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基于DOE的卷烟工业燃气锅炉节能优化分析

现代工业经济和信息化 2024年第3期14卷 106-109,112页

作者：曹贤新何雪辉刘龙涛陈思嘉黄鑫黎越峰江西中烟工业责任有限公司赣州卷烟厂江西赣州341000

燃气锅炉是卷烟工业中常用的动力能源设备,为卷烟生产过程提供饱和蒸汽.在锅炉运行中需要消耗大量能源,如何降低锅炉的能源消耗是卷烟厂节能减排的关键.气汽比是衡量锅炉运行效能的重要指标,因此,针对锅炉气汽比的现状,通过综合分析和... 详细信息

燃气锅炉是卷烟工业中常用的动力能源设备,为卷烟生产过程提供饱和蒸汽.在锅炉运行中需要消耗大量能源,如何降低锅炉的能源消耗是卷烟厂节能减排的关键.气汽比是衡量锅炉运行效能的重要指标,因此,针对锅炉气汽比的现状,通过综合分析和现场论证,确定了锅炉汽气比的主要影响因素,采用实验设计法(DOE)对锅炉运行参数进行优化,并对其效果进行了验证.结果表明,采取相应措施后,气汽比同比减少7.7%,其稳定性也得到了提升.

关键词：燃气锅炉节能气汽比实验设计法

Web Voice Browser Based on an ISLPC Text-to-Speech Algorithm

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Wuhan University Journal of Natural Sciences 2006年第5期11卷 1157-1160页

作者： liAO Rikun JI yuefeng li Hui College of Telecommunication Engineering BeijingUniversity of Posts and Telecommunications Beijing 100876China

A kind of Web voice browser based on improved synchronous linear predictive coding （ISLPC） and Text-toSpeech （TTS） algorithm and Internet application was proposed. The paper analyzes the features of TTS system with ISLPC speech synthesis and discusses the design and implementation of ISLPC TTS-based Web voice browser. The browser integrates Web technology, Chinese information processing, artificial intelligence and the key technology of Chinese ISLPC speech synthesis. It＇s a visual and audible web browser that can improve information precision for network users. The evaluation results show that ISLPC-based TTS model has a better performance than other browsers in voice quality and capability of identifying Chinese characters.

关键词： improved synchronous linear predictive coding (ISLPC) Text-to-Speech (TTS) Web voice browser voice quality

Discovery of a highly specific ^(18)F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1963-1975页

作者： Zhiwei Xiao Huiyi Wei Yi Xu Ahmed Haider Junjie Wei Shiyu Yuan Jian Rong Chunyu Zhao Guocong li Weibin Zhang Huangcan Chen yuefeng li lingling Zhang Jiyun Sun Shaojuan Zhang Hai-Bin Luo Sen Yan Qijun Cai Lu Hou Chao Che Steven H.liang Lu Wang Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI Centerthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital&Department of RadiologyHarvard Medical SchoolBostonMA 02114USA Department of Cardiology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Guangdong Landau Biotechnology Co.Ltd. Guangzhou 510555China Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570228China Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhou 510632China

As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium spiny neurons of the striatum,it has been implicated in a variety of neurological ***,inhibition of PDE10A has proven to be of potential use for the treatment of central nervous system(CNS)pathologies caused by dysfunction of the basal ganglia–of which the striatum constitutes the largest component.A PDE10A-targeted positron emission tomography(PET)radioligand would enable a better assessment of the pathophysiologic role of PDE10A,as well as confirm the relationship between target occupancy and administrated dose of a given drug candidate,thus accelerating the development of effective PDE10A *** this study,we designed and synthesized a novel ^(18)F-aryl PDE10A PET radioligand,codenamed[^(18)F]P10A-1910([^(18)F]9),in high radiochemical yield and molar activity via spirocyclic iodonium ylide-mediated radiofluorination.[^(18)F]9 possessed good in vitro binding affinity(IC_(50)=2.1 nmol/L)and selectivity towards ***,[^(18)F]9 exhibited reasonable lipophilicity(logD=3.50)and brain permeability(P_(app)>10×10^(−6) cm/s in MDCK-MDR1 cells).PET imaging studies of[^(18)F]9 revealed high striatal uptake and excellent in vivo specificity with reversible tracer *** studies in rodents revealed an improved plasma and brain stability of[^(18)F]9 when compared to the current reference standard for PDE10A-targeted PET,[^(18)F]***,dose–response experiments with a series of escalating doses of PDE10A inhibitor 1 in rhesus monkey brains confirmed the utility of[^(18)F]9 for evaluating target occupancy in vivo in higher *** conclusion,our results indicated that[^(18)F]9 is a promising PDE10A PET radioligand for clinical translation.

关键词： Phosphodiesterase 10A PET radioligand 18F Spirocyclic iodonium ylide Nonhuman primate Target occupancy

Effect of Sini San Freeze-dried powder on sleep-waking cycle in insomnia rats

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Journal of Traditional Chinese Medicine 2014年第5期34卷 572-575页

作者： Xingke Yan Zeguo Zhang Fuju Xu yuefeng li Tiantian Zhu Chongbing Ma Anguo liu Department of Pharmacy Department of AcupunctureGansu University of Traditional Chinese Medicine Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicines of Gansu Province Department of Acupuncture Gansu University of Traditional Chinese Medicine

OBJECTIVE: To investigate the effects of the Sini San at different doses on each sleeping state[slow-wave sleep 1(SWS1), slow-wave sleep 2(SWS2), rapid-eye-movement(REM), wakefulness(W)] in insomnia rats and to identify its mode of ac-tion for improving ***: The insomnia rats were randomly divided into a high-, medium- or low-dose group of Sini San(equal to crude drug 8.8, 4.4, or 2.2 g/kg, respectively) for seven consecutive ***: Compared with pre-administration,SWS2 was significantly increased after administration of the low dose. Compared with pre-administration, W was significantly decreased and SWS1,SWS2, and the total sleeping time(TST) were markedly increased after administration of the medium dose. Compared with pre-administration, W was significantly decreased and SWS1, SWS2, rapid-eye-movement sleep, and TST were significantly longer after administration of the high dose. The effects of Sini San on sleep-wake cycle are ***: The results suggest that Sini San extends SWS1 and SWS2, which increases the total sleeping time.

关键词：睡眠状态四逆散大鼠周期冻干粉慢波睡眠睡眠时间低剂量

Dt1 inhibits SWEET-mediated sucrose transport to regulate photoperiod-dependent seed weight in soybean

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Molecular Plant 2024年第3期17卷 496-508页

作者： Xiaoming li Zhonghui Chen Haiyang li lin Yue Cuirong Tan Hongjie liu Yilong Hu Yuhua Yang Xiani Yao lingping Kong Xiang Huangi Bin Yu Chunyu Zhang yuefeng Guan Baohui liu Fanjiang Kong Xingliang Hou Guangdong Provincial Key Laboratory of Applied Botany&State Key Laboratory of Plant Diversity and Specialty Crops South China Botanical GardenChinese Academyof SciencesGuangzhou510650China Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Guangzhou Key Laboratory of Crop Gene EditingInnovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China University of Chinese Academy of Sciences Beijing 100049China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China

Soybean is a photoperiod-sensitive short-day crop whose reproductive period and yield are markedly affected by day-length *** weight is one of the key traits determining the soybean yield;how-ever,the prominent genes that control the final seed weight of soybean and the mechanisms underlying the photoperiod's effect on this trait remain poorly *** this study,we identify SwW19 as a major locus controlling soybean seed weight by QTL mapping and determine Dt1,an orthologous gene of Arabidopsis TFL1 that is known to govern the soybean growth habit,as the causal gene of the SW19 *** showed that Dt1 is highly expressed in developing seeds and regulates photoperiod-dependent seed weight in *** analyses revealed that the Dt1 protein physically interacts with the sucrose transporter GmSWEET10a to negatively regulate the import of sucrose from seed coat to the embryo,thus modulating seed weight under long ***,Dt1 does not function in seed development under short days due to its very low ***,we discovered a novel natural allelic variant of Dt1(H4 haplotype)that decouples its pleiotropic effects on seed size and growth habit;i.e.,this variant remains functional in seed development but fails to regulate the stem growth habit of ***,our findings provide new insights into how soybean seed development responds to photoperiod at different latitudes,offering an ideal genetic component for improving soybean's yield by manipulating its seed weightandgrowth habit.

关键词： soybean seed weight photoperiod dt1 sucrose transport

Sedative and hypnotic effect of freeze-dried paeoniflorin and Sini San freeze-dried powder in pentobarbital sodium-induced mice

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Journal of Traditional Chinese Medicine 2014年第2期34卷 184-187页

作者： yuefeng li Pingan Wu Yanmei Ning Xingke Yan Tiantian Zhu Chongbing Ma Anguo liu Department of Pharmacy Gansu University of Chinese MedicineKey Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicines of Gansu ProvinceGansu College of Traditional Chinese Medicine Department of Acupuncture Gansu University of Traditional Chinese Medicine

OBJECTIVE: To investigate the sedative and hypnotic activity of paeoniflorin and freeze-dried Sini San powder on mice and provide a reliable method for determining the pharmacodynamic material basis of Sini ***: Male adult mice weighing 20-22 g were used in this study. Three experiments were carried out. Synergism with pentobarbital was used as an index for hypnotic effect. Loss of the righting reflex was used to determine the start of *** latency and sleeping time were recorded in each ***: The coefficient of variation of the suprathreshold dose(55 mg/kg) was significantly lower than that of the threshold dose. The sleep latency of mice was significantly decreased, and the sleeping time of mice was significantly prolonged. The effects of paeoniflorin and Sini San on prolonging the sleeping time of mice induced by pentobarbital sodium were significantly stronger than those in the control ***: Paeoniflorin produces significant sedative and hypnotic effects, and there is an obvious dose-effect relationship.

关键词：戊巴比妥钠成年小鼠芍药苷四逆散镇静剂冻干粉催眠冷冻干燥

Enhancing alkyne semi-hydrogenation through engineering metal-support interactions of Pd on oxides

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Nano Research 2024年第5期17卷 3707-3713页

作者： yuefeng Wu Xiaotong Lu Pengfei Cui Wenyu Jia Jun Zhou Yuan Wang Hussain Zahid Yuxin Wu Muhammad Umer Rafique Xiong Yin Baoshan li Leyu Wang Guolei Xiang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China

Supported Pd catalysts show superior activities for olefin productions from alkynes through semi-hydrogenation reactions,but over-hydrogenation into alkanes highly decreases olefin *** phenylacetylene semi-hydrogenation as a model reaction,here we explore the optimization approaches toward better Pd catalysts for alkyne semi-hydrogenation through investigating support effect and metal-support *** results show that the states of Pd with supports can be tuned by varying oxide reducibility,loading ratios,and *** our system,0.06 wt.%Pd on rutile-TiO_(2) nanorods shows the highest activity owing to the synergistic effects of single-atoms and *** reducibility can change the filling degrees of Pd 4d orbitals through varying interfacial bonding strengths,which further affect catalytic activity and selectivity.

关键词： alkyne semi-hydrogenation support effect metal-support interaction Pd catalyst single-atom catalyst

DYNAMIC SUBSTRUCTURING ANALYSISOF COMPOSITE STRUCTURES WITHNONliNEAR liNKS

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Chinese Journal of Aeronautics 1990年第3期5卷 168-177页

作者： Hu Haiyan, li yuefeng and Zhang AzhouNanjing Aeronautical Institute

The paper deals with the dynamic response prediction of the composite structure,which consists of two linear components coupled by some nonlinear vibration isolators. Based on the measured impulse response functions of the linear components, three kinds of dynamic equations of interfacial integration are proposed and a procedure to transform the dynamic equations of integral type into a set of ordinary differential equations is suggested. Computer simulations and a real test are given to verify the effectiveness of the theoretical results.

关键词： DYNAMIC SUBSTRUCTURING ANALYSISOF COMPOSITE STRUCTURES WITHNONliNEAR liNKS mode link

Expressing a human RNA demethylase as an assister improves gene-editing efficiency in plants

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Molecular Plant 2024年第3期17卷 363-366页

作者： Mengyan Bai Wenxin lin Chunyan Peng Peizhe Song Huaqin Kuang Jieni lin Jieping Zhang Jiyao Wang Bo Chen Huarong li Fanjiang Kong Guifang Jia yuefeng Guan Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Innovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China College of Agronomy China Agricultural UniversityBeijing 100193China College of life Sciences Fujian Agriculture and Forestry UniversityFuzhouFujian 350002China Synthetic and Functional Biomolecules Center Bejing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Kingagroot Co. Ltd.QingdaoShandong 266000China Tsinghua University-Peking University Joint Center for life Sciences Bejing 100871China

Dear Editor,Despite myriad successful applications of gene editing in plant functional genomics research and precision breeding,many challenges persist around the efficiency of gene-editing tools for many plant *** instance,soybean(Glycine max)is a major crop providing oil and protein to human diets and feedstock,but its gene-editing efficiency remains relatively low(Bai et al.,2019).

关键词： editing breeding