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Cytogenetic and molecular aberrations of multiple myeloma patients： a single-center study in Singapore

Chinese Medical Journal 2013年第10期126卷 1872-1877页

作者： lim Alvin Soon Tiong lim Tse Hui SEE Karen Hsu Shien NG Yit Jun TAN Yu Min CHO0 Natasha Swee Lian lim sherry xin er YEE Yenny LAU Lai Ching TIEN Sim Leng Kumar Sathish TAN Daryl Chen Lung Cytogenetics Laboratory Department of Pathology SingaporeGeneral Hospital Singapore School of Biological Sciences Nanyang Technological UniversitySingapore Temasek Applied Science School Temasek Polytechnic Singapore Department of Haematology Singapore General HospitalSingapore

Background Much is known about the cytogenetic lesions that characterize multiple myeloma （MM） patients from the USA, Europe, and East Asia. However, little has been published about the disease among Southeast Asians. The aim of this study was to determine the chromosomal abnormalities of MM patients in our Singapore population. Methods Forty-five newly-diagnosed, morphologically confirmed patients comprising 18 males and 27 females, aged 46-84 years （median 65 years） were investigated by karyotyping and fluorescence in situ hybridization （FISH）. FISH employing standard panel probes and lp36/lq21 and 6q21/15q22 probes was performed on diagnostic bone marrow samples. Results Thirty-four cases （75.6%） had karyotypic abnormalities. Including FISH, a total detection rate of 91.1% was at- tained. Numerical and complex structural aberrations were common to both hyperdiploid and non-hyperdiploid patients. Numerical gains of several recurring chromosomes were frequent among hyperdiploid patients while structural rear- rangements of several chromosomes including 8q24.1 and 14q32 characterized non-hyperdiploid patients. With FISH, immunoglobulin heavy chain （IGH） gene rearrangements, especially fibroblast growth factor receptor 3 （FGFR3）/IGH and RB1 deletion/monosomy 13 were the most common abnormalities （43.4%）. Amplification lq21 was 10 times more frequent （42.5%） than del（1p36） and del（6q21）. Conclusions We have successfully reported the comprehensive cytogenetic profiling of a cohort of newly-diagnosed myeloma patients in our population. This study indicates that the genetic and cytogenetic abnormalities, and their frequencies, in our study group are generally similar to other populations.

关键词： amp(l q21), del(13q) fluorescence in situ hybridization, immunoglobulin heavy chain, Southeast Asia

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Combination therapy with methylprednisolone,rituximab,and tofacitinib in antimelanoma differentiation-associated 5 gene dermatomyositis with rapidly progressive interstitial lung disease

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Rheumatology & Autoimmunity 2024年第2期4卷 122-125页

作者： Mona Manghani Weiyen lim Gin Tsen Chai xin Rong lim Choon Guan Chua Department of Rheumatology Allergy and ImmunologyTan Tock Seng HospitalSingapore CitySingapore Department of Preventative and Population Medicine Tan Tock Seng HospitalSingapore CitySingapore Department of Respiratory Medicine Tan Tock Seng HospitalSingapore CitySingapore Department of Respiratory MedicineTan Tock Seng HospitalSingapore CitySingapore

To the Editor,Anti-melanoma differentiation-associated gene 5(anti-MDA5)antibody-associated dermatomyositis(DM)presenting with rapidly progressive interstitial lung disease(RP-ILD)is extremely challenging to ***5 is a cytosolic viral RNA sensor that normally triggers an innate response resulting in interferon I *** of MDA5 expression can result in autoantibody formation,leading to overactivation of the type I interferon pathway,causing aberrant metabolic remodeling of peripheral B and T cells and a profibrotic response in the affected lungs.

关键词： interferon melanoma lung

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A Study on the Impact of Cheerleading on the Psychological Health of Female College Students

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Journal of Contemporary Educational Research 2024年第3期8卷 43-48页

作者： Haojun Zhao Seong Pek lim Zhuozhuo xin Lincoln University College 47301 Petaling JayaSelangorMalaysia Shandong Communication&Media College Jinan 250200Shandong ProvinceChina

This study investigates the effects of technical cheerleading and dance cheerleading on the psychological health of female college students by utilizing the Symptom Checklist-90(SCL-90),the Comprehensive Diagnostic Scale for Interpersonal Relationships,and the Social Adaptability Diagnostic *** findings indicate the following:(1)Technical cheerleading has a highly significant impact on sensitivity in interpersonal relationships,paranoia,and psychoticism,and a significant effect on anxiety and hostility;dance cheerleading has a highly significant effect on paranoia;(2)Both technical and dance cheerleading have minimal impact on the overall score distribution of interpersonal relationships among female college students,but the dimensions of their effects differ;(3)The impact of technical cheerleading on the social adaptability of female college students is more pronounced than that of dance cheerleading.

关键词： Technical cheerleading Dance cheerleading Female college students Psychological health

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The Impact of Sports Games on the Psychological Health of Middle School Students

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Journal of Contemporary Educational Research 2024年第3期8卷 95-100页

作者： Zhuozhuo xin Seong Pek lim Haojun Zhao Lincoln University College 47301 Petaling JayaSelangorMalaysia Qilu Normal University Jinan 250200Shandong ProvinceChina

This study conducted a 16-week comparative experiment with 160 students from Jinan No.5 Middle School in Shandong Province as the experimental *** the implementation of the experiment,the subjects were divided into two groups:an experimental group and a control *** experimental group was subjected to physical exercise interventions using sports game teaching methods during physical education class,while the control group followed traditional physical education teaching *** results showed that the psychological health status of the students in the experimental group was significantly better than that of the control group after the *** application of sports games helps to improve the psychological health of middle school students in the course of physical education,promoting a positive and forward direction in student psychology and is an effective means to enhance the psychological health level of middle school students.

关键词： Sports games Physical education Middle school students Psychological health

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Reinforcement Learning Based Dynamic Spectrum Access in Cognitive Internet of Vehicles

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China Communications 2021年第7期18卷 58-68页

作者： xin Liu Can Sun Mu Zhou Bin Lin Yuto lim School of Information and Communication Engineering Dalian University of TechnologyDalian 116024China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China Chongqing Key Lab of Mobile Communications Technology Chongqing University of Posts and TelecommunicationsChongqing 400065China Department of Communication Engineering Institute of Information Science TechnologyDalian Maritime UniversityDalian 116026China School of Information Science Japan Advanced Institute of Science and TechnologyIshikawa 923-1292Japan

Cognitive Internet of Vehicles(CIoV)can improve spectrum utilization by accessing the spectrum licensed to primary user(PU)under the premise of not disturbing the PU’s ***,the traditional static spectrum access makes the CIoV unable to adapt to the various spectrum *** this paper,a reinforcement learning based dynamic spectrum access scheme is proposed to improve the transmission performance of the CIoV in the licensed spectrum,and avoid causing harmful interference to the *** frame structure of the CIoV is separated into sensing period and access period,whereby the CIoV can optimize the transmission parameters in the access period according to the spectrum decisions in the sensing *** both detection probability and false alarm probability,a Q-learning based spectrum access algorithm is proposed for the CIoV to intelligently select the optimal channel,bandwidth and transmit power under the dynamic spectrum states and various spectrum sensing *** simulations have shown that compared with the traditional non-learning spectrum access algorithm,the proposed Q-learning algorithm can effectively improve the spectral efficiency and throughput of the CIoV as well as decrease the interference power to the PU.

关键词： cognitive Internet of vehicles reinforcement learning dynamic spectrum access Q-learning spectral efficiency

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On limiting Directions of Julia Sets of Entire Solutions of Complex Differential Equations

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Wuhan University Journal of Natural Sciences 2024年第4期29卷 357-364页

作者： XIA xin ZHANG Ying HUANG Zhigang School of Mathematical Sciences Suzhou University of Science and TechnologySuzhou 215009JiangsuChina Information Construction and Management Center Suzhou University of Science and TechnologySuzhou 215009JiangsuChina

Assume that f is a transcendental entire *** ray arg z=θ∈[0,2π]is said to be a limiting direction of the Julia set J(f)of f if there exists an unbounded sequence{z_(n)}■J(f)such that lim rn→∞ arg z_(n)=θ.In this paper,we mainly investigate the dynamical properties of Julia sets of entire solutions of the complex differential equations F(z)f^(n)(z)+P(z,f)=0,and f^(n)+A(z)P(z,f)=h(z),where P(z,f)is a differential polynomial in f and its derivatives,F(z),A(z)and h(z)are entire *** demonstrate the existence of close relationships Petrenko's deviations of the coefficients and the measures of limiting directions of entire solutions of the above two equations.

关键词： Julia set limiting direction entire function Petrenko's deviation

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Editorial: Special issue on “Internet of things and edge computing in the new 5G era”

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Digital Communications and Networks 2021年第2期7卷 167-169页

作者： xin Su Marek R.Ogiela Chang Choi Christian Esposito Kiho lim the College of Internet of Things Engineering Hohai UniversityChina world scientific associations 不详 University of Napoli Federico II in Italy Department of Computer Science at the University of South Dakota USA.

*** Recently,edge computing has evolved from concept to early-stage implementations because new use cases require a more remote computing and networking approach than a conventional,fully cloud-based *** companies,network providers and cloud companies are testing and launching early commercial products in the developed markets of the United States,Europe,China and Asia *** progress in edge trials continues,key issues remain to be resolved around the most viable location of the edge,the scale of the required edge investment,and the actual business models.

关键词： computing companies Internet

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Cultivation of microalgae for biodiesel production:A review on upstream and downstream processing

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Chinese Journal of Chemical Engineering 2018年第1期26卷 17-30页

作者： xin Bei Tan Man Kee Lam Yoshimitsu Uemura Jun Wei lim Chung Yiin Wong Keat Teong Lee Chemical Engineering Department Universiti Teknologi PETRONAS Centre for Biofuel and Biochemical Research Universiti Teknologi PETRONAS Fundamental and Applied Science Department Universiti Teknologi PETRONAS School of Chemical Engineering Universiti Sains MalaysiaEngineering Campus

Fluctuating market price of fossil fuel and overwhelming emission of greenhouse gases to the atmosphere have resulted in climate change and have been a global concern in this decade. Hence, biodiesel has become an alternative option to fossil diesel as it is renewable and environmentally friendly. Nevertheless, this alternative fuel that is usually derived from terrestrial oil crops will cause shortage in food supply and deforestation if mass production is realized. In recent years, cultivation of aquatic microorganism(particularly microalgae) to produce biodiesel is considered as a practical solution due to their high growth rate and ability to synthesize large quantity of lipid within their cell. However, the development of energy and cost-efficiency of microalgae cultivation system are the main issues in producing renewable microalgae biodiesel. Of late, wastewater or organic compost has been used as the cultivation medium as it can provide sufficient nutrients to sustain microalgae *** cultivation method and system are vitally important as these factors undoubtedly affect the final microalgae biomass and lipid yield. In this review, the cultivation system of microalgae, nutrients demanded for microalgae production, cell harvesting and drying, microalgae oil extraction, and utilization of microalgae biomass for biodiesel production are introduced and discussed. It is anticipated to convey clearer perspectives in upstream and downstream processes in microalgae-derived biodiesel production.

关键词： Microalgae Cultivation Lipid Biodiesel Harvesting

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Will not bagging an excised tumour immediately during partial nephrectomy possibly result in tumour seeding?A case report

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第3期5卷 128-130页

作者： xin Ling Teo Han Jie Lee Sey Kiat lim Department of Urology Changi General Hospital2 Simei Street 3529889Singapore

Partial nephrectomy is now a standard approach for small renal masses and tumour recurrences after partial nephrectomy are *** the absence of spillage,port site recurrences are most commonly *** report a case of tumour recurrence near the surgical site as well as beyond the posterior renal fascia and Gerotas fascia in a 60-year-old woman who underwent robot-assisted partial ne-phrectomy for a 4.6 cm suspicious left renal tumour despite the absence of gross tumour spillage or rupture *** showed a 5 cm clear cell renal cell carcinoma with negative surgical margins,nuclear grade 4 with focal malignant rhabdoid *** practice of not bagging the specimen immediately after tumour excision especially for higher risk tumours should be reviewed as there may be inadvertent microscopic spillage of tumour cells.

关键词： Tumour seeding Tumour recurrence Partial nephrectomy

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王水溶样酸溶法分解试样对磷矿石和磷精矿中氧化铝含量测定的影响

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云南化工 2024年第S1期51卷 55-57页

作者：陈鑫云南三环中化化肥有限公司云南昆明650000

利用《磷矿石和磷精矿中五氧化二磷含量的测定磷相酸喳琳重量法和容量法》(GB/T 1871.1-1995)检测磷矿石和磷精矿中五氧化二磷含量时,酸溶法(王水溶样法)后,按《磷矿石和磷精矿中氧化铝含量的测定容量法和分光光度法》(GB/T 1871.3-1995... 详细信息

利用《磷矿石和磷精矿中五氧化二磷含量的测定磷相酸喳琳重量法和容量法》(GB/T 1871.1-1995)检测磷矿石和磷精矿中五氧化二磷含量时,酸溶法(王水溶样法)后,按《磷矿石和磷精矿中氧化铝含量的测定容量法和分光光度法》(GB/T 1871.3-1995)进行,但用磷酸铁(铝)分离-EDTA容量法测定氧化铝含量时,遇到测定数据偏低、重现性差,以及磷矿购销合同执行中频繁出现氧化铝含量复检、仲裁纠纷争议等问题。对王水溶样酸溶法分解试样存在问题的原因进行了探讨,提出了酸溶法(王水溶样法)的适用范围,并建议增加氢氟酸-硫酸-高氯酸的酸溶法,以及采用新型仪器进行快速测量。

关键词：磷矿石和磷精矿酸溶法磷酸铁(铝)分离-EDTA容量法氧化铝含量

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