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后真相时代主观程序正义及其程序改造

江苏警官学院学报 2024年第2期39卷 23-32页

作者：李立景曲墨广西民族大学法学院广西民族大学民族法与区域治理研究协同创新中心

后真相时代公民对正义的理解与主观息息相关,建立在法感情理论、知情意行的心理结构与情本体的中国人性格特点上的主观程序正义理论比客观程序正义理论更能应对时代挑战、符合中国国情。凭借主观程序正义的引入,程序正义理论能够得到非... 详细信息

后真相时代公民对正义的理解与主观息息相关,建立在法感情理论、知情意行的心理结构与情本体的中国人性格特点上的主观程序正义理论比客观程序正义理论更能应对时代挑战、符合中国国情。凭借主观程序正义的引入,程序正义理论能够得到非教条化的、人性化的重构。将主观程序正义具体应用到程序之中,应通过算法对主观程序正义标准动态把控,同时对程序交往进行人格化改造,对询问与陈述理念进行叙事治疗视角改造,重构司法传播之维使法官与当事人角色互视,并在司法社工协同机制中嵌入社会心理服务。最终在实现程序正义的同时,达成纠纷实质解决目的。

关键词：主观程序正义后真相法感情知情意行情本体程序改造

急性呼吸窘迫综合征合并症对治疗及预后的影响

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医药论坛杂志 2024年第11期45卷 1142-1146页

作者：陈景行李娟张洋邢夏李立敬越丽霞安阳市人民医院呼吸与危重症医学科河南安阳455000 河南省人民医院公共事业发展部郑州450000

目的探讨合并症对急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者入院后治疗及生存状况的影响。方法选取2020年1月—2022年4月在安阳市人民医院ICU内进行有创或无创机械通气治疗的ARDS患者247例。应用logisitic回... 详细信息

目的探讨合并症对急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者入院后治疗及生存状况的影响。方法选取2020年1月—2022年4月在安阳市人民医院ICU内进行有创或无创机械通气治疗的ARDS患者247例。应用logisitic回归分析合并症数目和单一合并症对ARDS患者预后指标如院内死亡、ICU内死亡、应用生命维持装置的影响。结果相较于无合并症患者,存在合并症患者接受无创(mechanical ventilation,MV)的时间更长,有创MV时间更短;慢性呼吸衰竭、充血性心力衰竭、慢性肾衰竭、慢性肝衰竭、免疫功能不全、糖尿病、合并症数目多是ARDS患者ICU死亡的危险因素(P<0.05);慢性呼吸衰竭、充血性心力衰竭、慢性肾衰竭、慢性肝衰竭、免疫功能不全、糖尿病、合并症数目多是ARDS患者院内死亡的危险因素(P<0.05);慢性呼吸衰竭、充血性心力衰竭、慢性肾衰竭、慢性肝衰竭、免疫功能不全、糖尿病、合并症数目是ARDS患者应用生命维持装置的危险因素(P<0.05)。结论大多数ARDS患者存在明显的合并症,他们接受的治疗较少,预后较差。加强对这些患者的治疗必然是未来临床研究的重点。

关键词：合并症急性呼吸窘迫综合征预后

补阳还五汤改善糖尿病心肌损伤的配伍作用研究

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时珍国医国药 2024年第4期35卷 831-835页

作者：訾雪周凯旋鲍慧玮李丽静长春中医药大学吉林长春130117

目的观察补阳还五汤及其配伍对糖尿病小鼠心肌损伤的保护作用及其可能的作用机制,为临床应用提供理论基础和实验依据。方法以高脂饲料联合链脲佐菌素制备糖尿病模型小鼠,通过检测血糖、TC、TG、LDH、CK-MB、IL-2、TNF-α、MDA、SOD的水... 详细信息

目的观察补阳还五汤及其配伍对糖尿病小鼠心肌损伤的保护作用及其可能的作用机制,为临床应用提供理论基础和实验依据。方法以高脂饲料联合链脲佐菌素制备糖尿病模型小鼠,通过检测血糖、TC、TG、LDH、CK-MB、IL-2、TNF-α、MDA、SOD的水平;HE、Masson染色检测心肌组织病理学变化,Western Blot法检测心肌组织中MFN2、DRP1、MFF蛋白表达水平;观察补阳还五汤及其不同配伍组方干预糖尿病心肌损伤的作用,初步分析其作用机制。结果与模型组相比,补阳还五汤组的血脂明显降低(P<0.05),血清LDH、CK-MB、IL-2、TNF-α明显下降(P<0.05),补阳还五汤组和活血组心肌SOD活性明显升高(P<0.05),各给药组MDA含量明显降低(P<0.01)。病理染色结果显示,与正常组比较,模型组动物心肌细胞间隙变大排列不均,存在心肌损伤,心肌胶原纤维增多,经各组给药治疗,心肌病理变化有所改善。Western blot检测结果显示,与模型组相比,各组给药上调MFN2蛋白表达,下调DRP1、MFF蛋白表达。结论补阳还五汤可减轻糖尿病心肌损伤,其作用可能与抑制炎症反应缓解氧化应激损伤及调控线粒体动力学蛋白表达相关。

关键词：补阳还五汤糖尿病心肌损伤线粒体动力学配伍

User-oriented data acquisition chain task planningalgorithm for operationally responsive space satellite

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Journal of Systems Engineering and Electronics 2016年第5期27卷 1028-1039页

作者： Hao Chen Jun li Ning jing Jun li College of Electronic Science and Engineering National University of Defense TechnologyChangsha 410073China Unit 61726 of the PLA Wuhan 430074China

With the development of operationally responsive space（ORS） and on-board processing techniques, the end users canreceive the observation data from the ORS satellite directly. Tosatisfy the demand for reducing the requirements-tasking-effectscycle from one day to hours, the various resources of the wholedata acquisition chain （including satellites, ground stations, dataprocessing centers, users, etc.） should be taken into an overallconsideration, and the traditional batch task planning mode shouldbe transformed into the user-oriented task planning mode. Consideringthere are many approaches for data acquisition due tothe new techniques of ORS satellite, the data acquisition chaintask planning problem for ORS satellite can be seen as the multimodalroute planning problem. Thereby, a framework is presentedusing label-constrained shortest path technique with the conflictresolution. To apply this framework to solve the ORS satellite taskplanning problem, the preprocessing and the conflict resolutionstrategies are discussed in detail. Based on the above work, theuser-oriented data acquisition chain task planning algorithm forORS satellite is proposed. The exact solution can be obtainedin polynomial time using the proposed algorithm. The simulationexperiments validate the feasibility and the adaptability of the proposedapproach.

关键词： operationally responsive space (ORS) remote sensing,scheduling multi-modal route planning shortest path computationalcomplexity.

Dexamethasone enhances invasiveness ofAspergillusfumigatus conidia and fibronectin expression in A549 cells

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Chinese Medical Journal 2013年第17期126卷 3289-3294页

作者： li Tao li jing-chao QI Qian li Yu Department of Respiratory Medicine Qilu Hospital of Shandong University Jinan Shandong 250012 China

Background The efficacies of current treatments for invasive aspergillus （IA） are unsatisfactory and new therapeutic targets or regimens to treat IA are urgently needed. Previous studies have indicated that the ability of conidia to invade host cells is critical in IA development and fibronectin has a hand in the conidia adherence process. In the clinical setting, many patients who receive glucocorticoid for extended periods are susceptible to Aspergillus fumigatus （A. fumigatus） infection, for this reason we investigated the effect of glucocorticoid on conidia invasiveness by comparing the invasiveness of A. fumigatus conidia in the type II human alveolar cell line （A549） cultured with different concentrations of dexamethasone. We also explored the relationships between dexamethasone and fibronectin expression. Methods Following culture with anti-fibronectin antibodies and/or dexamethasone, type II human alveolar A549 cells were infected with conidia of A. fumigatus. After 4 hours, the extracellular free conidia were washed away and the remaining immobilized conidia were released using Triton-X 100 and quantified by counting the colony-forming units. The invasiveness of conidia was measured by calculating the invasion rate （%）. The transcription of the fibronectin gene in cells cultured with different concentrations of dexamethasone for 24 hours was tested by fluorogenic quantitative RT-PCR while the expression of fibronectinin cells cultured for 48 hours was tested by Western blotting and immunocytochemistry. Results A significant reduction in the invasiveness of conidia was seen in the cells cultured with anti-fibronectin antibody （（14.42±1.68）% vs. （19.17±2.53）%, P 〈0.05）, but no significant difference was observed in cells cultured with a combination of anti-fibronectin antibody and dexamethasone （6.37×10^-5 mol/L）. There was no correlation between the dexamethasone concentration and the invasiveness of conidia after dexamethasone pretreatment of cells for 4 ho

关键词： Aspergillus fumigatus conidia invasiveness dexamethasone fibronectin

Activation of catalase activity by a peroxisome-localized small heat shock protein Hsp17.6CⅡ

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Journal of Genetics and Genomics 2017年第8期44卷 395-404页

作者： guannan li jing li rong hao yan guo College of Biological Sciences China Agricultural University Beijing 100193 China

Plant catalases are important antioxidant enzymes and are indispensable for plant to cope with adverse environmental stresses. However, little is known how catalase activity is regulated especially at an organelle level. In this study, we identified that small heat shock protein Hsp17.6Cll （AT5GI2020） in- teracts with and activates catalases in the peroxisome of Arabidopsis thaliana. Although Hsp17.6Cll is classified into the cytosol-located small heat shock protein subfamily, we found that Hsp17.6Cli is located in the peroxisome. Moreover, Hsp17.6Cli contains a novel non-canonical peroxisome targeting signal 1 （PTS1）, QKL, 16 amino acids upstream from the C-terminus. The QKL signal peptide can partially locate GFP to peroxisome, and mutations in the tripeptide lead to the abolishment of this activity. In vitro catalase activity assay and holdase activity assay showed that Hsp17.6Cli increases CAT2 activity and prevents it from thermal aggregation. These results indicate that Hspl7.6Cli is a peroxisome-localized catalase chaperone. Overexpression of HsplK6II conferred enhanced catalase activity and tolerance to abiotic stresses in grabidopsis. Interestingly, overexpression of HspI7.6CII in catalase-deficient mutants, ncal-3 and cat2 cat3, failed to rescue their stress-sensitive phenotypes and catalase activity, suggesting that HsplT.6Cll-mediated stress response is dependent on NCA1 and catalase activity. Overall, we identified a novel peroxisome-located catalase chaperone that is involved in plant abiotic stress resis- tance by activating catalase activity.

关键词： ChaperoneHsp17.6CIIPTS1PeroxisomeCatalaseAbiotic stress tolerance

First-photon imaging via a hybrid penalty

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Photonics Research 2020年第3期8卷 325-330页

作者： XIAO PENG XIN-YU ZHAO li-jing li MING-JIE SUN School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China

First-photon imaging is a photon-efficient,computational imaging technique that reconstructs an image by recording only the first-photon arrival event at each spatial location and then optimizing the recorded photon *** optimization algorithm plays a vital role in image formation.A natural scene containing spatial correlation can be reconstructed by maximum likelihood of all spatial locations constrained with a sparsity regularization penalty,and different penalties lead to different *** l1-norm penalty of wavelet transform reconstructs major features but blurs edges and high-frequency details of the *** total variational penalty preserves edges better;however,it induces a"staircase effect,"which degrades image *** this work,we proposed a hybrid penalty to reconstruct better edge features while suppressing the staircase effect by combining wavelet l1-norm and total variation into one penalty *** of numerical simulations indicate that the proposed hybrid penalty reconstructed better images,which have an averaged root mean square error of 12.83%,5.68%,and 10.56%smaller than those of the images reconstructed by using only wavelet l1-norm penalty,total variation penalty,or recursive dyadic partitions method,*** results are in good agreement with the numerical ones,demonstrating the feasibility of the proposed hybrid *** been verified in a first-photon imaging system,the proposed hybrid penalty can be applied to other noise-removal optimization problems.

关键词： function. penalty photon

Baseline proteinuria, urinary osmotic pressure, and renal function as positive predictors of corticosteroids plus cyclophosphamide treatment efficacy in IgA nephropathy

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Chinese Medical Journal 2014年第9期127卷 1710-1714页

作者： Fang jing li Wenge li Duo Tan Zhao Nephrology Department China-Japan Friendship Hospital Beijing 100029 China

Background Very limited data are available on factors predictive of corticosteroids plus cyclophosphamide treatment efficacy on IgA nephropathy （IgAN）.The aim of the study was to research the clinical factors predictive of treatment efficacy in *** One hundred and fifty-nine patients with IgAN （proteinuria ≥2 g/d and estimated glomerular filtration rate 30-89 ml·min-1·1.73 m-2） were treated with corticosteroids/cyclophosphamide followed by a 12-month *** to their response,these patients were divided into remission group （proteinuria ＜0.5 g/d） and non-remission group （proteinuria ≥0.5 g/d）,and their clinical data *** In the present study,72.96％ of the individuals underwent a complete remission,and their response was related to baseline proteinuria,urinary osmotic pressure,and renal function （P ＜0.05）.Patients with baseline proteinuria more than 3 g/d,urinary osmotic pressure greater than 600 mOsm/L,and eGFR 60-89 ml·min-1·1.73 m-2 responded well to the combination of corticosteroids and cyclophosphamide （86.90％ vs.57.33％,P=0.000; 81.48％ vs.64.10％,P=0.014; 83.17％ vs.55.17％,P=0.000）.Conclusion The response to the combination of corticosteroids and cyclophosphamide might be well associated with baseline proteinuria,urinary osmotic pressure,and renal function in patients with IgAN.

关键词： IgA nephropathy, proteinuria urinary osmotic pressure renal function treatment efficacy

Clinical characteristics, diagnosis and management of respiratory distress syndrome in full-term neonates

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Chinese Medical Journal 2010年第19期123卷 2640-2644页

作者： liU jing SHI Yun DONG Jian-ying ZHENG Tian li jing-ya LU li-li liU jing-jing liANG jing ZHANG Hao FENG Zhi-chun Department of Neonatology & NICU Bayi Children's Hospital Affiliated to General Hospital of Beijing Military Command Beijing 100700 China

Background Respiratory distress syndrome （RDS） is one of the most common causes of neonatal respiratory failure and neonatal death, however, its clinical characteristics are very different from premature RDS, and these characteristics have not been well documented as yet. This study was to investigate the pathogenesis, clinical characteristics and management strategies of RDS in full-term neonates, with the aim of developing a working protocol for improving the outcome in full-term neonates with RDS. Methods A total of 125 full-term infants with RDS were enrolled in this study. Their clinical and laboratory data were collected for analyzing the characteristics of full-term neonatal RDS. Results （1） The 125 cases included 94 male and 31 female infants, vaginal delivery occurred in 80 cases and cesarean section in 45 cases. （2） The onset time of RDS was （3.11±3.59） hours after birth. （3）The possible reasons included severe perinatal infections in 63 patients, elective cesarean section in 34 cases, severe birth asphyxia in 12 patients, meconium aspiration syndrome in 9 patients, pulmonary hemorrhage in 4 patients and maternal diabetes in 3 patients. （4） Complications included multiple organ system failure （MOSF） in 49 patients, persistent pulmonary hypertension of newborn （PPHN） in 25 patients, acute renal failure in 18 patients, severe hyperkalemia in 25 patients, severe metabolic acidosis in 6 cases, severe myocardial injury in 9 cases, pulmonary hemorrhage in 3 cases, disseminated intravascular coagulation in 14 patients and shock in 12 patients.（5） Four patients died, the mortality was therefore 3.2% with the main cause of septicemia complicating of MOSF, but their prognosis was improved while comprehensive treatment measures including early mechanical ventilation and broad spectrum antibiotics were taken into account. Conclusions RDS is not an uncommon disease in full-term infants and is associated with a higher mortality, its clinical characteristics are very dif

关键词： respiratory distress syndrome clinical characteristics diagnostic criteria management strategies newborn full-term