Cancer metabolism and dietary interventions

作     者：Lin Qian Fan Zhang Miao Yin Qunying Lei Lin Qian;Fan Zhang;Miao Yin;Qunying Lei

作者机构：Fudan University Shanghai Cancer Center&Institutes of Biomedical SciencesCancer InstitutesKey Laboratory of Breast Cancer in ShanghaiShanghai Key Laboratory of Radiation OncologyShanghai Key Laboratory of Medical EpigeneticsShanghai Medical CollegeFudan UniversityShanghai 200030China Department of OncologyShanghai Medical CollegeFudan UniversityShanghai 200030China State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 200030China Lead ContactShanghai 200030China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2022年第19卷第2期

页      面：163-174页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Key R&D Program of China(Grant Nos.2020YFA0803402 and 2019YFA0801703) the Natural Science Foundation of China(Grant Nos.81790250/81790253,91959202,82121004,and 81872240) the Innovation Program of Shanghai Municipal Education Commission(Grant No.N173606). 

主　　题：Cancer metabolism diet intervention carbohydrate amino acid lipid 

摘      要：Metabolic remodeling is a key feature of cancer development.Knowledge of cancer metabolism has greatly expanded since the first observation of abnormal metabolism in cancer cells,the so-called Warburg effect.Malignant cells tend to modify cellular metabolism to favor specialized fermentation over the aerobic respiration usually used by most normal cells.Thus,targeted cancer therapies based on reprogramming nutrient or metabolite metabolism have received substantial attention both conceptually and in clinical practice.In particular,the management of nutrient availability is becoming more attractive in cancer treatment.In this review,we discuss recent findings on tumor metabolism and potential dietary interventions based on the specific characteristics of tumor metabolism.First,we present a comprehensive overview of changes in macronutrient metabolism.Carbohydrates,amino acids,and lipids,are rewired in the cancer microenvironment individually or systematically.Second,we summarize recent progress in cancer interventions applying different types of diets and specific nutrient restrictions in pre-clinical research or clinical trials.