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On demand CRISPR-mediated RNA N6-methyladenosine editing

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Genes & Diseases 2022年第6期9卷 1389-1390页

作者： Ying Xu Fu-sen liang Department of Chemistry Case Western Reserve UniversityClevelandOH 44106USA

There are over 170 types of chemical modifications discovered across all the RNA categories in living organisms,1 which constitute the epitranscriptome.2 Emerging as an additional mechanism of post-transcriptional regulation of genetic information,these RNA modifications and the epitranscriptome have been tightly associated with the RNA fate and various human diseases.

关键词： editing modification constitute

Fabrication of nano-grained negative temperature coefficient thermistors with high electrical stability

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Rare Metals 2021年第4期40卷 1014-1019页

作者： Miao-Miao Cui Xiao Zhang Kuan-Guan Liu Hai-Bo Li Mang-Mang Gao sen liang Ningxia Key Laboratory of Photovoltaic Materials Ningxia UniversityYinchuan 750021China School of Materials Science and Engineering North Minzu UniversityYinchuan 750021China

Dense nano-grained Ni_(0.7)Mn_(2.3O4) negative temperature coefficient(NTC) thermistors were fabricated by a novel two-step sintering approach that combines rapid sintering and principle of conventional two-step sintering *** were sintered at 1042℃ for 30 s in the first rapid step and then at 850-950℃ for 20 h in the second soaking *** phase,microstructure and electrical properties of sintered samples were studied by X-ray diffraction(XRD),scanning electron microscopy(SEM),resistance temperature relationship and aging *** samples show a single-phase cubic spinel structure and indicate a high relative density ranging from 84% to 91% of the theoretical ***,average grain sizes of sintered samples under SEM are distributed between 254 and 570 ***,the resistivity and the aging coefficient significantly decrease when soaking sintering temperature *** addition,the obtained material constant(B) ranges from 3931 to 3981 ***_(0.7)Mn_(2.3)O_(4)-3(soaking at 900℃) and Ni_(0.7)Mn_(2.3O4)-4(soaking at 950℃) present little aging behavior,implying great electrical stability.

关键词： Negative temperature coefficient thermistor Sintering Nano-grain Aging

Effect of Fuzheng Jiedu granule on immunological function and level of immune-related cytokines in immune-suppressed mice

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Journal of Integrative Agriculture 2016年第3期15卷 650-657页

作者： YU Zhan-mei HUANG Xian-hui YAN Chao-qun GAO Jin liang Zi-sen Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation College of Veterinary Medicine South China Agricultural University

Fuzheng Jiedu granule exhibits a number of health benefits and it is thought that the mechanisms involved in these effects are due to the modulation of immunity. In this article, we studied the effect of Fuzheng Jiedu granule on immunological function and the expression of immune-related cytokines in immune-suppressed mice. 72 mice were randomly divided into six groups, with 12 in each group. The control groups included an untreated group, a negative control group（Cyclophosphamide） and a positive control group（Astragalus polysaccharide）. There were three treated groups, which were given different doses of Fuzheng Jiedu granule： a low dose（100 mg kg^（–1））, a medium dose（400 mg kg^（–1）） and a high dose（600 mg kg^（–1））. With the exception of the untreated control animals, each group received an intraperitoneal injection of Cyclophosphamide（100 mg kg^（–1）） for 3 days to establish the immune-suppressed model. Mice were then treated for 19 consecutive days and, 24 h after the last treatment, blood was taken for the eyeballs and serum separation was performed. Analysis was made of the levels of related cytokines（IgA, IgG, IgM, IL-6, IFN-γ, C3, C4 and TNF-α）, the transformation of lymphocytes and the immune organ indexes. The results showed that Fuzheng Jiedu granule can improve the levels of cytokines, the rate of proliferation of lymphocytes and the immune organ indexes of immune-suppressed mice.

关键词： Fuzheng Jiedu granule immune suppression cytokines lymphocytes immune organ index

Facial landmark disentangled network with variational autoencoder

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Applied Mathematics(A Journal of Chinese Universities) 2022年第2期37卷 290-305页

作者： liang sen ZHOU Zhi-ze GUO Yu-dong GAO Xuan ZHANG Ju-yong BAO Hu-jun CAD&CG State Labs Zhejiang UniversityHangzhou 310027China School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China.

Learning disentangled representation of data is a key problem in deep ***,disentangling 2D facial landmarks into different factors(e.g.,identity and expression)is widely used in the applications of face reconstruction,face reenactment and talking head et al..However,due to the sparsity of landmarks and the lack of accurate labels for the factors,it is hard to learn the disentangled representation of *** address these problem,we propose a simple and effective model named FLD-VAE to disentangle arbitrary facial landmarks into identity and expression latent representations,which is based on a Variational Autoencoder ***,we propose three invariant loss functions in both latent and data levels to constrain the invariance of representations during training ***,we implement an identity preservation loss to further enhance the representation ability of identity *** the best of our knowledge,this is the first work to end-to-end disentangle identity and expression factors simultaneously from one single facial landmark.

关键词： disentanglement representation deep learning facial landmarks variational autoencoder

From Two-Dimensional Metal Organic Coordination Networks to Near-Infrared Luminescent PbS Nanoparticle/Layered Polymer Composite Materials

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Nano Research 2008年第3期1卷 195-202页

作者： Fang Cui Junhu Zhang Tieyu Cui sen liang Bao Li Quan Lin Bai Yang State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Two-dimensional(2-D)layered metal-organic coordination(lead methacrylate(LDMA))networks have been prepared in aqueous solution under mild conditions and their structure determined by single crystal *** the ligand used in our experiments is easily polymerized,these metal-organic coordination layers are therefore employed as precursors to fabricate cross-linked polymer layered materials throughγ-irradiated *** stabilities of the samples are signifi cantly improved afterγ-*** our knowledge,this is the fi rst time that covalent bonded polymer layered structures have been fabricated without the assistance of added surfactant or *** layered polymer materials cannot only act as alternatives to layered inorganic materials in some caustic environments,but also allow the generation of PbS nanoparticles(NPs)without aggregation in the polymer *** exposing the polymer layer to H2S gas at room temperature,uniform PbS nanoparticles with an average size of about 6 nm are generated in *** addition,the resulting PbS NPs exhibit near-infrared(NIR)luminescent properties,which suggests the composite materials may be useful as active optical elements at communication wavelengths from 1300 to 1550 nm.

关键词： PbS nanoparticles layered material near-infrared γ-irradiated polymerization in situ

Effect of Nanorod Diameters on Optical Properties of GaN-Based Dual-Color Nanorod Arrays

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Chinese Physics Letters 2019年第2期36卷 71-74页

作者： liang-sen Feng Zhe Liu Ning Zhang Bin Xue Jun-Xi Wang Jin-Min Li Institute of Semiconductors Chinese Academy of Sciences University of Chinese Academy of Sciences

Dual-color(blue and green) InGaN/GaN nanorod light-emitting diodes(LEDs) with three different nanorod diameters are fabricated. Enhancement of luminescence intensity per area is observed in blue and green wells,to varying degrees. When the diameter is 40 nm, it sharply decreases, which could be explained by the sidewall nonradiative recombination. Time-resolved photoluminescence is conducted to study the carrier lifetime. High recombination rate is observed in nanorod arrays, and is an order of magnitude less than that of the planar *** the diameter is 40 nm, the nonradiative lifetime decreases, and this explains the decrease of intensity. The3 D-FDTD simulations show the enhancement of light extraction out of geometry structure by calculating the transmittance of the nanorod arrays.

关键词： Optical Properties GaN-Based Dual-Color Nanorod Arrays

Pesticide residues in bayberry(Myrica rubra)and probabilistic risk assessment for consumers in Zhejiang,China

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Journal of Integrative Agriculture 2017年第9期16卷 2101-2109页

作者： YANG Gui-ling WANG Wen liang sen-miao YU Yi-jun ZHAO Hui-yu WANG Qiang QIAN Yong-zhong Key Laboratory of Agro-Product Quality and Safety Ministry of Agriculture~Institute of Quality Standards and Testing Technology for Agro-ProductsChinese Academy of Agricultural SciencesBeijing 100081P.R.China Laboratory of Quality&Safety Risk Assessment for Agro-Products(Hangzhou)/Key Laboratory for Pesticide Residue Detection Ministry of Agriculture/Institute of Quality and Standards for Agricultural ProductsZhejiang Academy of Agricultural SciencesHangzhou 310021P.R.China Zhejiang Bureau for Agriculture Hangzhou 310021P.R.China

As pesticide residues in bayberry has raised serious concern from the public in China, a monitoring survey was carried out during 2013–2014 and 157 samples were analyzed in total. Twenty-three pesticides were detected among the 44 pesticides analyzed and at least one pesticide was detected in 63% of 99 samples. Whereas 45.6% of samples were found with two or more pesticide residues, and 23.6% of samples with four or more pesticide residues. Probabilistic risk assessments indicated that estimated daily intake（EDI） of cyhalothrin at the P97.5th percentile level is 1.11 times larger than the acceptable daily intake（ADI） for children, the estimated short-term intake（ESTI） at the P97.5th percentile level is 1.9 and 1.78 times larger than the acute reference dose（ARf D） for adult and children, respectively, indicating the potential risk concern from pyrethroids. EDI of the pesticides with anti-androgenic effects ranged from 0.15–2.46 of ADI, the probability of exposure exceeding the ADI was 7.1 and 31.1% for adults and children, respectively, the probability of exposure of pyrethroids exceeding the ADI was 3.8% for children. Exposures for other pesticides and groups were below 1.0. Because the co-occurrence of frequency of cyhalothrin and cypermethrin was 9.55%, the combinations of pesticides detected with anti-androgenic effects has not been found in the present monitoring, the results indicate that the pesticide residues in bayberry will not constitute serious public health risk, however, they are significant for the management of pesticide use on bayberry and dietary health risk in China.

关键词： bayberry pesticide residues probabilistic risk assessment

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电站锅炉低NO_x排放的参数辨识

动力工程 2006年第5期26卷 670-675页

作者：梁森李凌上海电机学院电气工程系上海200240 上海理工大学动力工程学院上海200093

阐述了参数辨识和神经网络的基本概念,针对某电厂600 MW机组锅炉NOx排放状况,收集了大量有关锅炉运行参数、NOx排放量和锅炉效率等数据,建立了相应的数学模型,运用人工神经网络智能参数辨识方法,研究得出了NOx排放量与各运行参数以及锅... 详细信息

阐述了参数辨识和神经网络的基本概念,针对某电厂600 MW机组锅炉NOx排放状况,收集了大量有关锅炉运行参数、NOx排放量和锅炉效率等数据,建立了相应的数学模型,运用人工神经网络智能参数辨识方法,研究得出了NOx排放量与各运行参数以及锅炉效率的定量关系,为进一步提高锅炉运行的经济性,实现优化控制及低NOx排放提供了一种便捷的方法。

关键词：自动控制技术燃煤锅炉参数辨识人工神经网络建模

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中温共固化阻尼复合材料制备及层间结合性能

高分子材料科学与工程 2020年第6期36卷 63-69页

作者：郑长升梁森青岛理工大学机械与汽车工程学院山东青岛266520

基于树脂基体的固化工艺与阻尼材料的硫化特性,利用正交试验法研制了一种能够与酚醛树脂在165℃发生共固化的黏弹性阻尼材料。然后将阻尼材料制成阻尼胶浆,探索使用刷涂工艺将中间层制成带有阻尼薄膜的预浸料,最终按照设计的铺层顺序根... 详细信息

基于树脂基体的固化工艺与阻尼材料的硫化特性,利用正交试验法研制了一种能够与酚醛树脂在165℃发生共固化的黏弹性阻尼材料。然后将阻尼材料制成阻尼胶浆,探索使用刷涂工艺将中间层制成带有阻尼薄膜的预浸料,最终按照设计的铺层顺序根据共固化工艺制成玻璃纤维增强酚醛树脂基复合材料阻尼结构。通过层间剪切实验研究该复合材料结构的层间剪切性能,获得了层间剪切强度随阻尼层厚度的变化曲线。当阻尼层仅为0.1 mm时,其最大剪切力为4647 N,层间剪切强度达到7.435 MPa。随着阻尼层厚度的增大,共固化阻尼复合材料结构的层间剪切强度逐渐降低,实验研究表明,阻尼层与约束层间具有优异的层间结合性能。模态实验结果表明,共固化复合材料具有良好的阻尼层能。利用扫描电镜对其剪切失效面进行微观分析,结果表明树脂基体与阻尼材料具有良好的相容性。这为共固化阻尼复合材料的进一步应用提供了理论参考。

关键词：中温共固化阻尼复合材料阻尼薄膜阻尼层厚度层间剪切性能