A new cytotoxic cardenolide from the latex of Antiaris toxicaria

作     者：Yu Juan Gan Wen Li Mei You Xing Zhao Hao Fu Dai 

作者机构：Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 571101 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2009年第20卷第4期

页      面：450-452页

核心收录：

学科分类：0710[理学-生物学] 0907[农学-林学] 07[理学] 08[工学] 0829[工学-林业工程] 09[农学] 071002[理学-动物学] 

基　　金：supported by National Natural Science Foundation of China(No.30860345) National Basic Research Program of China(No.2007CB116306 National Nonprofit Institute Research Grant of CATAS-ITBB(No.ITBBZD200744) the Natural Science Foundation of Hainan(Nos.80671,30608) 

主　　题：Antiaris toxicaria Moraceae Toxicarioside E Cardenolide Cytotoxicity 

摘      要：A new cardenolide, toxicarioside E （1）, was isolated from the latex ofAntiaris toxicaria （Pers.） Lesch （Moraceae）. Its structure was elucidated on the basis of spectral data and chemical evidence. Compound 1 showed significant cytotoxicity against K562 and SGC-7901 cell lines in vitro by MTT method with the IC50 value of 0.026 and 0.027 μg/mL, respectively.