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Journal of Integrative Agriculture 2021年第9期20卷 2483-2490页

作者： WU Ping-xian ZHOU Jie WANG Kai chen De-juan yang Xi-di liU Yi-hui JIANG An-an SHEN lin-yuan JIN Long XIAO Wei-hang JIANG Yan-zhi li ming-zhou ZHU li ZENG yang-shuang XU Xu qiu Xiao-tian li xue-wei TANG Guo-qing Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China College of life Science Sichuan Agricultural UniversityYa’an 625014P.R.China sichuan Animal Husbandry Station Chengdu 610041P.R.China National Animal Husbandry Service Beijing 100125P.R.China

Birth weight(BW)and days to 100 kg(D100)are important economic traits that are both affected by ***,the genetic architecture of these quantitative traits is still ***-by-sequencing(GBS)data containing a large number of single nucleotide polymorphisms(SNPs)have become a powerful tool in genomic *** better understand their complex genetic structure,a total of 600 Yorkshire pigs were sequenced using GBS *** quality control,279787 SNPs were generated for subsequent genome-wide association study(GWAS).A total of 30 genome-wide SNPs(Psition:46226512 bp)were evaluated to affect both BW and D100 in Yorkshire pigs,indicating the pleiotropism in different *** the function of candidate genes,two genes,NSRP1 and DOCK7,were suggested as the most promising candidate genes involved in growth ***,use of GBS is able to identify novel variants and potential candidate genes for BW and D100,and provide an opportunity for improving pig growth traits using genomic selection in pigs.

关键词： genotyping-by-sequencing GWAS birth weight days to 100 kg Yorkshire pigs

Characterization of inflammatory factor-induced changes in mesenchymal stem cell exosomes and sequencing analysis of exosomal microRNAs

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World Journal of Stem Cells 2019年第10期11卷 859-890页

作者： chen huang Wen-Feng Luo Yu-Feng Ye li lin Zhe Wang ming-Hua Luo Qi-De Song xue-Ping He Han-Wei chen Yi Kong Yu-Kuan Tang Department of Minimally Invasive Interventional Radiology Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Jinan University Guangzhou 510632Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou 511400Guangdong ProvinceChina Jinan University Biomedical Translational Research Institute Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Pharmacy the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Radiology Shiyan People’s HospitalShenzhen 518108Guangdong ProvinceChina

BACKGROUND Treatments utilizing stems cells often require stem cells to be exposed to inflammatory environments,but the effects of such environments are *** To examine the effects of inflammatory cytokines on the morphology and quantity of mesenchymal stem cell exosomes(MSCs-exo)as well as the differential expression of microRNAs(miRNAs)in the *** MSCs were isolated from human umbilical tissue by enzymatic *** were then collected after a 48-h incubation period in a serum-free medium with one of the following the inflammatory cytokines:None(control),vascular cell adhesion molecule-1(VCAM-1),tumor necrosis factor(TNF)α,and interleukin(IL)*** morphology and quantity of each group of MSC exosomes were observed and *** miRNAs in MSCs-exo were *** compared the sequenced data with the miRBase and other non-coding databases in order to detect differentially expressed miRNAs and explore their target genes and regulatory *** vitro tube formation assays and Western blot were performed in endothelial cells which were used to assess the angiogenic potential of MSCs-exo after inflammatory cytokine *** MSCs-exo were numerous,small,and regularly shaped in the VCAM-1 ***αstimulated MSCs to secrete larger and irregular ***6 led to a reduced quantity of *** to the control group,the TNFαand IL6 groups had more downregulated differentially expressed miRNAs,particularly angiogenesis-related *** angiogenic potential of MSCs-exo declined after IL6 *** TNFαand IL6 may influence the expression of miRNAs that down-regulate the PI3K-AKT,MAPK,and VEGF signaling pathways;particularly,IL6 significantly down-regulates the PI3K-AKT signaling ***,inflammatory cytokines may lead to changes in exosomal miRNAs that abnormally impact cellular components,molecular function,and biological processes.

关键词： Mesenchymal stem cells Exosomes MiRNA Inflammatory cytokines Angiogenesis

High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi liu Qing-Yuan Qu Ying Lei Qi chen Yu-Xiu chen Meng-lin li xue-Yan Sun Ye-Jun Wu qiu-Sha huang Hai-Xia Fu Yuan Kong Yue-Ying li Qian-Fei Wang Xiao-Jun huang Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

Observation of spectral lines in the exceptional GRB 221009A

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-qiu Zhang Shao-lin Xiong Ji-Rong Mao Shuang-Nan Zhang Wang-chen xue Chao Zheng Jia-Cong liu Zhen Zhang Xi-Lu Wang ming-Yu Ge Shu-Xu Yi li-ming Song Zheng-Hua An Ce Cai Xin-Qiao li Wen-Xi Peng Wen-Jun Tan chen-Wei Wang Xiang-yang Wen Yue Wang Shuo Xiao Fan Zhang Peng Zhang shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China College of Electronic and Information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China

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Biomedical and Environmental Sciences 2009年第4期22卷 340-344页

作者： GONG chen li-JUN PEI JIAN huang XIN-ming SONG liANG-ming lin xue GU JIAN-XIN WU FANG WANG JI-LEI WU JIA-PENG chen JU-FEN liU ruO-LEI XIN TING ZHANG XIAO-YING ZHENG Institute of Population Research Peking University Beijing 100871 China Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China Capital Institute of Pediatrics Beijing 100020 China

Objective To study the prevalence of different types of neural tube defects （NTDs） in Luliang Prefecture, Shanxi province, where the prevalence of NTDs is unusually high and the correlation between NTDs prevalence and patterns. Methods A surveillance population-based birth defects was performed in Luliang Prefecture, Shanxi province. Results The results of our study showed that the prevalence of NTDs was 2-fold higher in Luliang Prefecture than in other areas of Shanxi province. Unusual patterns of NTDs were found, however, multiple NTDs were relatively common in Luliang Prefecture, accounting for over 13% of all NTDs cases in China. Conclusion The prevalence of NTDs is associated with its patterns.

关键词： Neural tube defects Epidemiology Geographic variation

Intratumoral CD103^(+)CD8^(+)T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma

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Cancer Communications 2023年第10期43卷 1143-1163页

作者： siqi Ren Tianjun Lan Fan Wu Suling chen xue Jiang Chuying Huo Zitian li Shule Xie Donghui Wu ruixin Wang Yanyan li lin qiu Guoxin huang Shurui li Xiaojuan Wang Meifeng Cen Tingting Cai Zhaoyu lin Jinsong li Bowen li Department of Oral and Maxillofacial Surgery Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangdongP.R.China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangdongP.R.China Department of Gynecological Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangdongP.R.China School of Stomatology Jilin UniversityJilinP.R.China Stomatology Hospital of Haizhu district GuangdongP.R.China

Background Immune cell heterogenicity is known to determine the therapeutic response to cancer *** chemoimmunotherapy(NACI)has shown clinical benefits in some patients with advanced head and neck squamous cell carcinoma(HNSCC),but the underlying mechanism behind this clinical response is *** efficacy of NACI needs to be potentiated by identifying accurate biomarkers to predict clinical ***,we attempted to identify molecules predicting NACI response in advanced *** We performed combined single-cell RNA sequencing(scRNA-seq)and multiplex immunofluorescence(mIHC)staining with tumor samples derived from NACI-treated HNSCC patients to identify a new tumor-infiltrating cell(TIL)subtype,CD103^(+)CD8^(+)TILs,associated with clinical response,while both in vitro and in vivo assays were carried out to determine its antitumor *** regulatory mechanism of the CD103^(+)CD8^(+)TILs population was examined by performing cell-cell interaction analysis of the scRNA-seq data and spatial analysis of the mIHC *** We established intratumoral CD103^(+)CD8^(+)TILs density as a determinant of NACI efficacy in *** scRNA-seq results indicated that the population of CD103^(+)CD8^(+)TILs was dramatically increased in the responders of NACI-treated HNSCC patients,while mIHC analysis confirmed the correlation between intratumoral CD103^(+)CD8^(+)TILs density and NACI efficacy in HNSCC *** receiver operating characteristic curve analysis defined this TIL subset as a potent marker to predict patient response to *** assays showed that CD103^(+)CD8^(+)TILs were tumor-reactive T cells,while programmed cell death protein-1(PD-1)blockade enhanced CD103^(+)CD8^(+)TILs cytotoxicity against tumor growth in ***,targeting the triggering receptor expressed on myeloid cells 2-positive(TREM2^(+))macrophages might enhance the population of CD103^(+)CD8^(+)TILs and facilitate antitumor immunity

关键词： CD103 CD8 head and neck squamous cell carcinoma neoadjuvant chemoimmunotherapy predictive marker tumor-infiltrating lymphocyte

In-flight Energy Calibration of the GECAM Gamma-ray Detectors

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Research in Astronomy and Astrophysics 2024年第10期24卷 48-57页

作者： rui Qiao Dong-Ya Guo Wen-Xi Peng Yan-qiu Zhang Shuo Xiao Shao-lin Xiong Chao Zheng Chao-yang li Jia-Cong liu Wang-chen xue Jian-Jian He Zheng-Hua An Da-li Zhang Xin-Qiao li li-ming Song shi-Jie Zheng Ke Gong Ya-Qing liu Xin-Ying Song Xiao-Yun Zhao Xiang-yang Wen Yan-Bing Xu Xiang Ma Xiao-Bo li Ping Wang Yue huang Ce Cai Qi-Bin Yi Yi Zhao chen-Wei Wang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China China West Normal University Nanchong 637002China Xiangtan University Xiangtan 411105China Beijing Normal University Beijing 100875China

The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient *** mission consists of two microsatellites which are planned to operate at the opposite sides of the *** GECAM satellite could detect and localize GRBs in about 8 keV-5 MeV with its 25 Gamma-Ray Detectors(GRDs).In this work,we report the in-flight energy calibration of GRDs using the characteristic gamma-ray lines in the background spectra,and show their performance evolution during the commissioning ***,a preliminary cross-calibration of energy response with Fermi GBM data is also presented,validating the energy response of GRDs.

关键词： (stars:)gamma-ray burst:general instrumentation:detectors methods:data analysis

高稳定性金属有机配位聚合物膜的制备及二甲苯分离性能

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高等学校化学学报 2013年第11期34卷 2457-2461页

作者：康子曦薛铭范黎黎黄麟卫国英裘式纶吉林大学化学学院无机合成与制备化学国家重点实验室长春130012

以常见的多孔二氧化硅为载体,采用晶种-二次生长法在溶剂热条件下制备了高稳定性的金属有机配位聚合物膜材料.通过X射线衍射、扫描电子显微镜、单组分气体透过率和二甲苯同分异构体分离等测试手段对材料的结构、形貌和性质等进行了表征... 详细信息

以常见的多孔二氧化硅为载体,采用晶种-二次生长法在溶剂热条件下制备了高稳定性的金属有机配位聚合物膜材料.通过X射线衍射、扫描电子显微镜、单组分气体透过率和二甲苯同分异构体分离等测试手段对材料的结构、形貌和性质等进行了表征.二甲苯同分异构体的渗透汽化分离结果表明,这种多孔膜材料对二甲苯混合物具有选择性吸附分离的性质.进一步通过热处理、超声处理和性能的重复表征,证明了该膜材料具有优良的热稳定性和机械稳定性,适于实际应用.

关键词：金属有机配位聚合物分离膜二甲苯同分异构体高稳定性

Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： Luo-Xi XIAO Zi-Yu WANG Jiang-Tao li Hai-Mei WANG Yi-ming HAO Pan ZHOU Yu-lin huang qiu-Ju DENG Yong-chen HAO Na yang li-Zhen HAN Zhao yang Ping-Ping JIA Yue QI Jing liU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONsiDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle

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Zoological Research 2022年第2期43卷 275-284页

作者： Chun-Long Yan Jun lin Yuan-Yuan huang Qing-Shan Gao Zheng-Yu Piao Shou-li Yuan li chen xue Ren Rong-Cai Ye Meng Dong Han-lin Zhang Hui-Qiao Zhou Xiao-Xiao Jiang Wan-Zhu Jin Xu-ming Zhou Chang-Guo Yan College of Agriculture Yanbian UniversityYanjiJilin 133000China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China North-East Cold Region Beef Cattle Science&Technology Innovation Ministry of Education Engineering Research Center Yanbian UniversityYanjiJilin 133000China Annoroad Gene Technology Co.Ltd Beijing 100176China

Environmental temperature serves as a major driver of adaptive changes in wild *** discover the mechanisms underpinning cold tolerance in domestic animals,we sequenced the genomes of 28 cattle from warm and cold areas across *** characterizing the population structure and demographic history,we identified two genetic clusters,i.e.,northern and southern groups,as well as a common historic population peak at 30 kilo years *** scan of cold-tolerant breeds determined potential candidate genes in the thermogenesis-related pathways that were under ***,functional analysis identified a substitution of PRDM16(p.P779 L)in northern cattle,which maintains brown adipocyte formation by boosting thermogenesis-related gene expression,indicating a vital role of this gene in cold *** findings provide a basis for genetic variation in domestic cattle shaped by environmental temperature and highlight the role of reverse mutation in livestock species.

关键词： Population genomics Cattle Cold tolerance PRDM16 Brown adipose tissue