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Scorpiones,Scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via PI3K/AKT/mTOR/HIF-1αSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第9期30卷 799-808页

作者： MAO Qi-yuan WANG Xue-qian lin Fei YU Ming-wei FAN Hui-ting ZHENG Qi LIU Lan-chun ZHANG Chu-chu LI Dao-rui lin hong-sheng Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Institute of Traditional Chinese Medicine Information China Academy of Chinese Medical SciencesBeijing100700China

Objective:To investigate whether Buthus martensii karsch(Scorpiones),Scolopendra subspinipes mutilans ***(Scolopendra)and Gekko gecko linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit lung cancer growth and metastasis by regulating phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α(PI3K/AKT/mTOR/HIF-1α)signaling ***:Male C57BL/6J mice were inoculated with luciferase labeled LL/2-luc-M38 cell suspension to develop lung cancer models,with rapamycin and cyclophosphamide as positive *** methyl cellulose solutions of Scorpiones,Scolopendra and Gekko were administered intragastrically as 0.33,0.33,and 0.83 g/kg,respectively once daily for 21 *** expression were detected every 7 days after inoculation,and tumor growth curves were *** was performed to determine CD31 and HIF-1αexpressions in tumor tissue and microvessel density(MVD)was *** blot was performed to detect the expression of PI3K/AKT/mTOR/HIF-1αsignaling pathway-related ***-linked immunosorbent assay was performed to detect serum basic fibroblast growth factor(bFGF),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)in ***:Scorpiones,Scolopendra and Gekko prolonged the survival time and inhibited lung cancer metastasis and expression of HIF-1α(all Pling pathway.

关键词： Scorpiones Scolopendra Gekko dredging collaterals and activating blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway

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Application Status of Chinese Medicine on Cancer Rehabilitation: A Preliminary Questionnaire Survey

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Chinese Journal of Integrative Medicine 2020年第12期26卷 890-896页

作者： YU Hui-yong WANG Xue-qian ZHANG Ying LIU Jie lin hong-sheng Department of Respiratory Beijing University of Chinese Medicine Third Affiliated HospitalBeijing(100029)China Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medicine SciencesBeijing(100053)China

Objective:To investigate the application status of Chinese medicine(CM)in cancer rehabilitation,so as to provide references for improving the level of CM cancer ***:A survey questionnaire regarding"application status of CM rehabilitation in cancer patients"for oncologists(doctor version)and cancer patients(patient version)were developed,*** September 2014 to November 2016,a total of 1,000 doctors from oncology department in 48 hospitals and 2,000 cancer patients from CM oncology department from 8 hospitals in China were recruited in this *** psychological,nutrition and exercise rehabilitation guidance for cancer patients provided by doctors,their mastery conditions regarding cancer staging treatment and CM syndrome differentiation,and recommendation from doctors on CM rehabilitation were *** patients’awareness on the importance of psychological,nutrition and exercise rehabilitation,as well as their knowledge and needs for rehabilitation were also *** impact of gender,age,professional title,hospitals grades of physicians on their knowledge of cancer staging treatment and CM syndrome differentiation,and the relationship between gender,age,education level and economic conditions and patient’s knowledge along with the needs of CM rehabilitation were further ***:Totally 1,000 questionnaires were issued to doctors and 963 questionnaires returned,among which 948 were valid representing a response rate of 94.80%.A total of 2,000 questionnaires were issued to patients and 1,705 valid data finally returned with a response rate of 85.25%.The survey showed that cancer patients generally paid much attention to psychological,nutritional and sports rehabilitation,and had a strong demand for CM *** of CM rehabilitation was not well provided by oncologists,and the rehabilitation guidance as well as CM rehabilitation measures were obviously insufficient in cancer *** an

关键词： cancer rehabilitation questionnaire survey Chinese medicine psychological rehabilitation nutrition rehabilitation exercise rehabilitation

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Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN^(-/-)/p53^(-/-) Prostate Cancer Cells In Vitro and Ex Vivo

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Chinese Journal of Integrative Medicine 2018年第2期24卷 109-116页

作者： PAN hong LU Li-yuan WANG Xue-qian LI Bin-xue Kathleen Kelly lin hong-sheng Clinical Medical College Beijing University of Chinese Medicine Laboratory of Oncology Guang'anmen HospitalChina Academy of Chinese Medical Sciences Laboratory of Genitourinary Cancer Pathogenesis Center for Cancer ResearchNational Cancer InstituteNational Institutes of Health

Objective： To investigate the effect of gambogic acid（GA） on the growth and cell death of castrate resistant prostate cancer（PC） with phosphate and tension homology（PTEN） and p53 genes deleted in vitro and ex vivo, and elucidate the underlying possible molecular mechanisms. Methods： PTEN^（-/-）/p53^（-/-）PC cells and Los Angeles prostate cancer-4（LAPC-4） cells were treated with GA for 24 h and 48 h, then cell viability was determined by cell proliferation assay. PTEN^（-/-）/p53^（-/-）PC cells organoids number was calculated under GA treatment for 1 week. In addition, cell titer glo assay was performed to analyze 3 dimensional cell viability of patients derived xenografts（PDX） 170.2 organoids. Flow cytometry was used to detect apoptotic cells treated with GA. And confocal image was performed to detect the apoptotic mitochondrial morphological changes. Apoptotic cell death related protein levels were measured through Western blot（WB） in GA treated cells and organoids. The expression levels of mitogen-activated protein kinases（MAPKs） pathway related ribonucleic acid（RNAs） and proteins were analyzed by reverse transcription polymerase chain reaction（RT-PCR） and WB, respectively. Results： The treatment of GA significantly reduced cell viability of PTEN^（-/-）/p53^（-/-）PC cells and LAPC-4 in a time-and concentration-dependent manner. In organoids, GA showed strong inhibition towards organoids＇ numbers and diameters and continuously led to a complete organoids inhibition with GA 150 nmol/L. Ex vivo results validated that GA 1 μmol/L inhibited 44.6% PDX170.2 organoids growth. As for mechanism, flow cytometry detected continuously increased apoptotic portion under GA treatment from 1.98% to 11.78%（6 h） and 29.94%（8 h, P〈0.05）. In addition, mitochondrial fragmentation emerged in GA treated cells indicated the mitochondrial apoptotic pathway might be involved. Furthermore, WB detected caspases-3,-9 activation and light chain（LC）-3 conversion with GA treatment. WB revealed decreased

关键词： gambogic acid prostate cancer apoptosis mitogen-activated protein kinase PTEN-/-/p53-/-

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林洪生从平衡论治肿瘤

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中华中医药杂志 2016年第2期31卷 510-512页

作者：刘浩林洪生中国中医科学院广安门医院北京100053

文章介绍林洪生教授从平衡论治肿瘤的学术观点,将其总结归纳为4个方面:扶正培本是维护肿瘤患者机体平衡的基础;掌握攻补平衡是中医肿瘤治疗的关键;应使局部治疗与整体治疗相互协调;积极倡导形神兼治,促进患者身心和谐。通过平衡治疗发... 详细信息

文章介绍林洪生教授从平衡论治肿瘤的学术观点,将其总结归纳为4个方面:扶正培本是维护肿瘤患者机体平衡的基础;掌握攻补平衡是中医肿瘤治疗的关键;应使局部治疗与整体治疗相互协调;积极倡导形神兼治,促进患者身心和谐。通过平衡治疗发挥中医药的优势,为肿瘤患者提供更好的治疗。

关键词：肿瘤中医平衡名医经验林洪生

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CAGCN:Centrality-Aware Graph Convolution Network for Anomaly Detection in Industrial Control Systems

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Journal of Computer Science & Technology 2024年第4期39卷 967-983页

作者： Jun Yang Yi-Qiang sheng Jin-lin Wang hong Ni National Network New Media Engineering Research Center Institute of AcousticsChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

In industrial control systems,the utilization of deep learning based methods achieves improvements for anomaly ***,most current methods ignore the association of inner components in industrial control *** industrial control systems,an anomaly component may affect the neighboring components;therefore,the connective relationship can help us to detect anomalies *** this paper,we propose a centrality-aware graph convolution network(CAGCN)for anomaly detection in industrial control *** the traditional graph convolution network(GCN)model,we utilize the concept of centrality to enhance the ability of graph convolution networks to deal with the inner relationship in industrial control *** experiments show that compared with GCN,our CAGCN has a better ability to utilize this relationship between components in industrial control *** performances of the model are evaluated on the Secure Water Treatment(SWaT)dataset and the Water Distribution(WADI)dataset,the two most common industrial control systems datasets in the field of industrial anomaly *** experimental results show that our CAGCN achieves better results on precision,recall,and F1 score than the state-of-the-art methods.

关键词： graph convolution network(GCN) data mining network centrality anomaly detection industrial control system

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Heterogeneous engineering of MnSe@NC@ReS_(2) core-shell nanowires for advanced sodium-/potassium-ion batteries

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Rare Metals 2024年第8期43卷 3713-3723页

作者： sheng-Jun Lu Jin-Yi lin Cai-hong Wang Yu-Fei Zhang Yi Zhang Hao-Sen Fan College of Materials Science and Metallurgy Engineering Guizhou University Guiyang 550025China School of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China

Sodium-ion batteries(SIBs) and potassium-ion batteries(PIBs) have been attracting great attentions and widely been exploited due to the abundant sodium/potassium ***,the preparation of high-powered anode materials for SIBs/PIBs plays a decisive role for the commercial applications of SIBs/PIBs in the *** selenides are a class of potential anode materials for SIBs/PIBs because of their small band gap and high electrical *** this work,MnSe and ReS_(2) core-shell nanowires connecting by polydopamine derived carbon nanotube(MnSe@NC@ReS_(2)) have been successfully synthesized from growing ReS_(2) nanosheets array on the surface of MnSe@NC nano wires,which present excellent Na^(+)/K^(+) storage *** applied as SIBs anode,the specific capacity of 300 mAh·g^(-1) was maintwined after 400 cycles at the current density of 1.0 A·g^(-1).Besides,it could also keep 120 mAh·g^(-1) specific capacity after 900 cycles at 1.0 A·g^(-1) for the anode of *** heterogeneous engineering and one-dimensional-two-dimensional(1D-2D) hybrid strategies could provide an ideal strategy for the synthesis of new hetero-structured anode materials with outstanding battery performance for SIBs and PIBs.

关键词： Heterogeneous engineering Core-shell nanowires MnSe@NC@ReS_(2)nanowires Na^(+)batteries K^(+)batteries

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Traveling Wave Characteristics Based Pilot Protection Scheme for Hybrid Cascaded HVDC Transmission line

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 971-980页

作者： Dalin Mu sheng lin Xiaopeng Li the School of Electrical Engineering Southwest Jiaotong UniversityChengdu 611756China the State Grid Sichuan Electric Power Research Institute Chengdu 610041China

The hybrid cascaded high-voltage direct current(HVDC)transmission system has various operation modes,and some operation modes have sharply increasing requirements for protection rapidity,while the traditional pilot differential protection(PDP)has poor rapidity,and even refuses to operate when faults occur on the DC ***,a novel pilot protection scheme based on traveling wave characteristics is ***,the adaptability of the traditional PDP applied in engineering is analyzed for different operation ***,the expressions of the forward traveling wave(FTW)and backward traveling wave(BTW)on the rectifier side and the inverter side are derived for different fault *** the theoretical derivation,the difference between the BTW and FTW on the rectifier side is less than zero,and the same is true on the inverter ***,in the event of an external fault of DC line,the difference between the BTW and FTW at nearfault terminal protection installation point is greater than ***,by summing over the product of the difference between BTW and FTW of the rectifier side and that of the inverter side,the fault identification criterion is *** simulation results show that the proposed pilot protection scheme can quickly and reliably identify the short-circuit faults of DC line in different operation modes.

关键词： Hybrid cascaded high-voltage direct current(HVDC)transmission system DC line operation mode pilot protection

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林洪生“固本清源”理论治疗原发性肝癌经验思想

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中华中医药杂志 2020年第8期35卷 3950-3953页

作者：毛启远周慧灵关靓李道睿林洪生北京中医药大学北京100029 中国中医科学院广安门医院肿瘤科北京100053

林洪生教授从事恶性肿瘤中西医结合诊疗工作数十年,将"固本清源"思想引入临床治疗,提倡中医分阶段论治与调养,即"五治五养"。文章通过总结分析林洪生教授"固本清源"理论治疗原发性肝癌经验思想,结合原发性肝癌中西医研究进展和临床病案... 详细信息

林洪生教授从事恶性肿瘤中西医结合诊疗工作数十年,将"固本清源"思想引入临床治疗,提倡中医分阶段论治与调养,即"五治五养"。文章通过总结分析林洪生教授"固本清源"理论治疗原发性肝癌经验思想,结合原发性肝癌中西医研究进展和临床病案,从病因病机、学术思想、辨证用药等方面,阐述了"固本清源"理论指导下中医治疗在改善原发性肝癌患者临床症状、提高生活质量、延长生存期等方面的积极作用,为中医药治疗原发性肝癌提供理论依据。

关键词：林洪生原发性肝癌固本清源经验思想病案

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Intra-thyroid esophageal duplication cyst:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2231-2236页

作者： hong-Guo lin Ming Liu Xue-Yang Huang Da-sheng Liu Department of Vascular Thyroid Surgery The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Esophageal cysts are relatively rare in clinical practice,with most of the literature comprising case *** cysts protruding into the thyroid gland are easily misdiagnosed as thyroid *** such cases have been reported so *** SUMMARY This article reports the case of a 31-year-old adult male diagnosed with thyroid nodules before *** patient underwent left thyroidectomy and *** the surgery,esophageal cysts were identified in the esophageal muscle and thyroid *** pathology results confirmed a nodular goiter combined with esophageal ***,the patient developed a neck infection and underwent another operation and broad-spectrum antibiotic treatment for *** We report the first clinical case of an esophageal cyst located within the thyroid gland that was successfully treated *** cyst located within the thyroid gland cause difficulties in *** the present study,the contents of the esophageal cysts were calcified foci,and a small amount of fluid mixture,which were easily misdiagnosed as thyroid nodules and misled the surgical methods.

关键词： Esophageal cysts Thyroid Diagnosed Surgery Case report

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Relative position of seeds driven the seedling growth are mediated by root-leaf traits

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Journal of Plant Ecology 2024年第2期17卷 24-35页

作者： Jing Zhu Xue-lin Wang Xing Jin Lan Jiang hong-Yu lin Yang Hu Jin-Fu Liu Zhong-sheng He College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002China Key Laboratory of Fujian Universities for Ecology and Resource Statistics Fujian Agriculture and Forestry UniversityFuzhou 350002China Zhenjiang Natural Resources and Planning Bureau Economic and Technological Development Zone Branch Zhenjiang 212132China

Variations in plant traits are indicative of plant adaptations to forest environments,and studying their relationships with tree growth provides valuable insights into forest *** spatial arrangement of plant seeds within the forest litter or soil critically infuences the variations of root-leaf traits,thereby affecting the adaptive strategies of emerging ***,our current understanding of the impacts of individual root-leaf traits on seedling growth in different relative position,and whether these traits together affect growth,remains *** study focuses on the dominant tree species,Castanopsis kawakamii,within the Sanming *** Nature Reserve of *** present experiment aimed to examine the variations in root-leaf traits of seedling,focus on the relative positions of seeds within different layers:beneath or above the litter layer,or within the bare soil layer(without litter).Our fndings provided evidence supporting a coordinated relationship between root and leaf traits,wherein leaf traits varied in conjunction with root traits in the relative positions of ***,we observed that seedlings exhibited higher values for specifc leaf area and average root diameter,while displaying lower root tissue *** mixed model explained 86.1%of the variation in root-leaf traits,surpassing the variation explained by the relative ***,soil nitrogen acted as a mediator,regulating the relationship between seedling growth and root-leaf traits,specifcally leaf dry matter content and root tissue ***,future studies should consider artifcially manipulating tree species diversity based on root-leaf traits characteristics to promote forest recovery.

关键词： relative growth rate coordination leaf traits root traits soil nitrogen content seed relative positions

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