchun 130021 Jilin Province China Department of Physiology Norman Bethune College of Medicine Jilin University Changchun 130021 Jilin Province China School of Public Health Jilin University Changchun 130021 Jilin Province China

5-hydroxytryptamine contributes to the control of activities of the dilator muscle in the upper respiratory tract, and is derived from the raphe nuclei, in which the habenular nucleus exerts a sustaJned inhibitory effect. In the present study, respiratory motion curve of the genJoglossus muscle and peripheral 5-hydroxytryptamine changes were observed following L-glutamate stimulation of the habenular nucleus of adult Wistar rats. Results showed that the rats had apnea and decreased plasma 5-hydroxytryptamine content after the neurons in habenular nucleus were excited. Genioglossus muscle electromyogram amplitude and integral were significantly reduced. The genioglossus myoelectric activity and respiratory motion curve were similar to obstructive sleep apnea syndrome, thus confirming that the habenular nucleus is the key nucleus involved in the pathogenesis of obstructive sleep apnea syndrome, and is the primary regulated center in the raphe nuclei. Stimulation of the habenular nucleus may suppress 5-hydroxytryptamine release and result in apnea, which is similar to obstructive sleep apnea syndrome.

关键词： sleep apnea habenular nucleus 5-hydroxytryptamine genioglossus neural electrophysiology neural regeneration

视神经鞘直径与眼球横径比值在脑水肿患者颅内压监测的应用

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中国当代医药 2024年第23期31卷 45-48,53页

作者：陈志鹏陈荣城林炜宏黄海平福建省漳州市医院神内脑血管病介入科福建漳州363500

目的探讨视神经鞘直径(ONSD)与眼球横径(ETD)比值在脑水肿患者颅内压(ICP)监测的应用价值。方法回顾性分析2022年1月至2023年10月福建省漳州市医院收治的50例脑水肿患者临床资料,所有患者均采用超声测定ONSD、ETD,并计算其比值;依据有... 详细信息

目的探讨视神经鞘直径(ONSD)与眼球横径(ETD)比值在脑水肿患者颅内压(ICP)监测的应用价值。方法回顾性分析2022年1月至2023年10月福建省漳州市医院收治的50例脑水肿患者临床资料,所有患者均采用超声测定ONSD、ETD,并计算其比值;依据有创颅内压监测数值将患者分为ICP升高组(n=31,≥200 mmHg)及ICP正常组(n=19,80~200 mmHg),以单因素及多因素logistic回归分析脑水肿患者ICP升高的影响因素,采用ROC曲线分析ONSD、ETD、ONSD/ETD对脑水肿患者ICP升高的预测价值,以Pearson相关性分析ONSD、ONSD/ETD与脑水肿患者ICP升高之间的关系。结果单因素分析结果显示,两组ONSD、ONSD/ETD比值、GCS评分、NIHSS评分、APACHEⅡ评分比较,差异有统计学意义(P<0.05);多因素logistic回归分析结果显示,ONSD(β=0.778,OR=2.177,95%CI=1.275~3.718)、ONSD/ETD比值(β=0.826,OR=2.284,95%CI=1.218~4.285)为脑水肿患者ICP升高的独立危险因素,差异有统计学意义(P<0.05)。ROC曲线结果显示,ONSD/ETD比值预测脑水肿患者ICP升高的AUC、特异度、灵敏度分别为0.952、96.80%、78.90%,预测效能高于ONSD,差异有统计学意义(P<0.05);ONSD/ETD比值与ICP呈正相关,差异有统计学意义(r=0.523,P<0.001)。结论ONSD/ETD比值是脑水肿患者ICP升高的危险因素,对脑水肿患者ICP升高具有较好的预测价值。

关键词：脑水肿颅内压视神经鞘直径/眼球横径比值预测价值