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The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-κB signaling pathway

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Chinese Journal of Natural Medicines 2021年第6期19卷 442-453页

作者： WU Yi MA Yi li Jing ZHOU Xue-lin li Lei XU Ping-Xiang li xiao-rong XUE Ming Department of Pharmacology Beijing Laboratory for Biomedical Detection Technology and InstrumentSchool of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Beijing Engineering Research Center for Nerve System Drugs Beijing 100053China Central Laboratory Capital Medical UniversityBeijing 100069China

Salidroside(SAL),a major bioactive compound of Rhodiola crenulata,has significant anti-hypoxia effect,however,its underlying molecular mechanism has not been *** order to explore the protective mechanism of SAL,the lactate dehydrogenase(LDH),reactive oxygen species(ROS),superoxide dismutase(SOD)and hypoxia-induced factor 1α(HIF-1α)were measured to establish the PC12 cell hypoxic *** staining and cell viability analyses were performed to evaluate the protective effects of *** metabolomics and bioinformatics methods were used to explore the protective effects of salidroside under hypoxia *** metabolite-protein interaction networks were further established and the protein expression level was examined by Western *** results showed that 59 endogenous metabolites changed and the expression of the hub proteins of CK2,p-PTEN/PTEN,PI3K,p-Akt/Akt,NF-κB p65 and Bcl-2 were increased,suggesting that SAL could increase the expression of CK2,which induced the phosphorylation and inactivation of PTEN,reduced the inhibitory effect on PI3K signaling pathways and activated the PI3K/Akt/NF-κB survival signaling *** study provided an important insight to reveal the protective molecular mechanism of SAL as a novel drug candidate.

关键词： Salidroside Hypoxia PC 12 Metabolomics PTEN PI3K/Akt/NF-κB

Direct Synthesis of Nitriles from Aldehydes in Ionic liquids

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Chemical Research in Chinese Universities 2011年第4期27卷 712-714页

作者： ZHANG Jun-li CHEN xiao-rong YU Yan-peng XU Kun-ling HUANG Jun State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemistry and Chemical Engineering Nanjing University of Technology Nanjing 210009 P. R. China

1 Introduction Ionic liquids（ILs） are environmentally acceptable solvents because they have low vapor pressure, high thermal stability and chemical stability, excellent solvent for organic and inorganic compounds. Therefore, they can be used as green solvents for a number of chemical processes, such as separa- tions and reactions. ILs are also used as catalysts in chemical reactions to accelerate reaction rate and improve selectivity.

关键词： Nitrile Aldehyde Hydroxylamine hydrochloride Ionic liquid

A Summary of the Research on the Rural Sages Culture

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Journal of literature and Art Studies 2018年第11期8卷 1581-1587页

作者： li xiao-rong Yancheng Institute of Technology JiangsuChina

As a cultural phenomenon rooted in the traditional rural society China,rural sages culture has played an important role in the inheritance of civilization and social *** new period,rural sages culture helps to cultivate rural civilization and promote the development of rural economy and rural social *** the process of innovation and development of rural sages culture,across the rural have all made great achievements,which initiatives in Zhejiang and Guangdong province is *** this basis,the mechanism to play rural sages’role mainly includes:researching rural sages culture,strengthening the construction of the scholarly society,attracting rural sages regression and remodeling of the rural elite etc.

关键词： summary research rural sage culture

Mouse strain differences in selective serotonin reuptake inhibitors sensitivity correlates with serotonin transporter binding and function

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中国药理学与毒理学杂志 2018年第9期32卷 710-711页

作者： JIN Zeng-liang CHEN xiao-fei li xiao-rong XIONG Jie ZHENG Yuan-yuan GAO Na-na li Yun-feng Beijing Key laboratory of Neuropsychopharmacology Beijing Institute of Pharmacology and Toxicology Department of Pharmacology School of Basic Medical SciencesCapital Medical University

OBJECTIVE Selective serotonin reuptake inhibitors(SSRIs) bind 5-HT transporters,leading to the accumulation of 5-HT and amelioration of *** different mouse strain showed different sensitivity to SSRIs in mouse models of depression,the reason for these strain differences remains ***,therefore,in the present study,we examined immobility time and locomotor activity in two mouse strains,namely,C57BL/6 J and DBA/2 J mice,and the effects of the SSRIs ***,we analyzed 5-HT transporter binding and reuptake inhibition in both strains to explore their relationship with the immobility and locomotor activity effects of the three SSRIs in these two mouse *** Strain differences in SSRI effects in the tail suspension test(TST) and forced swimming test(FST).To initiate our studies,we sought to confirm that SERT strain variation did not alter SERT protein expression,5-HT recognition,or uptake activity when expressed in C57BL/6 J and DBA/2 J *** binding assays were conducted to determine the affinity of the SSRIs for the 5-HT transporters in the two mouse *** SSRI citalopram dose-dependently reduced immobility time in both the FST and TST in DBA/2 J but not C57BL/6 J mouse strains,whereas fluoxetine showed opposite *** reduced immobility time similarly in both *** affinity of citalopram for the 5-HT transporter in DBA/2 J mice was 700-fold higher than that for in C57BL/6 J mice,whereas the affinity of fluoxetine in C57BL/6 J mice was 100-fold higher than that in the DBA/2 J ***,High citalopram concentrations were required to [3 H]5-HT uptake in C57BL/6 J but not DBA/2 J mouse cortical synaptosomes,whereas fluoxetine also showed opposite *** Immobility duration depends on 5-HT transporter binding levels,leading to apparent strain differences in immobility time in FST and ***,differences in 5-HT transporter binding may cause variations in SSRI

关键词： antidepressants mouse strains selective serotonin reuptake inhibitors

High Acoustic Nonlinearity of a liquid Containing Microbubbles

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Chinese Physics Letters 1999年第10期16卷 737-739页

作者： liU Jie-hui ZHANG Dong GONG Xiu-fen SHAO li-zheng li xiao-rong CHEN Xi ZHANG Qin-lan State Key Laboratory of Modern Acoustics Institute of AcousticsNanjing UniversityNanjing 210093 Wuxi No.1 People’s Hospital Wuxi 214002

The acoustic nonlinearity parameter B/A of a liquid containing microbubbles,sonicated dextrose albumin,has been measured by using second harmonic insert-substitution *** show that the value of nonlinearity parameter B/A for a bubbly liquid is significant and it obviously increases with increase of bubble number *** high nonlinearity of the bubbly liquid is mainly dependent on the microbubble nonlinear oscillation.

关键词： oscillation. density. method.

Management of venous stenosis in living donor liver transplant recipients

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World Journal of Gastroenterology 2009年第39期15卷 4969-4973页

作者： Jie Yang Ming-Qing Xu Lu-Nan Yan Wu-Sheng Lu xiao li Zheng-rong Shi Bo li Tian-Fu Wen Wen-Tao Wang Jia-Ying Yang Department of liver and Vascular Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM:To retrospectively evaluate the management and outcome of venous obstruction after living donor liver transplantation(LDLT).METHODS:From February 1999 to May 2009,1 intraoperative hepatic vein(HV) tension induced HV obstruction and 5 postoperative HV anastomotic stenosis occurred in 6 adult male LDLT *** portal vein(PV) anastomotic stenosis occurred in 1 pediatric left lobe *** ranged in age from 9 to 56 years(median,44 years).An air balloon was used to correct the intraoperative HV *** surgical reoperation,transjugular HV balloon dilatation with stent placement and transfemoral venous HV balloon dilatation was performed for HV stenosis on days 3,15,50,55,and 270 after LDLT,*** dilatation followed with stent placement via superior mesenteric vein was performed for the pediatric PV stenosis 168 d after ***:The intraoperative HV tension was corrected with an air *** recipient who underwent emergent reoperation for hepatic stenosis died of hemorrhagic shock and renal failure 2 d *** balloon dilatation via the transjugular and transfemoral venous approach was technically successful in all *** patient with early-onset HV stenosis receiving transjugular balloon dilatation and stent placement on the 15th postoperative day left hospital 1 wk later and disappeared,while the patient receiving the same interventional procedures on the 50th postoperative day died of graft failure and renal failure 2 wk *** patients with late-onset HV stenosis receiving balloon dilatation have survived for 8 and 4 mo without recurrent stenosis and ascites,*** dilatation and stent placement via the superior mesenteric venous approach was technically successful in the pediatric left lobe LDLT,and this patient has survived for 9 mo without recurrent PV stenosis and ***:Intraoperative balloon placement,emergent reoperation,proper interventional balloon dilatation and

关键词： living donor liver transplantation Venous obstruction Anastomotic stenosis Venoplasty Stent

Analysis of the key networks,metabolic pathways,and regulation substances of hypoxia based on the omics and zebrafish model

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中国药理学与毒理学杂志 2017年第10期31卷 1023-1024页

作者： Yi MA Bin-bin XIA Jing-yi li Zheng-chao XIA Ping-xiang XU li xiao-rong Ming XUE Department of Pharmacology School of Basic Medical SciencesCapital Medical University

OBJECTIVE Hypoxia is associated with many complicated pathophysiological and biochemical processes that integrated and regulated via the key gene,protein and endogenous metabolite *** to date,the exact molecular mechanism of hypoxia still remains *** this work,we further explore the molecular mechanism of hypoxia and adaption to attenuate the damage in zebrafish model that have potential to resist hypoxic *** The hypoxic zebrafish model was established in different concentration of oxygen with 3%,5%,10%,21%in *** brain tissue was separated and the RNA-seq was used to identify the differentially expressed *** related endogenous metabolites profiles were obtained by LC-HDMS,and the multivariate statistics was applied to discover the important metabolites candidates in hypoxic *** candidates were searched in HMDB,KEGG and lipid Maps *** The zebrafish hypoxic model was successfully constructed via the different concentration of oxygen,temperature and hypoxic *** activities of the related hypoxic metabolic enzymes and factors including HIF-1a,actate dehydrogenase(LDH)and citrate synthase(CS)were *** differences(P2)in the expression of 422 genes were observed between the normal and 3% hypoxic *** them,201 genes increased depended on the lower concentration of oxygen.53 metabolites were identified that had significant difference between the hypoxia and control groups(P1.5 and VIP>1.5).The ten key metabolites were increased gradually while six compounds were *** endogenous hypoxic metabolites of phenylalanine,D-glucosamine-6P and several important lipids with the relevant hub genes had similar change in hypoxic *** addition,the metabolic pathways of phenylalanine,glutamine and glycolipid were influenced in both the levels of genes and *** The up-regulation of phenylalanine,D-glucosamine-6P and lipid may hav

关键词： hypoxia adaptation metabolic pathway omics zebrafish model

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交通基础设施智能化研究进展

Engineering 2023年第5期24卷 239-252,I0007页

作者： Yan-liang Du Ting-Hua Yi xiao-Jun li xiao-li rong Long-Jun Dong Da-Wei Wang Yang Gao Zhen Leng College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518061China School of Civil Engineering Dalian University of TechnologyDalian 116023China School of Civil and Transportation Engineering Beijing University of Civil Engineering and ArchitectureBeijing 102616China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Resources and Safety Engineering Central South UniversityChangsha 410083China School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin 150090China School of Safety Engineering and Emergency Management Shijiazhuang Tiedao UniversityShijiazhuang 050043China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China

受最新材料科学、计算机技术、人工智能和自动控制技术的启发,新一代交通基础设施正在走向数字化和智能化。世界上许多主要发达国家都在因地制宜,积极推动智能创新技术在交通基础设施中的应用。本文首先简要介绍了交通基础设施智能化的... 详细信息

受最新材料科学、计算机技术、人工智能和自动控制技术的启发,新一代交通基础设施正在走向数字化和智能化。世界上许多主要发达国家都在因地制宜,积极推动智能创新技术在交通基础设施中的应用。本文首先简要介绍了交通基础设施智能化的基本概念、科学依据和发展历程。然后,按照设计、施工、运维、淘汰的全生命周期链条,系统分析了智能化技术的研究现状和面临的主要挑战。随后,以世界上第一条基于智能建设理念建设的铁路——北京-张家口高铁为例,全面介绍了智能技术的最新成就。最后,从标准体系、理论方法和人才培养三个维度对交通基础设施智能化的未来发展进行了探讨。

关键词：交通基础设施自动控制技术人工智能计算机技术全生命周期智能技术智能化技术人才培养

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陆游诗歌“化身梅”范式的建立及后世影响

中山大学学报（社会科学版） 2023年第6期63卷 37-46页

作者：李小荣福建师范大学闽台区域研究中心福州350007

陆游咏梅创作前后持续50余年,其取材方式、思想表达常与佛教相联系,这既是受到家族佛教信仰、诗学师承两种传统的影响所致,更和陆游一生好结交禅僧的社会生活经历息息相关。特别是淳熙五年(1178)秋松源崇岳禅师对他的印可,奠定了他此后... 详细信息

陆游咏梅创作前后持续50余年,其取材方式、思想表达常与佛教相联系,这既是受到家族佛教信仰、诗学师承两种传统的影响所致,更和陆游一生好结交禅僧的社会生活经历息息相关。特别是淳熙五年(1178)秋松源崇岳禅师对他的印可,奠定了他此后特殊“寻梅眼”的观物审美方式。再经24年的禅修实践和创作积淀,至嘉泰二年(1202)春,终于以超越前贤的创新意识,融汇“三时论门”“六根互用”和松源禅系的“华严意蕴”等多种佛教思想以及佛教文学的因子,创建了在明末清初以降具有深远影响的咏梅范式——“化身梅”。后世咏梅接受该范式影响的文本表现方式,主要有正引、反引、诗意图和组合型等四大类。

关键词：陆游诗歌化身梅范式后世影响

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