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Oridonin restores hepatic lipid homeostasis in an LXRa-ATGL/EPT1 axis-dependent manner

Journal of Pharmaceutical Analysis 2023年第11期13卷 1281-1295页

作者： Yulian Chen Huanguo Jiang Zhikun Zhan Jindi Lu Tanwei Gu Ping Yu Weimin liang Xi Zhang shilong Zhong Lan Tang NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou510515China Department of Pharmacy Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510515China

Hepatosteatosis is characterized by abnormal accumulation of triglycerides(TG),leading to prolonged and chronic inflammatory *** date,there is still a lack of effective and economical therapies for ***(ORI)is a major bioactive component extracted from the traditional Chinese medicinal herb Rabdosia *** this paper,we showed that ORI exerted significant protective effects against hepatic steatosis,inflammation and fibrosis,which was dependent on LXRa *** is reported that LXRa regulated lipid homeostasis between triglyceride(TG)and phosphatidylethanolamine(PE)by promoting ATGL and EPT1 ***,we implemented the lipidomic strategy and luciferase reporter assay to verify that ORI contributed to the homeostasis of lipids via the regulation of the ATGL gene associated with TG hydrolysis and the EPT1 gene related to PE synthesis in a LXRadependent manner,and the results showed the TG reduction and PE *** detail,hepatic TG overload and lipotoxicity were reversed after ORI treatment by modulating the ATGL and EPT1 genes,*** together,the data provide mechanistic insights to explain the bioactivity of ORI in attenuating TG accumulation and cytotoxicity and introduce exciting opportunities for developing novel natural activators of the LXRa-ATGL/EPT1 axis for pharmacologically treating hepatosteatosis and metabolic disorders.

关键词： Oridonin Lipid homeostasis TG reduction PE elevation LXRa-ATGL/EPT1 axis

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Progress in cancer therapy with functionalized Fe_(3)O_(4) nanomaterials

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Frontiers of Materials Science 2023年第3期17卷 57-70页

作者： Yuhui Wang Xuanyu Liu shilong Ma Xuhong He Chaiqiong Guo Ziwei liang Yinchun Hu Yan Wei Xiaojie Lian Di Huang Department of Biomedical Engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringShanxi Key Laboratory of Materials Strength&Structural ImpactTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Malignant neoplasms represent a significant global health *** address the need for accurate diagnosis and effective treatment,research is underway to develop therapeutic *** oxide nanoparticles(NPs),specifically Fe_(3)O_(4) NPs have been extensively studied as potential therapeutic agents for cancer due to their unique properties including magnetic targeting,favorable biocompatibility,high magnetic response sensitivity,prolonged in vivo circulation time,stable performance,and high *** ability to be integrated with magnetic hyperthermia,photodynamic therapy,and photothermal therapy has resulted in the widespread use of Fe_(3)O_(4) NPs in cancer diagnosis and treatment,making them a popular choice for such *** methods can be employed to synthesize magnetic Fe_(3)O_(4) NPs,which can then be surface-modified with biocompatible materials or active targeting *** systems can be created by combining Fe_(3)O_(4) NPs with *** combining various therapeutic approaches,more effective biomedical materials can be *** paper discusses the synthesis of Fe_(3)O_(4) NPs and the latest research advances in Fe_(3)O_(4)-based nanotherapeutic platforms,as well as their applications in the biomedical field.

关键词： Fe_(3)O_(4)NPs cancer treatment magnetic targeting magnetic thermotherapy

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Four decades of full-scale nitrous oxide emission inventory in China

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National Science Review 2024年第3期11卷 137-149页

作者： Minqi liang Zheyan Zhou Peiyang Ren Han Xiao Xu-Ri Zhongmin Hu shilong Piao Hanqin Tian Qing Tong Feng Zhou Jing Wei Wenping Yuan School of Atmospheric Sciences Guangdong Province Data Center of Terrestrial and Marine Ecosystems Carbon Cycle Sun Yat-sen University State Key Laboratory of Tibetan Plateau Earth System Resources and Environment Institute of Tibetan Plateau Research Chinese Academy of Sciences Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province Hainan University Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking University Schiller Institute for Integrated Science and Society Department of Earth and Environmental Sciences Boston College Institute of Energy Environment and Economy Tsinghua University Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)

China is among the top nitrous oxide（N2O）-emitting countries, but existing national inventories do not provide full-scale emissions including both natural and anthropogenic sources. We conducted a four-decade（1980–2020） of comprehensive quantification of Chinese N2O inventory using empirical emission factor method for anthropogenic sources and two up-to-date process-based models for natural sources. Total N2O emissions peaked at 2287.4（1774.8–2799.9） Gg N2O yr-1in 2018, and agriculture-developed regions, like the East, Northeast, and Central, were the top N2O-emitting regions. Agricultural N2O emissions have started to decrease after 2016 due to the decline of nitrogen fertilization applications, while, industrial and energetic sources have been dramatically increasing after 2005. N2O emissions from agriculture, industry,energy, and waste represented 49.3%, 26.4%, 17.5%, and 6.7% of the anthropogenic emissions in 2020,respectively, which revealed that it is imperative to prioritize N2O emission mitigation in agriculture,industry, and energy. Natural N2O sources, dominated by forests, have been steadily growing from 317.3（290.3–344.1） Gg N2O yr-1in 1980 to 376.2（335.5–407.2） Gg N2O yr-1in 2020. Our study produces a Full-scale Annual N2O dataset in China（FAN2020）, providing emergent counting to refine the current national N2O inventories.

关键词： nitrous oxide four decades anthropogenic sources natural sources

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Polygonatum Sibiricum Saponin-Lactic acid bacteria combination attenuate hyperglycemia in T2DM mice by modulating amino acid metabolism

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Food Science and Human Wellness 2024年

作者： Jiayuan Luo Mingjie Jia Shuang liang Yangyang Chai Yihong Bao shilong Jiang Colleage of Life Science， Northeast Forestry University Key Laboratory of Forest Food Resources Utilization of Heilongjiang Province Heilongjiang Feihe Dairy Industry

Some researches have shown that the combination of plant extracts and probiotics may be a better way to treat type 2 diabetes mellitus (T2DM) than a single intervention. However， there are still relatively few relevant reports in this aspect. Therefore， this study aims to investigate whether the treatment of polygonatum sibiricum saponin (PSS) and lactic acid bacteria (LAB) combination can better manage T2DM. And the anti-diabetes mechanism of the combination was studied from the perspectives of glucose metabolism， microbiome and metabolome. The results showed that PSS+LAB could better improve FBG level， insulin sensitivity， lipid metabolism disorder， and liver function. Protein analysis showed that PSS+LAB treatment significantly increased the expression of p-PI3K/PI3K， p-AKT/AKT， GLUT2， IRS2， and GSK-3β in the liver of T2DM mice， while inhibiting the expression of FOXO1. This combination positively regulated the composition and abundance of the gut microbiota. Metabolomic analysis showed that the combination treatment exhibited more changes in gut microbiota metabolites compared to PSS treatment alone. The alteration of gut microbiota by LAB+PSS led to significant changes in alanine， aspartate and glucose metabolism pathways. This study may provide a theoretical basis for the combined application of plant extracts and probiotics for the management of T2DM.

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The LpHsfA2-molecular module confers thermotolerance via fine tuning of its transcription in perennial ryegrass(Lolium perenne L.)

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Journal of Integrative Plant Biology 2024年第11期66卷 2346-2361页

作者： Guangjing Ma Zhihao Liu Shurui Song Jing Gao Shujie Liao shilong Cao Yan Xie Liwen Cao Longxing Hu Haichun Jing liang Chen CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Edible Wild Plants Conservation and Utilization Hubei Normal UniversityHuangshi 435002China Department of Pratacultural Sciences College of AgronomyHunan Agricultural UniversityChangsha 410128China Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China Academician Workstation of Agricultural High-tech Industrial Area of the Yellow River Delta National Center of Technology Innovation for Comprehensive Utilization of Saline-Alkali LandDongying 257300China

Temperature sensitivity and tolerance play a key role in plant survival and *** ryegrass(Lolium perenne L.),widely cultivated in cool-season for forage supply and turfgrass,is extremely susceptible to high temperatures,therefore serving as an excellent grass for dissecting the genomic and genetic basis of high-temperature *** this study,expression analysis revealed that LpHsfA2,an important gene associated with high-temperature tolerance in perennial ryegrass,is rapidly and substantially induced under heat ***,heat-tolerant varieties consistently display elevated expression levels of LpHsfA2 compared with heat-sensitive *** haplotype analysis of the LpHsfA2 promoter indicated an uneven distribution of two haplotypes(HsfA2^(Hap1) and HsfA2^(Hap2)) across varieties with differing heat ***,the HsfA2^(Hap1) allele is predominantly present in heat-tolerant varieties,while the HsfA2^(Hap2) allele exhibits the opposite *** of LpHsfA2 confers enhanced thermotolerance,whereas silencing of LpHsfA2 compromises heat ***,LpHsfA2 orchestrates its protective effects by directly binding to the promoters of LpHSP18.2 and LpAPX1 to activate their expression,preventing the non-specific misfolding of intracellular protein and the accumulation of reactive oxygen species in ***,LpHsf A4 and LpHsf A5 were shown to engage directly with the promoter of LpHsfA2,upregulating its expression as well as the expression of LpHSP18.2 and LpAPX1,thus contributing to enhanced heat ***,LpHsfA2 possesses autoregulatory ability by directly binding to its own promoter to modulate the *** on these findings,we propose a model for modulating the thermotolerance of perennial ryegrass by precisely regulating the expression of ***,these findings provide a scientific basis for the development of thermotolerant perennial ryegrass culti

关键词： haplotype heat shock transcription factors heat tolerance perennial ryegrass

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Warming-induced phenological mismatch between trees and shrubs explains high-elevation forest expansion

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National Science Review 2023年第10期10卷 62-71页

作者： Xiaoxia Li Eryuan liang J.Julio Camarero Sergio Rossi Jingtian Zhang Haifeng Zhu Yongshuo H.Fu Jian Sun Tao Wang shilong Piao Josep Pe?uelas State Key Laboratory of Tibetan Plateau Earth System Environment and Resources (TPESER)Institute of Tibetan Plateau ResearchChinese Academy of Sciences Laboratoire sur les écosystèmes terrestres boréaux Département des Sciences FondamentalesUniversité du Québec à Chicoutimi Instituto Pirenaico de Ecología (IPE-CSIC) College of Water Sciences Beijing Normal University CREAF Cerdanyola del Valles CSIC Global Ecology Unit CREAF-CSIC-UAB

Despite the importance of species interaction in modulating the range shifts of plants,little is known about the responses of coexisting life forms to a warmer ***,we combine long-term monitoring of cambial phenology in sympatric trees and shrubs at two treelines of the Tibetan Plateau,with a meta-analysis of ring-width series from 344 shrubs and 575 trees paired across 11 alpine treelines in the Northern *** a spring warming of +1℃,xylem resumption advances by 2-4 days in trees,but delays by 3-8 days in *** divergent phenological response to warming was due to shrubs being3.2 times more sensitive than trees to chilling *** winters increased the thermal requirement for cambial reactivation in shrubs,leading to a delayed response to warmer *** meta-analysis confirmed such a mechanism across continental *** warming-induced phenological mismatch may give a competitive advantage to trees over shrubs,which would provide a new explanation for increasing alpine treeline shifts under the context of climate change.

关键词： chilling climate warming forcing treeline shift xylogenesis

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不同鲜食甜玉米品种在横州市的比较试验分析

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广西农学报 2024年第3期39卷 18-24,33页

作者：梁世龙盛洁彭楷禤豪新高铭信王远能林成标沈永烨李玉邹成林横州市农业科学研究所广西横州530300 横州市百合镇农业水利站广西横州530300 横州市石塘镇农业水利站广西横州530300 横州市校椅镇农业水利站广西横州530300 广西农业职业技术大学广西南宁530007 广西壮族自治区农业科学院玉米研究所广西南宁530007

为促进广西鲜食甜玉米产业持续稳定发展,筛选适宜鲜食甜玉米新品种。以“粤甜16号”为对照,对10个甜玉米品种(“斯达甜230”“双甜728”“金银131”“墨琦”“斯达甜240”“荆恒甜19号”“京科甜909”“尚满帝”“百帝伟456”“粤甜16号... 详细信息

为促进广西鲜食甜玉米产业持续稳定发展,筛选适宜鲜食甜玉米新品种。以“粤甜16号”为对照,对10个甜玉米品种(“斯达甜230”“双甜728”“金银131”“墨琦”“斯达甜240”“荆恒甜19号”“京科甜909”“尚满帝”“百帝伟456”“粤甜16号”)在广西甜玉米主产区横州市进行品种比较试验,测定及分析其生育期、田间植株性状、病害情况、果穗性状和鲜穗产量等。“尚满帝”和“荆恒甜19号”鲜穗产量分别达到1533.0 kg/667 m^(2)和1448.8 kg/667 m^(2),较对照“粤甜16号”分别增产27.30%和20.31%,排名分居前两位。同时,它们都具有苗强、吐丝散粉间隔期短、植株抗倒伏性强、叶片数多、单穗重、穗大、粒重和综合抗病性强等特性,综合性状均表现较好。参试甜玉米品种“尚满帝”和“荆恒甜19号”综合性状表现较好,比较适宜在广西横州市推广种植。

关键词：甜玉米品种横州比较试验

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基于灰色关联分析法的12个糯玉米品种评价

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中国种业 2023年第12期 136-140页

作者：禤豪新梁世龙刘喻华盛洁彭楷王远能高铭信郑瑞花李玉邹成林广西横州市石塘镇农业水利站横州530300 广西横州市农业科学研究所横州530300 广西横州市百合镇农业水利站横州530300 广西横州市校椅镇农业水利站横州530300 广西农业职业技术大学南宁530007 广西壮族自治区农业科学院玉米研究所南宁530007

为筛选出综合性状优异的育种材料,应用灰色系统理论中的关联分析法,对参加2022年中鲜玉(北京)联合体东南区糯玉米试验广西横州点的12个糯玉米品种的12个农艺性状进行分析与综合评价。结果表明,各参试品种与理想品种的加权关联度大小顺... 详细信息

为筛选出综合性状优异的育种材料,应用灰色系统理论中的关联分析法,对参加2022年中鲜玉(北京)联合体东南区糯玉米试验广西横州点的12个糯玉米品种的12个农艺性状进行分析与综合评价。结果表明,各参试品种与理想品种的加权关联度大小顺序依次为:斯达糯54>锐玉926>徽彩甜糯1号>苏糯6号>京科糯2000GL>佳糯808>彩糯606>荆恒18-1>佳农861>金糯1913>美玉18号>苏玉糯5号。其中斯达糯54综合性状最好(r′=0.8593),锐玉926次之(r′=0.8080),徽彩甜糯1号第三(r′=0.7848),苏玉糯5号综合性状最差(r′=0.5806)。

关键词：糯玉米灰色关联分析法农艺性状品种评价

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An integrated single-shot spectrometer with large bandwidth-resolution ratio and wide operation temperature range

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PhotoniX 2023年第1期4卷 172-187页

作者： Ang Li Chang Wang Feixia Bao Wenji Fang Yuxin liang Rui Cheng shilong Pan Key Laboratory of Radar Imaging and Microwave Photonics Ministry of EducationNanjing University of Aeronautics and AstronauticsNanjing 210016China United Microelectronics Center Chongqing 40030China School of Instrument Science and Opto-Electronics Engineering Hefei University of TechnologyHefeiAnhui 230009China

There has been a rapidly growing demand for low-cost,integrated single-shot spectrometers to be embedded in portable intelligent *** though significant progress has been made in this area,two major problems are still remaining,namely the high temperature sensitivity and poor bandwidth-resolution ratio(BRR)that can’t meet the requirement of most *** this work,we present an integrated single-shot spectrometer relying on a silicon photonic circuit that has a footprint less than 3mm2,but could achieve broad operation bandwidth about 100 nm and high resolution up to 0.1 nm(with a BRR~1000).Moreover,for the first time,we demonstrate an integrated spectrometer that could operate within a wide temperature range(between 10 and 70 degrees Celsius)without additional power consumption for temperature management.

关键词： Optical spectrometers Silicon photonics Computational spectrometers Photonic integrated circuits

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火山喷发对陆地植被与碳循环影响的研究进展

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科学通报 2024年第2期69卷 160-168页

作者：张原梁尔源汪涛朴世龙中国科学院青藏高原研究所高寒生态重点实验室北京100101 Laboratory for Sciences of Climate and Environment Institute Pierre-Simon LaplaceFrench Alternative Energies and Atomic Energy Commission/French National Centre for Scientific Research/Versailles-St-Quentin UniversityGif sur Yvette 91191France 中国科学院青藏高原地球科学卓越创新中心北京100101 北京大学城市与环境学院北京100871

1991年,Pinatubo火山喷发导致全球大气二氧化碳浓度上升态势出现停滞,这一现象揭示了地球内部系统可以通过火山活动对地表生物地球化学循环产生重大影响.近些年,火山喷发对陆地生态系统的影响及其驱动机制引起科学界的广泛讨论.本文系... 详细信息

1991年,Pinatubo火山喷发导致全球大气二氧化碳浓度上升态势出现停滞,这一现象揭示了地球内部系统可以通过火山活动对地表生物地球化学循环产生重大影响.近些年,火山喷发对陆地生态系统的影响及其驱动机制引起科学界的广泛讨论.本文系统梳理了火山喷发对陆地生态系统影响的研究,总结了火山活动的辐射效应和气候效应对树木生长和陆地碳循环产生影响的机制.大型火山喷发形成的平流层气溶胶一方面引起散射辐射增加促进光合作用,另一方面,还引起总辐射减弱抑制光合作用,由于散射辐射的影响相比更强,总体上火山辐射效应有利于陆地碳汇的增加.火山的气候效应体现在全球尺度的降温和区域降水的改变.降温作用在低纬地区促进植被的光合作用,在高纬地区抑制光合作用,同时在全球尺度减弱生态系统的呼吸作用,总体上也有利于增加碳汇.对火山造成降水变化影响的评估目前还存在较大不确定性.在对这些机制总结的基础上,本文评述了当前的认识盲点和研究难点,以期为未来进一步推进火山喷发影响的研究、完善地球内外系统联动机制的认识提供参考.

关键词：火山爆发陆地生态系统火山冷却效应散射辐射碳循环

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