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Impact of uterine artery embolization on ovarian function and pregnancy outcome after uterine-fibroids treatment:A prospective study

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World Journal of Clinical Cases 2024年第15期12卷 2551-2559页

作者： Jing-Lei Liu Zhi-hui liang Bao Cui Jian-Yu Liu Li Sun Department of Interventional Treatment 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina Department of Obstetrics and Gynecology 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina

Uterine fibroids are benign tumors that originate from smooth muscle cells of the *** is the most common gynecological disorder,affecting up to 80%of women of reproductive *** fibroids can cause various symptoms such as abnormal uterine bleeding,pelvic pain,infertility,and pregnancy *** treatment options for uterine fibroids include medical therapy,surgical intervention,and minimally invasive *** To compare ovarian function of women with uterine fibroids who did or did not undergo uterine artery embolization(UAE).METHODS This prospective cohort study enrolled 87 women with symptomatic uterine fibroids who underwent UAE,and 87 women with the same symptoms who did not undergo UAE but received conservative management or other *** two groups were matched for age,body mass index,parity,and baseline characteristics of uterine *** primary outcome was ovarian function that was evaluated by serum levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and anti-Müllerian hormone(AMH),as well as ovarian reserve tests,such as antral follicle count(AFC)and ovarian volume(OV).The secondary outcome was fertility that was evaluated based on the menstrual cycle,ovulation,conception,pregnancy,and *** participants were followed-up for 36 months and assessed at 1,3,6,12,24,and 36 months after *** The study found that the most common minor complication of UAE was postembolization syndrome in 73.6% of women,resolving within a *** significant differences were observed between the UAE group and the control group in serum levels of reproductive hormones(FSH,LH,E2,AMH)and ovarian reserve indicators(AFC,OV)at any point up to 36 months ***,there were no significant differences in conception,pregnancy,or delivery rates,with the average time to conception and gestational age at delivery being similar between the two *** weights were also ***

关键词： Uterine fibroids Uterine artery embolization Ovarian function Fertility Pregnancy outcome Embolic agent

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B Vitamins Supplementation Can Improve Cognitive Functions and May Relate to the Enhancement of Transketolase Activity in A Rat Model of Cognitive Impairment Associated with High-fat Diets

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Current Medical Science 2021年第5期41卷 847-856页

作者： Ying ZHENG Zhi-yong CHEN Wen-jun MA Qiu-zhen WANG hui liang Ai-guo MA Department of Nutrition Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Institute of Nutrition and Health Medical College of Qingdao UniversityQingdao 266021China

Objective:To determine whether B vitamin treatment was sufficient to reduce cognitive impairment associated with high-fat diets in rats and to modulate transketolase(TK)expression and ***:To test this,we separated 50 rats into five groups that were either fed a standard chow diet(controls)or a high-fat diet(experimental groups HO,HI,H2,and H3).HO group animals received no additional dietary supplementation,while H1 group animals were administered 100 mg/kg body weight(BW)thiamine,100 mg/kg BW riboflavin,and 250 mg/kg BW niacin each day,and group H2 animals received daily doses of 100 mg/kg BW pyridoxine,100 mg/kg BW cobalamin,and 5 mg/kg BW *** in the H3 group received the B vitamin regimens administered to both H1 and H2 each ***:Over time,group HO exhibited greater increases in BW and fat mass relative to other *** spatial and memory capabilities in these animals were evaluated via conditioned taste aversion(CTA)and Morris Water Maze(MWM),we found B vitamin treatment was associated with significant improvements relative to untreated HO ***,B vitamin supplementation was associated with elevated TK expression in erythrocytes and hypothalamus of treated animals relative to those in HO(P<0.05).Conclusion:Together,these findings suggest B vitamin can modulate hypothalamic TK activity to reduce the severity of cognitive deficits in a rat model of *** such,B vitamin supplementation may be a beneficial method for reducing cognitive dysfunction in clinical settings associated with high-fat diets.

关键词： B vitamins obesity conditioned taste aversion Morris water maze cognition transketolase

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Optimization of Fermentation Medium for Epothilones Production with Sequential Statistical Approach

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Chemical Research in Chinese Universities 2010年第1期26卷 86-91页

作者： MENG Fan-xin LI You-xin GUO Wei-liang LU Jia-hui DU Lin-na TENG Li-rong College of Life Science Jilin University Changchun 130012 P. R. China

A sequential statistical approach was applied to optimizing the fermentation medium of epothilones（Epos） production by means of a mutant which was obtained by treating polyangium cellulosum ATCC 15384 with nitrite and ultraviolet. The effects of different carbon sources and nitrogen sources on the fermentation medium were tested, and the suitable ones were selected. Then a uniform design was employed to design the experiments. A linear model was developed for identifying the significant components in fermentation medium, while a third degree polynomial model was used for studying the relationship between the concentration of the components in fermentation medium and the yield of Epos（YEPs）. A pattern search method was used for searching the optimum fermentation medium in the test space, which was as follows（g/L）： potassium nitrate 8.00, soybean peptone 17.60, potassium hydrogen phos- phate 1.00, beef extraction 6.46, yeast extraction 1.00, calcium chloride 0.25, sodium chloride 1.00 and ferric chloride 0.02. The optimum fermentation medium was expected to result in a yield of Epos（YEPs） of 2.48 mg/L. The validation experiments with the optimum medium were performed in triplicate and the average yield of Epos was 2.45 mg/L which was 7.78 times higher than that of Epos prepared without optimization.

关键词： Statistical approach Epothilones Uniform design Optimization of fermentation medium

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Establishment of a Tumor-bearing Mouse Model Stably Expressing EGFP Labeled Human MUC1 VNTRs

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Chemical Research in Chinese Universities 2008年第4期24卷 505-510页

作者： ZHANG Shu-zi ZHANG Hai-hong ZHANG Wa SHI He-liang YU Xiang-hui KONG Wei LI Wei Vaccine Research Center College of Life Science Jilin University Changchun 130012 P R. China

Two eukaryotic vectors expressing 9 tandem repeats of human MUCI（VNTR）, VR1012-VNTR, and pEGFP-VNTR, were constructed by cloning VNTR gene into VR1012 and pEGFP, respectively. VNTR stably expressing murine Lewis lung carcinoma（LLC） cell line（VNTR^＋ LLC） was established by Lipofectamine-mediated transfection of pEGFP-VNTR into LLC cells. The EGFP expression was observed under a fluorescent microscope and VNTR expression in VNTR^＋ LLC cells was confirmed by means of Western blotting. A syngenic graft tumor model was generated by subcutaneous injection of VNTR^＋ LLC cells into C57/BL6 mice and tumor size increased rapidly with time and in a cell qumber dependent manner. VNTR mRNA expression in the tumor formed was confirmed by RT-PCR. After the third immunization mice were challenged subcutaneously with 5×10^5 VNTR^＋ LLC cells, a significant reduction of subcutaneous tumor growth was observed in the groups immunized with VNTR plasmid DNA compared with that in the groups immunized with the vector DNA alone. Thus, the suppression of subcutaneous tumor was antigen-specific. This model is useful for the development of tumor vaccines targeting MUCI VNTRs.

关键词： MUCI VNTR Tumor antigen Tumor model Tumor vaccine

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Design of Compilation System of New Generation Weather Radar Case Data

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Meteorological and Environmental Research 2022年第4期13卷 51-54页

作者： hui liang Wuzhou Meteorological Bureau Wuzhou 543002China

Based on updating of new generation weather radar software,compilation system of new generation weather radar case data could automatically back up data and compile radar *** C language and VC++6.0 development technology,the software realizes the automatic sorting and saving of radar base data,radar products and radar status information on different machines every day,and automatically creates various folders and files required for compiling *** inputting the days,date,start and end times,renaming and compression of the base data,product data and status information could be automatically completed,to realize automation,batch,process and standardization of case data *** putting into the radar business,the operation has been stable and *** working efficiency of business personnel has been improved,and a large number of manpower has been *** can be transplanted and popularized in other new generation weather radar stations.

关键词： New generation weather radar Compilation of individual case data Automation

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New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves

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Chinese Journal of Natural Medicines 2024年第2期22卷 161-170页

作者： SUN Zeshi LIN Shan WU Zhi-Li DONG Hong-Yuan XU Xi-Ke LI hui-liang WANG Jinxin School of Pharmacy Second Military Medical UniversityShanghai 200433China State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China

Our continued works on the chemical constituents of Ginkgo biloba(***)leaves has led to the isolation of two novel phenylbutenoids(1,2),along with five previously unidentified terpene glycosides(3−7).Among them,compounds 1 and 2 represent unique(Z)-phenylbutenoids,3−6 are megastigmane glycosides,and 7 is identified as a rare bilobanone glycoside(Fig.1).This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from *** chemical structures of these compounds were elucidated through extensive spectroscopic analysis,including HR-ESI-MS and various 1D and 2D NMR ***,the absolute configurations of these molecules were determined using Mosher’s method,ECD experiments,and Cu-KαX-ray crystallographic analyses.

关键词： Ginkgo biloba Phenylbutenoid Megastigmane glycoside Bilobanone glycoside

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Research on the Effect of Humanistic Nursing Care on Elderly Type 2 Diabetes Mellitus Patients

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Journal of Clinical and Nursing Research 2023年第5期7卷 84-88页

作者： hui liang Wunan Town Central Health Center Wuwei 733000Gansu ProvinceChina

Objective:To explore and analyze the effect of humanistic nursing care on elderly type 2 diabetes ***:100 elderly patients with type 2 diabetes who were treated in our hospital from May 2021-May 2023 were selected for this *** patients were divided into an experimental group and a reference group by flipping a coin,with 50 cases in each *** experimental group received humanistic nursing care,while the reference group received routine nursing *** blood glucose level,compliance and nursing satisfaction were compared between the two ***:Before the intervention,there was no statistically significant difference between the groups in pre-meal blood glucose,blood glucose 2 hours after eating,and glycosylated hemoglobin(P>0.05).After the intervention,pre-meal blood glucose,blood glucose 2 hours after eating,and glycosylated hemoglobin in the humanities group were significantly better than those in the reference group(P0.05).After the intervention,the compliance with diet,medication,examination,and exercise in the experimental group was significantly better than that of the reference group(P<0.05).The patients in the experimental group were significantly more satisfied with the nursing care received than the reference group(P<0.05).Conclusion:Humanistic nursing care can reduce blood sugar in elderly patients with type 2 diabetes,strengthen treatment compliance,and improve satisfaction.

关键词： Humanistic care and nursing Elderly type 2 diabetes mellitus Effect

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Novel High-nitrogen Energetic Compound Based on Semicarbazide-substituted Tetrazine

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Chemical Research in Chinese Universities 2012年第6期28卷 931-935页

作者： ZHANG Jlan-guo liang Yan-hui XIE Shao-hua FENG Jin-ling WANG Kun ZHANG Tong-lai State Key Laboratory of Explosion Science and Technology Beij'ing Institute of Technology Beo'ing 100081 P. R. China The 46th Institute of the Sixth Academy of China Aerospace Science & Industry Corporation Hohhot 010010 P. R. China

A novel energetic compound 3-（3,5-dimethylpyrazol-1-yl）-6-semicarbazide-1,2,4,5-tetrazine（DSTZ） was prepared and characterized by elemental analysis and Fourier transform infrared（FTIR） *** crystal structure was determined by X-ray single crystal diffraction *** crystal belongs to the monoclinic system with a P2 1 /c space group,a=0.9942（7） nm,b=0.5067（3） nm,c=1.1830（8） nm,β=109.616°,Z=2 and D c =1.475 g/cm *** extensive hydrogen bonds,the molecules were linked together to form a three-dimensional herringbone-like *** analysis of the compound was carried out via differential scanning calorimetry（DSC） and thermogravimetric-derivative thermogravimetry（TG-DTG）.Under a nitrogen atmosphere at a heating rate of 10 K/min,DSTZ decomposed directly in a range of 493―513 *** one intense exothermic process was observed and the decomposition products were all gaseous *** sensitivity properties were determined,showing that the title complex was insensitive to friction,impact and flame.

关键词： 1 2 4 5-Tetrazine Semicarbazide Crystal structure Sensitivity property

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MISCIBILITY,CRYSTALLIZATION AND MECHANICAL PROPERTIES OF PPC/PBS BLENDS

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Chinese Journal of Polymer Science 2007年第6期25卷 589-597页

作者： hui-liang Zhang Xiao-hong Sun Qing-yong Chen Min-qiao Ren Zhi-hao Zhang Hong-fang Zhang Zhi-shen Mo State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Graduate School of Chinese Academy of Science Changchun 130022 China

In this paper, melt blends of poly（propylene carbonate）（PPC） with poly（butylene succinate）（PBS） were characterized by dynamic mechanical analysis （DMA）, differential scanning calorimetry （DSC）, tensile testing, wide-angle X-ray diffraction （WAXD）, polarized optical microscopy and thermogravimetric analysis （TGA）. The results indicated that the glass transition temperature of PPC in the 90/10 PPC/PBS blend was decreased by about 11 K comparing with that of pure PPC. The presence of 10% PBS was partially miscible with PPC. The 90/10 PPC/PBS blend had better impact and tensile strength than those of the other PPC/PBS blends. The glass transition temperature of PPC in the 80/20, 70/30, and 60/40 PPC/PBS blends was improved by about 4.9 K, 4.2 K, and 13 K comparing with that of pure PPC, respectively; which indicated the immiscibility between PPC and PBS. The DSC results indicated that the crystallization of PBS became more difficult when the PPC content increased. The matrix of PPC hindered the crystallization process of PBS. While the content of PBS was above 20%, significant crystallization-induced phase separation was observed by polarized optical microscopy. It was found from the WAXD analysis that the crystal structure of PBS did not change, and the degree of crystallinity increased with increasing PBS content in the PPC/PBS blends.

关键词： Poly(propylene carbonate) Poly(butylene succinate) Miscibility Crystallization Mechanical properties.

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Mesothelin promotes cell proliferation in the remodeling of neonatal rat pancreas

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World Journal of Gastroenterology 2014年第22期20卷 6884-6896页

作者： Dan-Dan Yin liang-hui You Qing-Xin Yuan Xiao-Di liang Ning Wang Lin-Tao Wang Li Yuan Ke-Ming Wang Wei De Department of Central Laboratory the Second Affiliated Hospital of Southeast University 2th Department of Biochemistry and Molecular Biology Nanjing Medical University Department of Biochemistry and Molecular Biology Nanjing Medical University Department of Endocrinology First Affiliated Hospital of Nanjing Medical University Department of Oncology Second Affiliated Hospital of Nanjing Medical University

AIM: To investigate the effect of mesothelin in the remodeling of the endocrine pancreas in neonatal rats.

关键词： Mesothelin Pancreatic remodeling Cell proliferation Pancreatic development Small islets

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