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Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound

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Genes & Diseases 2024年第5期11卷 163-182页

作者： jin Tang Mingxuan Feng Dong Wang liang Zhang {2. Yang Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Engineering Research Center of Stem Cell TherapyChongqing 400014China department of Ultrasound The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Tongji Medical College Huazhong University of Science and TechnologyWuhanHubei 430074China

Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation ***,a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and *** stimulation with ultrasound,these proteins trigger a cascade of cellular activities and *** traditional ultrasound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease *** technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodulation,oncologic treatments,stem cell therapy,and *** current literature predominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of *** discuss ultrasound properties,the specific ultrasound-sensitive proteins employed in sonogenetics,and the technique’s potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell *** objective is to stimulate fresh perspectives for further research in this promising field.

关键词： Mechanosensitive channel Neuromodulation Sonogenetics Ultrasound Ultrasound-sensitive protein

Induction-by-stages of Dixmier algebras and orbit datum and its application

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Chinese Science Bulletin 1998年第10期43卷 818-820页

作者： liang ke {2. of mathematics, nankai University, tianjin 300071, china department of mathematics Nankai University Tianjin China

The purpose of the present note is to prove that the parabolic inductions of the orbit datum and Dixmier algebras can be induced by stages. And as an appliction, we have proved that for SO(2.+1, C), SP(2., C), F\-4 an... 详细信息

关键词： dixmier algebra orbit data representation of Lie group.

Neuropeptide Y receptor Y8b(npy8br)regulates feeding and digestion in Japanese medaka(Oryzias latipes)larvae:evidence from gene knockout

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 605-616页

作者： Xiaodan JIA ke LU Xufang liang College of Fisheries Chinese Perch Research CenterHuazhong Agricultural UniversityWuhan 430070China Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt Ministry of EducationWuhan 430070China

Neuropeptide Y receptor Y8(NPY8R)is a fish-specific receptor with two subtypes,NPY8AR and *** in expression levels during physiological processes or in vivo regulation after ventricular injection suggest that NPY8BR plays an important role in feeding regulation;this has been found in only a few fish,at *** order to better understand the physiological function of npy8br,especially in digestion,we used clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)technology to generate npy8br-/-japanese medaka(Oryzias latipes).We found that the deletion of npy8br in medaka larvae affected their feeding and digestion ability,ultimately affecting their ***,npy8br deficiency in medaka larvae resulted in decreased feed intake and decreased expression levels of orexigenic genes(npy and agrp).npy8br-/-medaka larvae fed for 10 d(10th day of feeding)still had incompletely digested brine shrimp(Artemia nauplii)in the digestive tract 8 h after feeding,the messenger RNA(mRNA)expression levels of digestion-related genes(amy,lpl,ctra,and ctrb)were significantly decreased,and the activity of amylase,trypsin,and lipase also significantly *** deletion of npy8br in medaka larvae inhibited the growth and significantly decreased the expression of growth-related genes(gh and igf1).Hematoxylin and eosin(H&E)sections of intestinal tissue showed that npy8br-/-medaka larvae had damaged intestine,thinned intestinal wall,and shortened intestinal *** far,this is the first npy8br gene knockout model established in fish and the first demonstration that npy8br plays an important role in digestion.

关键词： Neuropeptide Y receptor Y8b(npy8br) Japanese medaka(Oryzias latipes) Knockout Feeding Digestion

Exoskeleton active assistance strategy for human muscle activation reduction during linear and circular walking

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Advances in Manufacturing 2024年第3期12卷 484-496页

作者： Wen-Tao Sheng ke-Yao liang Hai-Bin Tang School of Intelligent Manufacturing Nanjing University of Science and TechnologyNanjing210094People’s Republic of China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin150001People’s Republic of China

The exoskeleton is employed to assist humans in various domains including military missions,rehabilitation,industrial operation,and activities of daily living(ADLs).Walking is a fundamental ADL,and exoskeletons are capable of reducing the activation and metabolism of lower extremity muscles through active assistance during *** improve the performance of active assistance strategy,this article proposes a framework using an active hip ***,it correlates to an already established Bayesian-based human gait recognition algorithm,with a particular focus on linear and circular walking within industrial and ADL *** theorizing this strategy for exoskeletons,this study further reveals,in part,the activation characteristics of human hip muscles for the instruction and regulation of active assistance duration and onset *** proposed active assistance strategy provides new insights for enhancing the performance of assistive robots and facilitating human robot interaction within the context of ADLs.

关键词： Human-robot interaction Hip exoskeleton Muscle activation Walking assistance

A Dual Domain Robust Reversible Watermarking Algorithm for Frame Grouping Videos Using Scene Smoothness

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Computers, Materials & Continua 2024年第6期79卷 5143-5174页

作者： Yucheng liang ke Niu Yingnan Zhang Yifei Meng College of Cryptographic Engineering Engineering University of the Chinese People’s Armed Police ForceXi’an710086China key Laboratory of Information Security of the Chinese People’s Armed Police Force Engineering University of the Chinese People’s Armed Police ForceXi’an710086China

The proposed robust reversible watermarking algorithm addresses the compatibility challenges between robustness and reversibility in existing video watermarking techniques by leveraging scene smoothness for frame grouping *** in the H.2.4 video coding standard,the algorithm first employs traditional robust watermark stitching technology to embed watermark information in the low-frequency coefficient domain of the U ***,it utilizes histogram migration techniques in the high-frequency coefficient domain of the U channel to embed auxiliary information,enabling successful watermark extraction and lossless recovery of the original video *** results demonstrate the algorithm’s strong imperceptibility,with each embedded frame in the experimental videos achieving a mean peak signal-to-noise ratio of 49.3830 dB and a mean structural similarity of *** with the three comparison algorithms,the performance of the two experimental indexes is improved by 7.59%and 0.4%on *** the same time,the proposed algorithm has strong robustness to both offline and online attacks:In the face of offline attacks,the average normalized correlation coefficient between the extracted watermark and the original watermark is 0.9989,and the average bit error rate is *** the face of online attacks,the normalized correlation coefficient between the extracted watermark and the original watermark is 0.8840,and the mean bit error rate is *** with the three comparison algorithms,the performance of the two experimental indexes is improved by 1.2.%and 18.16%on average,highlighting the algorithm’s ***,the algorithm exhibits low computational complexity,with the mean encoding and the mean decoding time differentials during experimental video processing being 3.934 and 2.2.3 s,respectively,underscoring its practical utility.

关键词： Robust reversible watermarking scene smoothness dual-domain U channel H.2.4 encoding standard

Quasi-periodically Forced Logistic Map with Weak Liouvillean Frequency

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2411-2435页

作者： jin Hao liang Lin Lin FU department of Applied mathematics Nanjing Forestry University School of mathematics and Statistics Shaoguan University

Consider a class of quasi-periodically forced logistic maps■whereωis an irrational frequency and c(θ) is a specific bimodal *** prove that under weak Liouvillean condition on frequency,the strange non-chaotic attra... 详细信息

关键词： 37C60 37C70 logistic map Lyapunov exponent Quasi-periodically forced strange non-chaotic attractor weak Liouvillean frequency

Regulation of Ti(C,N)deposition on hot surface of refractory in blast furnace hearth

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Journal of Iron and Steel Research International 2024年第6期31卷 1423-1435页

作者： Jian Cao Cui Wang Jjan-liang Zhang ke-xin Jiao Guo-hua Zhang State key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Ti(C,N)concentration was found to be lower on the hearth sidewall of a blast furnace and increased gradually toward the bottom of the blast *** Ti(C,N)protective layer in a blast furnace is ***,the formation of a Ti(C,N)protective layer was promoted by studying the heterogeneous nucleation principle of titanium compounds on different substances and regulation measures for the deposition process of titanium compounds on refractories or *** lattice disregistry between the titanium compounds and the main components in the refractory or the main impurities in the protective layer was calculated using a two-dimensional disregistry equation to study the heterogeneous nucleation principle of titanium *** results revealed that in refractory materials,the heterogeneous nucleation of carbonitride is weak when C,SiO_(2.,and Al_(2.O_(3) are used as heterogeneous nucleation substrates,and the heterogeneous nucleation of carbonitride is strong when TiO_(2. and SiC are used as heterogeneous nucleation *** nucleation phases,TiC,TiN,Ti(C_(0.3),N_(0.7)),and Ti(C_(0.5),N_(0.5))have similar heterogeneous nucleation ability in single component refractory,and the type of carbonitride has little effect on the lattice *** impurities in the protective layer as the substrate phases are not conducive to the heterogeneous nucleation of *** CaS was used as the substrate phase,the heterogeneous nucleation ability of carbonitride was the *** carbon and alumina were not conducive to the heterogeneous nucleation of carbonitride,but carbon was more unfavourable than alumina.

关键词： Ti(C,N) Lattice disregistry Lattice constant Heterogeneous nucleation Regulation measure

Effect of different anesthetic modalities with multimodal analgesia on postoperative pain level in colorectal tumor patients

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 364-371页

作者： Ji-Chun Tang Jia-Wei Ma jin-jin Jian Jie Shen {2.-{2. Cao department of Anesthesiology The Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina department of Anesthesiology People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture 843599Xinjiang Uygur Autonomous RegionChina department of Critical Care Medicine Jiangnan University Medical CenterWuxi 214122Jiangsu ProvinceChina department of Critical Care Medicine People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture843599Xinjiang Uygur Autonomous RegionChina

BACKGROUND According to clinical data,a significant percentage of patients experience pain after surgery,highlighting the importance of alleviating postoperative *** current approach involves intravenous self-control analgesia,often utilizing opioid analgesics such as morphine,sufentanil,and *** for colo-rectal cancer typically involves general ***,optimizing anes-thetic management and postoperative analgesic programs can effectively reduce perioperative stress and enhance postoperative *** study aims to analyze the impact of different anesthesia modalities with multimodal analgesia on patients'postoperative *** To explore the effects of different anesthesia methods coupled with multi-mode analgesia on postoperative pain in patients with colorectal *** Following the inclusion criteria and exclusion criteria,a total of 12. patients with colorectal cancer admitted to our hospital from January 2.2. to December 2.2. were included,of which 63 received general anesthesia coupled with multi-mode labor pain and were set as the control group,and 63 received general anesthesia associated with epidural anesthesia coupled with multi-mode labor pain and were set as the research *** data collection,the effects of postoperative analgesia,sedation,and recovery were *** Compared to the control group,the research group had shorter recovery times for orientation,extubation,eye-opening,and spontaneous respiration(P2. h and 48 h,higher Ramany scores at 6 h and 12.h,and improved cognitive function at 2. h,48 h,and 72.h(P10 levels were significantly reduced at various time points in the research group compared to the control group(P<0.05).Levels of CD3+,CD4+,and CD4+/CD8+were also lower in the research group at multiple time points(P<0.05).CONCLUSION For patients with colorectal cancer,g

关键词： Multimodal analgesia Anesthesia Colorectal cancer Postoperative pain

Optimization for epitaxial fabrication of infinite-layer nickelate superconductors

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Frontiers of physics 2024年第3期19卷 61-69页

作者： Minghui Xu Yan Zhao Xiang Ding Huaqian Leng Shu Zhang Jie Gong Haiyan Xiao Xiaotao Zu Huiqian Luo ke-jin Zhou Bing Huang {2. Qiao School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China Beijing Computational Science Research Center Beijing 100193China Diamond Light Source Harwell CampusDidcot OX110DEUnited Kingdom Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

The discovery of nickelates superconductor creates exciting opportunities to unconventional superconductivity. However, its synthesis is challenging and only a few groups worldwide can obtain samples with zero-resistance. This problem becomes the major barrier for this field. From plume dynamics perspective, we found the synthesis of superconducting nickelates is a complex process and the challenge is twofold, i.e., how to stabilize an ideal infinite-layer structure Nd_(0.8)Sr_(0.2.NiO_(2., and then how to make Nd_(0.8)Sr_(0.2.NiO_(2. superconducting? The competition between perovskite Nd_(0.8)Sr_(0.2.NiO_(3) and Ruddlesden−Popper defect phase is crucial for obtaining infinite-layer structure. Due to inequivalent angular distributions of condensate during laser ablation, the laser energy density is critical to obtain phase-pure Nd_(0.8)Sr_(0.2.NiO_(3). However, for obtaining superconductivity, both laser energy density and substrate temperature are very important. We also demonstrate the superconducting Nd_(0.8)Sr_(0.2.NiO_(2. epitaxial film is very stable in ambient conditions up to 512.days. Our results provide important insights for fabrication of superconducting infinite-layer nickelates towards future device applications.

关键词： nickelate superconductivity infinite-layer plasma condensate plume dynamics