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LA-ICP-MS zircon U-Pb dating of tuffites in the Sachakou Pb-Zn mining area, Karakorum, Xinjiang and its establishment of Early Triassic strata

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China Geology 2024年第1期7卷 150-152页

作者： Xiao-jian Zhao Nuo Li Kai Weng ming Wang Qing-lin Sui Deng-hui Chen Zhou-ping Guo Meng-qi jin Xi’an Center China Geological SurveyMinistry of Natural ResourcesXi’an 710054China Xinjiang Research Center for Mineral Resources Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China College of Geography and Remote Sensing Sciences Xinjiang UniversityUrumqi 830046China University of Chinese Academy of Sciences Beijing 100029China No.8 Geological Party Xinjiang Bureau of Geology and Mineral Exploration and DevelopmentAksu 843000China School of Resource&Environment and Safety Engineering University of South ChinaHengyang 421001China

*** In the past decade,a group of medium to giant lead-zinc deposits,represented by Huoshaoyun,Sachakou,and Yuanbaoling,have been discovered in the Aksai Chin region of Karakoram,*** are all located in the Mesozoic carbonate and clastic rock *** Sachakou leadzinc mining area is adjacent to the northwest of the Huoshaoyun lead-zinc mining area and is in the same stratigraphic layer as *** many scholars have been arguing about the type and age of Huoshaoyun lead-zinc mineralization,few scholars have paid attention to the classification of the ore-bearing strata in the *** stratigraphy of the Lower Permian Shenxianwan Group to the Upper Cretaceous Tielongtan Group is exposed in the Sachakou area of Karakorum,Xinjiang,however,the Late Permian-Early Triassic stratigraphy is missing(Fig.1a).Due to the harsh natural conditions in the area and the low level of work,the stratigraphic delineation is not exhaustive,and the regional lithology is dominated by carbonates and clastic rocks,which makes it difficult to identify the age of the regional lithology and causes problems for the exploration and research of lead-zinc in the area.

关键词： strata Triassic Xinjiang

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微流控芯片上细胞培养与分析方法研究进展

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分析科学学报 2017年第5期33卷 707-714页

作者：林路遥林金明清华大学化学系微量分析测试方法与仪器研制北京市重点实验室北京100084

微流控芯片以其强大的微流体和微小物质控制能力成为研究单细胞、细胞群落乃至生物组织的重要手段。在本篇综述中,我们将以微流控芯片上细胞体外培养模型的建立为主,对近几年来重要的研究工作加以评述,全面地介绍微流控技术在细胞生命... 详细信息

微流控芯片以其强大的微流体和微小物质控制能力成为研究单细胞、细胞群落乃至生物组织的重要手段。在本篇综述中,我们将以微流控芯片上细胞体外培养模型的建立为主,对近几年来重要的研究工作加以评述,全面地介绍微流控技术在细胞生命科学研究中应用的优势和未来发展方向,具体包括微流控芯片的细胞操控能力、细胞培养微环境的构建以及芯片联用检测手段,希望为从事这一领域研究工作的读者提供一些新的思路。

关键词：微流控芯片细胞分选细胞三维培养芯片器官

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Demyelinating neuropathy in patients with hepatitis B virus: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1766-1771页

作者： Xiao-Xiao Yan jin Huang jing lin Department of Neurology The Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina

BACKGROUND Hepatitis B rarely leads to demyelinating neuropathy,despite peripheral neuropathy being the first symptom of hepatitis B *** SUMMARY A 64-year-old man presented with sensorimotor symptoms in multiple peripheral *** testing showed that these symptoms were due to hepatitis *** undergoing treatment involving intravenous immunoglobulin and an antiviral agent,there was a notable improvement in his *** Although hepatitis B virus(HBV)infection is known to affect hepatocytes,it is crucial to recognize the range of additional manifestations linked to this *** connection between long-term HBV infection and demyelinating neuropathy has seldom been documented;hence,prompt diagnostic and treatment are *** patient's positive reaction to immunoglobulin seems to be associated with production of the antigen-antibody immune complex.

关键词： Hepatitis B virus infection Extrahepatic manifestations Demyelinating neuropathy Intravenous immunoglobulin Electroneuromyography Case report

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Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第3期30卷 230-242页

作者： WANG Yi CHEN ming-qi DAI lin-feng ZHANG Hai-dong WANG Xing Department of Critical Care Medicine Changzhou Hospital of Traditional of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineChangzhouJiangsu Province213000China Department of Critical Care Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing210029China

Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo ***:A sepsis mouse model was constructed through intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS).RAW264.7 cells were stimulated by 250 ng/m L LPS to establish an in vitro cell *** pharmacology analysis identified the key molecular pathway associated with FFD in *** ectopic expression and depletion experiments,the effect of FFD on multiple organ damage in septic mice,as well as on cell proliferation and apoptosis in relation to the mitogen-activated protein kinase 14/Forkhead Box O 3A(MAPK14/FOXO3A) signaling pathway,was ***:FFD reduced organ damage and inflammation in LPS-induced septic mice and suppressed LPS-induced macrophage apoptosis and inflammation in vitro(Pling pathway during *** confirmed by in vitro cell experiments,FFD inhibited the MAPK14 signaling pathway or FOXO3A expression to relieve LPS-induced macrophage apoptosis and inflammation(Pling pathway to inhibit LPS-induced macrophage apoptosis in the lung tissue of septic mice(Pling pathway.

关键词： sepsis Fangji Fuling Decoction mitogen-activated protein kinase 14/Forkhead Box O 3A signaling pathway inflammatory response apoptosis lung injury Chinese medicine

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Paleoenvironmental reconstruction and organic matter accumulation of the paleogene shahejie oil shale in the Zhanhua Sag, Bohai Bay Basin, Eastern China

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Petroleum Science 2024年第3期21卷 1552-1568页

作者： Xiao-lin Wang Xiao-Min Zhu jin Lai Xing-Yue lin Xiang Wang Yu-Shan Du Chao Huang Yu-Rui Zhu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Shengli Oilfield SINOPECDongying257000ShandongChina

The controlling factors of organic-rich shale accumulation is essential for the exploration and development of shale oil and gas *** sedimentary environment plays a vital role in the formation of organic-rich sediments in lacustrine *** article unravels the mineralogy,geochemistry,and paleoenvironmental evolution during the deposition of the Paleogene Shahejie Formation(Es_(3)^(L)).It discusses the effects of paleoclimate,paleosalinity,paleoredox conditions,paleowater depth,and paleoproductivity on organic matter(OM)***,the OM enrichment model was *** results show that the mineralogical compositions are mainly composed of calcite(avg.40.13%),quartz(avg.21.64%)and clay minerals(avg.24.07%),accompanied by dolomite(avg.7.07%),feldspar(avg.6.36%)and pyrite(avg.2.95%).The Es_(3)^(L) shale has a high abundance of OM,with total organic carbon(TOC)ranging from 1.07%to 5.12%.The organic matter type is mainly composed of type I-II_(1) kerogen,which is generally considered a good-quality source *** source of OM is a mixture of lower bacteria,algae,and *** the early sedimentary period,the paleoclimate was dry and cold,with high salinity,intense reducibility,and relatively low *** the late sedimentary period,the climate became warmer and more *** a result,the salinity decreased to a level that was suitable for biological reproduction,and productivity increased gradually due to the input of terrigenous *** and paleoclimate determined the environment of the sedimentary period,in addition,paleoproductivity and paleoredox condition indicated the formation and preservation conditions of *** warm and humid climate,brackish water,suitable reduction conditions and high productivity are the favorable conditions for the generation and preservation of organic *** research results may have implications for the genetic mechanisms of organic matter *** will provide theoret

关键词： Elemental geochemical Paleoenvironment Organic matter accumulation Paleogene shahejie formation Zhanhua Sag Bohai Bay Basin

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Implementation of gastrointestinal function protection in severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 521-522页

作者： Fu-Zheng Tao Rong-lin Jiang Shui-Fang jin Intensive Care Unit Taizhou Integrated Traditional Chinese and Western Medicine HospitalTaizhou 310075China Intensive Care Unit the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006China

Severe acute pancreatitis(SAP)is a serious systemic disease associated with strong local inflammatory reactions and serious systemic pathophysiological disorders caused by trypsin *** with SAP are prone to exhibit gastrointestinal ***,gastrointestinal dysfunction further aggravates the systemic inflammatory response and metabolic abnormalities,resulting in a more critical condition of *** dysfunction is considered to be the“trigger”of multiple organ dysfunction syndrome[1].Thus,it is important to maintain gastrointestinal homeostasis in the treatment of SAP.

关键词： gastrointestinal pancreatitis acute

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Meibomian glands segmentation in infrared images with limited annotation

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 401-407页

作者： Jia-Wen lin ling-Jie lin Feng Lu Tai-Chen Lai jing Zou lin-ling Guo Zhi-ming lin Li Li College of Computer and Data Science Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Shengli Clinical Medical College of Fujian Medical University Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial Hospital South BranchFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

●AIM:To investigate a pioneering framework for the segmentation of meibomian glands(MGs),using limited annotations to reduce the workload on ophthalmologists and enhance the efficiency of clinical diagnosis.●METHODS:Totally 203 infrared meibomian images from 138 patients with dry eye disease,accompanied by corresponding annotations,were gathered for the study.A rectified scribble-supervised gland segmentation(RSSGS)model,incorporating temporal ensemble prediction,uncertainty estimation,and a transformation equivariance constraint,was introduced to address constraints imposed by limited supervision information inherent in scribble *** viability and efficacy of the proposed model were assessed based on accuracy,intersection over union(IoU),and dice coefficient.●RESULTS:Using manual labels as the gold standard,RSSGS demonstrated outcomes with an accuracy of 93.54%,a dice coefficient of 78.02%,and an IoU of 64.18%.Notably,these performance metrics exceed the current weakly supervised state-of-the-art methods by 0.76%,2.06%,and 2.69%,***,despite achieving a substantial 80%reduction in annotation costs,it only lags behind fully annotated methods by 0.72%,1.51%,and 2.04%.●CONCLUSION:An innovative automatic segmentation model is developed for MGs in infrared eyelid images,using scribble annotation for *** model maintains an exceptionally high level of segmentation accuracy while substantially reducing training *** holds substantial utility for calculating clinical parameters,thereby greatly enhancing the diagnostic efficiency of ophthalmologists in evaluating meibomian gland dysfunction.

关键词： infrared meibomian glands images meibomian gland dysfunction meibomian glands segmentation weak supervision scribbled annotation

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Flexible MXene/sodium alginate composite fabric with high structural stability and oxidation resistance for electromagnetic interference shielding

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Nano Research 2024年第6期17卷 5326-5335页

作者： Hao-Wen Zhang Lu-Yao Yang Meng-lin Huang ming-Hua Cheng Zhe-Sheng Feng Fanbin Meng Zifeng lin Yan Wang School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054China Laboratory of Advanced Technologies of Materials(Ministry of Education) School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

Wearable electromagnetic interference(EMI)shielding fabrics with excellent electromagnetic shielding performance,oxidation resistance,and structural stability are highly demanded for the rapid development of electronic devices and wireless *** are metallic conductive materials with exceptional EMI shielding properties,but they are prone to oxidation in air and have poor structural stability and durability on fabric ***,we present a one-step assembly method to fabricate fabrics coated with MXenes and polymeric sodium alginate(SA)composite(MXene-SA).SA protects MXenes from oxidation and forms a stable interlayer structure by bonding to *** MXene-SA coated fabrics are breathable and flexible,and have a low sheet resistance of 2.12±0.08Ω/sq and a high EMI shielding performance of 37.05 dB at X-band,which is comparable to the best 42.31 ***,the MXene-SA coated fabrics exhibit high structural stability and oxidation resistance under various conditions of sonication disintegration,mechanical abuse,chemical corrosion,and humidity,compared to pure MXenes coated *** believe that the wearable and high-performance MXene-SA fabrics have great potential for the next generation of ultra-portable and wearable EMI shielding products.

关键词： MXenes electromagnetic interference shielding fabric one-step assembly

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Relationship between dietary niacin intake and erectile dysfunction:a population-based study

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Asian Journal of Andrology 2024年第4期26卷 382-388页

作者： Wei-Long lin Cheng Zheng Hao-Xu Wang Wei Zhang ming-En lin Department of Urology The First Affiliated Hospital of Shantou University Medical CollegeMedical College of Shantou UniversityShantou 515041China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510260China.

Existing research on the precise link between dietary niacin intake and erectile dysfunction(ED)is ***,this study aimed to investigate the potential association between dietary niacin intake and the risk of *** logistic regression and restricted cubic splines(RCSs)were used to examine the relationship between dietary niacin intake and *** interaction analysis was performed to assess the impact of different subgroups on the study *** addition,1:1 propensity score matching(PSM)was employed to adjust for potential confounding factors,ensuring the reliability of the *** analyzed data were collected from the 2001–2004 National Health and Nutrition Examination Survey(NHANES)in the *** study encompassed 3184 adults,among whom 863 participants were identified as having *** adjustments for potential confounders,the findings revealed that higher niacin intake,specifically in the highest tertile,was associated with a decreased risk of ED compared to that in the lowest tertile,showing an odds ratio(OR)of 0.56(95%confidence interval[CI]:0.37–0.85).Analysis of dose–response curves illustrated a negative correlation between dietary niacin intake and the risk of *** and interaction analyses fortified the consistency of these ***,PSM corroborated the validity of the *** study suggests an inverse association between dietary niacin intake and the risk of ***,establishing a cause-and-effect relationship remains elusive,and defining the safe threshold of niacin intake to prevent ED requires further investigation.

关键词： dietary niacin erectile dysfunction National Health and Nutrition Examination Survey propensity score matching

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A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy

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Chinese Chemical Letters 2024年第10期35卷 353-359页

作者： Han Han Bi-Te Chen Jia-Rong Ding jin-ming Si Tian-jiao Zhou Yi Wang Lei Xing Hu-lin Jjiang State Key Laboratory of Natural Medicines Department of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China College of Pharmacy .Yanbian UniversityYanji 133002China Department of Nephrology Changhai HospitalNaval Medical UniversityShanghai 200433China

Activated pancreatic stellate cells(PSCs)are the main source of collagen layer deposition and the key target in pancreatic ***,no effective treatment specific to pancreatic fibrosis clinically,owing to the drug accumulation blocked by the collagen barrier and thus it is difficult to inhibit activated PSCs ***,a PSCs-targeting nano-system based on“nanodrill”strategy(LA-PC)was designed to enhance the accumulation of all-trans retinoic acid(ATRA)in PSCs,relying on the platelet-derived growth factor receptor beta(PDGFRβ)-targeting peptide(p PB:C*SRNLIDC*)and collagenase(Col).After being injected into fibrotic mice via tail vein,the Col modified on LA-PC can remove the excess collagen layer,and the drug delivery efficiency through pPB targeting peptide was more than 5 times higher than that of free ATRA,as well as the degree of fibrosis significantly ***,this nano-system effectively inhibited platelet-derived growth factor subunit B(PDGF-BB)/PDGFRβaxis on PSCs via a down-regulated extracellular signal-regulated protein kinase(ERK)pathway,and accordingly reduced the level of ***,the smart platform provided a promising strategy for the treatment of pancreatic fibrosis to achieve the precise regulation of PSCs.

关键词： Pancreatic fibrosis Pancreatic stellate cells Liposome PDGFRβ pPB peptide

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