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Inducement of Sechenov inhibition by EtOH and NA in the Bufo toad

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Chinese Science Bulletin 2008年第8期53卷 1193-1196页

作者： li RuXin JIA ShanShan li yingzi CAO Yin CHENG XiuZhen XIE ZuoPing Department of Biological Sciences and Biotechnology National State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University Beijing 100084 China Department of Physiology Weifang Medical University Weifang 261042 China

Central inhibition, discovered by Sechenov in 1862, suggests that electrically stimulating the forebrain or medulla oblongata in frog generally suppresses reflexes. However, the underlying molecular mechanisms are still unclear. Using ethanol (EtOH), noradrenalin (NA), and other neurotransmitters in thalamic preparations, Sechenov inhibition was stimulated in Bufo toads in this study. The result showed that, similar to Sechenov inhibition, the acute application of EtOH or NA excited the thalamus and prolonged the latency of withdrawal reflex. Our study evidences the involvement of α-adrenoceptors in such central inhibition, and explains the role of acute EtOH application in the in- duction of reflex inhibition.

关键词：乙醇去甲肾上腺素抑制作用 NA 蟾蜍

The underappreciated role of fugitive VOCs in ozone formation and health risk assessment emitted from seven typical industries in China

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Journal of Environmental Sciences 2024年第2期136卷 647-657页

作者： Zhiling liang Yunjiang Yu Bingbing Sun Qian Yao Xihua lin Yongsheng Wang Jianping Zhang yingzi li Xuefeng Wang Zhengzheng Tang Shexia Ma College of Environmental and Chemical Engineering Shanghai University of Electric PowerShanghai 200090China State Environmental Protection Key Laboratory of Environmental Protection Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510535China Henan Jiyuan Ecological Environment Testing Center Jiyuan 454650China Ecological Environment Bureau of Jiyuan Production City Integration Demonstration Zone Jiyuan 454650China

Fugitive emission from industrial sources may result in ozone formation and health risk,while the exact contribution of this source remains incompletely *** this study,emission characteristics,ozone formation potential(OFP)and health risk of fugitive VOCs in7 representative industries were *** material industry was the dominant contributor to VOCs of fugitive emission in comparison with other *** OFP of VOCs from fugitive emission was in the range of 1.45×10^(3)-3.98×10^(5)μg/m^(3),with a higher value than that of organized emission in seven industries except for the coking industry and the chemical material industry,suggesting that fugitive VOCs should be taken into account while developing control ***,m,p-xylene,n-nonane,ethylene,vinyl chloridethe and other high OFP-contributing species were the major reactive species that should be *** risk assessment investigated non-cancer and cancer risks of fugitive VOCs in 7 industries were all above safe level(HR>1 and LCR>1×10^(-4)),posing remarkable health threats to human *** were the main contributor to non-cancer risk,while halohydrocarbons and aromatics contributed most to cancer risks,posing remarkable health threat on human *** findings highlighted the contribution of fugitive VOCs on ozone formation and health risk was underestimated,indicating which should be considered in emission control strategies of industrial sources.

关键词： Industrial sources Volatile organic compounds Fugitive emission Ozone formation potential Health risk assessment

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新型环保轮轨润滑脂研发的关键技术

中国铁道科学 2018年第3期39卷 138-144页

作者：李英姿中国铁道科学研究院金属及化学研究所北京100081

研制的新型环保轮轨润滑脂以植物油、酯类油、PAO复配的半合成油为基础油,以高级脂肪酸锂皂作为稠化剂,按照确定的优化配方加入抗氧剂、极压抗磨剂、防锈剂、防腐剂等添加剂,以及抗磨性能优良的非石墨固体润滑剂,采用特殊的成脂工艺制... 详细信息

研制的新型环保轮轨润滑脂以植物油、酯类油、PAO复配的半合成油为基础油,以高级脂肪酸锂皂作为稠化剂,按照确定的优化配方加入抗氧剂、极压抗磨剂、防锈剂、防腐剂等添加剂,以及抗磨性能优良的非石墨固体润滑剂,采用特殊的成脂工艺制成。室内理化性能、可生物降解性和毒性、低温模拟试验等综合评定结果表明,研制脂的抗磨性能、防锈抗腐蚀性能、低温性能优良,可生物降解性良好,无(或低)毒,无重金属、卤族等有害元素,易泵送、喷涂,综合性能达到国际同类脂水平。经过1年在机车上的现场运用试验,研制脂有效减小了机车轮缘的磨耗,满足了轮缘润滑的需要,可适用于-30℃以上温度范围的轮轨润滑。

关键词：轮轨润滑脂环保脂基础油添加剂理化性能可生物降解性毒性

Visual acuity is correlated with ischemia and neurodegeneration in patients with early stages of diabetic retinopathy

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Eye and Vision 2021年第1期8卷 385-395页

作者： Jin li Yue Zhou Feng Chen yingzi li Rong Zhou Chaoming Wu Huankai Yu Zhiyang lin Ce Shi Gu Zheng Yilei Shao Qi Chen Fan Lu Meixiao Shen School of Ophthalmology and Optometry Wenzhou Medical University270 Xueyuan RoadWenzhou 325027ZhejiangChina The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou 325027ZhejiangChina Department of Ophthalmology The Affiliated Hospital of Yangzhou UniversityYangzhou 225000JiangsuChina

Purpose:We investigated the effects of retinal ischemia,neurodegeneration,and subclinical edema on best-corrected visual acuity(BCVA)in the early stages of diabetic retinopathy(DR).Methods:Ischemia was evaluated by the microvascular parameters measured by optical coherence tomography *** and subclinical edema were identified by the intraretinal layer thickness obtained by optical coherence *** with nonproliferative diabetic retinopathy(n=132)from 89 patients were *** were classified as having normal BCVA(n=88[66.7%],Snellen equivalent≥20/20)or decreased BCVA(n=44[33.3%],Snellen equivalentlinical edema was explored in patients with and without decreased BCVA,and correlations between BCVA and these pathological pathways were ***:Vessel density in the deep retinal capillary plexus(DRCP)and thickness of ganglion cell layer plus inner plexiform layer(GCL-IPL)were significantly lower in eyes with decreased BCVA compared with eyes with normal BCVA(both P<0.05).In the final multiple regression predictive model,age,DRCP vessel density,and GCL-IPL thickness(all P≤0.044)were predictors of *** vessel density and GCL-IPL thickness have an interactive effect on visual *** proportions of ischemia and neurodegeneration were significantly higher in eyes with decreased BCVA than in eyes with normal BCVA(P=0.001 and P=0.004,respectively).Conclusion:During the natural course of the early stages of DR,ischemia and neurodegeneration were the main disease pathways associated with visual acuity,and the mechanisms varied among patients.

关键词： Diabetic retinopathy Visual acuity Optical coherence tomography Ischemia Neurodegeneration

Associated risk factors in the early stage of diabetic retinopathy

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Eye and Vision 2019年第1期6卷 191-200页

作者： Fan Tan Qi Chen Xiran Zhuang Chaoming Wu Yanying Qian Yuanyuan Wang Jianhua Wang Fan Lu Meixiao Shen yingzi li School of Ophthalmology and Optometry Wenzhou Medical University270 Xueyuan RoadWenzhouZhejiangChina325027 Department of Ophthalmology West China-Guang’an HospitalSichuan UniversityGuang’anSichuanChina Department of Ophthalmology Sichuan University West China HospitalChengduSichuanChina The Second Affiliated Hospital&Yuying Children’s Hospital of Wenzhou Medical University WenzhouZhejiangChina Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA Electrical and Computer Engineering University of MiamiMiamiFLUSA

Background:To investigate the retinal capillary density(RCD)of the macula using optical coherence tomography angiography(OCT-A)in type 2 diabetic patients and to further determine the association with risk ***:A total of 212 eyes from 212 subjects were recruited;subjects included diabetics with no retinopathy(NDR,n=90 eyes),diabetics with mild retinopathy DR(MDR,n=36 eyes),and healthy participants(Control,n=86 eyes).All participants underwent OCT-A *** was quantified by superficial and deep retinal capillary layers(SRCL and DRCL)from OCT-A ***:RCD in SRCL and DRCL was lower in NDR(Plications related to diabetes,and *** patients showed lower RCD in both the SRCL and DRCL when compared with healthy *** with age>55y,HbA1c>7%had significantly reduced DRCL(P8.2 mmol/L had significantly reduced SRCL and DRCL when compared to the other group of ***:Risk factors including older age,higher level of HbA1c,LDL-C and BUN,were associated with lower RCDs found in type 2 diabetic patients with and without mild DR by *** impairment of retinal capillary by OCT-A may play a key role in the early monitoring of management in diabetes.

关键词： Diabetic retinopathy Optical coherence tomography angiography Retinal capillary density Systematic risk factors

Pd-Catalyzed Stereospecific Glycosyl Cross-Coupling of Reversed Anomeric Stannanes for Modular Synthesis of Nonclassical C‑Glycosides

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Precision Chemistry 2024年第11期2卷 587-599页

作者： Guoqiang Cheng Bo Yang Yang Han Wei lin Siyuan Tao Yong Nian yingzi li Maciej A.Walczak Feng Zhu Frontiers Science Center for Transformative Molecules(FSCTM) Center for Chemical GlycobiologyShanghai Key Laboratory for Molecular Engineering of Chiral DrugsDepartment of Chemical BiologySchool of Chemistry and Chemical EngineeringZhangjiang Institute for Advanced StudyShanghai Jiao Tong UniversityShanghai 200240P.R.China School of Pharmacy Nanjing University of Chinese MedicineNanjingJiangsu 210023P.R.China Institute of Chemical Research of Catalonia(ICIQ) 43007 TarragonaSpain Department of Chemistry University of Colorado BoulderBoulderColorado 80309United States

Nonclassical C-glycosides,distinguished by their unique glycosidic bond connection mode,represent a promising avenue for the development of carbohydrate-based ***,the accessibility of nonclassical C-glycosides hinders broader investigations into their structural features and modes of ***,we present the first example of Pd-catalyzed stereospecific glycosylation of nonclassical anomeric stannanes with aryl or vinyl *** method furnishes desired nonclassical aryl and vinyl C-glycosides in good to excellent yields,while allowing for exclusive control of nonclassical anomeric *** significant note is the demonstration of the generality and practicality of this nonclassical C-glycosylation approach across more than 50 examples,encompassing various protected and unprotected saccharides,deoxy sugars,oligopeptides,and complex ***,biological evaluation indicates that nonclassical C-glycosylation modifications of drug molecules can positively impact their biological ***,extensive computational studies are conducted to elucidate the rationale behind differences in reaction reactivity,unveiling a transmetalation transition state containing silver(Ag)within a six-membered *** its remarkable controllability,predictability,and consistently high chemical selectivity and stereospecificity regarding nonclassical anomeric carbon and Z/E configuration,the method outlined in this study offers a unique solution to the longstanding challenge of accessing nonclassical C-glycosides with exclusive stereocontrol.

关键词： Glycosylation Cross-coupling Nonclassical C-glycosides Reversed anomeric stannanes Stereospecificity

联合国基于性别平等的语言政策:缘起、内容及影响

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云南师范大学学报（哲学社会科学版） 2022年第2期54卷 77-85页

作者：李英姿南开大学跨文化交流研究院天津300071

西方妇女运动的发展促使女性自我意识不断提高,随着社会性别主流化概念的推行,不同性别尤其是女性在语言方面遭遇的不平等问题愈发受到重视。这对语言政策产生了重大影响,并在世界范围内引发了语言使用的一系列变化。联合国在保证人权... 详细信息

西方妇女运动的发展促使女性自我意识不断提高,随着社会性别主流化概念的推行,不同性别尤其是女性在语言方面遭遇的不平等问题愈发受到重视。这对语言政策产生了重大影响,并在世界范围内引发了语言使用的一系列变化。联合国在保证人权的基础上出台了诸多关于语言性别平等的政策法规。文章探讨了这些政策法规产生的背景、具体内容以及对其他国家和国际组织等机构的影响。研究认为中国未来应充分发挥在联合国等国际组织语言政策相关文件制定、修订、评估等方面的作用,提高中国在语言治理议题包括语言性别平等方面的参与度和实践能力,进而提升中国语言治理规范的全球话语权,并推动区域合作和区域/全球治理的发展。

关键词：联合国语言政策性别平等

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中国现代文学研究会第九届年会综述

中国现代文学研究丛刊 2007年第4期 108-119页

作者：李英姿辽宁师范大学文学院 116029

由中国现代文学研究会主办、辽宁师范大学文学院承办的中国现代文学研究会第九届年会于2006年10月13日至15日在大连隆重召开。来自全国100余所高等院校、科研、出版机构等近260名从事中国现代文学研究和教学的专家、学者带着最新的学术... 详细信息

由中国现代文学研究会主办、辽宁师范大学文学院承办的中国现代文学研究会第九届年会于2006年10月13日至15日在大连隆重召开。来自全国100余所高等院校、科研、出版机构等近260名从事中国现代文学研究和教学的专家、学者带着最新的学术研究成果参加了会议。

关键词：中国现代文学研究文学研究会年会综述辽宁师范大学学术研究成果第九届年会高等院校出版机构

语言改革、教育普及与现代国家——浅议严修对中国语文现代化的推动

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南开学报（哲学社会科学版） 2022年第5期 126-133页

作者：李英姿南开大学跨文化交流研究院天津300071

清末民初,许多仁人志士尝试以语言文字改革作为中国社会现代化转型的突破口,严修即是其中的代表人物之一。他以支持官话合声字母、推动民族共同语形成所开展的一系列教育革新活动为切入点,探讨语言改革、教育普及与现代国家之间的密切... 详细信息

清末民初,许多仁人志士尝试以语言文字改革作为中国社会现代化转型的突破口,严修即是其中的代表人物之一。他以支持官话合声字母、推动民族共同语形成所开展的一系列教育革新活动为切入点,探讨语言改革、教育普及与现代国家之间的密切关系。严修在清末民初语文改革运动中发挥的引领作用极大地推动了中国语文现代化的进程,而在这一过程中西学东渐对其语言文字改革思想和实践有重要影响。

关键词：严修官话合声字母民族共同语教育普及现代国家