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“产教一体化”视域下新西兰职业教育改革探析

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成人教育 2024年第3期44卷 87-93页

作者：邹霞李文美曲阜师范大学教育学院山东曲阜273165

在高技能人才需求扩大、国家文化软实力竞争激烈、终身教育理念深入人心的背景下,新西兰职业教育迎来发展的新机遇,但同时也因其二元化人才培养模式、行业标准制定的主体单一使其陷入人才培养难以满足行业需求的困境中。在新一轮职业教... 详细信息

在高技能人才需求扩大、国家文化软实力竞争激烈、终身教育理念深入人心的背景下,新西兰职业教育迎来发展的新机遇,但同时也因其二元化人才培养模式、行业标准制定的主体单一使其陷入人才培养难以满足行业需求的困境中。在新一轮职业教育改革中,新西兰致力于推动职业教育产教一体化发展,通过设立劳动力发展委员会等机构,构建起一个系统的职业教育体系。为了加快构建中国式现代化职业教育体系,培养高素质技术技能人才,借鉴新西兰的改革经验,我国应通过加大地方政府的政策执行力度、充分发挥行业协会的枢纽作用、构建校企合作互惠机制等措施加快产教融合进程,助力职业教育高质量发展。

关键词：新西兰职业教育产教融合校企合作技能型社会

Effects of polar cortical cytoskeleton and unbalanced cortical surface tension on intercellular bridge thinning during cytokinesis

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Acta Mechanica Sinica 2011年第6期27卷 1081-1090页

作者： li Wang mei-wen An Xiao-Na li Fang Yang Yang liu Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of Technology 030024 Taiyuan China

To probe the contributions of polar cortical cytoskeleton and the surface tension of daughter cells to intercellular bridge thinning dynamics during cytokinesis,we applied cytochalasin D（CD） or colchicine（COLC） in a highly localized manner to polar regions of dividing normal rat kidney（NRK） *** observed cellular morphological changes and analyzed the intercellular bridge thinning trajectories of dividing cells with different polar cortical *** blebbistatin（BS） application was used to obtain cells losing active contractile force *** results show that locally released CD or colchicine at the polar region caused inhibition of cytokinesis before *** treatment at phases after ingression allowed completion of cytokinesis but dramatically influenced the trajectories of intercellular bridge *** single polar cortical actin induced transformation of the intercellular bridge thinning process,and polar cortical tension controlled deformation time of intercellular *** study provides a feasible framework to induce and analyze the effects of local changes in mechanical properties of cellular components on single cellular cytokinesis.

关键词： Cytokinesis Normal rat kidney epithelial cells Intercellular bridge Polar cortical cytoskeleton - Cortical surface tension

A new cytotoxic cardenolide from the latex of Antiaris toxicaria

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Chinese Chemical Letters 2009年第4期20卷 450-452页

作者： Yu Juan Gan wen li mei You Xing Zhao Hao Fu Dai Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 571101 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

A new cardenolide, toxicarioside E （1）, was isolated from the latex ofAntiaris toxicaria （Pers.） Lesch （Moraceae）. Its structure was elucidated on the basis of spectral data and chemical evidence. Compound 1 showed significant cytotoxicity against K562 and SGC-7901 cell lines in vitro by MTT method with the IC50 value of 0.026 and 0.027 μg/mL, respectively.

关键词： Antiaris toxicaria Moraceae Toxicarioside E Cardenolide Cytotoxicity

基于网络药理学和实验验证探讨三七总皂苷治疗糖尿病肾病的作用机制研究

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中国中药杂志 2024年第17期49卷 4607-4616页

作者：王洋琛耿若愚杨建华马冲代武郭娅丽张汉腾徐梓轩李新悦马鑫鑫胡君萍文丽梅省部共建中亚高发病成因与防治国家重点实验室新疆医科大学第一附属医院药学部新疆乌鲁木齐830011 新疆医科大学药学院新疆乌鲁木齐830017 新疆医科大学临床医学部新疆乌鲁木齐830017 新疆药物临床研究重点实验室新疆乌鲁木齐830011

基于网络药理学、分子对接、动物实验,探究三七总皂苷(Panax notoginseng saponins,PNS)对糖尿病肾病(diabetic kidney disease,DKD)的治疗作用及其机制。基于网络药理学筛选潜在作用靶点,利用STRING数据库构建蛋白-蛋白互作网络,将筛... 详细信息

基于网络药理学、分子对接、动物实验,探究三七总皂苷(Panax notoginseng saponins,PNS)对糖尿病肾病(diabetic kidney disease,DKD)的治疗作用及其机制。基于网络药理学筛选潜在作用靶点,利用STRING数据库构建蛋白-蛋白互作网络,将筛选的核心靶点进行基因本体论(Gene Ontology,GO)和京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)信号通路的富集分析,并构建“成分-靶点-通路”的可视化网络,预测PNS防治DKD的潜在作用机制。从PNS中筛选出5个有效成分,其治疗DKD的核心靶点有AKT1、STAT3、ESR1、HSP90AA1、MTOR等;通过KEGG分析发现PNS治疗DKD相关的通路有癌症通路、化学致癌-受体激活、PI3K-AKT信号通路等;通过GO分析发现PNS治疗DKD主要涉及的生物过程有蛋白质结合、同种蛋白质结合、酶结合以及ATP结合等生物过程。将40只雄性6周龄db/db小鼠随机分为模型组、达格列净组、PNS低剂量组、PNS高剂量组,每组10只,将10只同周龄db/m小鼠作为空白组。干预组灌胃给药干预8周,空白组和模型组每日给予等量蒸馏水灌胃,每天1次,监测小鼠体质量和空腹血糖,并检测肾脏指数、尿微量白蛋白、肌酐、尿微量白蛋白/肌酐比值及尿素含量。采用苏木精-伊红(HE)染色、过碘酸雪夫(PAS)染色、马松(Masson)染色观察PNS对db/db小鼠的肾脏保护作用。结果发现PNS可显著降低db/db小鼠的空腹血糖水平,改善其肾脏损伤情况。Western blot验证实验显示PNS干预组可降低p-AKT1、p-STAT3的蛋白表达水平及p-AKT1/AKT1、p-STAT3/STAT3比值。此外,PNS高剂量组可下调PIK3CA的蛋白表达水平。综上,三七总皂苷可能是通过PI3K-AKT信号通路抑制STAT3靶点蛋白发挥良好的糖尿病肾脏保护作用。

关键词：三七总皂苷糖尿病肾病网络药理学实验验证机制

A New Degraded Sesquiterpene from Marine Actinomycete Streptomyces sp. 0616208

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Chinese Chemical Letters 2006年第11期17卷 1463-1465页

作者： Xiu Chao XIE wen li mei You Xing ZHAO Kui HONG Hao Fu DAI State Key Laboratory. of Tropical Crops Biotechnology Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agriculture Sciences Haikou 571101 State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204

A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as （1α; 4aα; 5α, 7β, 8aβ）-5, 8a-dimethyl-decahydrona- phthalene-1, 4a, 7-triol on th... 详细信息

关键词： Marine actinomycete, Streptomyces sp., degraded sesquiterpene, (1α 4aα 5α, 7β, 8aβ)-5, 8a-dimethyl-decahydronaphthalene- 1,4a,7-triol.

A New Triterpene from Cephalomappa sinensis

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Chinese Chemical Letters 2001年第6期12卷 507-508页

作者： wen li mei Yun Bao MA Shao Hua WU Hao Fu DAI Da Gang WU Laboratory of Phytochemistry Kunming Institute of BotanyAcademia SinicaKunming 650204

A new triterpene 1, 1 beta, 2 alpha, 3 beta -trihydroxylup-20 (29) -ene was isolated from Cephalomappa sinensis. The structure was elucidated mainly on the basis of 1D and 2D NMR spectral means.

关键词： Triterpene Cephalomappa sinensis Euphorbiaceae

Chemical Activation of S/li2S in li-S Batteries by a Bidirectional Organic Redox Mediator

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 927-934页

作者： li, Chengqiu Zhou, Chaoyong mei, Shilin Yao, Changjiang Beijing Inst Technol Sch Mechatron Engn State Key Lab Explos Sci & Safety Protect Beijing 100081 Peoples R China Xian Safty Energy Technol Co Ltd Xian 710299 Peoples R China

The energy density and lifespan of prototype li-S batteries under high sulfur loading and lean electrolyte have been mainly restricted by the incomplete interconversion between insulating S8 and li2S. The introduction of an electrocatalyst has been preserved as an effective way to breakthrough the bottleneck of the interconversion rate. Herein, we demonstrate a novel bidirectional redox mediator, insoluble dithiobisphthalimide (DTPI), as the electrocatalyst for both S8 reduction and li2S oxidation. Due to the dual-functional role of both electron/li+ donor and acceptor, DTPI can efficiently accelerate the redox reactions during charge/discharge and significantly alleviate the incomplete conversion of sulfur species. Consequently, the li-S batteries with DTPI deliver superior specific capacity and cycling stability in comparison with those without DTPI. Especially, the redox mediator is scalable for synthesis and the DTPI-based 5 Ah pouch cell delivers a specific discharge capacity of around 870 mAhg(-1) at 0.1 C (1 C=1675 mA/g) without capacity fading over 80 cycles. The bidirectional catalysis mechanism has been studied through theoretical calculation and ex-situ characterization of the cathode materials. This work approves the effectiveness of bidirectional organic redox mediator in the construction of practical li-S batteries.

关键词： lithium-sulfur battery (LSB) Dithiobisphthalimide (DTPI) Organic redox mediator Interconversion liTHIUM FRAMEWORK

A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood

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Chinese Chemical Letters 2008年第8期19卷 934-936页

作者： Jun liu Jiao Wu You Xing Zhao Yuan Yuan Deng wen li mei Hao Fu Dai Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 571101 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

A new compound 8-chloro-5,6,7-trihydroxy-2-（3-hydroxy-4-methoxyphenethyl）-5,6,7,8-tetralaydro-4H-chromen-4-one （1） was isolated from the Chinese eaglewood [Aquilaria sinensis （Lour.） Gilg]. Its structure was elucidated on the basis of spectral data. Compound I showed cytotoxicity against human gastric cancer cell line （SGC-7901） in vitro by MTT method with the IC50 value of 14.6 μg/mL.

关键词： Chinese eaglewood Aquilaria sinensis Chromone Cytotoxicity

Two new epimeric pairs of iridoid from mangrove plant Scyphiphora hydrophyllacea

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Chinese Chemical Letters 2007年第12期18卷 1509-1511页

作者： Yan Bo Zeng wen li mei You Xing Zhao ling Zhuang Kui Hong Hao Fu Dai State Key Biotechnology Laboratory of Tropical Crops institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 571101 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming institute of Botany Chinese Academy of Sciences Kunming 650204 China

Two new epimeric pairs of iridoid scyphiphin A1 （la）, A2 （lb） and scyphiphin B 1 （2a）, B2 （2b） were isolated from Scyphiphora hydrophyllacea Gaertn. F. Their structures were elucidated by spectroscopic methods. The mixture of scyphiphin B 1 and scyphiphin B2 showed moderate cytotoxicity against human hepatoma SMMC-7721 cell line in vitro by MTT method.

关键词： Scyphiphora hydrophyllacea Gaertn. E Iridoid Cytotoxicity SMMC-7721