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中华医学杂志(英文版) 2024年第12期137卷 2024 May 21页

作者： Zhan Shuting Cheng Bo Liu Xiwen Li Jianfu Bai Ge Cai Qi Wang Huiting Xiang Yang Li Chunyan He Jianxing liang wenhua Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical University &amp Guangzhou Institute of Respiratory Health State Key Laboratory of Respiratory Disease &amp National Clinical Research Center for Respiratory Disease Guangzhou Guangdong China National Center for Respiratory Medicine State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Diseases Guangzhou Institute of Respiratory Health &amp The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China Southern Medical University Guangzhou Guangdong China Department of Respiratory and Critical Care Medicine The Tenth Affiliated Hospital of Southern Medical University Dongguan Guangdong China.

The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions:insights from a single-arm,phase II trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2202-2214页

作者： Bo Cheng Caichen Li Jianfu Li Longlong Gong Peng liang Ying Chen Shuting Zhan Shan Xiong Ran Zhong Hengrui liang Yi Feng Runchen Wang Haixuan Wang Hongbo Zheng Jun Liu Chengzhi Zhou Wenlong Shao Yuan Qiu Jiancong Sun Zhanhong Xie Zhu liang Chenglin Yang Xiuyu Cai Chunxia Su Wei Wang Jianxing He wenhua liang Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Medical Department Genecast Biotechnology Co.LtdWuxiChina Department of Radiation Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Respiratory Medicine the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Department of Cardiothoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiangChina Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenChina Department of VIP Inpatient Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaSun Yat-sen UniversityGuangzhouChina Department of Medical Oncology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina

Immune checkpoint inhibitors targeting the programmed cell death-1(PD-1)protein significantly improve survival in patients with advanced non-small-cell lung cancer(NSCLC),but its impact on early-stage ground-glass opacity(GGO)lesions remains unclear.This is a single-arm,phase II trial(NCT04026841)using Simon’s optimal two-stage design,of which 4 doses of sintilimab(200 mg per 3 weeks)were administrated in 36 enrolled multiple primary lung cancer(MPLC)patients with persistent high-risk(Lung-RADS category 4 or had progressed within 6 months)GGOs.The primary endpoint was objective response rate(ORR).T/B/NK-cell subpopulations,TCR-seq,cytokines,exosomal RNA,and multiplexed immunohistochemistry(mIHC)were monitored and compared between responders and non-responders.Finally,two intent-to-treat(ITT)lesions(pure-GGO or GGO-predominant)showed responses(ORR:5.6%,2/36),and no patients had progressive disease(PD).No grade 3-5 TRAEs occurred.The total response rate considering two ITT lesions and three non-intent-to-treat(NITT)lesions(pure-solid or solid-predominant)was 13.9%(5/36).The proportion of CD8^(+)T cells,the ratio of CD8^(+)/CD4^(+),and the TCR clonality value were significantly higher in the peripheral blood of responders before treatment and decreased over time.Correspondingly,the mIHC analysis showed more CD8^(+)T cells infiltrated in responders.Besides,responders’cytokine concentrations of EGF and CTLA-4 increased during treatment.The exosomal expression of fatty acid metabolism and oxidative phosphorylation gene signatures were down-regulated among responders.Collectively,PD-1 inhibitor showed certain activity on high-risk pulmonary GGO lesions without safety concerns.Such effects were associated with specific T-cell re-distribution,EGF/CTLA-4 cytokine compensation,and regulation of metabolism pathways.

关键词： lesions metabolism doses

Light at night and lung cancer risk:A worldwide interdisciplinary and time-series study

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 56-62页

作者： Runchen Wang Qixia Wang Jianfu Li Jianrong Zhang Shixuan Lyu Wenhao Chi Zhiming Ye Xuanzhuang Lu Ying Shi Yubin Wang Xinjian Wu Ruiyu Hu Mónica Pérez-Ríos Jianxing He wenhua liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhouGuangdong 510120China Department of Respiratory Disease China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Centre for Cancer Research&Department of General Practice Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneVictorian Comprehensive Cancer CentreMelbourneVictoria 3010Australia Department of Civil Engineering University of BristolBristolBS81TRUK Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Nanshan School Guangzhou Medical UniversityGuangzhouGuangdong 511436China State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan UniversityWuhanHubei 430079China GNSS Research Center Wuhan UniversityWuhanHubei 430079China First Clinical School Guangzhou Medical UniversityGuangzhouGuangdong 511436China Preventive Medicine and Public Health Department University of Santiago de CompostelaCIBER de Epidemiología y Salud Pública(CIBERESP)Health Research Institute of Santiago de Compostela(IDIS)Santiago de CompostelaGalicia 15782Spain Southern Medical University GuangzhouGuangdong 510515China

Background:Light at night(LAN)has become a concern in interdisciplinary research in recent years.This global interdisciplinary study aimed to explore the exposure-lag-response association between LAN exposure and lung cancer incidence.Methods:LAN data were obtained from the Defense Meteorological Satellite Program’s Operational Linescan System.Data of lung cancer incidence,socio-demographic index,and smoking prevalence of populations in 201 countries/territories from 1992 to 2018 were collected from the Global Burden of Disease Study.Spearman correlation tests and population-weighted linear regression analysis were used to evaluate the correlation between LAN exposure and lung cancer incidence.A distributed lag nonlinear model(DLNM)was used to assess the exposure-lag effects of LAN exposure on lung cancer incidence.Results:The Spearman correlation coefficients were 0.286-0.355 and the population-weighted linear regression correlation coefficients were 0.361-0.527.After adjustment for socio-demographic index and smoking preva-lence,the Spearman correlation coefficients were 0.264-0.357 and the population-weighted linear regression correlation coefficients were 0.346-0.497.In the DLNM,the maximum relative risk was 1.04(1.02-1.06)at LAN exposure of 8.6 with a 2.6-year lag time.After adjustment for socio-demographic index and smoking prevalence,the maximum relative risk was 1.05(1.02-1.07)at LAN exposure of 8.6 with a 2.4-year lag time.Conclusion:High LAN exposure was associated with increased lung cancer incidence,and this effect had a specific lag period.Compared with traditional individual-level studies,this group-level study provides a novel paradigm of effective,efficient,and scalable screening for risk factors.

关键词： Light at night Satellite imagery Lung cancer Distributed lag nonlinear model(DLNM) Melatonin

Additive Effects of QTLs/Genes on Rice Grain Size Traits Revealed by Genetic Comparisons

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Rice science 2023年第3期30卷 171-175,I0002-I0013页

作者： HE Lei liang wenhua HU Jiang ZHAO Chunfang YAO Shu CHEN Tao ZHU Zhen ZHAO Qingyong LU Kai ZHAO Ling ZHOU Lihui QIAN Qian WANG Cailin ZHANG Yadong Institute of Food Crops Jiangsu Academy of Agricultural Science/Key Laboratory of Jiangsu Province for Agrobiology/Key Laboratory of Germplasm Innovation in Downstream of Huaihe River(Nanjing)Ministry of Agriculture and Rural AffairsNanjing 210014China East China Branch of National Center of Technology Innovation for Saline-Alkali Tolerant Rice Nanjing 210014China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 311400China

Grain size is controlled by many QTLs and/or genes.Despite intensive study,the genetic interactions between these QTLs/genes remain largely unclear.We previously found that the japonica large-grain rice cultivar TD70 with 1000-grain weight of 68.6 g carries superior alleles at the loci GW2,GS3,qGL3,GS5 and GW8,all of which are known to control grain size,while the indica rice variety Kasalath with 1000-grain weight of 19.1 g has normal alleles at these loci.

关键词： cultivar alleles Traits

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基于肺-肠轴探讨中西医干预哮喘的研究进展

中医药临床杂志 2024年第4期36卷 789-794页

作者：庞欣梁文华山东中医药大学山东济南250000 山东省青岛市中医医院山东青岛266000

支气管哮喘是临床常见的一种以气道慢性炎症为特征的呼吸系统疾病,其发病机制尚不明确。近年来,微生物学和分子生物学的快速发展让“肺-肠轴”这一概念成为新的热点。肺-肠轴是指存在于呼吸系统与肠道微生物之间的相互作用和调节机制,... 详细信息

支气管哮喘是临床常见的一种以气道慢性炎症为特征的呼吸系统疾病,其发病机制尚不明确。近年来,微生物学和分子生物学的快速发展让“肺-肠轴”这一概念成为新的热点。肺-肠轴是指存在于呼吸系统与肠道微生物之间的相互作用和调节机制,这个观点与中医“肺与大肠相表里”理论所见略同。随着哮喘疾病的不断增多,肺-肠轴成为一个备受关注的课题,深入研究肺-肠轴或有助于寻找治疗哮喘的新靶点。临床经验表明,中西医结合治疗哮喘可显著改善肺功能指标和临床评估标准,并能够降低哮喘的复发率和控制药物的使用量。其中,西医以抗生素药物为治疗哮喘的主要手段,具有见效快的优势,但也容易引起不良反应。中药治疗具有减轻哮喘症状、不良发应少和改善生活质量等显著优势,其中的针灸和推拿等中医技术均可增强防御力和调节免疫功能。中西医结合干预哮喘有着明显的临床疗效和广阔的应用前景。故该研究通过肺-肠轴理论阐述中西医干预哮喘的研究进展,以细致深入的进行机制探究,旨在为临床通过肺-肠轴理论采取合理的中西医干预哮喘措施提供依据。

关键词：肺肠轴中西医干预支气管哮喘

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印尼煤在配煤炼焦中的应用

燃料与化工 2024年第2期55卷 26-29页

作者：梁文华曹贵杰迁安中化煤化工有限责任公司唐山064404

对印尼煤煤质指标评价进行分析,结合公司整体煤炭资源情况,与肥煤、焦煤、1/3焦煤做质量比对,分析优缺点,尝试代替部分1/3焦煤、焦煤配煤炼焦使用。在配煤中作为1/3焦煤使用,焦炭质量稳定,起到降灰的作用。

关键词：印尼煤煤质评价配煤

Advances in lung cancer screening and early detection

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Cancer Biology & Medicine 2022年第5期19卷 591-608页

作者： Caichen Li Huiting Wang Yu Jiang Wenhai Fu Xiwen Liu Ran Zhong Bo Cheng Feng Zhu Yang Xiang Jianxing He wenhua liang Department of Thoracic Oncology and Surgery the First Affiliated Hospital of Guangzhou Medical UniversityChina National Center for Respiratory MedicineChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhou 510120China Dongguan Affiliated Hospital of Southern Medical University Dongguan People HospitalDongguan 523059China Department of Internal Medicine Detroit Medical Center Sinai-Grace HospitalDetroitMichigan 48235USA Department of Thoracic Surgery Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China Department of Oncology the First People’s Hospital of ZhaoqingZhaoqing 526020China

Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health worldwide.Two randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer screening.However,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation exposure.This review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related issues.Second,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is presented.Third,current explorations of strategies for suspected malignancy are summarized.Overall,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer.

关键词： Lung cancer screening low-dose CT early detection strategies biomarkers

广州女性低剂量CT肺癌筛查结果及高危因素探索

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中国肺癌杂志 2024年第5期27卷 345-358页

作者：卢炫庄邱秋霞杨春玉黎才琛李坚福熊珊程博周楚静杜小芹张屹何建行梁文华钟南山广州医科大学附属第一医院广州510120 广州呼吸健康研究院广州510120 广州医科大学南山学院广州511436 广州市卫生健康委员会广州510080 南方医科大学广州510515

背景与目的肺癌高居中国恶性肿瘤发病率和死亡率之首。既往肺癌筛查试验大多为针对吸烟者等高危人群的选择性筛查,然而亚洲肺癌病例非吸烟女性占相当比例。本研究旨在评估广州市社区女性的肺癌患病率并探究肺癌高危因素。方法采用胸部... 详细信息

背景与目的肺癌高居中国恶性肿瘤发病率和死亡率之首。既往肺癌筛查试验大多为针对吸烟者等高危人群的选择性筛查,然而亚洲肺癌病例非吸烟女性占相当比例。本研究旨在评估广州市社区女性的肺癌患病率并探究肺癌高危因素。方法采用胸部低剂量计算机断层扫描(low-dose computed tomography,LDCT)对广州市40-74岁女性居民行肺癌筛查,并根据2018版《中国肺癌低剂量螺旋CT筛查指南》对肺结节进行分类管理及计算阳性结节和肺癌检出率。筛查对象在行检查前均须完成“肺癌危险因素调研问卷”,后对问卷危险因素进行最小绝对收缩和选择算子惩罚Logistic回归分析。结果分析共纳入6256名女性,发现阳性结节1228例(19.63%),确诊肺癌117例(1.87%),其中原位癌6例,I期103例(占肺癌比例88.03%)。根据问卷变量行最小绝对收缩和选择算子(Least absolute shrinkage and selection operator,LASSO)惩罚Logistic回归分析发现,年龄≥50岁(OR=1.07,95%CI:1.06-1.07)、个人恶性肿瘤史(OR=3.29,95%CI:3.22-3.37)、纺织职业(OR=1.10,95%CI:1.08-1.13)、小时候使用煤为燃料(OR=1.14,95%CI:1.13-1.16)以及食物过敏史(OR=1.10,95%CI:1.07-1.13)是该地区女性肺癌的高危因素。结论胸部LDCT可以发现大量早期肺癌,可用于女性肺癌筛查。年龄≥50岁、个人恶性肿瘤史、纺织职业、小时候使用煤为燃料和食物过敏史是该地区女性人群肺癌的高危因素,需提高该群体对肺癌早筛的重视程度。

关键词：肺肿瘤低剂量CT 早期筛查高危因素

Towards zero lung cancer

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第4期1卷 195-197页

作者： wenhua liang Jianxing He Nanshan Zhong The First Affiliated Hospital of Guangzhou Medical University China State Key Laboratory of Respiratory DiseaseNational Center for Respiratory MedicineGuangzhouGuangdong 510120China

Edited by:Peifang Wei.Lung cancer is the leading cause of cancer-related deaths worldwide and the third leading cause of death among population in China.1 Over the past 30 years,the incidence of lung cancer in China has been con-tinuously increasing.It is estimated that there are currently 0.8 to 1 million newly diagnosed cases of lung cancer in China each year.2 And this number is expected to continue increasing for a period.On the other hand,in recent years.

关键词： lung cancer China

Predilection site and risk factor of second primary cancer:A pancancer analysis based on the SEER database

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Chinese Medical Journal 2023年第12期136卷 1500-1502页

作者： Shan Xiong Hengrui liang Peng liang Xiuyu Cai Caichen Li Ran Zhong Jianfu Li Bo Cheng Feng Zhu Limin Ou Zisheng Chen Yi Zhao Hongsheng Deng Zhuxing Chen Zhichao Liu Zhanhong Xie Feng Li Jianxing He wenhua liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China Department of General Internal Medicine Sun Yat-sen University Cancer CentreState Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineGuangzhouGuangdong 510160China Department of General Internal Medicine Detroit Médica Center Sinai-Grace HospitalDetroit MI 48235USA Department of Oncology The First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510660China Department of Respiratory Medicine The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuanGuangdong 511518China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China

To the Editor:Over the past few years,the number of cancer survivors has continued to increase,primarily driven by the growing and aging population and the improvements in cancer detection and treatment.More than 16.9 million Americans with prior cancers were alive on January 1,2019,and the number of cancer survivors was estimated to reach>22.1 million by January 1,2030.[1]The lifetime risk of individual second primary cancer(SPC)has been confirmed when confronted with such a large amount of cancer survivors.[2]Definition of specific site is shown in supplementary material,http://***/CM9/B616.

关键词： lifetime continued primarily