检索结果-南通市图书馆

Expressions of the γ_2 chain of laminin-5 and secreted protein acidic and rich in cysteine in esophageal squamous cell carcinoma and their relation to prognosis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2011年第1期30卷 69-78页

作者： Li-Yan Xue Shuang-Mei Zou Shan Zheng Xiu-Yun Liu Peng Wen Yan-ling Yuan Dong-Mei lin ning Lu Department of Pathology Cancer Institute/Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100021 P. R. China

Previous studies have shown that the expressions of the γ2 chain of laminin-5 and secreted protein acidic and rich in cysteine (SPARC) play important roles in oncogenesis and the development of carcinoma. To assess the expressions of laminin-5 γ2 chain and SPARC in esophageal squamous cell carcinoma (SCC), and to clarify the prognostic significance of the expressions of laminin-5 γ2 chain and SPARC in esophageal SCC, we detected the expressions of laminin-5 γ2 chain and SPARC in cancer tissue and corresponding normal mucosa from 116 patients with advanced (stages II-IV) esophageal SCC using the tissue microarray-based immunohistochemistry and analyzed the correlation of the expressions with clinicopathologic characteristics and survival. We found that in normal esophageal tissues, laminin-5 γ2 chain was expressed in the basement membrane, whereas in esophageal SCC tissues, laminin-5 γ2 chain was expressed in the cytoplasm of carcinoma cells, with a positive rate of 72.4%. SPARC was not detected in normal esophageal mucosa, but was expressed in stromal fibroblasts in 84.6% of esophageal SCC cases and in cancer cells in 7.8% of esophageal SCC cases. There was a significant correlation between laminin-5 γ2 chain and stromal SPARC expression in esophageal SCC (Spearman's rho = 0.423, P < 0.001). The expressions of both laminin-5 γ2 chain and stromal SPARC were correlated with survival (P = 0.032 and P = 0.034, respectively). In stage-II esophageal SCC, the expression of laminin-5 γ2 chain was significantly correlated with survival (P = 0.023), while the expression of SPARC was not significantly correlated with survival (P = 0.154). Patients with elevated levels of laminin-5 γ2 chain and SPARC expressions had a poorer prognosis than did those lacking elevated levels of laminin-5 γ2 chain expression and/or elevated levels of SPARC expression (P = 0.001). In stage-II esophageal SCC, patients with elevated levels of laminin-5 γ2 chain and SPARC expressions had a poorer prog

关键词：层粘连蛋白鳞状细胞癌食管癌半胱氨酸分泌蛋白链表预后蛋白表达

Isolated hepatic tuberculosis associated with portal vein thrombosis and hepatitis B virus coinfection:A case report and review of the literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第30期9卷 9310-9319页

作者： Shu-Mei Zheng ning lin Shan-Hong Tang Jia-Yi Yang Hai-Qiong Wang Shu-Lan Luo Yong Zhang Dong Mu Department of Gastroenterology and Hepatology The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina Department of Clinical Nutrition The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina School of Medical Imaging Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

BACKGROUND While tuberculosis(TB)itself is a common disease,isolated TB of the liver is a rare *** involvement of the liver is more commonly a part of a disseminated disease of the hepatic *** contrast,isolated hepatic TB spread through the portal vein from the gastrointestinal tract is seldom encountered in clinical practice,with only a few sporadic cases and short series available in the current *** complications,such as portal vein thrombosis(PVT),have rarely been reported *** SUMMARY A 22-year-old man was hospitalized with complaints of a 3-mo history of fever and weight loss of approximately 10 *** had a 10-year hepatitis B virus(HBV)infection in his medical ***-enhanced computed tomography(CECT)confirmed hepatosplenomegaly,with hypodensity of the right lobe of the liver and 2.1 cm thrombosis of the right branch of the portal vein.A liver biopsy showed epithelioid granulomas with a background of caseating *** staining showed acid-fast bacilli within the *** patient was diagnosed with isolated hepatic TB with ***-TB therapy(ATT),including isoniazid,rifapentine,ethambutol,and pyrazinamide,was *** with ATT,the patient was treated with entecavir as an antiviral medication against HBV and dabigatran as an *** remained asymptomatic,and follow-up sonography of the abdomen at 4 mo showed complete resolution of the *** Upon diagnosis of hepatic TB associated with PVT and HBV coinfection,ATT and anticoagulants should be initiated to prevent subsequent portal *** therapy against HBV should also be administered to prevent severe hepatic injury.

关键词： Hepatic tuberculosis Portal vein thrombosis Hepatitis B virus Case report

Revealing Quasi-1D Volume Expansion in Na-/K-Ion Battery Anodes:A Case Study of Sb_(2)O_(3)Microbelts

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2021年第5期3卷 1306-1315页

作者： Zheng Yi Daliang Fang Wanqun Zhang Jie Tian Shimou Chen Jianbo Liang ning lin Yitai Qian Department of Applied Chemistry Hefei National Laboratory for Physical Science at MicroscaleUniversity of Science and Technology of ChinaHefei 230026 Beijing Key Laboratory of Ionic Liquid Clean Process CAS Key Laboratory of Green Process and EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190 Chemistry Experiment Teaching Center University of Science and Technology of ChinaAnhuli 230026 Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026 Department of Chemistry Capital Normal UniversityBeijing 100048

Tailoring a rational structure to control the huge volume variation is practical in regulating alkali-ion battery performance on the basis of the anisotropic properties of crystallized anode ***,a double-serrated orthorhombic antimony oxide(Sb_(2)O_(3))microbelt was prepared by a thermally induced recrystallization/sublimation *** situ transmission electron microscopy(TEM),in situ X-ray powder diffraction(XRD),and ex situ scanning electron microscopy(SEM)measurements demonstrate that Sb_(2)O_(3)microbelts exhibit a quasi-one-dimensional expansion perpendicular to the belt(along the[100]direction)during *** unconstrained microbelt surface space can appropriately accommodate the oriented volume ***,Sb_(2)O_(3)microbelts exhibit enhanced cycling and rate performance in half-cell sodium-ion batteries *** support of reduced graphene oxide(RGO),Sb_(2)O_(3)@RGOcomposites deliver good rate capability(312.3 mAh g−1 at 3 A g−1)for sodium-ion full-cell batteries and good cycling performance(473.9 mAh g−1 at 100 mA g−1 after 100 cycles)for half-cell potassium-ion *** situ Raman measurements reveal that the conversion/alloying-type Sb_(2)O_(3)anode undergoes a fully reversible alloying reaction and partially reversible conversion mechanism,which explains its irreversible capacity during the first *** delicate structural design and clarification of the alkali-ion storage mechanisms facilitate the development of Sb_(2)O_(3)anodes for energy storage applications.

关键词： anisotropic volume expansion microbelts Sb_(2)O_(3) sodium-ion batteries in situ characterizations

Biomass-based production of trimellitic and trimesic acids

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第8期9卷 1267-1278页

作者： lin Yuan Yancheng Hu Guangyi Li Fengan Han Aiqin Wang Yu Cong Tao Zhang Feng Wang ning Li CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan District School of Chemical Engineering and Technology China University of Mining and Technology State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of Sciences

The production of industrial chemicals with renewable biomass feedstock holds potential to aid the world in pursuing a carbon-neutral *** and trimesic acids are important commodity chemicals in industry that are prepared by the oxidation of petroleum-derived *** reduce the dependence on the limited oil source,we develop a potential sustainable alternative towards trimellitic and trimesic acids using biomass-based 2-methyl-2,4-pentandiol （MPD）,acrylate and crotonaldehyde as starting *** process for trimellitic acid includes dehydration/D-A reaction of MPD and acrylate,flow aromatization over Pd/C catalyst,hydrolysis and catalytic aerobic oxidation （60%overall yield）.The challenging regioselectivity issue of D-A reaction is tackled by a matched combination of temperature and deep eutectic solvent ChCl/*** can also participate in the reaction,followed by Pd/C-catalyzed decarbonylation/dehydrogenation and oxidation to provide trimesic acid in 54%overall *** cycle assessment implies that compared to conventional fossil process,our biomass-based routes present a potential in reducing carbon emissions.

关键词： Biomass Trimellitic acid Trimesic acid Deep eutectic solvent Dehydration/D-A reaction

A quantitative study of airway ultrasound in predicting difficult laryngoscopy:A prospective study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2023年第6期26卷 351-356页

作者： lin ning Xing Zhu Hong-Chao Li Shi-Jie Zhou Qi-Wei Zhang Hong-Yu Zou Qing-Xiang Mao Hong Yan Department of Anaesthesiology Army Medical Center of PLADaping Hospital of Army Medical UniversityChongqingChina Laboratory of Anaesthesia Center Army Medical Center of PLADaping Hospital of Army Medical UniversityChongqingChina Anaesthesia Center Army Medical Center of PLADaping Hospital of Army Medical UniversityChongqingChina

Purpose:As common clinical screening tests cannot effectively predict a difficult airway,and unanticipated difficult laryngoscopy remains a challenge for *** herein used ultrasound to develop some point-of-care predictors for difficult ***:This prospective observational study included 502 patients who underwent laryngoscopy and a detailed sonographic *** under 18 years old,or with maxillofacial deformities or fractures,limited mouth opening,limited neck movement or history of neck surgery were excluded from the *** views of all patients were scored and grouping using the modified Cormack-Lehane(CL)scoring *** measurements acquired comprised tongue width,the longitudinal cross-sectional area of the tongue,tongue volume,the mandible-hyoid bone distance,the hyoid boneglottis distance,the mandible-hyoid bone-glottis angle,the skin-thyrohyoid membrane distance,the glottis-superior edge of the thyroid cartilage distance(DGTC),the skin-hyoid bone distance,and the epiglottis midway-skin *** and Chi-square were used to compare differences between *** regression was used to identify risk factors for difficult laryngoscopy and it was visualized by receiver operating characteristic curves and nomogram.R version 3.6.3 and SPSS version 26.0 were used for statistical ***:Difficult laryngoscopy was indicated in 49 patients(CL grade III-IV)and easy laryngoscopy in 453 patients(CL grade I-II).The ultrasound-measured mandible-hyoid bone-glottis angle and DGTC significantly differed between the 2 groups(p<0.001).Difficult laryngoscopy was predicted by an area under the curve(AUC)of 0.930 with a threshold mandible-hyoid bone-glottis angle of 125.5and by an AUC of 0.722 with a threshold DGTC of 1.22 *** longitudinal cross-sectional area of the tongue,tongue width,tongue volume,the mandible-hyoid distance,and the hyoid-glottis distance did not significantly differ between the groups.C

关键词： Airway management Intubation Ultrasonography Airway Difficult laryngoscopy

Tuning microstructures of TC4 ELI to improve explosion resistance

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第3期33卷 78-99页

作者： Changle Zhang Yangwei Wang lin Wang Zixuan ning Guoju Li Dongping Chen Zhi-Wei Yan Yuchen Song Xucai Wang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing 100081China State Key Laboratory of Explosive Science and Technology Beijing Institute of TechnologyBeijing 100081China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China School of Aeronautical Engineering Zhengzhou University of AeronauticsHenan ProvinceZhengzhou 450046China Shanxi Jiangyang Chemical Co. Ltd.Shanxi ProvinceTaiyuan 030041China Shandong Institute of Non-metallic Materials Shandong ProvinceJinan 250031China

A reasonable heat treatment process for TC4 ELI titanium alloy is crucial to tune microstructures to improve its explosion ***,there is limited investigation on tuning microstructures of TC4 ELI to improve explosion ***,the current challenge is quantifying microstructural changes'effects on explosion resistance and incorporating microstructural changes into finite element *** work aims to tune microstructures to improve explosion resistance and elucidate their anti-explosion mechanism,and find a suitable method to incorporate microstructural changes into finite element *** this work,we systematically study the deformation and failure characteristics of TC4 ELI plates with varying microstructures using an air explosion test and LS-DYNA finite element *** Johnson-Cook(JC)constitutive parameters are used to quantify the effects of microstructural changes on explosion resistance and incorporate microstructural changes into finite element *** of the heat treatment,one plate has equiaxed microstructure and the other has bimodal *** convex of the plate after the explosion has a quadratic relationship with the charge mass,and the simulation results demonstrate high reliability,with the error less than 17.5%.Therefore,it is feasible to obtain corresponding JC constitutive parameters based on the differences in microstructures and mechanical properties and characterize the effects of microstructural changes on explosion *** bimodal target exhibits excellent deformation *** response of bimodal microstructure to the shock wave may be more intense under explosive *** well-coordinated structure of the bimodal target enhances its resistance to deformation.

关键词： Microstructure Finite element modelling Parameter optimization Failure characteristics Explosion resistance

现代社会生活的批判与中国社会秩序的当代建构

在线全文

学校读者我要写书评

暂无评论

南京师大学报（社会科学版） 2016年第4期 80-85页

作者：宁琳东北农业大学国际文化教育学院

寻脉现代西方资本主义国家的社会流动、优才统治、科层组织的影响以及对现代人生活及其观念的改变,可以发现,当代西方"才华和无用的幽灵"以及无根基的知识缘由驱逐着"匠人精神",凸显没有任何个性和生命活性的"数据",逐渐边缘化了个体的... 详细信息

寻脉现代西方资本主义国家的社会流动、优才统治、科层组织的影响以及对现代人生活及其观念的改变,可以发现,当代西方"才华和无用的幽灵"以及无根基的知识缘由驱逐着"匠人精神",凸显没有任何个性和生命活性的"数据",逐渐边缘化了个体的精神理念、审美情趣以及个人偏好,因而生命在"无根"之状中无价值性地存活,这导致了精神与人格分裂成了西方现代人的共同病症。如此,透视现代生活,找寻现代社会的新生活进程与确认新的价值坐标,摆脱所谓人的内在、外在能力的挖掘之取向,锁定"交易"的边界,超越"技能社会"、"技能经济"并进而超越由主义的斯密模式和军事化的韦伯模式,解构现代人生活的"焦虑感"、"恐惧感"与"虚无感",从被遗弃的生存感重新找回、建构自我的幸福。只有认识、批判资本主义文化的病症,才可融入并超越现代社会的历史局限,寻到人自我解放的道路。

关键词：资本主义现代社会社会秩序匠人精神

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

狗仔花饮片标准汤剂的质量标准研究

广西医科大学学报 2024年第6期41卷 897-904页

作者：南惠玲程艳薇李秧岭李芳婵罗宇东林宁钟益宁陈清广西中医药大学中医药壮瑶医药研究院南宁530200 广西中医药大学药学院南宁530200 广西壮瑶药工程技术研究中心南宁530200 广西中医药大学百年乐制药有限公司南宁530023

目的:制备狗仔花标准汤剂,建立狗仔花标准汤剂质量标准,为后续狗仔花配方颗粒及其相关制剂质量标准的制定提供参考。方法:制备15批狗仔花标准汤剂,建立狗仔花饮片和标准汤剂特征图谱,确认共有峰,通过共有峰传递数、指标成分转移率和出... 详细信息

目的:制备狗仔花标准汤剂,建立狗仔花标准汤剂质量标准,为后续狗仔花配方颗粒及其相关制剂质量标准的制定提供参考。方法:制备15批狗仔花标准汤剂,建立狗仔花饮片和标准汤剂特征图谱,确认共有峰,通过共有峰传递数、指标成分转移率和出膏率对标准汤剂进行量值传递规律分析。结果:狗仔花饮片和标准汤剂特征图谱均标定出7个相同的共有峰,说明共有峰均能从饮片传递到标准汤剂中,饮片和标准汤剂特征图谱相似度均>0.9。15批标准汤剂绿原酸的含量为0.25~0.40 mg/g,均值为0.34 mg/g,转移率为26.19%~38.52%;咖啡酸的含量为0.07~0.12 mg/g,转移率为84.37%~134.93%。15批狗仔花标准汤剂出膏率在11.53%~14.02%,浸出物在6.42%~9.16%。结论:本研究建立的高效液相色谱(HPLC)特征图谱和含量测定方法呈现良好的精密度、重复性和稳定性,为狗仔花饮片及其制剂质量标准的制定提供参考,同时为狗仔花中药配方颗粒产品质量控制奠定基础。

关键词：狗仔花标准汤剂高效液相色谱特征图谱质量评价

在线全文

学校读者我要写书评

暂无评论

论“文革”对鲁迅的研究

江苏社会科学 2011年第2期 193-198页

作者：林宁南京大学中国新文学研究中心博士研究生210093

文革时期对鲁迅的研究,与文革特性高度一致,一切从政治需要出发,远离对象本体,为我所用、削足适履,在研究内容上将鲁迅设计为"角斗士";在研究路径和研究队伍上呈现为一种非常态,完全抛弃学术立场、学理原则,丧失了文学研究的独立品格和... 详细信息

文革时期对鲁迅的研究,与文革特性高度一致,一切从政治需要出发,远离对象本体,为我所用、削足适履,在研究内容上将鲁迅设计为"角斗士";在研究路径和研究队伍上呈现为一种非常态,完全抛弃学术立场、学理原则,丧失了文学研究的独立品格和主体精神。

关键词：文革鲁迅研究

维普期刊数据库博看期刊