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钻井液活度测量仪器研制

石油天然气学报 2006年第6期28卷 164-165页

作者：郑力会单正锋刘东中国石油大学(北京)石油天然气工程学院北京102249

钻井液活度的高低影响钻井液抑制性的强弱。电子湿度计可以直接测量溶液上部密闭空间的相对湿度,而不能直接测量溶液的活度。研制了一种测量钻井液活度的电子湿度计。用已知活度的CaCl2和NaCl饱和溶液及蒸馏水标定研制的电子湿度计,建... 详细信息

钻井液活度的高低影响钻井液抑制性的强弱。电子湿度计可以直接测量溶液上部密闭空间的相对湿度,而不能直接测量溶液的活度。研制了一种测量钻井液活度的电子湿度计。用已知活度的CaCl2和NaCl饱和溶液及蒸馏水标定研制的电子湿度计,建立相对湿度与活度之间的关系式。用此仪器测得Ca(NO3)2和(NH4)2SO4饱和溶液的相对湿度,用相对湿度与活度之间的关系式求出两无机盐溶液的活度,与文献测定的2种无机盐活度进行对比,误差在5%以内。

关键词：钻井液活度电子湿度计相对湿度

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叶片型面测量编程与误差处理技术

计量学报 2013年第2期34卷 128-133页

作者：蔺小军李宜明李政辉高春西北工业大学现代设计与集成制造技术教育部重点实验室陕西西安710072

针对航空发动机叶片三坐标测量机（CMM）测量，进行了自动测量编程与误差处理两个方面的研究。提出了一种基于已知叶片CAD模型提取测量点理论坐标值与计算法向矢量的方法，矢量计算采用微平面法。数据处理时，采用ICP算法进行配准消除... 详细信息

针对航空发动机叶片三坐标测量机（CMM）测量，进行了自动测量编程与误差处理两个方面的研究。提出了一种基于已知叶片CAD模型提取测量点理论坐标值与计算法向矢量的方法，矢量计算采用微平面法。数据处理时，采用ICP算法进行配准消除了系统误差，从而得到叶片型面误差。开发了测量点坐标值与矢量计算以及配准程序。实例证明该方法可靠、有效。

关键词：计量学叶片测量 CMM 法向矢量 ICP算法配准误差处理

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng zheng Borui Zhang Sonata S Y Yau Kwok-Fai So li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

我国职业教育推行“分类培养”的现实需求与实施路径研究

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南方职业教育学刊 2021年第1期11卷 67-73页

作者：李辉政永州职业技术学院工程学院湖南永州425100

自《中华人民共和国职业教育法》1996年颁布以来,我国职业教育经历了二十多年的发展历程,取得了巨大成就。当前职业教育正面临招生多元化、生源参差不齐的问题,为提升职业教育办学水平和人才培养质量,应探索实施"分类培养"模式。"分类培... 详细信息

自《中华人民共和国职业教育法》1996年颁布以来,我国职业教育经历了二十多年的发展历程,取得了巨大成就。当前职业教育正面临招生多元化、生源参差不齐的问题,为提升职业教育办学水平和人才培养质量,应探索实施"分类培养"模式。"分类培养"有利于满足培养对象的个性需求,促进产教深度融合,推动经济社会健康发展。具体可从培养对象合理分流、构建和完善分类教学体系、提升职业教育"三教"水准等方面探索实施"分类培养";从深化产教融合、吸纳社会资源、加强政策引领、完善制度体系、强化监管等方面保障"分类培养"的实施,推动我国职业教育行稳致远。

关键词： “分类培养” 职业教育产教融合校企合作 “三教”改革

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

毛细管电泳电化学淌度移动法测定利尿剂和牛血清白蛋白结合常数

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分析化学 2009年第1期37卷 115-118页

作者：郑丽辉郑新宇童萍陈国南张兰福州大学食品安全分析与检测教育部重点实验室运动科学研究中心福建农林大学生命科学学院

采用毛细管电泳淌度移动法研究了利尿剂氢氯噻嗪(HCT),布美他尼(BMTN)与牛血清白蛋白(BSA)的结合常数。使用未涂层的毛细管柱(70cm×25μmi.d.),中性H3BO3-Na2B4O7-NaCl(Palitzsch,pH7.4)缓冲溶液,在800mV工作电位,分离电压9kV和电动进... 详细信息

采用毛细管电泳淌度移动法研究了利尿剂氢氯噻嗪(HCT),布美他尼(BMTN)与牛血清白蛋白(BSA)的结合常数。使用未涂层的毛细管柱(70cm×25μmi.d.),中性H3BO3-Na2B4O7-NaCl(Palitzsch,pH7.4)缓冲溶液,在800mV工作电位,分离电压9kV和电动进样9kV×8s的条件下,测得HCT,BMTN与BSA的结合常数分别为2.45×104L/moL,1.19×104L/moL。得到的结合常数值与经典紫外分光光度法测定的值相近。实验表明,本方法可以作为研究药物与蛋白相互作用的一种快速、简便的检测方法。

关键词：毛细管电泳电化学检测法结合常数利尿剂

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金融危机视角下中国产业结构调整与提升研究

经济问题 2009年第5期357卷 31-33页

作者：李正辉刘思明湖南大学统计学院长沙410079

愈演愈烈的金融危机对我国经济带来了很大的冲击,同时也给我国产业结构调整提供了难得的机遇。分析了金融危机影响较大的产业,主要有纺织、玩具、钢铁等;并对这些产业的行业特征进行了研究,发现这些产业具有高污染、高耗能以及劳动密集... 详细信息

愈演愈烈的金融危机对我国经济带来了很大的冲击,同时也给我国产业结构调整提供了难得的机遇。分析了金融危机影响较大的产业,主要有纺织、玩具、钢铁等;并对这些产业的行业特征进行了研究,发现这些产业具有高污染、高耗能以及劳动密集两大特点;最后对我国的产业结构调整和提升提出了相关的对策。

关键词：金融危机产业结构调整提升

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑life lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang li Qifeng zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous li deposition and highly reversible li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous li+flux lithium metal battery

毛细管电泳安培法用于尿样中β-阻断剂类兴奋剂药物的研究

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分析化学 2008年第12期36卷 1624-1628页

作者：宋子旺童萍郑丽辉张兰福州大学食品安全分析与检测教育部重点实验室福州大学运动科学研究中心

利用毛细管电泳-安培法检测联用技术,建立了一种简单、灵敏、快速同时分离检测人体尿液中两种β-阻断剂类兴奋剂药物索他洛尔和塞利洛尔的新方法。以直径300μm的铂圆盘电极为检测电极（铂丝为辅助电极,Ag/AgCl为参比电极）,在0.950 V... 详细信息

利用毛细管电泳-安培法检测联用技术,建立了一种简单、灵敏、快速同时分离检测人体尿液中两种β-阻断剂类兴奋剂药物索他洛尔和塞利洛尔的新方法。以直径300μm的铂圆盘电极为检测电极（铂丝为辅助电极,Ag/AgCl为参比电极）,在0.950 V的检测电位下,30 mmol/L Clark-Lubs缓冲体系（pH9.60）中,两种分析物在8 min内达到基线分离。在最佳条件下,其峰电流与0.15;0 mg/L索他洛尔与0.30;0 mg/L塞利洛尔呈现良好的线性关系,检出限分别为0.05 mg/L和0.09 mg/L,并将建立的方法成功地应用于人体尿样的分析。进一步研究了人体尿液中索他洛尔36 h内的排泄曲线及索他洛尔在尿液中的排泄规律,对奥运会中的兴奋剂快速检测具有一定的应用价值。

关键词：毛细管电泳安培法检测 β-阻断剂兴奋剂索他洛尔塞利洛尔