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Effects of Chinese Medicine on Symptoms,Syndrome Evolution,and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge:A Prospective Cohort and Nested Case-Control Study

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Chinese Journal of Integrative Medicine 2021年第4期27卷 245-251页

作者： li li GOU Chun-yan li Xue-mei SONG Wen-yan WANG Xiao-jun li hong-ying li hong-yan li Xiu-hui Integrated Traditional Chinese and Western Medicine Center Beijing Youan HospitalCapital Medical UniversityBeijing(100069)China Chronic Disease Management Center Beijing Youan HospitalCapital Medical UniversityBeijing(100069)China Department of Radiology Beijing Youan HospitalCapital Medical UniversityBeijing(100069)China

Objective:To observe the changes of symptoms,Chinese medicine(CM)syndrome,and lung inflammation absorption during convalescence in patients with coronavirus disease 2019(COVID-19)who had not totally recovered after hospital discharge and whether CM could promote the improvement ***:This study was designed as a prospective cohort and nested case-control study.A total of 96 eligible patients with COVID-19 in convalescence were enrolled from Beijing Youan Hospital and Beijing Huimin Hospital and followed up from the hospital discharged *** were divided into the CM(64 cases)and the control groups(32 cases)based on the treatment with or without CM and followed up at 14,28,56,and 84 days after *** the CM group,patients received the 28-day CM treatment according to two types of CM *** in clinical symptoms,CM syndrome,and absorption of lung inflammation were ***:All the 96 patients completed the 84-day follow-up from January 21 to March 28,*** the 84th day of follow-up,respiratory symptoms were less than 5%.There was no significant difference in the improvement rates of symptoms,including fatigue,sputum,cough,dry throat,thirst,and upset,between the two groups(P>0.05).Totally 82 patients(85.42%)showed complete lung inflammation absorption at the 84-day *** day 14,the CM group had a significantly higher absorption rate than the control group(P<0.05)and the relative risk of absorption for CM *** group was 3.029(95%confidence interval:1.026-8.940).The proportions of CM syndrome types changed with time prolonging:the proportion of the pathogen residue syndrome gradually decreased,and the proportion of both qi and yin deficiency syndrome gradually ***:Patients with COVID-19 in convalescence had symptoms and lung inflammation after hospital discharge and recovered with time *** could improve lung inflammation for early *** types of CM syndrome can be transformed wi

关键词： COVID-19 convalescent patient Chinese medicine syndrome evolution pneumonia absorption

Reanalysis of the RXTE observations of the black-hole candidate XTE J1650-500 in the 2001/2002 outburst

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Research in Astronomy and Astrophysics 2012年第3期12卷 269-286页

作者： li-hong yan Jian-Cheng Wang National Astronomical Observatories/Yunnan Observatory Chinese Academy of SciencesKunming 650011China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650011China Graduate University of Chinese Academy of Sciences Beijing 100049China

We present the results of the spectral fits made to 59 Rossi X-ray Timing Explorer （RXTE） observations of the Galactic X-Ray Black-Hole Candidate XTE J1650–500 covering the first 30d of its 2001/2002 outburst when the source was in a transition from the hard state to the soft state. The photon spectra can be well fit- ted with a phenomenological model of a power-law/cutoff power-law and a physical model of bulk-motion Comptonization. The spectral properties smoothly evolve away from the hard state and then stay in the soft state. The fitting results of the physical model reveal the peak of the burst had a flux of 2.90 × 10-8 erg cm-2 s-1 in the 2–100 keV energy range and was observed on 2001 Sep. 9; it transitioned to the hard state. The total flux decays by a factor of ～3 as it evolves into the soft state. The photon index Γ increases from ～1.5 in the hard state and stays at ～2.5 in the soft state. We found that the effective area of the high-energy X-ray emission region （the Compton cloud） decreases, i.e. the area of the Compton cloud decreases by a factor of ～23 during the transition from the hard state to the soft state. Combining the new radio and quasi-periodic oscillation studies, the model of total flux in the 2–100 keV energy range, the jet emission and the timing analysis during the state transition, we suggest a possible geometry and evolution for the （jet＋corona＋disk） system, like that proposed by Kalemci et al. based on enhanced lags and peak frequency shift during the transition.

关键词： accretion accretion disks—black hole physics—X-rays binaries: in- dividual (XTE J1650–500)—X-rays: stars

Origin of power-law X-ray emission in the steep power-law state of X-ray binaries

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Research in Astronomy and Astrophysics 2011年第6期11卷 631-636页

作者： li-hong yan Jian-Cheng Wang Yunnan Observatory /National Astronomical Observatories Key Laboratory for the Structure and Evolution of Celestial ObjectsChinese Academy of SciencesKunming 650011China Graduate School of Chinese Academy of Sciences Beijing 100049China

We present a new explanation for the origin of the steep power-law（SPL） state of X-ray *** power-law component of X-ray emission is the synchrotron radiation of relativistic electrons in highly magnetized compact spots orbiting near the inner stable circular orbit of a black *** has a hard spectrum that extends to above MeV energies,which is determined by the electron acceleration *** photons are then down-scattered by the surrounding plasma to form an observed steep *** discuss the relevance of the model to high-frequency quasi-periodic oscillations and the extremely high luminosity of the SPL state.

关键词： accretion accretion disks-black hole physics-radiation mechanisms:nonthermal-X-rays:binaries

Analysis of subscription characteristics and user mobility in different types of MMORPGs

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 121-128页

作者： PENG Hui SUN yan-li WU hong School of Economics and Management Beijing University of Posts and Telecommunications Beijing 100876 China

Massively multiplayer online role-playing game（MMORPG） is one of the fastest-growing segments of the online game *** subscription refers to game accounts logged in during a certain period of *** user mobility explains the dynamics of subscriber size *** article explores the subscription characteristics and user mobility in different types of *** is found that subscription characteristics in different types of MMORPGs are marked by *** one hand,the curve of competition-based game subscription is linear,and the stability period is short,therefore it is necessary for the game operators to introduce new versions *** the other hand,the gradient rate of subscription in the community-based game is slow at first and then fast,and the stability period is long,hence it will take the game operator a long cycle to launch a new *** difference of subscription curve is caused by the fact that user mobility in competition-based game is higher than in the community-based game,as attractiveness of community-based game can maintain a longer period due to network *** purpose of the study is to help the game operator to understand the development stage and features of the game and to make effective decisions to attract more players.

关键词： virtual reality online game subscription characteristics user mobility subscription curve life cycle MMORPG

20(S)-20-O-Camptothecin β-Aminopropionate: Novel Synthesis and Antitumor Activity in vitro

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Chemical Research in Chinese Universities 2006年第6期22卷 727-731页

作者： li Yu-yan YOU Qi-dong WANG Lei CHEN Sheng CHEN Xiao-guang li yan li hong-yan Department of Medicinal Chemistry School of Pharmacy China Pharmaceutical University Nanjing 210009 P. R. China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College eijing 100050 P.R. China

To improve the biological anticancer activity of 20 （S）-camptothecin, a novel class of 20 （S）-20-O-camptotheein β-aminopropionates were designed and synthesized with eamptothecins as the starting materials, through acylation with acryloyl chloride followed by Michael＇s addition. Twelve esters, 1a-1d, 4a-4d and 5a-5d, were synthesized and evaluated by using MTT assay method. The results demonstrate that all these compounds show a potential eytotoxicity on KB, HT-29, HCT-8, and Bel7402 tumor cell lines. Some compounds, 1d, 4c, 5b, 5c and 5d, show a higher cytoto-xicity on KB and HCT-8 compared with eamptotheein.

关键词： Camptothecin β-Aminopropionate Anticancer Synthesis

Vertex Distinguishing Equitable Total Chromatic Number of Join Graph

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Acta Mathematicae Applicatae Sinica 2007年第3期23卷 433-438页

作者： Zhi-wen Wang li-hong yan Zhong-fuZhang Department of Mathematics of Yeungnam University Daedong Kyongsan Kyongbuk 712-749 Korea Department of Mathematics of Xianyang Normal University Xianyang 712000 China School of Mathematics of Lanzhou Jiaotong University Lanzhou 730070 China

A vertex distinguishing equitable total coloring of graph G is a proper total coloring of graph G such that any two distinct vertices＇ coloring sets are not identical and the difference of the elements colored by any two colors is not more than 1. In this paper we shall give vertex distinguishing equitable total chromatic number of join graphs Pn VPn, Cn VCn and prove that they satisfy conjecture 3, namely, the chromatic numbers of vertex distinguishing total and vertex distinguishing equitable total are the same for join graphs Pn V Pn and Cn ∨ Cn.

关键词： Path cycle join graph vertex distinguishing equitable total chromatic number

Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第6期8卷 428-434页

作者： XIANG yan li Yu-hong Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To compare the effects of epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine on propofol requirements, the time to loss of consciousness （LOC）, effect-site propofol concentrations, and the hemodynamic variables during induction of general anesthesia guided by bispectral index （BIS） were studied. Methods： Forty-five patients were divided into three groups to receive epidurally administered saline （Group S）, 1.5% （w/w） lidocaine （Group L）, or 0,5% （w/w） ropivacaine （Group R） Propofol infusion was started to produce blood concentration of 4 lag/ml. Once the BIS value reached 40-50, endotracheal intubation was facilitated by 0.1 mg/kg vecuronium. Measurements included the time to LOC, effect-site propofol concentrations, total propofol dose, mean arterial blood pressure （MABP）, and heart rate （HR） at different study time points. Results： During induction of anesthesia, both Groups L and R were similar for the time to LOC, effect-site propofol concentrations, total propofol dose, MABP, HR, and BIS. The total doses of propofol administered until 1 min post-intubation were significantly less in patients of Groups R and L compared with Group S. MABP and HR were significantly lower following propofol induction compared with baseline values in the three groups, or MABP was significantly increased following intubation as compared with that prior to intubation in Group S but not in Groups R and L while HR was significantly increased following intubation in the three groups. Conclusion： Epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine has similar effects on the time to LOC, effect-site propofol concentrations, total propofol dose, and the hemodynamic variables during induction of general anesthesia.

关键词： Propofol lidocaine Ropivacaine Epidural anethesia Bispectral index

Expression and clinical significance of S100A2 and p63 in esophageal carcinoma

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World Journal of Gastroenterology 2009年第33期15卷 4183-4188页

作者： li-Yu cao Yu Yin Hao li yan Jiang hong-Fu Zhang Department of Pathology Anhui Medical University Hefei 230032 Anhui Province China

AIM： TO investigate the expression and clinical significance of S100A2 mRNA and protein, p63 protein in esophageal squamous cell carcinoma （ESCC） and their roles in carcinogenesis and progression of esophageal carcinoma （EC）. METHODS： Immunohistochemical staining （S-P method） for S100A2 and p63 protein were performed in 40 samples of ESCC and 40 samples of normal esophageal mucosa. In situ hybridization （ISH） was used to detect the expression of S100A2 mRNA. RESULTS： Expression of S100A2 mRNA in ESCC was positive in 77.5% of samples, which was lower than that in normal mucosa （100%） by ISH （P = 0.002）. The expression level of S100A2 mRNA was closely related to differentiation and and node-metastasis （P = 0.012, P = 0.008）. Expression of $100A2 protein was positive in 72.5% of ESCC samples and expression of p63 protein was positive in 37.5% of ESCC samples, and was lower than that in normal mucosa （100%）（P = 0.000）. The expression of S100A2 protein was correlated with the differentiation and node-metastasis （P = 0.007, P = 0.001）, but no relationship was observed between the expression of p63 protein and clinical pathological manifestations. S100A2 protein was positively correlated with the expression of S100A2 mRNA, and negatively associated with the expression of p63 protein （P = 0.000, P = 0.002）. CONCLUSION： S100A2 and p63 protein both play important roles in the carcinogenesis of ESCC. An investigation into the combined expression of S100A2 and p63 may be helpful in early diagnosis and in evaluating the prognosis of ESCC.

关键词： Immunohistochemistry In situ hybridization Esophageal carcinoma p63 S100A2

The Generalized Inverse of Singular Integral Operators on an Open Arc and Its Applications

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Wuhan University Journal of Natural Sciences 2001年第4期6卷 747-753页

作者： li hong-yan Wang Xiao-ling School of Mathematics and Statistics Wuhan University Wuhan 430072 China

After choosing weight functions suitably, we define a Banach spaceH ω μ (L) and discuss the generalized inverse of singular integral operators on an open arc. Using the generalized inverse, we obtain the solutions f... 详细信息

关键词： open arc generalized inverse singular integral equations with kernel having singularities of order one