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Characterization of inthomycin biosynthetic gene cluster revealing new insights into carboxamide formation

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Chinese Journal of Natural Medicines 2020年第9期18卷 677-683页

作者： WANG Yong-Jiang WANG li HE xin XU Dong-Dong TANG Jun MA Ya-Tuan YAN Yi-Jun gu yu-cheng yang Jing huang sheng-xiong State Key Laboratory of Phytochemistry and P/ant Resources in West China and CAS Center for Excellence in Molecular Plant SciencesKunming Institute of BotanyChinese Academy of SciencesKunming 650201.China College of Chemistry and Pharmacy Norhwest Agriculture and Forestry UniversityYangling 712100.China Savaid Medical School University of Chinese Academy of ScienrcesBejing 100049.China Syngenta Jelott's Hill International Research Centre BracknellBerkshire RG426EYU.K.

Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain. Inthomycin B(1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8. Identification of the gene cluster for inthomycin biosynthesis as well as the ^(15)N-labeled glycine incorporation into inthomycins are described. Combined with the gene deletion of the rare P450 domain in the NRPS module, a formation mechanism of carboxamide moiety in inthomycins was proposed via an oxidative release of the assembly chain assisted by the P450 domain.

关键词： Inthomycins Biosynthesis Gene cluster Carboxamide P450

Off-pump anteroapical aneurysm plication for left ventricular post-infarction aneurysm： long-term results

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Chinese Medical Journal 2012年第18期125卷 3228-3235页

作者： huang xin-sheng gu cheng-xiong yang Jun-feng WEI Hua li Jing-xing yu yang FANG Ying liU Rui li hai-tao ZHOU Qi-wen Department of Cardtiac Surgery Beijing An Zhen Hospital CapitalMedical University China Beijing 100029

Background The temporal response to off-pump anteroapical aneurysm plication has not been well defined. We have evaluated the long-term clinical and functional results of this technique and compared the efficacy with the patch modeling repair. Methods From March 2005 to May 2010, 163 （115 men and 48 women） consecutive patients were operated on for post-infarction left ventricular aneurysm （LVA）, 54 patients underwent patch remodeling （group A） and 109 patients underwent off-pump anteroapical aneurysm plication repair （group B）. All patients had simultaneous coronary revascularization, other operative procedures included septoplasty in eight and ablation of ventricular tachycardia in six. Follow-up ranged from 1 to 5 years, short-term and mid-term outcomes, including complications, cardiac function, and mortality, were assessed. Results Early mortality was 1.8% for all patients （group A 1 death vs. group B 2 deaths, not significant （NS））. Peri-operative support included intraaortic balloon pumping in 16 （9.8%）, （group A 6 patients vs. group B 10 patients, NS） and inotropic drugs in 84 （51.5%）, （group A 34 vs. group B 50, NS）. During a mean follow-up of （3.7±0.8） years, eight patients died, with four due to cardiac-related causes. No patient required transplantation, and two required use of an implantable cardioverter-defibrillator for ventricular tachycardia. Survival at 1 and 5 years was 95% and 86%, respectively. It did not differ significantly between group A and group B. Functional class improved from 2.90±0.59 to 1.65±0.54 among the mid-term survivors （P 〈0.001）, with no significant difference between the two groups. Pre-operative risk factors for mortality or poor function were ejection fraction （EF）〈0.35 （OR=7.9, 95% CI 1.6-40.0）; congestive heart failure （CHF）（OR=4.4, 95% CI 1.0-19.0）; end-systolic volume index （ESVI）〉80 ml/m2 （OR=3.7, 95% CI 1.0-14.0）; and advanced age 〉70 years （OR=2.4, 95% CI 1.0-12.0）.

关键词： coronary artery bypass, off-pump cardiac surgical procedures, aneurysm myocardial infarction

Anteroapical aneurysm plication improves mechanical intraventricular dyssynchrony in patients with anterior myocardial infarction

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Chinese Medical Journal 2012年第7期125卷 1242-1248页

作者： huang xin-sheng gu cheng-xiong yang Jun-feng WEI Hua yu yang ZHOU Qi-wen Department of Cardiac Surgery Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Background Left ventricular （LV） dyssynchrony has been described to occur in patients with myocardial infarction. Dyssynchrony of left ventricular mechanical contraction produces adverse hemodynamic consequences. This study aimed to test the capacity of geometric rebuilding by aneurysm plication to restore a more synchronous contractile pattern after a mechanical, rather than electrical, intervention. Methods A total of sixty patients with anterior myocardial infarction, QRS duration 〈120 ms, electively undergoing operation between January 2008 and January 2010 were included for analysis. Real-time 3-dimensional echocardiography was performed to assess LV function, LV systolic and diastolic dyssynchrony by measuring ejection fraction （EF）, peak ejection rate （PER）, peak filling rate （PFR） and LV dyssynchrony. LV dyssynchrony was defined as the systolic dyssynchrony of the time to reach the minimum systolic volume for 16 LV segments, expressed in percent cardiac cycle, systolic dyssynchrony index （SDI）. We compared changes of LV dyssynchrony at different interval times. Results LV contraction was significantly asynchronous because preoperative SDI was higher, EF, PER and PFR were lowered. Compared with function after operation, LV mechanical intraventricular resynchronization was improved with decreased SDI （（8.7_＋0.5） % vs. （14.3_＋1.6） %, P=0.01）; LV function was improved with EF increasing （（43_＋9）% vs. （37_＋7）%, P=0.001）, and LV systolic and diastolic dyssynchrony was improved with more rapid PFR （199.4_＋15.6 vs. 148.4_＋21.2, P=0.002） and PER （212.4_＋14.5 vs. 156.3_＋_26.2, P=0.001）. Conclusions Systolic and diastolic dyssynchrony was highly prevalent in patients with aneurysm, irrespective of QRS duration. Aneurvsm olication oroduces a mechanical *** rP.~***.

关键词： echocardiography myocardial contraction aneurysm cardiac surgical procedure

Advanced Space-based Solar Observatory(ASO-S):an overview

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Research in Astronomy and Astrophysics 2019年第11期19卷 3-10页

作者： Wei-Qun Gan cheng Zhu yuan-Yong Deng Hui li yang Su hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng yu huang Jian-Feng yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen cheng Fang Yi-Hua Yan Jun lin Wei-Ming xiong Bin Chen hai-Chao Bao Cai-Xia Cao Yan-Ping Bai tao Wang Bing-Long Chen xin-yu li Ye Zhang li Feng Jiang-tao Su Ying li Wei Chen You-Ping li Ying-Na Su hai-Yan Wu Mei gu Lei huang Xue-Jun Tang Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Nanjing Institute of Astronomical Optics&Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China Changchun Institute of Optics Fine Mechanics and PhysicsChangchun 130033China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China yunnan Observatories Chinese Academy of SciencesKunming 650011China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Beijing Special Engineering and Design Institute Beijing 100028China Beijing Institute of Tracking and Telecommunications Technology Beijing 100094China Shanghai Academy of Spaceflight Technology Shanghai 201109China

The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar *** scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single ***-S is scheduled to be launched into a 720 km Sun-synchronous orbit in *** paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C.

关键词： space vehicles instruments-Sun magnetic fields-Sun flares-Sun CMEs-Sun UV radiation-Sun X-ray,gamma-rays

Astronomical Site Monitoring System at lijiang Observatory

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Research in Astronomy and Astrophysics 2020年第9期20卷 291-308页

作者： yu-xin xin Jin-Ming Bai Bao-li Lun yu-Feng Fan Chuan-Jun Wang Xiao-Wei liu Xiao guang yu Kai Ye Teng-Fei Song liang Chang Shou-sheng He Jji-Rong Mao liang Xu Ding-Rong xiong Xi-liang Zhang Jian-guo Wang Xu Ding hai-cheng Feng Xiang-Kun liu yang huang Bing-Qiu Chen yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Center for Astronomical Mega-Sciences Chinese Academy of SciencesBeijing 100101China South-Western Institute for Astronomy Research Yunnan UiversityKunming 650500China

We installed two sets of Astronomical Site Monitoring Systems(ASMSs)at lijiang Observatory(GMG),for the running of the 2.4-meter lijiang optical telescope(LJT)and the 1.6-meter Multi-channel Photometric Survey Telescope(Mephisto).The Mephisto is under *** ASMS has been running on robotic mode since *** core instruments:Cloud Sensor,All-Sky Camera and AutonomousDIMM that are developed by our group,together with the commercial Meteorological Station and Sky Quality Meter,are combined into the astronomical optical site monitoring *** new Cloud Sensor's Cloud-Clear Relationship is presented for the first time,which is used to calculate the All-Sky cloud *** designed the Autonomous-DIMM located on a tower,with the same height as *** seeing data have been observed for a full ***'s data for the year 2019 are also analysed in detail,which are valuable to observers.

关键词： Astronomical Site Monitoring System lijiang Observatory Cloud Sensor Autonomous-DIMM

Beneficial effects of moderate to vigorous physical activity on cardiovascular disease among Chinese adults

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Journal of Geriatric Cardiology 2020年第2期17卷 85-95页

作者： Qiong liU Fang-Chao liU Ke-Yong huang Jian-xin li Xue-li yang xin-Yan WANG Ji-Chun CHEN Xiao-Qing liU Jie CAO Chong SHEN ling yu Fang-Hong LU Xian-Ping WU lian-cheng ZHAO Ying li Dong-sheng HU Xiang-Feng LU Jian-Feng huang Dong-Feng gu Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijingChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhouChina Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjingChina Department of Cardiology Fujian Provincial HospitalFuzhouChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinanChina Sichuan Center for Disease Control and Prevention ChengduChina Department of Prevention Medicine Shenzhen University School of MedicineShenzhenChina

Background In China,lack of evidence remains a significant challenge for the national initiative to promote physical activity(PA).We aimed to quantify the beneficial effects of meeting or maintaining the recommended PA level[150 minutes per week(min/wk)of moderate PA or 75 min/wk of vigorous PA or an equivalent combination]on incident cardiovascular disease(CVD)among Chinese *** We included 100,560 participants without history of CVD from three cohorts in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)*** proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for CVD events and its subtypes,including stroke,coronary heart disease,heart failure,and CVD *** During a median follow-up of 7.3 years(range:6–15 years),777,163 person-years and 4693 incident CVD events were *** with participants who were inactive at baseline,the multivariable adjusted HR(95%CI)of developing CVD was 0.74(0.69–0.79)for those who met recommended moderate to vigorous physical activity(MVPA)level at ***,the risk of CVD incidence was reduced with increment of MVPA(Ptrendline and follow-up,those keeping active over the period of follow-up had a substantial lower risk of incident CVD with the HR(95%CI)of 0.57(0.43–0.77).Conclusions The findings demonstrated that meeting and maintaining the recommended MVPA level could reduce the cardiovascular *** adoption of the PA recommendations would have considerable health impacts to the Chinese population.

关键词： Cardiovascular disease China Cohort study Physical activity

lifestyle improvement and the reduced risk of cardiovascular disease:the China-PAR project

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Journal of Geriatric Cardiology 2023年第11期20卷 779-787页

作者： Ying-Ying JIANG Fang-Chao liU Chong SHEN Jian-xin li Ke-Yong huang Xue-li yang Ji-Chun CHEN Xiao-Qing liU Jie CAO Shu-Feng CHEN ling yu Ying-xin ZHAO Xian-Ping WU lian-cheng ZHAO Ying li Dong-sheng HU Jian-Feng huang Xiang-Feng LU Dong-Feng gu Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijingChina Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijingChina Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjinChina Division of Epidemiology Guangdong Provincial People's Hospital and Cardiovascular InstituteGuangzhouChina Department of Cardiology Fujian Provincial HospitalFuzhouChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinanChina Sichuan Center for Disease Control and Prevention ChengduChina Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhouChina Department of Epidemiology and Health Statistics School of Public HealthShenzhen University Health Science CenterShenzhenChina School of Medicine Southern University of Science and TechnologyShenzhenChina

BACKGROUND The benefits of healthy lifestyles are well recognized. However, the extent to which improving unhealthy lifestyles reduces cardiovascular disease(CVD) risk needs to be discussed. We evaluated the impact of lifestyle improvement on CVD incidence using data from the China-PAR project(Prediction for Atherosclerotic Cardiovascular Disease Risk in China).METHODS A total of 12,588 participants free of CVD were followed up for three visits after the baseline examination. Changes in four lifestyle factors(LFs)(smoking, diet, physical activity, and alcohol consumption) were assessed through questionnaires from the baseline to the first follow-up visit. Cox proportional hazard models were used to estimate hazard ratios(HRs) and corresponding 95% confidence intervals(CIs). The risk advancement periods(RAPs: the age difference between exposed and unexposed participants reaching the same incident CVD risk) and population-attributable risk percentage(PAR%) were also *** A total of 909 incident CVD cases occurred over a median follow-up of 11.14 years. Compared with maintaining 0-1healthy LFs, maintaining 3–4 healthy LFs was associated with a 40% risk reduction of incident CVD(HR = 0.60, 95% CI: 0.45–0.79)and delayed CVD risk by 6.31 years(RAP:-6.31 [-9.92,-2.70] years). The PAR% of maintaining 3–4 unhealthy LFs was 22.0%compared to maintaining 0-1 unhealthy LFs. Besides, compared with maintaining two healthy LFs, improving healthy LFs from 2to 3–4 was associated with a 23% lower risk of CVD(HR = 0.77, 95% CI: 0.60–0.98).CONCLUSIONS Long-term sustenance of healthy lifestyles or improving unhealthy lifestyles can reduce and delay CVD risk.

关键词： hazard maintaining alcohol

Effects of the total physical activity and its changes on incidence, progression, and remission of hypertension

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Journal of Geriatric Cardiology 2021年第3期18卷 175-184页

作者： Can CAI Fang-Chao liU Jian-xin li Ke-Yong huang Xue-li yang Ji-Chun CHEN Xiao-Qing liU Jie CAO Shu-Feng CHEN Chong SHEN ling yu Fang-Hong LU Xian-Ping WU lian-cheng ZHAO Ying li Dong-sheng HU Jian-Feng huang Xiao-yang ZHOU Xiang-Feng LU Dong-Feng gu Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhou 510080China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Cardiology Fujian Provincial HospitalFuzhou 350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinan 250062China Sichuan Center for Disease Control and Prevention Chengdu 610041China Department of Epidemiology and Health Statistics School of Public HealthShenzhen University Health Science CenterShenzhen 518060China

OBJECTIVES Moderate to vigorous physical activity is recommended to prevent hypertension according to the current ***,the degree to which the total physical activity(TPA)and its changes benefit normotensives and hypertensives is *** aimed to examine the effects of TPA and its changes on the incidence,progression,and remission of hypertension in the large-scale prospective *** A total of 73,077 participants(55,101 normotensives and 17,976 hypertensives)were eligible for TPA *** a mean follow-up of 7.16 years(394,038 person-years),12,211 hypertension cases were *** was estimated as metabolic equivalents and categorized into *** proportional hazards regression and multivariable logistic regression were used to estimate associations of TPA and changes in TPA with incident hypertension and progression/remission of *** Compared with the lowest quartile of TPA,normotensives at the third and the highest quartile had a decreased risk of incident hypertension,with hazard ratios(HRs)of 0.86[95%confidence interval(CI):0.81−0.91]and 0.81(95%CI:0.77−0.86),*** at the highest quartile of TPA demonstrated a decreased risk of progression of hypertension[odds ratio(OR)=0.87,95%CI:0.79−0.95],and an increased probability of hypertension remission(OR=1.17,95%CI:1.05−1.29).Moreover,getting active from a sedentary lifestyle during the follow-up period could reduce 25%(HR=0.75,95%CI:0.58−0.96)risk of incident hypertension,whereas those becoming sedentary did not achieve benefit from initially being *** Our findings indicated that increasing and maintaining TPA levels could benefit normotensives,whereas higher TPA levels were needed to effectively control progression and improve remission of *** activity played undoubtedly an essential role in both primary and secondary prevention of hypertension.

关键词： hypertension remission prevention

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-Wei yang Yong-Hao Chen Rong liu Bang-Jiao Ye Jie Wen hai-Rui guo Zi-Jie Han Qi-Ping Chen Zhong-Wei Wen Wei-li Sun Han Yi xing-Yan liu tao Ye Jiang-Bo Bai Qi An Jie Bao yu Bao Ping Cao Hao-Lei Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao gu Chang-Cai Han guo-Zhu He Yong-cheng He yang Hong Yi-Wei Hu Han-xiong huang Xi-Ru huang Hao-yu Jiang Wei Jiang Zhi-Jie Jiang Han-tao Jing ling Kang Bo li Chao li Jia-Wen li Qiang li Xiao li yang li Jie liu Shu-Bin liu Ze Long guang-yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-xin Tan Jing-yu Tang xin-Yi Tang Bin-Bin Tian li-Jiao Wang Peng-cheng Wang Zhao-Hui Wang Xiao-guang Wu Xuan Wu li-Kun Xie Xiao-yun yang li yu tao yu Yong-Ji yu guo-Hui Zhang lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang yu-liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source