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Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging

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Journal of Pharmaceutical Analysis 2022年第4期12卷 530-540页

作者： Rui-lin Liu Ru-qian Cai School of Pharmacy Xuzhou Medical UniversityXuzhou221004China Department of Pharmaceutical Analysis School of PharmacyXi'an Jiaotong UniversityXi'an710061China

Fluorescence imaging is a noninvasive and dynamic real-time imaging technique;however,it exhibits poor spatial resolution in centimeter-deep tissues because biological tissues are highly scattering media for optical radiation.The recently developed ultrasound-controlled fluorescence(UCF)imaging is a novel imaging technique that can overcome this bottleneck.Previous studies suggest that the effective contrast agent and sensitive imaging system are the two pivotal factors for generating high-resolution UCF images ex vivo and/or in vivo.Here,this review highlights the recent advances(2015e2020)in the design and synthesis of contrast agents and the improvement of imaging systems to realize high-resolution UCF imaging of deep tissues.The imaging performances of various UCF systems,including the signal-to-noise ratio,imaging resolution,and imaging depth,are specifically discussed.In addition,the challenges and prospects are highlighted.With continuously increasing research interest in this field and emerging multidisciplinary applications,UCF imaging with higher spatial resolution and larger imaging depth may be developed shortly,which is expected to have a far-reaching impact on disease surveillance and/or therapy.

关键词： Ultrasound-controlled fluorescence imaging Temperature-sensitive NIR probes High-resolution Deep tissue Molecular diagnosis

Novel Bilayer-Shelled N,O-Doped Hollow Porous Carbon Microspheres as High Performance Anode for Potassium-Ion Hybrid Capacitors

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Nano-Micro Letters 2023年第9期15卷 423-435页

作者： Zhen Pan Yong qian Yang Li Xiaoning Xie Ning lin Yitai qian Department of Applied Chemistry University of Science and Technology of ChinaHefei 230026People’s Republic of China Yongjiang Laboratory Ningbo 315202People’s Republic of China China National Building Material Design&Research Institute Co. Ltd.No.208Huazhong RoadGongshu DistrictHangzhou 310022People’s Republic of China

With the advantages of high energy/power density,long cycling life and low cost,dual-carbon potassium ion hybrid capacitors(PIHCs)have great potential in the field of energy storage.Here,a novel bilayer-shelled N,O-doped hollow porous carbon microspheres(NOHPC)anode has been prepared by a self-template method,which is consisted of a dense thin shell and a hollow porous spherical core.Excitingly,the NOHPC anode possesses a high K-storage capacity of 325.9 mA h g^(−1)at 0.1 A g^(−1)and a capacity of 201.1 mAh g^(−1)at 5 A g^(−1)after 6000 cycles.In combination with ex situ characterizations and density functional theory calculations,the high reversible capacity has been demonstrated to be attributed to the co-doping of N/O heteroatoms and porous structure improved K+adsorption and intercalation capabilities,and the stable long-cycling performance originating from the bilayer-shelled hollow porous carbon sphere structure.Meanwhile,the hollow porous activated carbon microspheres(HPAC)cathode with a high specific surface area(1472.65 m^(2)g^(−1))deriving from etching NOHPC with KOH,contributing to a high electrochemical adsorption capacity of 71.2 mAh g^(−1)at 1 A g^(−1).Notably,the NOHPC//HPAC PIHC delivers a high energy density of 90.1 Wh kg^(−1)at a power density of 939.6 W kg^(−1)after 6000 consecutive charge-discharge cycles.

关键词： Self-template method Bilayer-shelled hollow porous structure N,O-doped carbon microspheres Dual-carbon potassium‐ion hybrid capacitor

Bionic iontronics based on nano-confined structures

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Nano Research 2023年第9期16卷 11718-11730页

作者： Han qian Di Wei Zhong lin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The Moore’s law in silicone-based electronics is reaching its limit and the energy efficiency of the most sophisticated electronics to mimic the iontronic logic circuit in single-celled organisms is still inferior to their natural counterpart.Unlike electronics,iontronics is widely present in nature,and provides the fundamentals for many life activities through the transmission and conversion of information and energy via ions.Moreover,as nanotechnology and fabrication processes continue to advance,highly efficient iontronics could be enabled by creation of asymmetry from nano-confined unipolar ion transport through various nanohierarchical structures of materials.The introduction of bionic design and nanostructures has made it possible for ions to demonstrate numerous anomalous behaviours and entirely new mechanisms,which are governed by complex interfacial interactions.In this review,we discuss the origins,development,mechanism,and applications of bionic iontronics and analyze the unique benefits as well as the practicality of iontronics from a variety of perspectives.Iontronics,as an emerging field of research with innumerable challenges and opportunities for exploring the theory and applications of ions as transport carriers,promises to provide new insights in many subjects covering energy and sensing,etc.,and establishes a new paradigm in investigating the ionic-electric signal transduction interface for futuristic iontronic logic circuit and neuromorphic computing.

关键词： iontronics electronics nano-confined ion transport nanofluidic asymmetry

Effect of demineralization on pyrolysis characteristics of LPS coal based on its chemical structure

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International Journal of Coal Science & Technology 2023年第2期10卷 181-195页

作者： LIN Qian Jinkai Xue Chao Tao Chao Ma Xiaopeng Jiang Feiqiang Guo School of Low-Carbon Energy and Power Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Clean Energy Utilization Zhejiang University310027 HangzhouChina

The critical issue in developing mature Oxy-Coal Combustion Steam System technology could be the reactivity of deminer-alized coal which,is closely related to its chemical structure.The chemical structures of Liupanshui raw coal(LPS-R)and Liupanshui demineralized coal(LPS-D)were analyzed by FTIR and solid-state 13C-NMR.The pyrolysis experiments were carried out by TG,and the pyrolysis kinetics was analyzed by three iso-conversional methods.FTIR and 13C-NMR results suggested that the carbon structure of LPS coal was not altered greatly,while demineralization promoted the maturity of coal and the condensation degree of the aromatic ring,making the chemical structure of coal more stable.The oxygen-containing functional groups with low bond energy were reduced,and the ratio of aromatic carbon with high bond energy was increased,decreasing the pyrolysis reactivity.DTG curve-fitting results revealed that the thermal weight loss of LPS coal mainly came from the cleavage of aliphatic covalent bonds.By pyrolysis kinetics analysis of LPS-R and LPS-D,the apparent activation energies were 76±4 to 463±5 kJ/mol and 84±2 to 758±12 kJ/mol,respectively,under different conversion rates.The reactivity of the demineralized coal was inhibited to some extent,as the apparent activation energy of pyrolysis for LPS-D increased by acid treatment.

关键词： Demineralization Chemical structure of coal Coal pyrolysis Pyrolysis kinetics Iso-conversional

Selective N-Methylation of N-Methylaniline with CO_(2) and H_(2) over Cu/In_(2)O_(3) Catalyst

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Chinese Journal of Chemistry 2024年第3期42卷 276-282页

作者： Huan Zheng Bo qian lin He State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China University of Chinese Academy of Sciences Beijing100049 China

N-Methylation of amines with CO_(2) and H2 is a potential approach for CO_(2) utilization because N-methylated amines can be used as solvents and organic intermediates. In_(2)O_(3)-supported Cu (Cu/In_(2)O_(3)) acts as an effective heterogeneous catalyst for N-methylation reaction of N-methylaniline (MA) with CO_(2) and H_(2),showing higher N,N-dimethylaniline (DMA) selectivity than other supported Cu catalysts. On one hand,the dispersion of Cu can be improved by the defective In_(2)O_(3) support. On the other hand,In_(2)O_(3) support is active in the dissociative adsorption of CO_(2) through C—O bond breaking. In addition,the H_(2) dissociation ability of In_(2)O_(3) can also be enhanced by Cu. The combination of Cu and In_(2)O_(3) is effective in the activation of CO_(2),the adsorption of intermediate N-methylformanilide (MFA),the hydrogenation of MFA to DMA and the prohibition of C—N bond cleavage side reactions,thereby enhancing the reaction rate of MA conversion and the selectivity to DMA.

关键词： N-Methylation CO_(2) Cu/In_(2)O_(3) Supported catalysts Heterogeneous catalysis

US monetary policy uncertainty and RMB deviations from covered interest parity

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Economic and Political Studies 2023年第1期11卷 75-98页

作者： Zhitao lin Xingwang qian School of Economics Jinan UniversityGuangzhouChina Department of Economics and Finance SUNY Buffalo State CollegeBuffaloNYUSA

This paper examines how US monetary policy uncertainty(MPU)affects RMB deviations from covered interest parity(CIP)and how this effect is influenced by China’s capital controls,the RMB exchange rate regime,and international reserves that constrain the transmitting channel of US MPU shocks.Our findings show that US MPU has a spill-over effect and creates deviations from RMB CIP.Capital controls insulate uncertainty shocks and alleviate the US MPU spill-over effect.There are some evidence that inter-national reserves alleviate and the liberalised RMB exchange rate regime magnifies the spill-over effect.However,their effects become insignificant in the presence of capital controls.Moreover,the US MPU effect on RMB CIP deviations becomes prominent after the 2008 global financial crisis.

关键词： US MPU deviation from CIP RMB cross-currency basis capital controls exchange rate regime international reserves

Stabilizing and boosting I/O performance for file systems with journaling on NVMe SSD

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Science China(Information Sciences) 2022年第3期65卷 95-109页

作者： LIN Qian Bin TANG Baoliu YE Jianyu WU Xiaoliang WANG Sanglu LU National Key Laboratory for Novel Software Technology State Grid Electric Power Research Institute

Many journaling file systems currently use non-volatile memory-express(NVMe) solid-state drives(SSDs) as external journal devices to improve the input and output(I/O) performance. However,when facing microwrite workloads, which are typical of many applications, they suffer from severe I/O fluctuations and the NVMe SSD utilization is extremely low. The experimental results indicate that this phenomenon arises mainly because writing back data to backend file systems on hard disk drives is much slower than journal writing, causing journal writing to frequently freeze because of the two-phase mechanism.We, therefore, propose a merging-in-memory(MIM) acceleration architecture to stabilize and boost the I/O performance for such journaling file systems. MIM employs an efficient data structure of hash-table-based multiple linked lists in memory, which not only merges random microwrites into sequential large blocks to speed up writebacks but also provides additional gains in terms of reducing the frequency of write addressing and object opening and closing. Using a prototype implementation in Ceph File Store, we experimentally show that MIM not only eliminates severe fluctuations but also improves the I/O operations per second by roughly 1×–12× and reduces the write latency by 75%–98%.

关键词： journaling file systems NVMe SSD microwrite merging hash table Ceph

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林谦教授气血理论治疗阵发房颤的经验总结

中国社区医师 2019年第36期35卷 114-114,116页

作者：丛欢欢林谦朝阳区十八里店社区卫生服务中心北京100122 北京中医药大学东直门医院北京100700

房颤是临床中较为常见的一种疾病,西医治疗效果欠佳,常反复发作。中医治疗房颤有其独特理念及非同寻常的疗效。气血理论是其中重要的一种中医治疗手段,本文旨在介绍林谦教授气血理论治疗阵发房颤的经验,仅供临床探讨。

关键词：林谦教授气血理论阵发房颤

Role of Mitophagy in Myocardial Ischemia/Reperfusion Injury and Chinese Medicine Treatment

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Chinese Journal of Integrative Medicine 2023年第1期29卷 81-88页

作者： XIA Jun-yan CHEN Cong LIN Qian CUI Jie WAN Jie LI Yan LI Dong Department of Cardiology Dongfang Hospitalthe Second Affiliated Hospital of Beijing University of Chinese MedicineBeijing100078China Department of Cardiology Dongzhimen Hospitalthe First Affiliated Hospital of Beijing University of Chinese MedicineBeijing100007China

Mitophagy is one of the important targets for the prevention and treatment of myocardial ischemia/reperfusion injury(MIRI).Moderate mitophagy can remove damaged mitochondria,inhibit excessive reactive oxygen species accumulation,and protect mitochondria from damage.However,excessive enhancement of mitophagy greatly reduces adenosine triphosphate production and energy supply for cell survival,and aggravates cell death.How dysfunctional mitochondria are selectively recognized and engulfed is related to the interaction of adaptors on the mitochondrial membrane,which mainly include phosphatase and tensin homolog deleted on chromosome ten(PTEN)-induced kinase 1/Parkin,hypoxia-inducible factor-1α/Bcl-2 and adenovirus e1b19k Da interacting protein 3,FUN-14 domain containing protein 1 receptor-mediated mitophagy pathway and so on.In this review,the authors briefly summarize the main pathways currently studied on mitophagy and the relationship between mitophagy and MIRI,and incorporate and analyze research data on prevention and treatment of MIRI with Chinese medicine,thereby provide relevant theoretical basis and treatment ideas for clinical prevention of MIRI.

关键词： mitophagy myocardial ischemia/reperfusion injury PTEN-induced kinase 1/Parkin hypoxia-inducible factor-1α/Bcl-2 and adenovirus e1b19k Da interacting protein 3 FUN-14 domain containing protein 1 Chinese medicine