Inducement of Sechenov inhibition by EtOH and NA in the Bufo toad

作     者：LI RuXin JIA ShanShan LI YingZi CAO Yin CHENG XiuZhen XIE ZuoPing 

作者机构：Department of Biological Sciences and Biotechnology National State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University Beijing 100084 China Department of Physiology Weifang Medical University Weifang 261042 China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2008年第53卷第8期

页      面：1193-1196页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：the Major State Basic Research Development Program of China (973 Program) (Grant No. 2005CB522503) 

主　　题：乙醇 去甲肾上腺素 抑制作用 NA 蟾蜍 

摘      要：Central inhibition, discovered by Sechenov in 1862, suggests that electrically stimulating the forebrain or medulla oblongata in frog generally suppresses reflexes. However, the underlying molecular mechanisms are still unclear. Using ethanol (EtOH), noradrenalin (NA), and other neurotransmitters in thalamic preparations, Sechenov inhibition was stimulated in Bufo toads in this study. The result showed that, similar to Sechenov inhibition, the acute application of EtOH or NA excited the thalamus and prolonged the latency of withdrawal reflex. Our study evidences the involvement of α-adrenoceptors in such central inhibition, and explains the role of acute EtOH application in the in- duction of reflex inhibition.