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Metallurgical Source of Cryogenic Intergranular Fracture of Fe-38Mn Austenitic Alloy

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Journal of Iron and Steel Research International 2000年第1期7卷 31-35页

作者： FU Rui-dong ZHENG Yang-zeng li shao-hua ZHOU Hui-hua Yanshan University Central Iron & Steel Research Institute Tsinghua University

SEM and Field emitting TEM-EDAX were used to investigate the fracture surface of series impact specimens and the grain boundary chemistries of VIM(vacuum-inductionmelted) Fe-38 Mn austenitic alloy before and after ESR(electroslag remelting,).The quantity and the size of inclusions were also *** results show that the VIM Fe-38 Mn austenitinic alloy water-quenched from 1 100 C undergoes an obvious ductile-to-brittle transition,and the impact work at ambient temperature is 242 J,the corresponding fracture surface exhibits a dimple ***,the impact work at 77 K of VIM alloy is only 25 J and the fracture mode is IGF(intergranular fracture).After ESR,the impact work at ambient temperature is 320 J and the fracture surface exhibits a character of "volcano lava"(meaning excellent toughness);The impact work at 77 K is up to 300 J and the fracture mode is micro void coalescence mixed with *** segregation of Mn is not found in all specimens,but the segregation of S is observed,and the S segregation is decreased after *** examined results of inclusions show that ESR reduces the quantity and improves the morphology of *** the above results it can be seen that the cryogenic IGF of VIM Fe-38 Mn austenitic alloy is related to the S segregation at grain *** ESR the decrease in the quantity and size of inclusion results in the increase of the impact work at ambient temperature,while the restriction of IGF is related to the decrease in the total level,and hence in the grain boundary segregation of S.

关键词： rich Mn austenitic alloy cryogenic intergranular fracture grain boundary segregation electroslag remelting

Using capillary electrophoresis mobility shift assay to study the interaction of CdTe quantum dots with bovine serum albumin

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Chinese Chemical Letters 2008年第6期19卷 707-710页

作者： li Wen shao Chao Qing Dong Xiang Yi Huang Ji Cun Ren College of Chemistry ＆ Chemical Engineering Shanghai Jiaotong University Shanghai 200240 China

In this work, the capillary electrophoresis mobility shift assay （CEMSA） was first adopted to study the interaction of protein with quantum dots （QDs）. In this study, bovine serum albumin （BSA） and CdTe QDs were used as model samples. We observed that BSA was facilely adsorbed to CdTe QDs surface, and the QD-BSA complex was formed by a 1：1 stoichiometric ratio. A value of 2.17 4-0.27 × 10^6 mol^-1 L^-1 （at 25 ℃） for the association constant was obtained by CEMSA.

关键词： CdTe quantum dots Bovine serum albumin Capillary electrophoresis mobility shift assay Interaction

Tongxinluo Ameliorates Myocardial Ischemia-Reperfusion Injury Mainly via Activating Parkin-Mediated Mitophagy and Downregulating Ubiquitin-Proteasome System

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Chinese Journal of Integrative Medicine 2021年第7期27卷 542-550页

作者： YANG Hong-xing WANG Peng WANG Ning-ning li shao-dan YANG Ming-hui Dongzhimen Hospital Beijing University of Chinese MedicineBeijing100029China Institute of Radiation Medicine Academy of Military Medical SciencesBeijing100850China Department of Traditional Chinese Medicine Chinese People's Liberation Army General HospitalBeijing100853China

Objective To investigate the protective effects and mechanism of Chinese herbal compound Tongxinluo Capsule(通心络胶囊,TXL)on the Parkin-mediated mitophagy and the ubiquitin-proteasome system in a rat model of myocardial ischemia-reperfusion injury(MIRI).Methods Seventy adult male Sprague-Dawley rats were randomly divided into 7 groups:sham group,MIRI group,low-and high-dose TXL(0.5 and 1 g·kg^(-1)·d^(-1),respectively)groups,atorvastatin(ATV)group(7.2 g·kg^(-1)·d^(-1)),chloroquine(CQ)group(10 g·kg^(-1)·d^(-1)),and highdose TXL+CQ *** pharmacological administration for 7 days,rats underwent left anterior descending artery ligation surgery to establish the MIRI models with 50 min ischemia followed by 4 h *** was taken for cardiac troponin I(cTnI)detection and hearts were harvested for infarct staining and apoptosis *** autophagy or mitophagy proteins and ubiquitinated proteins were detected by Western *** Compared with the sham group,the MIRI group exhibited a larger infarcted area(27.13%±0.01%,Plished the activation of autophagy flux and the PINK1/Parkin pathway induced by high-dose of *** TXL ameliorates MIRI via activating Parkin-mediated mitophagy in *** downregulation of the ubiquitin-proteasome system is also involved.

关键词： Chinese medicine mitophagy ischemia-reperfusion injury Parkin ubiquitin

The Impact of Bias Row Noise to Photometric Accuracy:Case Study Based on a Scientific CMOS Detector

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Research in Astronomy and Astrophysics 2024年第2期24卷 228-246页

作者： li shao Hu Zhan Chao liu Haonan Chi Qiuyan Luo Huaipu Mu Wenzhong Shi National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China University of Chinese Academy of Sciences Beijing 100049China Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 100875China

We tested a new model of CMOS detector manufactured by the Gpixel Inc,for potential space astronomical *** laboratory,we obtain some bias images under the typical application *** these bias images,clear random row noise pattern is *** row noise also contains some characteristic spatial *** quantitatively estimated the impact of this feature to photometric measurements,by making simulated *** compared different bias noise types under strict parameter *** result shows the row noise will significantly deteriorate the photometric *** effectively increases the readout noise by a factor ***,if it is properly removed,the image quality and photometric accuracy will be significantly improved.

关键词： instrumentation detectors-methods statistical-techniques image processing

Pancreatic head carcinoma:clinical analysis of 189 cases

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 79-84页

作者： Hua, Yun-Peng liang, li-Jian Peng, Bao-Gang li, shao-Qiang Huang, Jie-Fu Sun Yat Sen Univ Affiliated Hosp 1 Dept Hepatobiliary Surg Guangzhou 510080 Guangdong Peoples R China

BACKGROUND: Pancreatic cancer is a lethal disease with an increasing incidence. We retrospectively reviewed the clinical data on diagnosis and treatment of pancreatic head carcinoma, and analyzed the factors affecting prognosis of the disease. METHODS: The data of 189 patients with pancreatic head carcinoma treated from September 1, 1995 to August 31, 2005 were reviewed retrospectively. Ninety-four patients treated from September 1, 2000 to August 31, 2005 were followed up in April 2008. The median survival time (MST) and 1- to 5-year cumulative survival rates of the patients were calculated by the life table method and the Kaplan-Meier method. Cox regression was used to screen out significant risk factors. RESULTS: 96.9% of the patients were more than 40 years old, and the male/female ratio was 1.63. The detection rate of transabdominal ultrasonography (US), computed tomography (CT), endoscopic ultrasonography (EUS), and serum tumor marker CA19-9 were 82.0%, 93.1%, 94.7% and 79.8%, respectively. The MST of patients with pancreatic head carcinoma was 360 +/- 60 days. The 1- to 5-year cumulative survival rates were 50.0%, 19.2%, 12.1%, 9.4% and 4.7%, respectively. However, patients with unresectable tumor survived for a shorter time (183 +/- 18 days). Their 1- to 2-year cumulative survival rates were 28.3% and 0.0%. Cox regression analysis showed that in pancreatic head carcinoma, the independent predictors for prognosis included tumor size, invasion of the superior mesenteric vessel, and radical resection. The MST of patients with pancreatic head carcinoma after radical resection was 510 days, significantly longer than that of patients undergoing non-specific treatment and palliative therapy (225 days). In addition, patients with slight jaundice survived for the longest time (533 +/- 51 days), compared with patients with severe jaundice (236 +/- 43 days) and without jaundice (392 +/- 109 days). CONCLUSIONS: Pancreatic head carcinoma is easily misdiagnosed, and is us

关键词： pancreatic head carcinoma surgical procedure diagnosis prognosis

Biotransformation differences of ginsenoside compound K mediated by the gut microbiota from diabetic patients and healthy subjects

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Chinese Journal of Natural Medicines 2023年第10期21卷 723-729页

作者： HUANG Sutianzi shao li CHEN Manyun WANG lin liU Jing ZHANG Wei HUANG Weihua Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangsha 410008China Institute of Clinical Pharmacology Hunan Key Laboratory of PharmacogeneticsCentral South UniversityChangsha 410078China The First Affiliated Hospital of Shantou University Medical College Shantou 515041China Department of Pharmacognosy School of PharmacyHunan University of Chinese MedicineChangsha 410128China

Many natural products can be bio-converted by the gut microbiota to influence pertinent *** compound K(GCK)is a potential anti-type 2 diabetes(T2D)saponin,which is mainly bio-transformed into protopanaxadiol(PPD)by the gut *** have shown that the gut microbiota between diabetic patients and healthy subjects are significantly ***,we aimed to characterize the biotransformation of GCK mediated by the gut microbiota from diabetic patients and healthy *** on 16S rRNA gene sequencing,the results indicated the bacterial profiles were considerably different between the two groups,especially Alistipes and Parabacteroides that increased in healthy *** quantitative analysis of GCK and PPD showed that gut microbiota from the diabetic patients metabolized GCK slower than healthy subjects through liquid chromatography tandem mass spectrometry(LC-MS/MS).The selected strain *** and *** exhibited a different metabolic capability of *** conclusion,the different biotransformation capacity for GCK may impact its anti-diabetic potency.

关键词： Ginsenoside compound K Gut microbiota Biotransformation Diabetes

Atomistic study on tensile fracture of densified silica glass and its dependence on strain rate

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Chinese Physics B 2020年第12期29卷 498-505页

作者： Zhi-Qiang Hu Jian-li shao Yi-Fan Xie Yong Mei State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Science China University of Mining and TechnologyBeijing 100083China Institute of Defense Engineering AMSPLABeijing 100036China

Densification is a major feature of silica glass that has received widespread *** work investigates the fracture behavior of densified silica glass upon uniaxial tension based on atomistic *** is shown that the tensile strength of the silica glass approximately experiences a parabolic reduction with the initial density,while the densified samples show a faster power growth with the increase of strain ***,the fracture strain and strain energy increase significantly when the densification exceeds a certain threshold,but fracture strain tends to the same value and strain energy becomes closer for different densified samples at extreme high strain *** views indicate that all the cracks are formed by the aggregation of nanoscale *** transition from brittleness fracture to ductility fracture can be found with the increase of strain rate,as a few fracture cracks change into a network distribution of many small ***,for the high densified sample,there appears an evident plastic flow before fracture,which leads to the crack number less than the normal silica glass at the high strain ***,the coordinated silicon analysis suggests that high strain rate tension will especially lead to the transition from 4-to 3-fold Si when the high densified sample is in plastic flow.

关键词： silica glass densification fracture strain rate atomistic simulation

The Effects of Space Dimension and Temperature on the Cross Mating of Three Cryptic Species of the Bemisia tabaci Complex in China

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Journal of Integrative Agriculture 2012年第2期11卷 197-205页

作者： li Xiao-xi li shao-jian XUE Xia Muhammad Z Ahmed REN Shun-xiang Andrew G S Cuthbertson QIU Bao-li Department of Entomology South China Agricultural University Guangzhou 510640 P.R.China Polytechnic College Hebei University of Science and Technology Shijiazhuang 050018 P.R.China Department of Genetics University of Pretoria Pretoria 0002 South Africa The Food and Environment Research Agency Sand Hutton Y041 1LZ United Kindom

The sweetpotato whitefly Bemisia tabaci（Homoptera：Aleyrodidae）is a destructive pest of agriculture and horticulture *** phylogenetic analysis using mitochondrial cytochrome oxidase 1 sequences indicates that this whitefly is a species complex including at least 24 morphologically indistinguishable but genetically distinct cryptic *** this study,the inter-species crosses of Middle East-Asia Minor 1（MEAM1）,Mediterranean（MED）and Asia II 7 cryptic species,which were referred to as B,Q and Cv biotypes before,were conducted in two different devices,leaf cages（7 cm3）and cylinder cages（280 cm3）,and at three temperatures of 22,30 and 38°*** indicated that no female progeny were produced in the reciprocal cross between MEAM1×Asia II 7,between MED×Asia II 7 cryptic species neither in leaf cage nor in cylinder cages,while 0.81 and 1.37% of females in the offspring were recorded in the reciprocal cross between MEAM1×MED in leaf cage *** 0.95-0.98% female progeny were recorded in the reciprocal cross between MEAM1×MED at 30°C,0.77% female progeny were recorded in the single cross direction between MEAM1 × MED at 22°C,and no female progeny were found in their reciprocal cross at 38°C in leaf *** findings indicated that neither space dimension nor temperature have a significant effect on the hybridization of different *** cryptic species.

关键词： Bemisia tabaci cross mating cryptic species reproductive isolation space dimension temperature

Clinical characteristics and corticosteroid therapy in patients with autoimmune-hepatitis-induced liver failure

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World Journal of Gastroenterology 2014年第23期20卷 7473-7479页

作者： Bing Zhu shao-li You Zhi-Hong Wan Hong-ling liu Yi-Hui Rong Hong Zang shao-Jie Xin liver Failure Treatment and Research Center 302~(nd) Military Hospital

AIM: To investigate the clinical features, response to corticosteroids, and prognosis of autoimmune hepatitis (AIH)-induced liver failure in China.

关键词： Autoimmune hepatitis liver failure Autoantibody Prognosis Corticosteroid therapy