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Highly selective and eco-friendly dihydroisoquinoline synthesis via Cu/Co synergistic catalysis in Cu NPs@MOFs catalyst under mild conditions

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Science China Chemistry 2024年第5期67卷 1561-1568页

作者： peng-fei Guo Ze-Long Liang Yue-E Jiao Hang Xu Bin Zhao Key Laboratory of Advanced Energy Material Chemistry Renewable Energy Conversion and Storage CenterDepartment of ChemistryNankai UniversityTianjin 300071China

3,4-Dihydroisoquinoline(DHIQ)is an important precursor used in the production of drugs for treating cancer,HIV,Alzheimer's disease,*** studies on DHIQ synthesis show low catalytic selectivity due to the susceptible over-oxidation feedstock of1,2,3,4-tetrahydroisoquinoline(THIQ),which often requires alkali ***,it is desirable yet challenging to explore a highly selective and efficient oxydehydrogenation capacity for DHIQ synthesis under eco-friendly reaction ***,a novel framework 1 was synthesized,exhibiting 1D channels with the size of 4.6 A×9.6 A and high solvent/p H/thermal stability.A stable framework allows it to encapsulate Cu nanoparticles(NPs)to form Cu NPs@1-x(x=1,2,3,and 4)with varying loading amounts of Cu NPs at 2.0 wt%,3.0 wt%,4.0 wt%,and 6.0 wt%,*** NPs@1-3 could selectively catalyze the reaction from THIQ to DHIQ with a high selectivity of 98%and a recorded turnover frequency(TOF)of 22.1 h-1under eco-friendly mild *** corresponding catalytic activity can maintain at least five recyclings and can be further applied to gram-scale ***,the efficient preparation of DHIQ catalyzed by Cu NPs@1-3 could be realized even under air ***,the anticancer molecule precursor synthesis of 6,7-dimethoxy-3,4-dihydroisoquinoline was also selectively catalyzed by Cu NPs@*** investigations revealed that high catalytic performance can be attributed to the stable framework and the synergistic catalytic effect of the loaded Cu NPs and Co metal *** importantly,this work represents the first example of MOF catalysts for selectively thermo-catalytic DHIQ synthesis and demonstrates a simple approach to obtain efficient catalysts for selective oxydehydrogenation in the production of unsaturated compounds.

关键词： metal-organic frameworks Cu NPs@MOFs 3 4-dihydroisoquinoline selective oxydehydrogenation synergistic catalysis

Isolation and culture of human primary osteoblasts:Comparing the effects of differences in method details on osteoblast characteristics

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Genes & Diseases 2024年第2期11卷 546-549页

作者： fei Chen Yan Zhang Pai peng Xiao-Ting Huang Zi-Han Qiu Bao-Cheng Liu Tie-lin Yang Bo Yang Yan Guo Key Laboratory of Biomedical Information Engineering of Ministry of Education Biomedical Informatics & Genomics CenterSchool of Life Science and TechnologyXi'an Jiaotong UniversityXi'anShaanxi 710049China Department of Orthopaedics Shannxi Provincial People's Hospital (The Third Affiliated Hospital of Xi'an Jiaotong University)Xi'anShaanxi 710068China

Osteoblasts are essential in the maintenance of human bone homeostasis.1 The abnormal formation and impaired differentiation ability of osteoblasts are pivotal factors leading to bone-related diseases,suggesting that an indepth study of osteoblasts can provide novel treatment strategies for these diseases.2 Human primary osteoblasts are precious experimental models in bone-related research.3 However,the isolation and culture of human primary osteoblasts still have some difficulties and ***,we refined a method to isolate and culture human primary osteoblasts by taking cancellous bone through a bone tissue sampler and pre-digesting it with pancreatin,which makes the process easier,cheaper,and more ***,we compared the effects of the subtle changes in isolation and culture methods on the phenotype of human primary osteoblasts and examined the differences in morphology,proliferation,and differentiation between micro-explants cultured osteoblasts(MECOBs)and explants cultured osteoblasts(EC-OBs).

关键词： impaired culture details

Psychological intervention based on social cognitive theory: Treating pain, anxiety, and depression in perioperative patients

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World Journal of Psychiatry 2024年第8期14卷 1199-1207页

作者： Hai-Jian Mao lin-fei Wang Chun lin Department of Surgical Anesthesiology The First People’s Hospital of Lin’an DistrictHangzhouHangzhou 311300Zhejiang ProvinceChina Department of Gastrointestinal Surgery Hangzhou First People’s HospitalHangzhou 310006Zhejiang ProvinceChina Department of Comprehensive Intervention The First People’s Hospital of Lin’an DistrictHangzhouHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Surgery is an effective method for treating certain *** such as disease,preoperative fear and tension,surgical stress,postoperative pain,and related complications directly affect the smooth progression and outcome of *** may experience a series of psychological and physiological changes during the perioperative period,resulting in anxiety and depression,which may reduce the pain threshold and worsen their *** We enrolled 200 patients who underwent surgical care at The First People’s Hospital of lin’an District,Hangzhou between January and December *** were categorized into a routine intervention group(n=103)and a psychological intervention group(n=97),based on the intervention strategies *** assessment tools,including the self-rating anxiety scale(SAS),the self-rating depression scale(SDS),and the Connor–Davidson Resilience scale,were used to measure patients’negative states and *** pre-and post-intervention scores for these metrics in the two groups were then *** In the psychological intervention group,the SAS and SDS scores(31.56±5.18 and 31.46±4.57,respectively)were significantly reduced compared to the routine intervention group(P<0.05).The visual analog scale pain scores at 12 and 24 hours after intervention(6.85±1.21,4.24±0.72)were notably higher than those in the routine intervention group(P<0.05).The psychological intervention group also demonstrated superior scores in perseverance(36.08±3.29),self-reliance(22.63±2.91),optimism(11.42±1.98),and resilience(70.13±5.37),compared to the routine intervention group(P<0.05).Additionally,the psychological intervention group’s confrontation score(23.16±4.29)was higher(P<0.05).This group also reported lower scores in avoidance(9.28±1.94)and yielding(6.19±1.92)(P<0.05).Lastly,the Short Form 36 Health Survey scores were significantly higher in the psychological intervention group,indicating a better quality of life(P<0.05).CONCLUSION

关键词： Perioperative period Social cognitive theory Psychological intervention Pain Anxiety and depression

Selective photosynthesis of imines from biomass-derived aldehydes over Ni/TiO_(2)

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Rare Metals 2024年第3期43卷 1116-1124页

作者： Wu-lin Li Qing-Qing Zhang lin Dong Wen-Jun Zhang Li-Li lin Zu-peng Chen Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing210037China Institute of Industrial Catalysis State Key Laboratory of Green Chemistry Synthesis TechnologyCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

Photocatalytic reductive amination of biomass-derived aldehydes is a desirable way to selectively upgrade biomass into value-added nitrogen-containing chemicals under mild ***,it is challenging to produce imines in high selectivity because of the undesirable side reactions caused by the activity of functional ***,we demonstrate the highly reactive and selective production of imines from biomass derived aldehydes via the photocatalytic reductive amination,using a defective TiO_(2)supported nickel *** employment of methanol as the hydrogen donor and ammonia solution as the nitrogen source avoids the use of high-pressure H_(2)and expensive amines,rendering the current catalytic process safe,economical,and environmentally *** depth investigations attribute the improved separation and transfer of photogenerated charge carriers to the presence of oxygen vacancies and decorated Ni nanoparticles,thereby accelerating the production of imines from benzaldehyde amination(conversion,95.8%;seleetivity,95.2%).Furthermore,the developed system could be easily translated to the photocatalytic conversions of various biomass derived aldehydes,which provided an example of a cost-effective and sustainable approach for the valorization of biomass derived feedstocks.

关键词： Photocatalysis Biomass derivatives Imines Reduction amination Heterogeneous catalyst

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湿型砂造型主要材料特性及配比工艺方案

铸造 2021年第7期70卷 839-840,841,842,843页

作者：林鹏飞黄石东贝铸造有限公司湖北黄石435106

对膨润土、混配煤粉、原砂和除尘灰等湿型砂造型材料的重要特性进行检测和分析,对比了不同配比工艺方案的材料成本及铸件质量,获得了湿型砂造型主要材料特性的重要控制点和低成本高稳定性湿型砂的最优配比工艺方案。

关键词：膨润土混配煤粉原砂除尘灰湿型砂配比

Joined AZ31B Magnesium Alloys with Ag Interlayer by Ultrasonic-Induced Transient Liquid Phase Bonding in Air

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1177-1185页

作者： Qian Wang peng Yu Haoran lin Chongzhi Guo Xiaoqiang Hu Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China School of Rare Earths University of Science and Technology of ChinaHefei230026China Shenyang 7D New Materials Equipment Co.LTD. Shenyang110076China Shenyang National Laboratory of Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

AZ31B magnesium alloys are commonly used in lightweight structures of automobile and aerospace *** this work,the ultrasonic-induced transient liquid phase bonding technique is deployed to joint AZ31B magnesium alloys at 490℃ with Ag interlayer in the *** effect of ultrasonic vibration on microstructure and mechanical properties of welding seam is *** vibration duration increases,the width of the welding seam increases firstly and then *** the ultrasound vibration sustained for one second,the eutectic reaction occurred in the contacting interface between Ag interlayer and the base metal AZ31B,resulting in formation of liquid phase and metallurgical *** the ultrasound vibration sustained for seven second,the width of the welding seam increased to a maximum of about 303.1μm and the average shear bond strength of the welding joint attained the peak value of about 66.87 *** the ultrasound vibration sustained over seven seconds,the liquid phase is gradually squeezed out and the width of the welding seam decreases.α-Mg and AgMg_(3) can be observed in the welding *** analysis shows thatα-Mg has a certain strengthening *** whole process of appearance,growth and integration ofα-Mg is analyzed.

关键词： Ultrasonic bonding Magnesium alloy Silver Microstructure Intermetallic compound

Fine-tuning growth in gold nanostructures from achiral 2D to chiral 3D geometries

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Nano Research 2024年第7期17卷 6654-6660页

作者： Lili Tan Zhi Chen Chengyu Xiao Zhiyong Geng Yinran Jin Chaoyang Wei fei Teng Wenlong Fu peng-peng Wang State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Enriching the library of chiral plasmonic structures is of significant importance in advancing their applicability across diverse domains such as biosensing,nanophotonics,and ***,employing triangle nanoplates as growth seeds,we synthesized a novel class of chiral-shaped plasmonic nanostructures through a wet chemical strategy with dipeptide as chiral inducers,including chiral tri-blade boomerangs,concave rhombic dodecahedrons,and *** structural diversity in chiral plasmonic nanostructures was elucidated through their continuous morphological evolution from two-dimensional to threedimensional *** fine-tuning of chiroptical properties was achieved by precisely manipulating crucial synthetic parameters such as the amount of chiral molecules,seeds,and gold precursor that significantly influenced chiral structure *** findings provide a promising avenue for enriching chiral materials with highly sophisticated structures,facilitating a fundamental understanding of the relationship between structural nuances and chiroptical properties.

关键词： plasmonic nanostructures geometric chirality circular dichroism fine-tuning

Memristor-based spiking neural networks:cooperative development of neural network architecture/algorithms and memristors

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Chip 2024年第2期3卷 62-78页

作者： Huihui peng lin Gan Xin Guo School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Inspired by the structure and principles of the human brain,spike neural networks(SNNs)appear as the latest generation of artificial neural networks,attracting significant and universal attention due to their remarkable low-energy transmission by pulse and powerful capability for large-scale parallel *** research on artificial neural networks gradually change from software simulation into hardware ***,such a process is fraught with *** particular,memristors are highly anticipated hardware candidates owing to their fastprogramming speed,low power consumption,and compatibility with the complementary metal–oxide semiconductor(CMOS)*** this review,we start from the basic principles of SNNs,and then introduced memristor-based technologies for hardware implementation of SNNs,and further discuss the feasibility of integrating customized algorithm optimization to promote efficient and energy-saving SNN hardware ***,based on the existing memristor technology,we summarize the current problems and challenges in this field.

关键词： Spike neural networks Hardware Memristor Algorithm Cooperative development

Clinical,Neuroimaging,and Pathological Analyses of 13 Chinese Leigh Syndrome Patients with Mitochondrial DNA Mutations

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Chinese Medical Journal 2018年第22期131卷 2705-2712页

作者： Xiao-lin Yu Chuan-Zhu Yan Kun-Qian Ji peng-fei lin Xue-Bi Xu Ting-Jun Dai Wei Li Yu-Ying Zhao Department of Geriatrics Medicine Qilu HospitalShandong UniversityJinanShandong 250012China Department of Neurology Research Institute of Neuromuscular and Neurodegenerative DiseasesQilu HospitalShandong UniversityJinanShandong 250012China Key Laboratory of Cardiovascular Proteomics of Shandong Province Qilu HospitalShandong UniversityJinanShandong 250012China Mitochondrial Medicine Laboratory Qilu Hospital (Qingdao)Shandong UniversityQingdaoShandong 266035China Brain Science Research Institute Shandong UniversityJinanShandong 250012China

Background: Leigh syndrome(LS) is a rare disease caused by mitochondrial defects and has high phenotypic and genotypic *** analyzed the clinical symptoms, neuroimaging, muscular histopathology, and genotypes of 13 Chinese LS patients with mitochondrial DNA(mtDNA) ***: Mutations in mtDNA were identified by targeted sequencing. The brain imaging features on magnetic resonance imaging(MRI)were analyzed. The levels of lactate in fasting blood and cerebrospinal fluid(CSF) were routinely tested. The levels of urinary organic acids, plasma amino acids, and acylcarnitines were examined with gas chromatography–mass spectrometry and tandem mass *** histopathological traits of skeletal muscles were analyzed under ***: Among 13 patients, mutations of MT?NDs(n = 8) and MT?ATP6(n = 4) genes were most common. Strabismus(8/13), muscle weakness(8/13), and ataxia(5/13) were also common, especially for the patients with late?onset age after 2 years old. However, respiratory distress was common in patients with early?onset age before 2 years old. The most frequently affected brain area in these patients was the brain stem(12/13), particularly the dorsal part of midbrain, followed by basal ganglia(6/13), thalamus(6/13), cerebellum(5/13),and supratentorial white matter(2/13). Besides, the elevated lactate levels in CSF(6/6) were more common than those in serum(7/13).However, the analysis of abnormal plasma amino acid and urinary organic acid showed limited results(0/3 and 1/4, respectively). Muscular histopathology showed mitochondrial myopathy in the three late?onset patients but not in the early?onset ***: Noninvasive genetic screening is recommended for mtDNA mutations in MT?NDs and MT?ATP6 genes in patients with ophthalmoplegia, muscle weakness, ataxia, and respiratory disorder. Furthermore, the lactate detection in CSF and the brain MRI scanning are suggested as the diagnosis methods for LS patients with mtDNA mutat

关键词： Clinical Features Leigh Syndrome Mitochondrial DNA Neuroimaging Pathology