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EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells

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Chinese Journal of Natural Medicines 2022年第4期20卷 290-300页

作者： DU Bing-Xin lin pei lin Jun School of Life Sciences and Health Engineering Jiangnan UniversityWuxi 214122China

Catechins have been proven to exert antitumor effects in different kinds of ***,the underlying mechanisms have not been completely clarified *** study aimed to assess the effects and mechanisms of(-)-epigallocatechin-3-gallate(EGCG)and(-)-epicatechin-3-gallate(ECG)on human melanoma skin A375 *** showed that EGCG and ECG inhibited the proliferation of A375 cells and ECG showed better inhibitory *** cytometry analysis had shown that EGCG and ECG induced apoptosis and led to cell cycle *** and ECG decreased Bcl-2 expression and upregulated Caspase-3 protein level,indicating the development of ***,EGCG and ECG could decreased mitochondrial membrane potential of A375 *** addition,the expression of Beclin-1,LC3 and Sirt3 were downregulated at protein levels,which known to be associated with *** autophagy was increased by rapamycin,the apoptotic trend was not change,indicating that apoptosis and autophagy are ***,EGCG and ECG treatments decreased phosphorylated-AMPK(p-AMPK)and increased the ratios of P-PI3K,p-AKT and p-mTOR in melanoma ***,EGCG and ECG induced apoptosis via mitochondrial signaling pathway,downregulated autophagy through modulating the AMPK/mTOR and PI3K/AKT/mTOR signaling *** indicated that EGCG and ECG may be utilized in human melanoma treatment.

关键词： EGCG ECG Apoptosis Autophagy PI3K/AKT/mTOR

Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells

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Chinese Journal of Natural Medicines 2022年第12期20卷 937-947页

作者： HONG Mengsa XIAO Kun lin pei lin Jun School of Life sciences and Health Engineering Jiangnan UniversityWuxi 214122China

This study was designed to investigate the effects of five Rutaceae family ethanol extracts(FRFEE):Citrus medica linn(CML),Citrus aurantium ***(CAD),Citrus medica ***(Noot.)Swingle(CMS),Citrus sinensis ***(CSO)and Zanthoxylum bungeanum Maxim(ZBM)on retarding the progression of H_(2)O_(2) and LPS-induced HaCaT *** inflammatory injury model was established by H_(2)O_(2) and *** alleviative effects of FRFEE were evaluated by detecting the activity of superoxide dismutase(SOD),glutathione(GSH)and the generation of reactive oxygen species(ROS).The inflammatory signaling pathways of NF-κB and JAK-STAT3 were detected by Western blotting,the mRNA expression levels of inflammatory factors and skin barrier factors were detected by RT-PCR.50%ethanol extracts of five medicinal and food homologous herbs of Rutaceae family showed different levels of anti-oxidant and anti-inflammatory *** FRFEE effectively improved SOD and GSH content and decreased ROS ***,FRFEE strongly suppressed two inflammatory signaling pathways NF-κB and *** RT-PCR examination of inflammatory factors and skin barrier factor revealed significant anti-inflammatory effects of *** was worth noting that among the five extracts,Zanthoxylum bungeanum Maxim extract had the best anti-inflammatory and anti-oxidation *** addition,it could strongly inhibit the expression of psoriasis factor *** summary,these results suggested that Zanthoxylum bungeanum Maxim extract could be used as an anti-psoriatic agent in the treatment of psoriasis among FRFEE.

关键词： Rutaceae Medicinal and food homologous herbs Oxidative stress Anti-inflammation Psoriasis

A soft-contact hybrid electromagnetic–triboelectric nanogenerator for self-powered water splitting towards hydrogen production

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Nano Research 2024年第7期17卷 6567-6574页

作者： Fuxue Ma Yingjie Wu Shuge Dai pei lin Junlu Sun lin Dong Key Laboratory of Material Physics of Ministry of Education and School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450000China

The effective acquisition of hydrogen energy from the ocean offers a promising sustainable solution for increasing global energy ***,a self-powered high-efficient hydrogen generation system is proposed by integrating a triboelectric–electromagnetic hybrid nanogenerator(TEHG),power management circuit(PMC),and an electrolytic *** the wind triggering,as-fabricated TEHG can effectively convert breeze energy into electric energy,which demonstrates a high output current of 20.3 mA at a speed rotation of 700 rpm and the maximal output power of 13.8 mW at a load of 10 MΩ.Remarkably,asdesigned self-powered system can perform a steady and continuous water splitting to produce hydrogen(1.5μL·min^(−1))by adding a matching capacitor between the PMC and electrolytic *** the circuit,the capacitor can not only function as a charge compensation source for water splitting,but also stabilize the working *** other self-powered water splitting systems,the proposed system does not need catalysts or the complex electrical energy storage/release process,thus improving the hydrogen production efficiency and reducing the *** work provides an effective strategy for clean hydrogen energy production and demonstrates the huge potential of the constructed self-powered system toward carbon neutralization.

关键词： wind energy harvester hybrid nanogenerator energy conversion and management hydrogen energy production

Production of laccase by Coriolus versicolor and its application in decolorization of dyestuffs: (Ⅱ) Decolorization of dyes by laccase containing fermentation broth with or without self-immobilized mycelia

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Journal of Environmental Sciences 2003年第1期15卷 5-8页

作者： lin Jian ping LIAN Wei XIA Li ming CEN pei lin Department of Chemical Engineering and Bioengineering Zhejiang UniversityHangzhou 310027China.

The capability of decolorization for commercial dyes by Coriolus versicolor fermentation broth containing laccase with or without immobilized mycelium was evaluated. With cell free fermentation broth containing laccase, high decolorization ratio was achieved for acid orange 7, but not for the other dyes concerned. The immobilized mycelium was proved to be more efficient than the cell free system. All the four dyestuffs studied were found being decolourized with certain extent by immobilized mycelium. The repeated batch decolorization was carried out with satisfactory results. The experimental data showed that the continuous decolorization of wastewater from a printing and dyeing industry was possible by using the self immobilized C. Versicolor.

关键词： laccase textile dyes immobilized mycelium decolorization Coriolus versicolor

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Medium optimization for enhanced production of cytosine-substituted mildiomycin analogue (MIL-C) by Streptoverticillium rimofaciens ZJU 5119

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第1期9卷 77-84页

作者： Dan YE Zhi-nan XU pei-lin CEN Department of Chemical and Biochemical Engineering Zhejiang University Hangzhou 310027 China

Cytosine-substituted mildiomycin analogue （MIL-C） was produced effectively by supplementing cytosine into the culture of Streptoverticillium rimofaciens. In order to improve the yield of MIL-C, statistically-based experimental designs were applied to optimize the fermentation medium for S. rimofaciens ZJU 5119. Fifteen culture conditions were examined for their significances on MIL-C production using Plackett-Burman design. The Plackett-Burrnan design and one-variable-at-a-time design indicated that glucose and rice meal as the complex carbon sources, and peanut cake meal and NH4NO3 as the complex nitrogen sources were beneficial for MIL-C production in S. rimofaciens ZJU 5119. The results of further central composition design （CCD） showed that the optimal concentration of glucose, rice meal and peanut cake meal were 18.7 g/L, 64.8 g/L and 65.1 g/L, respectively. By using this optimal fermentation medium, the MIL-C concentration was increased up to 1336.5 mg/L, an approximate 3.8-fold improvement over the previous concentration （350.0 mg/L） with un-optimized medium. This work will be very helpful to the large-scale production of MIL-C in the future.

关键词： Cytosine-substituted mildiomycin analogue (MIL-C) Plackett-Burman design Response surface methodology Streptoverticillium rimofaciens Nucleoside antibiotic

THE ANALYSIS OF INTRASEASONAL LONG ROSSBY WAVE SPEED IN THE SUBTROPICAL PACIFIC OCEAN

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Journal of Hydrodynamics 2006年第1期18卷 55-62页

作者： lin Xiao-pei WU De-xing LAN Jian Physical Oceanography Laboratory Ocean University of China Qingdao 266003 China

The analysis of the satellite altimeter data suggests that the propagating speed of intraseasonal long Rossby wave amplified in the subtropical Pacific Ocean is faster than that of first mode baroclinic free Rossby wave predicted by the liner theory and the propagating speed of intrascasonal long Rossby wave reflected in the eastern boundary of Pacific Ocean agrees basically with the liner theory speed of first mode baroelinic free P, ossby wave. If we do not distinguish the two kinds of hmg Rossby waves and estimate the Rossby wave speed in the whole basin, the phase speed is merely 25% higher than the linear theory long Rossby wave speed. The acceleration of the propagating speed of intraseasonal long Rossby wave amplified in the subtropical Pacific Ocean is due to the existence of westward thermolcline mean flow.

关键词： Rossby wave baroclinic instability critical frequency

Target prediction and activity verification for the antidepressant action of Huangqin(Radix Scutellariae Baicalensis)

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Journal of Traditional Chinese Medicine 2021年第6期41卷 845-852页

作者： LI Ganggang LU Ye HE pei ZHANG Shiyue CHENG Yating ZHANG Shaodan pei lin School of Basic Medical Sciences Hebei University of Chinese MedicineShijiazhuang 050051China Hebei Key Laboratory of Turbidity Hebei Academy of Chinese Medicine SciencesShijiazhuang 050011China Department of pediatrics Second Hospital of Hebei Medical UniversityShijiazhuang 050073China Department of Traditional Chinese Medicine Anyang Vocational and Technical CollegeAnyang 455000China

OBJECTIVE:To decipher the antidepressant targets and mechanisms of Huangqin(Radix Scutellariae Baicalensis)(RSB)by a novel computational system based on prediction and experimental ***:The putative targets of RSB against depression were identified from Traditional Chinese Medicine Systems Pharmacology(TCMSP)and Drug ***,protein-protein interaction network of the anti-depression targets of RSB were identified,and differentially expressed genes(DEGs)of depression were mined from the NCBI ***,Kyoto Encyclopedia of Genes and Genomes and Gene Ontology were used to analysis the common ***,the selected pathways and functions were verified by ***:Thirty active compounds in RSB were predicted with high confidence by TCMSP and DrugBank,and seventy-one DEGs were identified in the GEO ***,eight core target proteins were screened out by descending order of degree value,including ACHE,IL6,SLC6A4,FOS,SLC6A3,MAOB,DPP4,and *** target genes were further found to be associated with pathways involved in neuronal apoptosis,such as pathways in cancer,Toll-like receptor signaling pathway,and TNF *** cell proliferation assay and wound-healing assay results showed that RSB does not affect PC12 cell proliferation and ***,RSB protected PC12 cells from oxidative stress induced by H2O2 via inhibiting autophagy and *** revealed significant changes in mice treated with 400 mg/kg RSB compared with the lipopolysaccharide *** possible mechanism for the antidepressive action of RSB is by reducing the expression of LC3-B in CA1 ***:Our research partially expounds the mechanism of the antidepressant effect of RSB by the combination of network pharmacology prediction and experimental ***,it is also conducive to the application of Traditional Chinese Medicine within modern medicine.

关键词： depression Huangqin(Radix Scutellariae Baicalensis) network pharmacology prediction and verification

THE RELATIONSHIP BETWEEN THE TAIWAN WARM CURRENT AND TSUSHIMA WARM CURRENT

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Journal of Hydrodynamics 2009年第2期21卷 212-218页

作者： ZHENG pei-nan WU De-xing lin Xiao-pei Physical Oceanography Laboratory Ocean University of China Qingdao 266100 China Marine Environmental Ensuring of the Headquarters of General Staff Beijing 100081 China

The Taiwan Warm Current （TWC） and the Tsushima Warm Current （TSWC） flow northward over the shelf in the East China Sea （ECS）, which some previous studies regard as a Taiwan-Tsushima Warm Current （TTWC） System. But the roles of the TWC and TSWC in the formation of the TTWC system have not been clarified. This article will show that the TSWC is more important in the TTWC system. Using a three-dimensional baroclinic model, we conducted several numerical experiments to reveal the dynamic relationship between the TWC and TSWC. The results show that the TWC has little effect on the TSWC, while the TSWC has a significant effect on the TWC. A source-sink driven mechanism along isobaths may be used to explain this phenomenon The perennial northward flow through the Tsushima Strait pumps the response over the northern shelf in the ECS that gives rise to the TWC. Although the TSWC is located at the ＂downstream＂ region, it could induce about 0.5 Sv to TWC in annual mean values.

关键词： Taiwan-Tsushima warm current system POM source-sink driven circulation

Piezo-phototronic and pyro-phototronic effects to enhance Cu（In, Ga）Se2 thin film solar cells

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Nano Research 2018年第7期11卷 3877-3885页

作者： Laipan Zhu pei lin Baodong Chen Longfei wang Libo Chen Ding Li Zhong lin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 China College of Nanoscience and Technology University of ChineseAcademy of Sciences Beijing 100049 China

Cu（In, Ga）Se2 （CIGS）-based materials have gained remarkable attention for thin-film photovoltaic applications due to their high absorption coefficient, tunable bandgap, compositional tolerance, outstanding stabilities, and high efficiency. A small increase in the efficiency of CIGS solar cells has huge economic impact and practical importance. As such, we fabricated a flexible CIGS solar cell on a mica substrate and demonstrated the enhanced device performance through the piezo- and pyro-phototronic effects based on a ZnO thin film. The device showed enhanced energy conversion efficiency from 13.48% to 14.23% by decreasing the temperature from 31 to 2℃ at a rate of - 0.6℃·s^-1 via the pyro-phototronic effect, and further enhanced from 14.23% to 14.37% via the piezo-phototronic effect by further applying a static compressive strain. A pyro-electric nanogenerator effect was also found to promote the performance of the CIGS solar cell at the beginning of the cooling process. The manipulated energy band of the CIGS/CdS/ZnO heterojunction under the influence of the inner pyroelectric and piezoelectric potentials is believed to contribute to these phenomena. Applying the piezo- and pyro-phototronic effects simultaneously offers a new opportunity for enhancing the output performance of commercial thin film solar cells.

关键词： CIGS solar cell pyro-phototronic effect piezo-phototronic effect piezopotential pyropotential