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Integrating 16S sequencing and metabolomics study on anti-rheumatic mechanisms against collagen-induced arthritis of Wantong Jingu Tablet

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Chinese Journal of Natural Medicines 2022年第2期20卷 120-132页

作者： li zhao-dong QI Fang-Yuan li Fan Department of Pathogenobiology the Key Laboratory of ZoonosisMinistry of Education of ChinaSchool of Basic MedicineJilin UniversityChangchun 130000China Key Laboratory for Bionics Engineering Ministry of Education of ChinaJilin UniversityChangchun 130000China Engineering Research Center for Medical Biomaterials of Jilin Province Jilin UniversityChangchun 130000China Key Laboratory for Biomedical Materials of Jilin Province Jilin UniversityChangchun 130000China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaUrumqi 830000China

Wantong Jingu Tablet(WJT),a mixture of traditional Chinese medicine,was reported to relieve the symptoms of rheumatoid arthritis(RA),but its pharmacological mechanism was not completely *** aim of this study was to investigate the therapeutic mechanisms of WJT for RA in *** effects of WJT on joint pathology,as well as the levels of Bax,Bcl-2,caspase-3,cleaved-caspase-3,ERK1/2,pERK1/2,TNF-α,IL-1β,and IL-6 were measured using collagen-induced arthritis(CIA)*** intestinal flora composition and the metabolites alteration were analyzed by 16S rDNA sequencing and metabolomics method,*** found that WJT ameliorated the severity of the CIA rats which might be mediated by inducing apoptosis,inactivating the MEK/ERK signals and reducing the production of pro-inflammatory ***,in part,relieved the gut microbiota dysbiosis,especially bacterial phylum Bacteroidetes,Tenericutes and Deferribacteres,as well as bacterial genus Vibrio,Macrococcus and Vagococcus.3’-N-debenzoyl-2’-deoxytaxol,tubulysin B,and magnoline were significantly associated with the specific *** identified serotonin,glutathione disulfide,N-acetylneuraminic acid,naphthalene and thromboxane B2 as targeted molecules via *** findings contributed to the understanding of RA pathogenesis,and WJT played essential roles in gut microbiota health and metabolite modulation in the CIA rats.

关键词： Rheumatoid arthritis 16S rDNA sequencing Metabolomics Pathogenesis Wantong Jingu Tablet

Investigation on halogen-doped n-type SnTe thermoelectrics

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Rare Metals 2022年第11期41卷 3803-3814页

作者： Chang-Rong Guo Bing-Chao Qin dong-Yang Wang li-dong zhao School of Materials Science and Engineering Beihang UniversityBeijing100191China

Recent theoretical predictions and experimental findings on the transport properties of n-type SnTe have triggered extensive researches on this simple binary compound,despite the realization of n-type SnTe being a great ***,Cl as a donor dopant can effectively regulate the position of Fermi level in Sn_(0.6)Pb_(0.4)Te matrix and successfully achieve the n-type transport behavior in *** outstanding power factor of~14.7μW·cm^(-1)·K^(-2) at 300 K was obtained for Cl-doped Sn_(0.6)Pb_(0.4)Te *** combining the experimental analysis with theoretical calculations,the transport properties of n-type SnTe thermoelectrics doped with different halogen dopants(Cl,Br,and I)were then systematically investigated and *** results demonstrated that Br and I had better doping efficiencies compared with Cl,which contributed to the well-optimized carrier concentrations of~1.03×10^(19)and~1.11×10^(19)cm^(-3)at 300 K,*** improved n-type carrier concentrations effectively lead to the significant enhancement on the thermoelectric performance of n-type *** study further promoted the experimental progress and deep interpretation of the transport features in n-type SnTe *** present results could also be crucial for the development of n-type counterparts for SnTe-based thermoelectric devices.

关键词： Thermoelectric performance n-type SnTe Halogen doping Doping efficiency

Origin of off-centering effect and the influence on heat transport in thermoelectrics

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Materials Futures

Materials Futures 2024年第1期3卷 142-149页

作者： Hongyao Xie li-dong zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China

Recently,off-centering behavior has been discovered in a series of thermoelectric *** behavior indicates that the constituent atoms of the lattice displace from their coordination centers,leading to the locally distorted state and local symmetry breaking,while the material still retains its original crystallographic *** effect has been proved to be the root cause of ultralow thermal conductivity in off-centering materials,and is considered as an effective tool to regulate the thermal conductivity and improve the thermoelectric ***,we present a collection of recently discovered off-centering compounds,discuss their electronic origins and local coordination structures,and illuminate the underlying mechanism of the off-centering effect on phonon transport and thermal *** paper presents a comprehensive view of our current understanding to the off-centering effect,and provides a new idea for designing high performance thermoelectrics.

关键词： thermoelectric thermal conductivity off-centering behavior acoustic-optical phonon scattering

Enhanced thermoelectric performance in Cl-doped BiSbSe_(3) with optimal carrier concentration and effective mass

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Journal of Materials Science & Technology 2021年第11期70卷 67-72页

作者： Sining Wang lizhong Su Yuting Qiu Yu Xiao li-dong zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191China Beihang School Beihang UniversityBeijing 100191China

Possessing inherently low thermal conductivity,BiSbSe_(3) is a promising thermoelectric material for medium ***,to substantially optimize the thermoelectric performance of BiSbSe_(3),researchers mainly focus on the strategies to improve its electrical transport *** these strongly coupled thermoelectric parameters,carrier concentration and effective mass are two intrinsic variables to decisively affect the electrical transport *** this work,Cl as a donor dopant is effective to provide extra electrons in n-type BiSbSe_(3),and the carrier concentration and effective mass can be well optimized simultaneously with increasing Cl content owing to the multiple conduction bands in BiSbSe_(3).What’s more,maximum weighted mobility~53 cm^(2)V^(-1)s^(-1)is obtained in Cl-doped BiSbSe_(3),which contributes to a largely enhanced power factor~4.8μW cm^(-1)K^(-2)at room temperature and outperforms other halogen-doped BiSbSe_(3) ***,combining the significantly enhanced power factor and maintained low thermal conductivity,a maximum ZT~1.0 is achieved in Cl-doped BiSbSe_(3) at 800 K.

关键词： BiSbSe_(3) Thermoelectric performance Effective mass Carrier concentration

Slowing down the heat in thermoelectrics

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InfoMat 2021年第7期3卷 755-789页

作者： Bingchao Qin dongyang Wang li-dong zhao School of Materials Science and Engineering Beihang UniversityBeijingChina

Heat transport has various applications in solid *** particular,the thermoelectric technology provides an alternative approach to traditional methods for waste heat recovery and solid-state refrigeration by enabling direct and reversible conversion between heat and *** enhancing the thermoelectric performance of the materials,attempts must be made to slow down the heat transport by minimizing their thermal conductivity(κ).In this study,a continuously developing heat transport model is reviewed *** models for predicting the lattice thermal conductivity(κlat)of materials are summarized,which are significant for the rapid screening of thermoelectric materials with lowκ***,typical strategies,including the introduction of extrinsic phonon scattering centers with multidimensions and internal physical mechanisms of materials with intrinsically lowκlat,for slowing down the heat transport are *** defect centers with multidimensions substantially scatter various-frequency phonons;the intrinsically lowκlat in materials with various crystal structures can be attributed to the strong anharmonicity resulting from weak chemical bonding,resonant bonding,low-lying optical modes,liquid-like sublattices,off-center atoms,and complex crystal *** review provides an overall understanding of heat transport in thermoelectric materials and proposes effective approaches for slowing down the heat transport to depressκlat for the enhancement of thermoelectric performance.

关键词： anharmonicity heat transport phonon scattering thermal conductivity thermoelectric materials

Estimation of the potential performance in p-type SnSe crystals through evaluating weighted mobility and effective mass

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Journal of Materiomics 2020年第4期6卷 671-676页

作者： Bingchao Qin Wenke He li-dong zhao School of Materials Science and Engineering Beihang UniversityBeijing100191China

It has been proved that the thermoelectric performance of p-type SnSe crystals can be optimized through enhancing carrier *** calculations of electronic band structure elucidate that this approach can be interpreted by including multiple valence *** better estimate the potential performance,we proposed the transport properties for p-type SnSe crystals and analyzed the weighted mobility from the experimental *** weighted mobility approaches~600 cm^(2)V1s1 when the carrier concentration is as high as~6.31019 cm*** with obtained lattice thermal conductivity,through rising carrier concentration,the quality factor B possesses significant improvements of~235%and 138%at 300 K and 773 K,*** comparing weighted mobility and Hall mobility,two effective mass values~0.9 me and 1.8 me can be derived using carrier *** is expected that the ZT~1.0 at 300K and ZT~2.9 at 773 K can be obtained when the carrier concentration of~8.01019 cm3 and the effective mass~1.8 me were *** work provides an alternative way to comprehend the performance optimization in thermoelectric community.

关键词： Thermoelectric p-type SnSe crystals Weighted mobility Quality factor Effective mass

High thermoelectric figure of merit ZT>1 in SnS polycrystals

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Journal of Materiomics 2020年第1期6卷 77-85页

作者： Asfandiyar Bowen Cai li-dong zhao Jing-Feng li State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China School of Materials Science and Engineering Beihang UniversityBeijing100191China

Eco-friendly tin sulfide(SnS)has attracted increasing attention in the thermoelectric community because of its elemental abundance and analogous crystal structure to SnSe as a new thermoelectric ***,so far no high dimensionless thermoelectric figure of merit ZT>1 was reported in SnS *** work found an effective strategy for enhancing the thermoelectric performance of ptype polycrystalline SnS by Ag doping and vacancy engineering,leading to three orders of magnitude increase in carrier concentration and optimized effective mass and carrier *** a result of the enhanced electrical conductivity,three times higher power factor ~3.85 μW/cm K^(2) at 877 K is realized in Sn_(0.995)Ag_(0.005)S ***,nanostructuring with Ag nano-precipitates were formed in the Agdoped SnS ***,with introducing Sn vacancies in the crystal structure of Sn_(0.995-vac)Ag_(0.005)S,the power factor further enhanced to~4.25 μW/cm K^(2).In addition to the low-frequency phonons scattering by Ag nano-precipitates,dislocations strengthens the scattering of mid-frequency phonon,leading to an ultralow lattice thermal conductivity <0.5 W/m K above 800 K and a record high ZT up to 1.1 at 877 K in Sn_(0.99)Ag_(0.005)S polycrystals.

关键词： Thermoelectric tin sulfide Spark plasma sintering Nanoprecipitation Dislocation

Predicting the Potential Performance in P-Type SnS Crystals via Utilizing the Weighted Mobility and Quality Factor

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Chinese Physics Letters 2020年第8期37卷 88-93页

作者： Wenke He Bingchao Qin li-dong zhao Affiliations School of Materials Science and Engineering Beihang UniversityBeijing 100191China

The figure of merit ZT is the direct embodiment of thermoelectric performance for a given ***,as an indicator of performance improvement,the only ZT value is not good enough to identify its outstanding inherent properties,which are highly sought in thermoelectric ***,we utilize one powerful parameter to reveal the outstanding properties of a given *** weighted mobility is used to estimate the carrier transports of p-type SnS crystals,including the differences in doping level,carrier scattering and electronic band *** analyze the difference in carrier scattering mechanism for different crystal forms with the same doping level,then evaluate and confirm the temperature-dependent evolution of electronic band structures in ***,we calculate the quality factor B based on the weighted mobility,and establish the relationship between ZT and B to further predict the potential performance in p-type SnS crystals with low cost and earth abundance,which can be realized through taking advantage of the inherent material property,thus improving B factor to achieve optimal thermoelectric level.

关键词： scattering doping utilize

Thermoelectric transport properties of Pb-Sn-Te-Se system

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Rare Metals 2018年第4期37卷 343-350页

作者： Bing-Chao Qin Yu Xiao Yi-Ming Zhou li-dong zhao School of Materials Science and Engineering Beihang University Beijing 100191 China

IV-VI compounds are considered as promising thermoelectric materials, and high thermoelectric performance was achieved in IV-VI solid solutions. In this work, the thermoelectric properties of Pb-Sn-Te-Se-based solid solutions were systematically investigated. Among these solid solutions, it is found that a figure of merit （ZT） peak value of 1.0 at 873 K can be obtained in （PbTe）0.5（SnTe）o.5, on account of the combination of superior electrical properties in SnTe and low thermal conductivity in PbTe. Furthermore, we investigated and summarized the thermoelectric transport properties and proposed the thermoelectric performance maps for the IV- VI solid solutions in Pb-Sn-Te-Se system. This comprehensive investigation on Pb-Sn-Te-Se-based solid solutions can effectively guide and scan thermoelectric performance for a given unknown composition and enhance the thermoelectric properties in IV-VI compounds.

关键词： Thermoelectric materials Electricalconductivity Thermal conductivity Pb-Sn-Te-Se system Solid solutions