Nanocarriers for siRNA delivery to overcome cancer multidrug resistance

作     者：MENG QingShuo YIN Qi LI YaPing 

作者机构：Center of PharmaceuticsShanghai Institute of Materia MedicaChinese Academy of Sciences 

出 版 物：《Chinese Science Bulletin》 (Chinese Science Bulletin)

年 卷 期：2013年第58卷第33期

页      面：4021-4030页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Basic Research Program of China(2010CB934000,2012CB932502,2013CB932503) the National Natural Science Foundation of China(30925041,81270047) Shanghai Elitist Program(11XD1406200) 

主　　题：siRNA 纳米载体 递送 耐药性 癌症 阳离子聚合物 多药耐药 RNAi 

摘      要：Multidrug resistance(MDR)is an extremely complexed phenomenon in tumor chemotherapy and is one of the major obstacles for successful *** of RNA interference(RNAi)offers a new strategy with great potential to reverse *** genes,which contribute to the emerging of MDR,can be silenced by ***,many natural barriers have to be overcome for efficient and safe delivery of *** recent years,the various kinds of nanocarriers,such as liposomes,cationic polymers,and inorganic materials,have been developed to deliver siRNA and show good results in reversing *** review mainly summarizes the barriers in siRNA delivery and recent progress in designing nanotechnology-based siRNA delivery systems to overcome tumor MDR.