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Association between Low Ambient Temperature and the Severity of Acute Ischemic Stroke

Journal of Clinical and Nursing Research 2024年第5期8卷 83-94页

作者： Xinyi Huang Liming Shu Su Xiao Qiuhong Jiang Shiliang Yang Hualiang liang Hua Hong liang Luo Department of Critical Care Medicine The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107GuangdongChina Department of Neurology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260GuangdongChina The Second Xiangya Hospital of Central South University Changsha 410011HunanChina Department of Neurology National Key Clinical Department and Key Discipline of NeurologyThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080GuangdongChina Department of General Practice Shenshan Central HospitalSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityShanweiChina 516600GuangdongChina School of Public Health Sun Yat-sen UniversityGuangzhou 510080GuangdongChina

Objective:To explore the relationships among ambient temperature,ischemic stroke severity,and blood ***:Meteorological data(2005–2015)were collected from the Guangzhou Meteorological Data *** stroke patients from the Department of Neurology of the First Affiliated Hospital,Sun Yat-sen University were retrospectively evaluated,each winter from 2005 to *** demographics,baseline measurements,and National Institute of Health Stroke Scale(NIHSS)score were ***:Three hundred sixty-two patients were *** median latency from symptom onset to admission was 2 d(IQR:1–3 d).During recruitment,the highest and lowest temperatures were 39℃and 1.3℃,*** was the most common comorbidity(75.1%).NIHSS scores at admission and discharge were higher in the cold-exposed group than in the controls regardless of the average temperature at *** addition,systolic and diastolic blood pressure values at admission were higher in the cold-exposed group than in the *** stratified by hypertensive status,the average and minimum temperatures at admission were negatively associated with systolic and diastolic blood pressure values in hypertensive *** in the average and minimum temperatures at symptom onset were associated with more severe ***:Ischemic stroke patients with symptom onset in winter had higher systolic blood pressure values and more serious neurologic deficits upon admission.

关键词： Low ambient temperature Stroke Blood pressure Severity

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配户当差与里甲制:明初杂泛差役派征机制探析

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中山大学学报（社会科学版） 2024年第2期64卷 135-145页

作者：丁亮辽宁师范大学历史文化学院大连116000

明初杂役包括官厅差役和驿递夫役在内,普遍采用“配户当差”的佥派办法。人户一旦佥点应当某种杂役便成为杂役户,固定地在一个地点长期服役,直至消乏佥替。但“配户当差”制在永乐以后出现弊端,主要是皂隶等官厅杂役凭借特权寻租,而驿... 详细信息

明初杂役包括官厅差役和驿递夫役在内,普遍采用“配户当差”的佥派办法。人户一旦佥点应当某种杂役便成为杂役户,固定地在一个地点长期服役,直至消乏佥替。但“配户当差”制在永乐以后出现弊端,主要是皂隶等官厅杂役凭借特权寻租,而驿递夫役负担较重,均长期不得佥替。永宣以后,一部分徭役改为每年轮充,开启了均徭法改革的历程。据新发现的“试行黄册”史料可知,明代里甲中存在较多的虚拟户和“带管畸零户”,且国家规定的点差标准很高,杂役基本要人户朋充服役。因此官府在确定所需杂役的数量以后,必须通过里甲组织的协调才能完成杂役户的佥点。但考虑到里甲内部的实际应役户数不多且徭役的附带财政责任不重的情况,里甲制与“配户当差”制之间并不发生冲突。

关键词：明初杂泛差役派征机制配户当差里甲制

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Crystal structure and hydrogen storage properties of(La,Ce)Ni_(5-x)M_x(M = Al, Fe, or Co) alloys

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International Journal of Minerals,Metallurgy and Materials 2019年第1期26卷 108-113页

作者： Wan-liang Mi Zhao-sen Liu Toru Kimura Atsunori Kamegawa Hai-liang Wang School of Energy and Environmental Engineering University of Science and Technology Beijing Research Center for Environmentally Friendly Materials Engineering (Muroran MATERIA) Muroran Institute of Technology

The effects of partial substitution of La by Ce and Ni by Al, Fe, or Co in LaNi_5-based alloys on hydrogen storage performance were systematically studied. All samples were prepared using vacuum arc melting in an argon atmosphere. The results showed that for LaNi_(5-x)M_x(M = Al, Fe, or Co) alloys, the lattice constants and unit cell volumes increased with an increasing amount of Al and Fe. On the other hand, these parameters decreased upon partial substitution of La by Ce. In addition, the lattice constant remained almost constant in the La_(0.6)Ce_(0.4)Ni_(5–x)Cox alloys regardless of the value of x(x = 0.3, 0.6, or 0.9), as Ce might enhance the homogeneity of the CaCu_5-type phase in Co-containing alloys. The hydrogen storage properties of the alloys were investigated using pressure, composition, and temperature isotherms. The experimental results showed that the plateau pressure decreased with an increasing content of Al, Fe, or Co, but it increased with Ce addition. Furthermore, the plateau pressures of all Co-containing alloys were almost identical upon substitution with Ce. Finally, the enthalpy(ΔH) and entropy(ΔS) values for all alloys were calculated using van't Hoff plots. The relationship between the lattice parameters and enthalpy changes for hydrogenation will be discussed.

关键词： metal hydride LaNi5 hydrogen storage alloys partial substitution P-C-T curves thermodynamics

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全尺寸飞行器地面振动试验数字化协同探索与实践

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航空工程进展 2024年第2期15卷 90-100页

作者：白春玉梁森宋巧治中国飞机强度研究所强度与结构完整性全国重点实验室西安710065 中国飞机强度研究所陕西省振动冲击与噪声重点实验室西安710065 中国飞机强度研究所航空噪声与振动航空科技重点实验室西安710065

全尺寸飞行器地面振动试验具有协调界面多、试验系统复杂、实施周期长、试验风险高等特点,面向先进飞行器高效协同研制需求,必须引入数字化手段提升物理试验能力。通过梳理传统模式飞行器地面振动试验流程,剖析数字化协同试验要素,从试... 详细信息

全尺寸飞行器地面振动试验具有协调界面多、试验系统复杂、实施周期长、试验风险高等特点,面向先进飞行器高效协同研制需求,必须引入数字化手段提升物理试验能力。通过梳理传统模式飞行器地面振动试验流程,剖析数字化协同试验要素,从试验方案与实施流程的数字化、试验对象的数字化、试验系统的数字化等方面出发,探索并初步构建全尺寸飞行器地面振动试验的数字化方案。指出当前数字化协同模式对降低试验风险、提高试验效率具有显著助益,未来需要进一步推进数实融合仿真、应用平台开发,以推动数字化成熟落地。

关键词：全尺寸飞行器地面振动试验模态测试数字化试验并行协同

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E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular Carcinoma Development by Inhibiting Pyroptosis

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 25-35页

作者： Cuicui Xiao Jiao Gong Yusheng Jie Weicheng liang Yan Tai Wei Qin Tongyu Lu Yutian Chong Ziqing Hei Bo Hu Qi Zhang Biotherapy Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Anesthesiology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Key Laboratory of Liver Disease of Guangdong Province Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Laboratory Medicine Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Cell-Gene Therapy Translational Medicine Research Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Background and Aims:As a subunit of the condensin complex,NCAPG has an important role in maintaining chromosome condensation,but its biological function and regulatory mechanism in hepatocellular carcinoma(HCC)remains ***:The prognostic ability of NCAPG in HCC patients was examined by univariate and multivariate Cox regression *** curves were plotted to compare the predictive ability of NCAPG and *** luciferase reporter system,and ChIP were used to investigate transcriptional potential of E2F1 to *** was observed by scanning electron *** expression of NCAPG,E2F1,and major proteins constituting NLRP3 inflammasome was determined by western blotting and *** in vivo tumor formation assay was conducted to verify the in vitro ***:Up-regulated NCAPG was identified in HCC tissues compared with adjacent tissue and high NCAPG was positively correlated with poor *** NCAPG mRNA level was a prognostic factor in HCC patients and also a diagnostic factor with higher predictive ability compared with AFP[AUROC 0.766(95%CI:0.650–0.881)vs.0.649(95%CI 0.506–0.793)].HBx transfection resulted in concomitant up-regulation of E2F1 and NCAPG.E2F1 significantly increased the activity of luciferase reporter fused with NCAPG reporter,and the interaction of E2F1 and NCAPG gene was confirmed by *** of E2F1 resulted in significant down-regulation of *** of NCAPG promote pyroptosis mediated by NLRP3 inflammasome activation in multiple HCC cell lines and also suppressed tumorigenesis in ***:We identified a novel role of NCAPG in the regulation of NLRP3 inflammasome-mediated pyroptosis,which was regulated by its upstream transactivator,*** role of E2F1-NCAPG-NLRP3 regulation of pyroptosis network may be a potential target in HCC treatment.

关键词： NCAPG Hepatocellular carcinoma Pyroptosis NLRP3 inflammasome Serum marker circulating RNA.

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On demand CRISPR-mediated RNA N6-methyladenosine editing

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Genes & Diseases 2022年第6期9卷 1389-1390页

作者： Ying Xu Fu-sen liang Department of Chemistry Case Western Reserve UniversityClevelandOH 44106USA

There are over 170 types of chemical modifications discovered across all the RNA categories in living organisms,1 which constitute the epitranscriptome.2 Emerging as an additional mechanism of post-transcriptional regulation of genetic information,these RNA modifications and the epitranscriptome have been tightly associated with the RNA fate and various human diseases.

关键词： editing modification constitute

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A new autophagy-related nomogram and mechanism in multiple myeloma

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Genes & Diseases 2024年第5期11卷 29-32页

作者： Hanying Huang Yang Li Ziang Zhu Yang Liu Weida Wang Shuzhao Chen Xiaoping Wu Yun Wang Yanzhou Chen Huanxin Lin Yang liang Lingling Shu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Hematologic Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Radiation Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Key Laboratory of Neurosurgery in Guangdong Province Southern Medical UniversityGuangzhouGuangdong 510060China Department of Neurosurgery Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510060China State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong Kong 999077China

Multiple myeloma(MM)is the second most common hematological *** is characterized by high drug resistance,easy recurrence,and poor prognosis,and remains *** models or scoring modalities can be used to predict the survival prognosis of MM patients;however,these predictions are still not accurate *** have previously found that scorings related to bone marrow microenvironment metabolism can improve predictive efficacy.

关键词： metabolism prognosis myeloma

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Precisely Tailoring the First Coordination Shell of Metal Centers in Porous Nitrogen-Doped Carbon Promoting Electroreduction of CO^(2)Under Neutral Condition

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CCS Chemistry 2024年第8期6卷 1978-1986页

作者： Cheng-Peng liang Jia-Run Huang Hao-Lin Zhu Zhen-Hua Zhao Can Yu Pei-Qin Liao Xiao-Ming Chen MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular EngineeringSchool of ChemistrySun Yat-sen UniversityGuangzhouGuangdong 510275 Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049

Precise regulation of the coordination environment of a metal active center is very important but remains a ***,single-atom Ni catalysts with a combined N-and C-coordination structure(Ni-NC_(3))and N-coordination structure(Ni-N4)were prepared by modulating the side groups of organic ligands in the corresponding precursor metal–azolate *** with the Ni-N4 site,the d-band center of 3d orbitals of the Ni atom in Ni-NC_(3)was more significantly shifted to the Fermi energy level;thus,the Ni-NC_(3)catalytic site was superior to activating CO_(2)molecule into the*COOH *** a result,Ni-NC_(3)exhibited an exceptionally high performance for CO_(2)-to-CO conversion with a Faradaic efficiency of 98.4%,an energy efficiency of>50%,as well as an industrial current density of∼300 mA cm^(−2) in neutral *** high performance could be retained for at least 70 *** work reveals the importance of modulating the coordination environment in the electrochemical CO_(2)reduction reaction and provides a possible way to rational design of electrocatalysts for highly efficient conversion of CO_(2)to target products.

关键词： single-atom Ni catalysts first coordination shell porous nitrogen-doped carbon electrochemical CO_(2)reduction reaction coordination environment

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基于快速信息收集和虚拟训练序列的低复杂度双向水声信道精准估计

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大连海事大学学报 2024年第3期50卷 13-22页

作者：陈建军曲亚东梁俊燕孙冬雪李森青岛理工大学信息与控制工程学院山东青岛266525 大连海事大学信息科学技术学院辽宁大连116026

针对运动水声通信难以低复杂度精准获取时变信道状态信息的问题,提出基于快速信息收集和虚拟训练序列(FIC⁃VT)的低复杂度双向水声信道精准估计算法。采用叠加训练(ST)方案,将符号序列和训练序列线性叠加,使得训练序列持续传输,提高时变... 详细信息

针对运动水声通信难以低复杂度精准获取时变信道状态信息的问题,提出基于快速信息收集和虚拟训练序列(FIC⁃VT)的低复杂度双向水声信道精准估计算法。采用叠加训练(ST)方案,将符号序列和训练序列线性叠加,使得训练序列持续传输,提高时变信道跟踪能力。基于置信传播,提出FIC⁃VT算法,将一块数据分成多个短块,每个短块又分成多个子段,通过快速信息收集算法,将多个子段的信道信息进行融合,从而获得每个短块的低复杂度局部信道估计。利用短块间的信道相关性,对多个短块的信道信息进行双向信息融合,从而获得当前短块的低复杂度全局信道估计。基于Turbo均衡,将估计的符号序列虚拟为训练序列(VT),通过迭代计算实现时变水声信道低复杂度精准估计。本文算法由快速傅里叶变换(FFT)实现,每个抽头计算复杂度仅为对数级。计算机仿真、水池运动通信试验和胶州湾运动通信试验验证了本文算法的有效性。

关键词：时变水声信道低复杂度双向信道估计快速信息收集虚拟训练序列叠加训练快速傅里叶变换(FFT)

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河弧菌Ⅵ型分泌系统组成、功能及调控研究进展

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中国人兽共患病学报 2024年第6期40卷 571-577页

作者：韩雨冀赛森程倩黄元铭段然梁未丽传染病溯源预警与智能决策全国重点实验室中国疾病预防控制中心传染病预防控制所北京102206

Ⅵ型分泌系统(TypeⅥSecretion System,T6SS)是细菌中新发现的一种以直接接触方式释放毒性效应蛋白杀死真核“捕食者”或原核“竞争对手”的蛋白分泌装置,被喻为细菌的“分子武器”,在细菌环境适应性、致病性和基因的水平转移等方面都... 详细信息

Ⅵ型分泌系统(TypeⅥSecretion System,T6SS)是细菌中新发现的一种以直接接触方式释放毒性效应蛋白杀死真核“捕食者”或原核“竞争对手”的蛋白分泌装置,被喻为细菌的“分子武器”,在细菌环境适应性、致病性和基因的水平转移等方面都发挥重要作用。约25%的革兰氏阴性细菌基因组中存在T6SS编码基因簇,存在广泛,越来越多的研究支持T6SS是细菌间生态位竞争的关键因素。T6SS发挥生物学功能的效应蛋白具有高度多样性,并不具有保守的特征序列,涉及的调控机制复杂,因此是T6SS研究领域的热点和难点。河弧菌(***)作为一种新发的食源性病原菌,T6SS的数量、组成和生理功能具有独特性,与其广泛的环境适应性及致病性有关。本文综述了河弧菌T6SS的组成结构、功能活性及调控机制等。

关键词： Ⅵ型分泌系统河弧菌效应蛋白弧菌属

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