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Sexual,physical and overall adverse effects in patients treated with 5a-reductase inhibitors:a systematic review and meta-analysis

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Asian Journal of Andrology 2022年第4期24卷 390-397页

作者： Jun-jie zhang Xiao shi Ting Wu Meng-Da zhang Jin Tang guang-ming Yin Zhi Long Le-Ye He lin Qi Long Wang Department of Urology The Third Xiangya HospitalCentral South UniversityChangsha 410008China Department of Urology Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gastroenterology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Cardiovascular Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410013China

Postfinasteride syndrome(PFS)is a term coined to characterize a constellation of reported undesirable sexual,physical,and neuropsychiatric side *** the present study,we conducted the meta-analysis to demonstrate whether the use of 5α-reductase inhibitors(5ARIs)increases the risk of PFS-like adverse effects.A search of studies published until May 10,2020,was performed using PubMed,EMBASE,and the Cochrane *** included randomized controlled trials with at least one comparison between male patients receiving 5ARIs versus placebo for the treatment of benign prostatic hyperplasia(BPH)or androgenetic alopecia(AGA),and identified 34 studies from 28 articles that met our eligibility *** the random-effects model,the overall use of 5ARIs exhibited a 1.87-fold risk of PFS-like adverse effects during the trial(95%confidence interval[CI]:1.64-2.14).Regarding specific types of adverse effects,the use of 5ARIs had a 1.89-fold risk of sexual adverse effects(95%CI:1.74-2.05)and was associated with an increased risk of physical adverse effects(relative risk[RR]:1.31,95%CI:0.80-2.15),albeit without statistical *** meta-analysis helped to better define the adverse effects caused by *** concluded that the overall use of 5ARIs significantly increased the risk of PFS-like adverse effects in men with AGA or BPH during *** awareness of and education on the PFS-like adverse effects are necessary for clinicians.

关键词： 5α-reductase inhibitors adverse effects androgenetic alopecia benign prostatic hyperplasia postfinasteride syndrome

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NT-proBNP与急进高原人群心肺适能的相关性分析

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解放军医学杂志 2024年第9期49卷 998-1003页

作者：李平平叶筱葳杨杰秦浙学卞士柱张继航高旭滨孙梦佳刘振吕海霖贾倩羽杨媛淇杨冰洁黄岚陆军军医大学第二附属医院心血管内科/陆军军医大学全军高原医学临床重点专科重庆400037

目的探讨低海拔基线血清氨基末端脑钠肽前体(NT-proBNP)水平与急进高原后心肺适能的相关性。方法2022年6月于陆军军医大学第二附属医院招募受试者46人,其中男19人,女27人。所有受试者在低海拔地区(海拔300 m)完成心肺运动功能试验(CPET... 详细信息

目的探讨低海拔基线血清氨基末端脑钠肽前体(NT-proBNP)水平与急进高原后心肺适能的相关性。方法2022年6月于陆军军医大学第二附属医院招募受试者46人,其中男19人,女27人。所有受试者在低海拔地区(海拔300 m)完成心肺运动功能试验(CPET)、血清学心肌细胞相关标志物和多种代谢物检测后,乘坐飞机到达高原(海拔3900 m)。在进驻高原后的第2、3天,分别再次完成生物标志物检测和CPET。比较受试者急进高原前后血清生物标志物和CPET关键指标的变化情况,分析血清中多种心肌细胞相关标志物和代谢物水平与高原心肺适能的相关性。结果与低海拔地区相比,急进高原后最大摄氧量下降[(25.41±6.20) ml/(***) vs.(30.17±5.01) ml/(***),P0.05)。相关分析结果显示,低海拔NT-proBNP(r=-0.768,P<0.001)和高原NT-proBNP(r=-0.791,P<0.001)分别与高原的最大摄氧量呈明显负相关;多元线性回归分析显示,低海拔最大摄氧量(t=2.069,P=0.045)、低海拔NTproBNP(t=-2.436,P=0.020)和高原NT-proBNP(t=-3.578,P=0.001)是高原心肺适能的独立影响因素。结论急进高原后心肺适能明显降低,低海拔基线NT-proBNP水平与急进高原后心肺适能密切相关,是高原心肺适能的潜在预测指标。

关键词：心肺适能高原氨基末端脑钠肽前体心肺运动试验

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Scene-trait coping style of military rescuers in Wenchuan earthquake

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中国应用生理学杂志 2014年第6期30卷 538-543页

作者： li-yi zhang Xin-yang SUN ling-ming KONG De-hua TU liang zhang guang-yao li Zi-xiang SONG Chun-xia chen Gao-feng YAO jie shi Prevention and Treatment Center of Psychological Diseases No. 102 Hospital of Chinese PLA Changzhou 213003 Department of Psychology and Psychiatry the Second Military Medical University Shanghai 200433 Department ofPsychiatry Ma'anshan Central Hospital Ma'anshan 243000 First Psychiatric Health Center of Civil Affairs Bureau Shanghai 201105 Department of Psychology No. 102 Hospital of Chinese PLA Changzhou 213003 Departmentof Pediatric Psychiatry No. 102 Hospital of Chinese PLA Changzhou 213003 Department of Psychology GeneralHospital of the Second Artillery Force of the PLA Beijing 100085 China

Objective This study aimed to explore the scene-trait coping style of military rescuers in Wenchuan earthquake in an effort to provide scientific evidences for mental intervention program for Chinese military *** By cluster sampling,a total of 151 military rescuers and 331 control servicemen were administered the military personnel scene-trait coping style scale(MPSTCSS).Results All active coping factor scores,and passive coping factor scores of affection,health and economy in the rescuer group were significantly higher than those in control group(Plitary tasks,military experience and personal development than those of the 21-below age subgroup,3-year minus service subgroup and the soldier subgroup,respectively(Plief servicemen can cope with stressful situations better than control group by taking active coping *** officers,servicemen older than 21 years,and servicemen with more service duration than3 years could usually take active coping style.

关键词：军事任务地震救援场景汶川风格因子得分整群抽样救援人员

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Mannose-binding lectin 2 rs11003123 polymorphism is associated with the development of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis in the Chinese population

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Hepatobiliary & Pancreatic Diseases International 2016年第3期15卷 282-288页

作者： Pu-Sen Wang Jing Kuai Hao li Chun-guang Wang Bao-jie shi lin Zhong Department of General Surgery Shanghai General HospitalShanghai Jiaotong University School of Medicine Department of Hepatobiliary Surgery Weifang People’s Hospital

BACKGROUND： Mannose-binding lectin 2 （MBL2） plays a key role in the host immune response, but whether it is associ- ated with hepatocellular carcinoma （HCC） is not dear. The present study aimed to identify the association between MBL2 gene polymorphisms and HCC in patients with hepatitis B virus （I-IBV）-related cirrhosis in the Chinese population.

关键词： mannose-binding lectin 2 polymorphism hepatitis B cirrhosis hepatocellular carcinoma

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深海圆筒型FPSO总体设计

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船海工程 2024年第3期53卷 90-94页

作者：彭小佳张广磊李俊汲邓石赵洁江欣桐海南省深海技术创新中心海南三亚572000 海洋石油工程股份有限公司天津300451

针对圆筒型FPSO总体设计在主尺度设计、水动力分析、系泊系统设计等方面存在的技术挑战,分别对比不同圆筒直径和垂荡板直径的运动RAO,分析船体设计关键参数和系泊设计关键参数的影响,提出水动力试验校准分析的步骤和重量控制的方法。主... 详细信息

针对圆筒型FPSO总体设计在主尺度设计、水动力分析、系泊系统设计等方面存在的技术挑战,分别对比不同圆筒直径和垂荡板直径的运动RAO,分析船体设计关键参数和系泊设计关键参数的影响,提出水动力试验校准分析的步骤和重量控制的方法。主尺度设计中最关键的主尺度参数是圆筒直径和垂荡板直径,圆筒直径越小或者垂荡板直径越大,垂荡响应越小,圆筒直径越大,横摇运动响应越小。圆筒型FPSO的水动力分析建议同时开展频域分析和时域分析。

关键词：圆筒型FPSO 总体设计水动力分析重量控制

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Genomic Variations in the Tea Leafhopper Reveal the Basis of Its Adaptive Evolution

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1092-1105页

作者： Qian Zhao Longqing shi Weiyi He Jinyu li shijun You Shuai chen Jing lin Yibin Wang liwen zhang guang yang liette Vasseur Minsheng You State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Institute of Applied EcologyFujian Agriculture and Forestry UniversityFuzhou 350002China Institute of Rice Fujian Academy of Agricultural SciencesFuzhou 350018China Tea Research Institute Fujian Academy of Agricultural SciencesFuzhou 350001China Center for Genomics and Biotechnology Fujian Agriculture and Forestry UniversityFuzhou 350002China Department of Biological Sciences Brock UniversitySt.CatharinesON L2S 3A1Canada

Tea green leafhopper(TGL),Empoasca onukii,is of biological and economic *** numerous studies,the mechanisms underlying its adaptation and evolution remain ***,we use previously untapped genome and population genetics approaches to examine how the pest adapted to different environmental variables and thus has expanded *** complete a chromosome-level assembly and annotation of the *** genome,showing notable expansions of gene families associated with adaptation to chemoreception and *** signals indicating balancing selection highlight metabolic pathways involved in adaptation to a wide range of tea varieties grown across ecologically diverse *** of genetic variations among 54 *** samples unveil the population structure and evolutionary history across different tea-growing regions in *** results demonstrate that the genomic changes in key pathways,including those linked to metabolism,circadian rhythms,and immune system functions,may underlie the successful spread and adaptation of *** work highlights the genetic and molecular basis underlying the evolutionary success of a species with broad economic impacts,and provides insights into insect adaptation to host plants,which will ultimately facilitate more sustainable pest management.

关键词： Tea green leafhopper Genomic variation Population genetics Local adaptation Evolutionary history

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Effect of surface modification on thermal expansion of Zr_(2)WP_(2)O_(12)/aromatic polyimides based composites

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Tungsten 2023年第1期5卷 179-188页

作者： Xin-Wei shi Sen zhang Qiang Zhou Jing li Bai-lin Zhu liu-jie xu Qi-Long Gao School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Henan Key Laboratory of High-Temperature Structural and Functional Materials Henan University of Science and TechnologyLuoyang 471003China

Surface modification is a fascinating way to improve the compounding effect between inorganic fillers and *** this study,zirconium tungsten phosphate(ZWP) with negative thermal expansion was surface modified by silane coupling agent 3-(Trimethoxysilyl)propyl *** effects of surface modification and the modification mechanism were analyzed in detail by X-ray diffractometer,scanning electron microscopy,Fourier transform infrared spectroscopy and thermal mechanical *** surface modification could effectively reduce the thermal expansion properties of the *** the added amount of 3-methacryloxypropyl trimethoxysilaneSilane(trade name:KH570) is 0.50 wt%,the thermal expansion coefficient of ZWP/Aromatic polyimide composite decreased by 9.76%.The surface modification also can effectively improve the dielectric performance of aromatic *** present work provides one new way to improve the thermal expansion behavior of composites.

关键词： Negative thermal expansion Tungsten Surface modification Polyimide composite Silane coupling agent

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Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第2期12卷 135-142页

作者： jie GAO Cui-rong SUN jie-hong yang Jian-mei shi Yue-guang DU Yu-yan zhang Jin-hui li Hai-tong WAN Department of Chemistry Zhejiang University Hangzhou 310027 China Institute of Cardio-Cerebrovascular Disease Zhejiang Chinese Medical University Hangzhou 310053 China

The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. （RPL）, a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride （CCI4）-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine ami- notransferase （ALT） and aspartate aminotransferase （AST） levels caused by CCI4 intoxication. It also significantly prevented the decrease in superoxide dismutase （SOD） activity and the increase in malondialdehyde （MDA） content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry （HPLC-MS/MS） revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL.

关键词： Rubus parvifofius L. High-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) Hepatoprotective activity Antioxidant activity

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Effect of primary tumor side on survival outcomes in metastatic colorectal cancer patients after hepatic arterial infusion chemotherapy

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World Journal of Gastrointestinal Oncology 2018年第11期10卷 431-438页

作者： Hang-Yu zhang Jian-Hai Guo Song Gao Hui chen Xiao-Dong Wang Peng-Jun zhang Peng liu guang Cao Hai-Feng xu lin-Zhong Zhu Ren-jie yang Jian li xu Zhu Cancer Biotherapy Centre the First Affiliated Hospital of Zhejiang University Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Interventional Therapy Peking University Cancer Hospital and Institute

AIM To analyze the survival data between patients diagnosed with right-sided primary(RSP) tumors and patients diagnosed with left-sided primary(LSP) tumors after hepatic arterial infusion chemotherapy(HAIC) at our *** A retrospective analysis of pretreated metastatic colorectal cancer patients who received HAIC from May 2006 to August 2015 was conducted. A Cox proportional hazard regression analysis was used to assess the long-term survival outcomes. The mean and median age of patients was 61 years(range 27-85 years). There were 115 males and 53 females in our *** One hundred sixty-eight patients were enrolled in this study. The overall response rate was 28.9% in LSP patients and 27.3% in RSP patients. The disease control rate was 76.3% in LSP patients and 69.7% in RSP patients. The median overall survival in response to HAIC was 16.3 mo in the LSP arm and 9.3 mo in the RSP arm(P = 0.164). The median progression-free survival was 5.7 mo in the LSP arm and 4.2 mo in the RSP arm(P = 0.851).CONCLUSION There was no significant difference in survival between LSP patients and RSP patients after HAIC. Further prospective studies are needed to confirm these findings.

关键词： Colorectal cancer Hepatic arterial infusion chemotherapy Primary tumor side Local treatment Hepatic metastasis

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天语计划——寻找第二个太阳系及探索动态宇宙

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天文学报 2024年第4期65卷 1-43页

作者：冯发波芮易成杜芝茂林清张聪聪周丹崔开明 OGIHARA Masahiro 杨明林杰蔡永志杨涛只庞晓莹简明杰李文雄郭恒潇史弦史建春李荐扬郭康柔姚嵩陈啊明贾鹏谭先瑜 JENKINS S.James 蒋宏轩张铭缘李可欣肖光耀郑书玥宣一帆郑捷何敏 JONES R.A.Hugh 宋翠英上海交通大学李政道研究所上海201210 上海交通大学物理与天文学院上海200240 上海天文馆(上海科技馆分馆) 上海200127 中国科学院上海天文台上海200030 同济大学测绘与地理信息学院上海200092 中国科学院星系宇宙学重点实验室(中国科学技术大学) 合肥230026 中国科学技术大学天文与空间科学学院合肥230026 中国科学院云南天文台昆明650216 中国科学院天体结构与演化重点实验室昆明650216 国际超新星中心-云南省国际超新星研究重点实验室昆明650216 西安交通大学物理学院西安710049 西交利物浦大学物理系苏州215123 上海师范大学上海市星系与宇宙学半解析研究重点实验室上海200234 Department of Astronomy Stockholm University Stockholm11421 中国科学院国家天文台北京100101 中山大学大气科学学院珠海519082 太原理工大学电子信息与光学工程学院太原030024 Instituto de Estudios Astrofısicos Facultad de Ingenierıa y CienciasUniversidad Diego Portales Santiago8170641 Centro de Astrof´ısica y Tecnologıas Afines(CATA)Santiago 8480000 山东大学空间与物理学院山东省光学天文与日地空间环境重点实验室威海264209 中国科学院国家天文台中国科学院天文光学技术重点实验室北京100101 Centre for Astrophysics Research University of Hertfordshire HertfordshireAL109AB 清华大学天体物理研究中心北京100084

像木星和土星这样的冷巨行星对类地行星的形成和宜居性起到了关键作用,因此,对像太阳系这样具有多个冷巨行星的系统的搜寻具有重要意义.Kepler以及TESS (Transiting Exoplanet Survey Satellite)太空望远镜成功地通过凌星的方法发现了... 详细信息

像木星和土星这样的冷巨行星对类地行星的形成和宜居性起到了关键作用,因此,对像太阳系这样具有多个冷巨行星的系统的搜寻具有重要意义.Kepler以及TESS (Transiting Exoplanet Survey Satellite)太空望远镜成功地通过凌星的方法发现了大量短周期行星,然而这些巡天项目的观测基线不足以发现更长周期的行星.为此,天语计划将部署两台1m望远镜(天语一号和天语二号),用于结合天语和其他计划的数据通过凌星法来发现冷巨行星及其他行星,并最终发现类太阳系.天语一号具有约10平方度的视场以及高速CMOS (complementary metal-oxide-semiconductor)科学相机,将对超过1000万颗恒星每小时进行一次高精度测光采样,并通过天语二号的多波段测光、光谱仪以及高分辨率成像对天语一号发现的候选行星进行确认.天语望远镜将放置于海拔约4000m的中国青海冷湖,是目前中国境内最好观测台址之一.天语对亮于14等星的测光精度为0.1%,对亮于18等星的测光精度优于1%,天语预计在5yr内将在类太阳周期发现超过300颗凌星行星,其中包括约17颗冷巨行星.基于系统轨道共面以及孪生地球发生率为10%的假设,天语预计将发现1-2个类太阳系,并可被未来的地球2.0计划所证实.此外,天语还将通过多种巡天观测模式测量从亚秒到周时标的光变,探测不同时标的时域现象,包括超新星早期光变、稀有变星和双星、潮汐瓦解事件、Be星、彗星活动以及系外小行星等.这些发现不仅将深化我们对宇宙的理解,还将为公众科学和科普提供重要平台.

关键词：技术:测光行星与卫星:探测行星与卫星:形成恒星:超新星:普通恒星:变星:普通小行星:普通恒星:伽马射线暴:普通

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