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Straightforward Sulfonamidation via Metabisulfite-Mediated CrossCoupling of Nitroarenes and Boronic Acids under Transition-Metal-Free Conditionst

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Chinese Journal of Chemistry 2020年第12期38卷 1521-1525页

作者： yaping li Ming Wang Xuefeng Jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Norm al University3663 North Zhongshan RoadShanghai 200062China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China

of main observation and conclusion A straightforward multicomponent sufonamidation of nitroarenes,sodium metabisulfite and boronicacids was established under transition-mnetal-free conditions to access diverse sulfonamides from readily avilable and low-cost materials *** salt sodium metabisulfite not only served as a sulfur dioxide source,but also played a key role for both activator and reductant ***,naturlly occuring biomolecules and pharmaceuticals with multiple heteroatorms and sensitive functional groups were intensivly investigated in this transformtion providing versatile sulionamides collectively,further mechanistic studies demonstrated that nitrosoarene is thekey intermediate,and the activation of boronic acid is the rate-determining step in the transformation.

关键词： boron Transition straight

Smart drug delivery systems to overcome drug resistance in cancer immunotherapy

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Cancer Biology & Medicine 2023年第4期20卷 248-267页

作者： Wenzhe Yi Dan Yan Dangge Wang yaping li State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Department of Pharmaceutics School of PharmacyNanjing Medical UniversityNanjing 211116China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264000China

Cancer immunotherapy,a therapeutic approach that inhibits tumors by activating or strengthening anti-tumor immunity,is currently an important clinical strategy for cancer treatment;however,tumors can develop drug resistance to immune surveillance,resulting in poor response rates and low therapeutic *** addition,changes in genes and signaling pathways in tumor cells prevent susceptibility to immunotherapeutic ***,tumors create an immunosuppressive microenvironment via immunosuppressive cells and secrete molecules that hinder immune cell and immune modulator infiltration or induce immune cell *** address these challenges,smart drug delivery systems(SDDSs)have been developed to overcome tumor cell resistance to immunomodulators,restore or boost immune cell activity,and magnify immune *** combat resistance to small molecules and monoclonal antibodies,SDDSs are used to co-deliver numerous therapeutic agents to tumor cells or immunosuppressive cells,thus increasing the drug concentration at the target site and improving ***,we discuss how SDDSs overcome drug resistance during cancer immunotherapy,with a focus on recent SDDS advances in thwarting drug resistance in immunotherapy by combining immunogenic cell death with immunotherapy and reversing the tumor immunosuppressive *** that modulate the interferon signaling pathway and improve the efficacy of cell therapies are also ***,we discuss potential future SDDS perspectives in overcoming drug resistance in cancer *** believe that this review will contribute to the rational design of SDDSs and development of novel techniques to overcome immunotherapy resistance.

关键词： Cancer immunotherapy drug resistance smart drug delivery system immunosuppressive microenvironment immune cell

Nanocarriers for siRNA delivery to overcome cancer multidrug resistance

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Chinese Science Bulletin 2013年第33期58卷 4021-4030页

作者： MENG QingShuo YIN Qi li yaping Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of Sciences

Multidrug resistance(MDR)is an extremely complexed phenomenon in tumor chemotherapy and is one of the major obstacles for successful *** of RNA interference(RNAi)offers a new strategy with great potential to reverse *** genes,which contribute to the emerging of MDR,can be silenced by ***,many natural barriers have to be overcome for efficient and safe delivery of *** recent years,the various kinds of nanocarriers,such as liposomes,cationic polymers,and inorganic materials,have been developed to deliver siRNA and show good results in reversing *** review mainly summarizes the barriers in siRNA delivery and recent progress in designing nanotechnology-based siRNA delivery systems to overcome tumor MDR.

关键词： siRNA 纳米载体递送耐药性癌症阳离子聚合物多药耐药 RNAi

Facile Fabrication of Polymeric Ionic liquid Grafted Porous Polymer Monolith for Mixed-Mode High Performance liquid Chromatography

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Chinese Journal of Chemistry 2014年第7期32卷 619-625页

作者： yaping li li Qi Ying Shen Haizhi Zhang Huimin Ma Beijing National Laboratory of Molecular Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

A novel polymeric ionic liquid grafted porous polymer monolith has been facilely fabricated for mixed-mode *** column is prepared from poly(glycidyl methacrylate-co-ethylene dimethacrylate)monolith through hydrolyzation of the epoxy moieties into hydroxyl groups,followed by“grafting from”polymerization of ionic liquid of 1-vinyl-3-butylimidazolium *** modification is characterized by scanning electron microscope,infrared spectroscopy,elemental analysis and mercury intrusion *** HPLC performance of developed column is evaluated by separating acidic vitamin B analytes,neutral steroids and basic aromatic amines in mixed-mode chromatography on a single column,*** ionic liquid affords the monolith with both enhanced separation ability and improved column efficiency.

关键词： porous polymer monolith ionic liquid mixed-mode chromatography

Current approaches of nanomedicines in the market and various stage of clinical translation

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3028-3048页

作者： Xiaoting Shan Xiang Gong Jie li Jingyuan Wen yaping li Zhiwen Zhang State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China School of Pharmacy University of AucklandAuckland 1142New Zealand

Compared with traditional drug therapy,nanomedicines exhibit intriguing biological features to increase therapeutic efficiency,reduce toxicity and achieve targeting *** review provides a snapshot of nanomedicines that have been currently launched or in the clinical trials,which manifests a diversified trend in carrier types,applied indications and mechanisms of *** the perspective of indications,this article presents an overview of the applications of nanomedicines involving the prevention,diagnosis and treatment of various diseases,which include cancer,infections,blood disorders,cardiovascular diseases,immuno-associated diseases and nervous system diseases,***,the review provides some considerations and perspectives in the research and development of nanomedicines to facilitate their translations in clinic.

关键词： Nanomedicines Nanoparticles liposomes Vaccines Marketed products Clinical translations Disease-driven design Quality by design

Synthesis of liquid-like Trisilanol Isobutyl-POSS NOHM and Its Application in Capturing CO2

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Chemical Research in Chinese Universities 2015年第3期31卷 484-488页

作者： BAI Haipeng ZHENG yaping li Peipei ZHANG Aibo School of Natural and Applied Science Northwestern Polytechnical University Xi&#39 an 710072 P.R.China

The trisilanol isobutyl polyhedral oligomeric silsesquioxane（POSS） was fabricated into liquid-like nano- particle organic hybrid materials（NOHMs） with ）,-（2,3-epoxypropoxy）propytrimethoxysilane as corona and polyethe- ramine M2070 as canopy, and the product was called liquid-like POSS NOHM. The liquid-like POSS NOHM has a low viscosity at room temperature without any solvent and the mass fraction of trisilanol isobutyl POSS was 23.38%. The liquid-like POSS NOHM shows great CO2 capturing property with a capacity of 2.108 mmol/g（PCO2=6 MPa）. The physical adsorption increased obviously with the pressure going up and it may make a difference between liquid-like POSS NOHMs and traditional monoethamolamine（MEA） based CO2 absorbent. The recycle property was also studied. The NOHM behaved as fresh product even after 10 cycles.

关键词： liquid-like nanoparticle organic hybrid material Polyhedral oligomeric silsesquioxane CO2 capture

Optimal Frequency Regulation Based on Characterizing the Air Conditioning Cluster by Online Deep Learning

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CSEE Journal of Power and Energy Systems 2022年第5期8卷 1373-1387页

作者： Yeyan Xu liangzhong Yao Siyang liao yaping li Jian Xu Fan Cheng School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China China Electric Power Research Institute Nanjing 210008China China Electric Power Research Institute Beijing 100085China

The air conditioning cluster(ACC)is a potential candidate to provide frequency regulation ***,the effective assessment of the ACC willing reserve capacity is often an obstacle for existing demand response(DR)programs,influenced by incentive prices,temperatures,*** this paper,the complex relationship between the ACC willing reserve capacity and its key influence factors is defined as a demand response characteristic(DRC).To learn about DRC along with real-time frequency regulation,an online deep learning-based DRC(ODLDRC)modeling methodology is designed to continuously retrain the deep neural network-based *** ODL-DRC model trained by incoming new data does not require massive historical training data,which makes it more ***,the coordinate operation between ODL-DRC modeling and optimal frequency regulation(OFR)is presented.A robust decentralized sliding mode controller(DSMC)is designed to manage the ACC response power in primary frequency regulation against any ACC response *** ODL-DRC model-based OFR scheme is formulated by taking the learning error into ***,the ODL-DRC model can be applied to minimize the total operational cost while maintaining frequency stability,without waiting for a well-trained *** simulation cases validate the superiority of the OFR based on characterizing the ACC by online learning,which can capture the real DRC and simultaneously optimize the regulation performance with strong robustness against any ACC response uncertainty and learning error.

关键词： Air conditioning demand response characteristic online deep learning optimal frequency regulation sliding mode control

Analysis of GC×GC fingerprints from medicinal materials using a novel contour detection algorithm:A case of Curcuma wenyujin

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Journal of Pharmaceutical Analysis 2024年第4期14卷 542-551页

作者： Xinyue Yang Yingyu Sima Xuhuai Luo yaping li Min He Department of Pharmaceutical Engineering School of Chemical EngineeringXiangtan UniversityXiangtanHunan411105China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha410082China Department of Quality Control Xiangtan Central HospitalXiangtanHunan411100China

This study introduces an innovative contour detection algorithm,PeakCET,designed for rapid and efficient analysis of natural product image fingerprints using comprehensive two-dimensional gas chromatogram(GC×GC).This method innovatively combines contour edge tracking with affinity propagation(AP)clustering for peak detection in GC×GC fingerprints,the first in this *** edge tracking signif-icantly reduces false positives caused by“burr”signals,while AP clustering enhances detection accuracy in the face of false *** efficacy of this approach is demonstrated using three medicinal products derived from Curcuma *** not only performs contour detection but also employs inter-group peak matching and peak-volume percentage calculations to assess the compositional similarities and differences among various ***,this algorithm compares the GC×GC fingerprints of Radix/Rhizoma Curcumae Wenyujin with those of products from different botanical *** findings reveal that genetic and geographical factors influence the accumulation of secondary metabolites in various plant *** sample exhibits unique characteristic components alongside common ones,and vari-ations in content may influence their therapeutic *** research establishes a foundational data-set for the quality assessment of Curcuma products and paves the way for the application of computer vision techniques in two-dimensional(2D)fingerprint analysis of GC×GC data.

关键词： GC×GC Image fingerprints Contour detection Clustering of mass spectra Curcuma products

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肉苁蓉种子离散元仿真参数标定

农机化研究 2025年第2期47卷 19-26,53页

作者：白志业蒙贺伟彭慧杰戚江涛李亚萍坎杂石河子大学机械电气工程学院新疆石河子832000

为寻求肉苁蓉种子离散元模型的物料特性参数,采用物理和仿真试验相结合的方法,以不同物性参数组合下肉苁蓉种子休止角为响应值,采用Plackett-Burman试验对参数进行筛选,获取显著性参数,即肉苁蓉种间静摩擦因数、肉苁蓉种间动摩擦因数、... 详细信息

为寻求肉苁蓉种子离散元模型的物料特性参数,采用物理和仿真试验相结合的方法,以不同物性参数组合下肉苁蓉种子休止角为响应值,采用Plackett-Burman试验对参数进行筛选,获取显著性参数,即肉苁蓉种间静摩擦因数、肉苁蓉种间动摩擦因数、肉苁蓉种子-钢板静摩擦因数、肉苁蓉种子-钢板恢复系数。通过Box-Behnken试验建立休止角与显著性参数回归模型并优化,获取接触参数最优值,即肉苁蓉种间静摩擦因数为0.65、肉苁蓉种间动摩擦因数为0.07、肉苁蓉种子-钢板恢复因数为0.54、肉苁蓉种子-钢板静摩擦因数为0.43。通过仿真与物理试验对比验证,得到二者相对误差为2.05%,表明标定参数可为肉苁蓉种子播种机械仿真提供数据依据。

关键词：肉苁蓉种子休止角离散元参数标定播种机械