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Vortex dynamics and entropy generation in separated transitional flow over a compressor blade at various incidence angles

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Chinese Journal of Aeronautics 2022年第3期35卷 42-52页

作者： Mingyang WANG Ziliang li Ge HAN Chengwu YANG Shengfeng ZHAO Yanfeng ZHANG xin’gen LU Key Laboratory of light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The transition process within a Laminar Separation Bubble(LSB)that formed on a compressor blade surface was investigated using Large Eddy Simulations(LESs)at a Reynolds number of 1.5×10;and incidence angles of 0°,+3°,and+5°.The vortex dynamics in the separated shear layers were compared at various incidence angles and its effects on the loss generation were clarified through entropy *** showed that transition onset,which was accurately identified by the linear Stability Theory(LST),was significantly promoted at the increased incidence *** such,the development of LSB was suppressed and the relative role of viscous instability played in the transition process was *** the incidence angle of 0°,two-dimensional spanwise vortices detached from the blade surface and roiled up periodically,which were further stretched and eventually evolved into large-scale hairpin *** time passed,the fully developed hairpin vortices broke down into small-scale ***,the flow near the wall reversely ejected into the outer separated shear layers and a sweeping process happened subsequently,forcing the separated shear layers to reattach and accelerating the generation of turbulent *** comparison,the strength of vortex rolling-up was weakened at higher incidence angles,and the vortex pairing and breakdown of large-scale vortices were less ***,the level of turbulent fluctuations that generated in the separated shear layers was *** entropy analysis showed that the turbulent dissipation effect related to the Reynolds shear stresses determined the largest amount of positive entropy generation,which declined to a lower level as the incidence angle increased from 0°to+5°.Correspondingly,the profile loss was reduced by 50.4%.

关键词： Aerodynamic performance Compressor airfoil Entropy Incidence angle Separation bubble Vortex dynamics

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Novel mechanism of hepatobiliary system damage and immunoglobulin G4 elevation caused by Clonorchis sinensis infection

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World Journal of Clinical Cases 2021年第23期9卷 6639-6653页

作者： xin-He Zhang Die Huang Yi-ling li Bing Chang Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

Clonorchis sinensis infection is still a major public health *** is estimated that more than 15 million people worldwide are infected,especially in Northeast China,Taiwan,South Korea,and North *** detection of Clonorchis sinensis eggs in feces and bile is still the only gold standard for the diagnosis of Clonorchis sinensis infection,and new detection methods are needed to improve the detection *** Clonorchis sinensis invades the human body,it mainly parasitizes the hepatobiliary ***,it is closely related to hepatobiliary diseases such as cholangitis,bile duct stones,liver fibrosis,and *** increase in immunoglobulin G4(IgG4)caused by Clonorchis sinensis infection is rare and there are few reports about the relevant *** may be related to the inflammatory factors interleukin(IL)-4,IL-10,and IL-13 produced by human phagocytes,T cells,B cells,and other immune cells in the process of resisting the invasion of Clonorchis ***,this finding still needs further clarification and *** article reviews the epidemiology,clinical manifestations,serology,imaging,pathogenic mechanism,and control measures of Clonorchis sinensis infection to help establish the diagnostic process for Clonorchis *** report novel mechanisms of IgG4 elevation due to Clonorchis sinensis infection to provide more experience and a theoretical basis for clinical diagnosis and treatment of this infection.

关键词： liver damage Bile duct damage Hepatobiliary system destruction Clonorchis sinensis infection Immunoglobulin G4 Clinical manifestations

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Impact of intracellular innate immune receptors on immunometabolism

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Cellular & Molecular Immunology 2022年第3期19卷 337-351页

作者： Wei-Chun Chou Elena Rampanelli xin li Jenny P-Y.Ting lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC27599USA Department of Genetics University of North Carolina at Chapel HillChapel HillNC27599USA Amsterdam UMC(University Medical Center location AMC)Department of Experimental Vascular MedicineAGEM(Amsterdam Gastroenterology Endocrinology Metabolism)InstituteMeibergdreef 91105 AZAmsterdamThe Netherlands Comparative Immunology Research Center College of Veterinary MedicineChina Agricultural UniversityBeijing100193China

Immunometabolism,which is the metabolic reprogramming of anaerobic glycolysis,oxidative phosphorylation,and metabolite synthesis upon immune cell activation,has gained importance as a regulator of the homeostasis,activation,proliferation,and differentiation of innate and adaptive immune cell subsets that function as key factors in *** changes in epithelial and other stromal cells in response to different stimulatory signals are also crucial in infection,inflammation,cancer,autoimmune diseases,and metabolic *** crosstalk between the PI3K-AKT-mTOR and LKB1-AMPK signaling pathways is critical for modulating both immune and nonimmune cell *** bidirectional interaction between immune cells and metabolism is a topic of intense ***-like receptors(TLRs),cytokine receptors,and T and B cell receptors have been shown to activate multiple downstream metabolic ***,how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well *** goal of this review is to examine the link between immunometabolism and the functions of several intracellular innate immune sensors or receptors,such as nucleotide-binding and leucine-rich repeat-containing receptors(NLRs,or NOD-like receptors),absent in melanoma 2(AIM2)-like receptors(ALRs),and the cyclic dinucleotide receptor stimulator of interferon genes(STING).We will focus on recent advances and describe the impact of these intracellular innate immune receptors on multiple metabolic *** appropriate,this review will provide a brief contextual connection to pathogenic infections,autoimmune diseases,cancers,metabolic disorders,and/or inflammatory bowel diseases.

关键词： Immunometabolism NLRs NLRP3/AIM2 inflammasomes innate sensors/receptors STING AKT-mTOR

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Gallium bismuth halide GaBi-X2 （X = I, Br, CI） monolayers with distorted hexagonal framework： Novel room- temperature quantum spin Hall insulators

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Nano Research 2017年第6期10卷 2168-2180页

作者： linyang li Ortwin Leenaerts Xiangru Kong xin Chen Mingwen Zhao Francois M. Peeters Department of Physics University of Antwerp Groenenborgerlaan 171 B-2020 Antwerp Belgium International Center for Quantum Materials Peking University Beijing 100871 China School of Physics and State Key Laboratory of Crystal Materials Shandong University Jinan 250700 China

Quantum spin Hall （QSH） insulators with a large topologically nontrivial bulk gap are crucial for future applications of the QSH effect. Among these, group III-V monolayers and their halides, which have a chair structure （regular hexagonal framework）, have been widely studied. Using first-principles calculations, we formulate a new structure model for the functionalized group III-V monolayers, which consist of rectangular GaBi-X2 （X = I, Br, C1） monolayers with a distorted hexagonal framework （DHF）. These structures have a far lower energy than the GaBi-X2 monolayers with a chair structure. Remarkably, the DHF GaBi-X2 monolayers are all QSH insulators, which exhibit sizeable nontrivial band gaps ranging from 0.17 to 0.39 eV. The band gaps can be widely tuned by applying different spin-orbit coupling strengths, resulting in a distorted Dirac cone.

关键词： quantum spin Hall (QSH)insulators,first-principles calculations,GaBi-X2 (X = L Br Cl)monolayers,distorted hexagonal framework,distorted Dirac cone

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Effect of temperature difference load of 32 m simply supported box beam bridge on track vertical irregularity

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Journal of Modern Transportation 2015年第4期23卷 262-271页

作者： Kaize Xie Jun xing li Wang Chunxiang Tian rong Chen Ping Wang MOE Key Laboratory of High-Speed Railway Engineering Southwest Jiaotong University China Railway Eryuan Engineering Group Co.Ltd

In order to study the effect of temperature difference load （TDL） along the vertical direction of a simply supported beam bridge section on the vertical irregularity, a rail-bridge-piers calculation model was established. Taking 32 m simply supported box beam bridge which is widely used in the construction of pas- senger dedicated line in China as an example, influences of the temperature variation between the bottom and top of the bridge, temperature curve index, type of temperature gradient, and beam height on track vertical irregularity were analyzed with the model. The results show that TDL has more effects on long wave track irregularity than on short one, and the wavelength mainly affected is approxi- mately equal to the beam span. The amplitude of irregu- larity caused by TDL is largely affected by the temperature variation, temperature curve index, and type of temperature gradient, so it is necessary to monitor the temperaturedistribution of bridges in different regions to provide accurate calculation parameters. In order to avoid the irregularity exceeding the limit values, the height of 32, 48, and 64 m simply supported box beam bridges must not be less than 2.15, 3.2, and 4.05 m, respectively.

关键词： Simply supported beam bridge Temperaturegradient Vertical irregularity - Beam height

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Photoelectrochemical performance of birnessite films and photoelectrocatalytic activity toward oxidation of phenol

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Journal of Environmental Sciences 2017年第2期29卷 259-267页

作者： Huiqin Zhang Hongrui Ding xin Wang Cuiping Zeng Anhuai Lu Yan li Changqiu Wang The Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space Sciences Peking University Institutes of Science and Development Chinese Academy of Sciences

Birnessite films on fluorine-doped tin oxide（FTO） coated glass were prepared by cathodic reduction of aqueous KMnO4. The deposited birnessite films were characterized with X-ray diffraction, Raman spectroscopy, scanning electron microscopy and atomic force *** photoelectrochemical activity of birnessite films was investigated and a remarkable photocurrent in response to visible light was observed in the presence of phenol, resulting from localized manganese d–d transitions. Based on this result, the photoelectrocatalytic oxidation of phenol was investigated. Compared with phenol degradation by the electrochemical oxidation process or photocatalysis separately, a synergetic photoelectrocatalytic degradation effect was observed in the presence of the birnessite film coated FTO *** degradation ratios were influenced by film thickness and initial phenol concentrations. Phenol degradation with the thinnest birnessite film and initial phenol concentration of 10 mg/L showed the highest efficiency of 91.4% after 8 hr. Meanwhile, the kinetics of phenol removal was fit well by the pseudofirst-order kinetic model.

关键词： Birnessite Photoelectrochemical activity Photocurrent Photoelectrocatalytic oxidation Phenol

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COSSET＋： Crowdsourced Missing Value Imputation Optimized by Knowledge Base

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Journal of Computer Science & Technology 2017年第5期32卷 845-857页

作者： Hong-Zhi Wang Zhi-xin Qi Ruo-Xi Shi Jian-Zhong li Hong Gao School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China

Missing value imputation with crowdsourcing is a novel method in data cleaning to capture missing values that could hardly be filled with automatic approaches. However, the time cost and overhead in crowdsourcing are high. Therefore, we have to reduce cost and guarantee the accuracy of crowdsourced imputation. To achieve the optimization goal, we present COSSET+, a crowdsourced framework optimized by knowledge base. We combine the advantages of both knowledge-based filter and crowdsourcing platform to capture missing values. Since the amount of crowd values will affect the cost of COSSET+, we aim to select partial missing values to be crowdsourced. We prove that the crowd value selection problem is an NP-hard problem and develop an approximation algorithm for this problem. Extensive experimental results demonstrate the efficiency and effectiveness of the proposed approaches.

关键词： crowdsourcing missing value imputation knowledge base optimization

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Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIla as anti-tumor strategy

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Protein & Cell 2014年第6期5卷 457-468页

作者： Jiangmei li Lunfeng Zhang Zhen Gao Hua Kang Guohua rong Xu Zhang Chang Chen National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Department of General Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China Tianjin Research Center of Basic Medical Science Tianjin Medical University Tianjin 300070 China Beijing Institute for Brain Disorders Beijing 100069 China

Our previous studies indicate that phosphatidylinositol 4-kinase Ila can promote the growth of multi-malignant tumors via HER-2/PI3K and MAPK pathways. However, the molecular mechanisms of this pathway and its potential for clinical application remain unknown. In this study, we found that PI4KIla could be an ideal combinatorial target for EGFR treatment via regulating EGFR degradation. Results showed that PI4KIla knockdown reduced EGFR protein level, and the expression of Pi4KIla shows a strong correlation with EGFR in human breast cancer tissues （r= 0.77, P 〈 0.01）. PI4KIla knockdown greatly prolonged the effects and decreased the effective dosage of AG-1478, a specific inhibitor of EGFR. In addition, it significantly enhanced AG1478-induced inhibition of tumor cell survival and strengthened the effect of the EGFR-targeting anti-cancer drug Iressa in xenograft tumor models. Mechanistically, we found that PI4KIla suppression increased EGFR ligand-independent degradation. Quantitative proteomic analysis by stable isotope labeling with amino acids in cell culture （SlLAC） and LC-MS/MS suggested that HsPg0 mediated the effect of PI4KIla on EGFR. Furthermore, we found that combined inhibition of PI4KIla and EGFR suppressed both PI3K/AKT and MAPK/ERK pathways, and resulted in downregulation of multiple oncogenes like PRDX2, FASN, MTA2, ultimately leading to suppression of tumor growth. Therefore, we conclude that combined inhibition of PI4KIla and EGFR exerts a multiple anti-tumor effect. Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIla presents a novel strategy to combat EGFR-dependent tumors.

关键词： phosphatidylinositol 4-kinase Ila (PI4KIla)EGFR dual inhibition enhanced anti-tumor effect breastcancer. Iressa

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Changes in Runout Distances of Debris Flows over Time in the Wenchuan Earthquake Zone

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Journal of Mountain Science 2013年第2期10卷 281-292页

作者： ZHANG Shuai ZHANG li-Min CHEN Hong-xin YUAN Quan PAN Hua Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology Sichuan xingshu Highway Construction Development Co.Ltd

A large number of debris flows occurred in the Wenchuan earthquake zone after the 12 May 2008 *** risks posed by these debris flows were rather *** appropriate model is required to predict the possible runout distance and impacted *** paper describes a study on the runout characteristics of the debris flows that occurred in the Wenchuan earthquake zone over the past four years.A total of 120 debris flows are *** multivariate regression models are established for the runout distances of hill-slope debris flows and channelized debris *** control variables include type of debris flow,debris flow volume,and elevation *** of the debris flows occurring before and after the earthquake shows that the runout distance increased after the earthquake due to sufficient material supply and increased mobility of the source *** addition,the runout distances of annual debris flow events in 2008,2010 and 2011 are analyzed and *** is a tendency that the runout distance decreases over time due to the decreasing source material volume and possible changes of debris flow *** between the debris flows in the earthquake zone and the debris flows in Swiss Alps,Canada,Austria,and Japan shows that the former have a smaller mobility.

关键词： Debris flow Rainfall Runout distance Landslide Wenchuan earthquake Risk assessment

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Texture,Grain Boundary Characterization and Segregation of Phosphorus in an Annealed Interstitial Free Steel

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Journal of Iron and Steel Research International 2014年第9期21卷 844-848页

作者： xin-li SONG Kun PENG Ze-xi YUAN Juan JIA Jing liU li-xia FAN State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology

The {111} fiND plane texture, grain boundary characterization and grain boundary segregation of phos- phorus are investigated for the phosphorus added high strength interstitial free （IF） steel annealed at 810℃ for 60 s to 180 s. The results show that the maximum volume fraction of {111} fiND plane texture is about 85% and the grain boundary Segregation peak of phosphorus is about 14 at. % for the steel annealed at 810℃ for 120 s. The ∑3 and other low-∑CSL （coincident site lattice） boundaries are lowest for the steel annealed for 120 s. Segregation of phosphorus is also found at low angle grain boundaries.

关键词： high strength IF steel texturel grain boundary characterization segregation

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