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Biomedical and Environmental Sciences 2024年第7期37卷 716-725页

作者： Weijia Zhang Jierong Zhao Qikai Yin Shenghui Liu Ruichen Wang Shihong Fu Fan Li Ying He Kai Nie Guodong liang Songtao Xu guang Yang Huanyu Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China School of Basic Medicine and Public Health Jinan UniversityGuangzhou 510000GuangdongChina

Objective Genotypes(G)1,3,and 5 of the Japanese encephalitis virus(JEV)have been isolated in China,but the dominant genotype circulating in Chinese coastal areas remains *** searched for G5 JEV-infected cases and attempted to elucidate which JEV genotype was most closely related to human Japanese encephalitis(JE)in the coastal provinces of *** In this study,we collected serum specimens from patients with JE in three coastal provinces of China(guangdong,Zhejiang,and Shandong)from 2018 to 2020 and conducted JEV cross-neutralization tests against G1,G3,and *** Acute serum specimens from clinically reported JE cases were obtained for laboratory confirmation from hospitals in Shandong(92 patients),Zhejiang(192 patients),and guangdong(77 patients),China,from 2018 to *** of the 361 serum specimens were laboratory-confirmed to be infected with *** cases were confirmed to be infected with G1 JEV,32 with G3 JEV,and two with G5 *** G3 was the primary infection genotype among JE cases with a definite infection genotype,and the infection caused by G5 JEV was confirmed serologically in China.

关键词： Japanese encephalitis virus Serological investigation Plaque reduction neutralization test Cross-neutralization test Genotype

Regeneration of photovoltaic industry silicon waste toward high-performance lithium-ion battery anode

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Rare Metals 2024年第10期43卷 4948-4960页

作者： Kai Wang Xiao-Bin Zhong Yue-Xian Song Yao-Hui Zhang Yan-Gang Zhang Xiao-Gang You Pu-guang Ji Kurbanov Mirtemir Shodievich Umedjon Khalilov Gong-Kai Wang Xin Zhang Xing-liang Yao Feng Li Jun-Fei liang Hua Wang School of Energy and Power Engineering North University of China Zhongyuan Critical Metals Laboratory Zhengzhou University Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Material Science and EngineeringHebei University of Technology Arifov Institute of Ion-Plasma and Laser Technologies Academy of Sciences of the Republic of Uzbekistan New Uzbekistan University Arifov Institute of Ion-Plasma and Laser Technologies Academy of Sciences of Uzbekistan University of Antwerp School of Chemistry Beihang University

The diamond-wire sawing silicon waste（DWSSW） from the photovoltaic industry has been widely considered as a low-cost raw material for lithium-ion battery silicon-based electrode,but the effect mechanism of impurities presents in DWSSW on lithium storage performance is still not well understood;meanwhile,it is urgent to develop a strategy for changing DWSSW particles into high-performance electrode *** this work,the occurrence state of impurities presents in DWSSW was carefully analyzed using in situ Ar ion etching technology Then,the novel Si@C@SiOx@PAl-NDC composite was designed through in situ encapsulation *** obtained Si@C@SiOx@PAl-NDC electrode shows a high first capacity of 2343.4 mAh·g-1with an initial Coulombic efficiency （ICE） of 84.4%under current density of 1.0 A·g-1,and can deliver an impressive capacity of 984.9 mAh·g-1after 200 *** numerical simulation modeling calculations,the increase in proportion of Si4+/Si0and Si3+/Si0valence states in SiOxlayer leads to a decrease in von Mises stress,which ultimately improves the cycling structural ***,the porous 2D-3D aluminum/nitrogen （Al/N） co-doped carbon layer and nanowires on SiOxlayer can provide abundant active sites for lithium storage due to its developed hierarchical pores structure,which facilitates ion transport What is more,the performance of Si@C@SiOx@PAl-NDC//LiFePO4full cell shows its great potential in practical application.

关键词： Aluminum/nitrogen co-doped In situ encapsulation Lithium-ion batteries Porous carbon nanowires Sawing silicon waste

左卡尼汀对过氧化氢诱导的心肌细胞凋亡的抑制作用(英文)

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中国药理学与毒理学杂志 2012年第5期26卷 602-609页

作者：梁春光戴红良黄雷王东海王洪新辽宁医学院分子生物学与新药开发重点实验室辽宁锦州121001 锦州市食品药品检验所辽宁锦州121000 大同煤总医院山西大同037003

目的探讨左旋尼汀对心肌细胞凋亡的抑制作用及其可能的作用机制。方法采用培养的新生乳大鼠心肌细胞制备H2O2200μmol.L-1氧化损伤模型。实验分为正常对照组、H2O2200μmol.L-1模型组、左卡尼汀(0.3,0.6及1.2 mmol.L-1)组、左卡尼汀1.2 ... 详细信息

目的探讨左旋尼汀对心肌细胞凋亡的抑制作用及其可能的作用机制。方法采用培养的新生乳大鼠心肌细胞制备H2O2200μmol.L-1氧化损伤模型。实验分为正常对照组、H2O2200μmol.L-1模型组、左卡尼汀(0.3,0.6及1.2 mmol.L-1)组、左卡尼汀1.2 mmol.L-1+H2O2200μmol.L-1组。左卡尼汀0.3,0.6和1.2 mmol.L-1作用1 h后加入H2O2200μmol.L-1培养12 h,MTT法测定心肌细胞存活率,流式细胞仪测定心肌细胞的凋亡率,Western印迹法测定胱天蛋白酶3表达;用试剂盒方法检测过氧化物歧化酶(SOD)活性和丙二醛(MDA)水平。左卡尼汀1.2 mmol.L-1作用5 min后加入H2O2200μmol.L-1,采用Till阳离子测定系统监测5 min的心肌细胞[Ca2+]i瞬间变化。结果 H2O2200μmol.L-1作用于心肌细胞12 h能引起心肌细胞凋亡。左卡尼汀0.3,0.6和1.2 mmol.L-1能够不同程度的逆转由H2O2所致的损伤,使SOD活性明显增加,MDA水平明显降低(P<0.01)。左卡尼汀1.2 mmol.L-1作用最强,能够明显降低心肌细胞胱天蛋白酶3表达(P<0.01),明显降低H2O2引起的[Ca2+]i瞬间变化升高(P<0.01),但对于H2O2引起无钙血清培养的心肌细胞静息钙升高无影响。结论左卡尼汀能够抑制由H2O2引起的心肌细胞凋亡,该抑制作用可能与其保护细胞膜和减轻钙通道的损害、纠正[Ca2+]i瞬变失调及其抗氧化作用有关。

关键词：左卡尼汀过氧化氢肌细胞,心脏细胞凋亡细胞内钙离子

Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 408-420页

作者： FENG Min-chao LUO Fang HUANG liang-jiang LI Kai CHEN Zu-min LI Hui YAO chun QIN Bai-jun CHEN Guo-zhong The First Clinical Medical College Guangxi University of Traditional Chinese MedicineNanning 530000China guangxi Key Laboratory of Molecular Biology of Traditional Chinese Medicine and Preventive Medicine Nanning 530000China Graduate School Guangxi University of Traditional Chinese MedicineNanning 530000China Department of Gastroenterology the First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530023China

Objective: To identify the core targets of Rheum palmatum L. and Salvia miltiorrhiza Bge.,(Dahuang-Danshen, DH-DS) and the mechanism underlying its therapeutic efficacy in acute pancreatitis(AP)using a network pharmacology approach and validate the findings in animal experiments. Methods: Network pharmacology analysis was used to elucidate the mechanisms underlying the therapeutic effects of DH-DS in AP. The reliability of the results was verified by molecular docking simulation and molecular dynamics ***, the results of network pharmacology enrichment analysis were verified by immunohistochemistry,Western blot analysis and real-time quantitative PCR, respectively. Results: Sixty-seven common targets of DH-DS in AP were identified and mitogen-activated protein kinase 3(MAPK3), Janus kinase 2(JAK2), signal transducer and activator of transcription 3(STAT3), protein c-Fos(FOS) were identified as core targets in the protein interaction(PPI) network analysis. Gene ontology analysis showed that cellular response to organic substance was the main functions of DH-DS in AP, and Kyoto Encyclopedia of Genes and Genomes analysis showed that the main pathway included Th17 cell differentiation. Molecular docking simulation confirmed that DH-DS binds with strong affinity to MAPK3, STAT3 and FOS. Molecular dynamics simulation revealed that FOS-isotanshinone Ⅱ and STAT3-dan-shexinkum d had good binding capacity. Animal experiments indicated that compared with the AP model group, DH-DS treatment effectively alleviated AP by inhibiting the expression of interleukin-1β, interleukin-6 and tumor necrosis factor-α, and blocking the activation of Th17 cell differentiation(P<0.01). Conclusion: DH-DS could inhibit the expression of inflammatory factors and protect pancreatic tissues,which would be functioned by regulating Th17 cell differentiation-related m RNA and protein expressions.

关键词： Rheum palmatum L. Salvia miltiorrhiza Bge. molecular docking simulation network pharmacology acute pancreatitis Th17 cell differentiation

Stimulated Brillouin interaction between guided phonons and photons in a lithium niobate waveguide

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 173-175页

作者： Yuan-Hao Yang Jia-Qi Wang Zheng-Xu Zhu Xin-Biao Xu Qiang Zhang Juanjuan Lu Yu Zeng chun-Hua Dong Luyan Sun guang-Can Guo Chang-Ling Zou CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Quantum Information Institute for Interdisciplinary Information SciencesTsinghua UniversityBeijing 100084China

The Brillouin scattering is one of the strongest nonlinear optical effects in dielectrics[1].In particular,the backward Brillouin scattering(BBS)provides an efficient method to achieve low-noise optical gain for active photonics[2]and the coherent interconnects between 10 GHz phonons and photons[3].However,previous studies on BBS are primarily limited to the unconfined phonons[1]or phonon confined in suspended structures[4-6].

关键词： scattering waveguide Brillouin

Experimental Study on Hydrodynamic Load Characteristics for A Typical Cross-Section of A Submerged Floating Tunnel

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China Ocean Engineering 2024年第5期38卷 893-903页

作者： ZHANG Hong-qian YANG Zhi-wen LI Shao-wu YUAN chun-guang ZHANG Hua-qing National Engineering Research Center for Port Hydraulic Construction Technology Tianjin University National Engineering Research Center for Port Hydraulic Construction Technology Tianjin Research Institute for Water Transport EngineeringM.O.T.

The typical cross-sectional form of a submerged floating tunnel plays a significant role in the dynamic response of the tunnel itself,which directly affects the overall *** this work,a series of experiments involving wave action on a submerged floating tube cross section is reported to study its hydrodynamic load *** typical cross section tube cylinders,circular and rectangular,are *** are carried out in a wave flume with waves of relatively low Keulegan-Carpenter（KC） *** relative depths of submergence of 0,0.25 and 0.5are *** measured wave forces in regular waves are used to analyze the horizontal force,vertical force and torque,and then the drag coefficient（Cd） and inertia coefficient（Cm） are *** results show that the drag coefficients at low KC numbers are large and decrease sharply with increasing KC *** inertial coefficient Cmvalues in the vertical direction are about 70% larger than those in the horizontal *** an increase in aspect ratio（the ratio of the height to width of the structure）,the ratio of inertia coefficient in the horizontal direction to that in the vertical direction increases *** inertia force coefficient is very sensitive to the submerged water depth and aspect *** existing results may overestimate the actual force value.

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Ultrahigh thermoelectric properties of p‐type Bi_(x)Sb_(2−x)Te_(3)thin films with exceptional flexibility for wearable energy harvesting

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Carbon Energy 2024年第8期6卷 273-284页

作者： Zhuang‐Hao Zheng Yi‐Ming Zhong Yi‐Liu Li Mohammad Nisar Adil Mansoor Fu Li Shuo Chen guang‐Xing liang Ping Fan Dongyan Xu Meng Wei Yue‐Xing Chen Shenzhen Key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenChina Department of Mechanical and Automation Engineering The Chinese University of Hong KongSha TinChina

Use of a flexible thermoelectric source is a feasible approach to realizing selfpowered wearable electronics and the Internet of *** thin films are promising candidates for fabricating flexible power supply,but obtaining highthermoelectric‐performance thin films remains a big *** the present work,a p‐type Bi_(x)Sb_(2−x)Te_(3)thin film is designed with a high figure of merit of 1.11 at 393 K and exceptional flexibility(less than 5%increase in resistance after 1000 cycles of bending at a radius of∼5 mm).The favorable comprehensive performance of the Bi_(x)Sb_(2−x)Te_(3)flexible thin film is due to its excellent crystallinity,optimized carrier concentration,and low elastic modulus,which have been verified by experiments and theoretical ***,a flexible device is fabricated using the prepared p‐type Bi_(x)Sb_(2−x)Te_(3)and n‐type Ag_(2)Se thin ***,an outstanding power density of∼1028μWcm^(−2)is achieved at a temperature difference of 25 *** work extends a novel concept to the fabrication of highperformance flexible thin films and devices for wearable energy harvesting.

关键词： Bi_(x)Sb_(2−x)Te_(3) electrical transport properties flexibility thermoelectric

Extensive carbon cycle between peatland and vegetation: Insights from high net primary productivity of the Middle Jurassic in northwestern China

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Journal of Palaeogeography 2024年第4期13卷 1016-1028页

作者： Yang-Yang Huang Hao liang Long-Yi Shao Bin Yang Baruch Spiro Jia-Min Zhou Jing Lu Tan-guang Fan State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources College of Geoscience and Surveying Engineering China University of Mining and Technology (Beijing) Research Institute of Exploration & Development PetroChina Tuha Oilfield Company Exploration Company PetroChina Tuha Oilfield Company Department of Earth Sciences Natural History Museum School of Marine Sciences University of Haifa

Peatlands have obvious carbon storage capacity and are crucial in mitigating global climate *** the end-product of peatlands,coals have preserved a large amount of palaeoenvironmental *** carbon accumulation rate and the net primary productivity （NPP） of coal-forming peatlands can be used as proxies for recovering palaeoenvironments.A super-thick coal seam （42°35'N,91°25'E） was developed in the Middle Jurassic Xishanyao Formation in the Shaerhu coalfield in the southern margin of the Tuha （Turpan-Hami） Basin,northwestern *** this study,we use the time series analysis to identify the periods of Milankovitch orbital cycles in the Gamma-ray curve of this super-thick （124.85 m） coal and then use the obtained cycle periods of 405 ka,173 ka,44 ka,37.6 ka,22.5 ka to calculate the timeframe of the coalforming peatlands which ranges from 2703.44 to 2975.11 *** that the carbon content of the coal seam is 78.32%and the carbon loss during the coalification is about 25.80%,the carbon accumulation rate of the targeted coal seam is estimated to be 58.47-64.34 g C/m2·a,and the NPP is estimated to be252.28-277.63 g C/m2·*** main palaeoenvironmental factors controlling the NPP of peatlands are CO2content,palaeolatitude and *** reduced NPP values of the palaeo-peatlands in the Shaerhu coalfield can be attributed to the mid-palaeolatitude and/or too low atmospheric *** a certain extent,the NPP of palaeo-peatlands reflects the changes in atmospheric CO2,which can further reveal the dynamic response of the global carbon cycle to climate ***,predicting the level of NPP in the Middle Jurassic and studying the final destination of carbon in the ecosystem are beneficial to understanding the coal-forming process and palaeoenvironment.

关键词： Xishanyao Formation Super-thick coal Milankovitch cycle Carbon accumulation rate Carbon cycle

Multimorbidity and mortality among older patients with coronary heart disease in Shenzhen,China

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Journal of Geriatric Cardiology 2024年第1期21卷 81-89页

作者： Fu-Rong LI Shuang WANG Xia LI Zhi-Yuan CHENG Cheng JIN chun-Bao MO Jing ZHENG Feng-Chao liang Dong-Feng GU Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine Southern University of Science and TechnologyShenzhenGuangdongChina School of Public Health and Emergency Management Southern University of Science and TechnologyShenzhenGuangdongChina Shenzhen Health Development Research and Data Management Center ShenzhenChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

BACKGROUND The current understanding of the magnitude and consequences of multimorbidity in Chinese older adults with coronary heart disease(CHD)is *** aimed to assess the association and population-attributable fractions(PAFs)between multimorbidity and mortality among hospitalized older patients who were diagnosed with CHD in Shenzhen,*** We conducted a retrospective cohort study of older Chinese patients(aged≥65 years)who were diagnosed with *** proportional hazards models were used to estimate the associations between multimorbidity and all-cause and cardiovascular disease(CVD)*** also calculated the *** The study comprised 76,455 older hospitalized patients who were diagnosed with CHD between January 1,2016,and August 31,*** them,70,217(91.9%)had multimorbidity,defined as the presence of at least one of the predefined 14 chronic *** with cancer,hemorrhagic stroke and chronic liver disease had the worst overall death risk,with adjusted HRs(95%CIs)of 4.05(3.77,4.38),2.22(1.94,2.53),and 1.85(1.63,2.11),*** CVD mortality,the highest risk was observed for hemorrhagic stroke,ischemic stroke,and chronic kidney disease;the corresponding adjusted HRs(95%CIs)were 3.24(2.77,3.79),1.91(1.79,2.04),and 1.81(1.64,1.99),***-cause mortality was mostly attributable to cancer,heart failure and ischemic stroke,with PAFs of 11.8,10.2,and 9.1,*** for CVD mortality,the leading PAFs were heart failure,ischemic stroke and diabetes;the corresponding PAFs were 18.0,15.7,and 6.1,*** Multimorbidity was common and had a significant impact on mortality among older patients with CHD in Shenzhen,***,heart failure,ischemic stroke and diabetes are the primary contributors to ***,prioritizing improved treatment and management of these comorbidities is essential for the survival prognosis of CHD patients from a holistic public health perspective.

关键词： patients morbidity mortality

Gene cloning,protein expression,and enzymatic characterization of a double-stranded RNA degrading enzyme in Apolygus lucorum

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Insect Science 2024年第1期31卷 119-133页

作者： Jie-Yu Zhang Jing Zhao Keyan Zhu-Salzman Qin-Qin Ji Yi-Ping Jiang Liu-Bin Xiao De-Jin Xu guang-chun Xu Lin-Quan Ge Yong-An Tan College of Plant Protection Yangzhou UniversityYangzhouJiangsu ProvinceChina Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjingJiangsu ProvinceChina Department of Entomology Texas A&M UniversityCollege StationTXUSA Taizhou Customs of the People's Republic of China TaizhouJiangsu ProvinceChina

RNA interference(RNAi)is a powerful tool that post-transcriptionally silences target genes in eukaryotic ***,silencing efficacy varies greatly among different insect ***,we met with little success when attempting to knock down genes in the mirid bug Apolygus lucorum via dsRNA *** disappearance of double-stranded RNA(dsRNA)could be a potential factor that restricts RNAi ***,we found that dsRNA can be degraded in midgut fluids,and a dsRNase of ***(AldsRNase)was identified and *** alignment indicated that its 6 key amino acid residues and the Mg2+-binding site were similar to those of other insects’*** signal peptide and endonuclease non-specific domain shared high sequence identity with the brown-winged green stinkbug Plautia stali *** showed high salivary gland and midgut expression and was continuously expressed through the whole life cycle,with peaks at the 4th instar ecdysis in the whole *** purified AldsRNase protein obtained by heterologously expressed can rapidly degrade *** comparing the substrate specificity of AldsRNase,3 specific substrates(dsRNA,small interfering RNA,and dsDNA)were all degraded,and the most efficient degradation is ***,immunofluorescence revealed that AldsRNase was expressed in the cytoplasm of midgut *** cloning and functional study of AldsRNase,the enzyme activity and substrate specificity of the recombinant protein,as well as the subcellular localization of nuclease,the reason for the disappearance of dsRNA was explained,which was useful in improving RNAi efficiency in *** and related species.

关键词： Apolygus lucorum cloning dsRNase enzymatic activity protein expression