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Chinese Chemical Letters 2006年第6期17卷 795-798页

作者： li Bo NIE Jian Rong CHEN Yu qing MIAO Nong Yue HE College of Chemistry and life Science Zhejiang Normal University Jinhua 321004 Key Laboratory of Green-packaging and Application of Bionanotechnology of Hunan Province Hunan University of Technology Zhuzhou 412008 State Key Laboratory of Bioelectronics Southeast University Nanjing 210096

Colloid gold nanoparticle-based layer-by-layer amplification approach was applied to enhance the electrochemical detection sensitivity of DNA hybridization at carbon nanotube modified carbon paste electrodes （CNTPEs）. Streptavidin was immobilized onto the surface of CNTPEs, and the conjugation of biotin labeled target oligonucle,otides to the above immobilized streptavidin was performed, followed by the hybridization of target oligonucleotides with the gold nanoparticle-labeled DNA probe and then the layer-by-layer enhanced connection of gold nanoparticles, on which oligonucleotides complementary to the DNA probe were attached, to the hybridization system. The differential pulse voltammetry （DPV） signal of total gold nanoparticles was monitored. It was found that the layer-by-layer colloidal gold DPV detection enhanced the sensitivity by about one order of magnitude compared with that of one-layer detection. One-base mismatched DNA and complementary DNA could be distinguished clearly.

关键词： Carbon nanotubes carbon paste electrode gold nanoparticles layer-by-layer amplifycation sensitivity.

Predicted essential proteins of Plasmodium falciparum for potential drug targets

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 352-354页

作者： qing-Feng He li Deng Qin-Ying Xu Zheng Shao Department of Parasitology Guangdong Medical College

Objective:To identify novel drug targets for treatment of Plasmodium ***: Local *** were used to find the proteins non-homologous to human essential proteins as novel drug *** domains of novel drug targets were identified by InterPro and Pfam.3D structures of potential drug targets were predicated by the SWISS-MODEL workspace. ligands and ligand-binding sites of the proteins were searched by ***:Three essential proteins were identified that might be considered as potential drug ***37254.1 belonged to 1-deoxy-D-xylulose 5-phosphate reductoisomerase,CAD50499.1 belonged to chorismale synthase,CAD51220.1 belonged to FAD binging 3 family,but the function of CAD51220.1 was *** 3D structures,ligands and ligand-binding sites of AAM37254.1 and CAD50499.1 were successfully ***:Two of these potential drug targets are key enzymes in 2-C-methyl-d-erythritol 4-phosphate pathway and shikimate pathway, which are absent in humans,so these two essential proteins are good potential drug *** function and 3D structures of CAD50499.1 is still unknown,it still need further study.

关键词： Plasmodium falciparum Essential proteins Database of essential genes Druggability Potential drug targets

Solution-processed top-contact electrodes strategy for organic crystalline field-effect transistor arrays

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Nano Research 2022年第2期15卷 858-863页

作者： Xi Zhang Xiaotong Zhao limei Rao Jing Zhang Mingchao Xiao Danlei Zhu Chunlei li Xiaosong Shi jie liu jie liu Lang Jiang Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of the Chinese Academy of Sciences Beijing 100049China

Organic crystals,especially ultra-thin two-dimensional(2D)ones such as monolayer molecular crystals,are fragile and vulnerable to traditional vacuum *** to now,most of the methods reported for fabricating organic field-effect transistors(OFETs)with top-electrodes on the 2D molecular crystals are based on mechanical-transfer *** method for large scale in-situ electrode deposition is *** this work,the silver mirror reaction(SMR)is introduced to construct top-contact electrodes on 2D organic crystalline thin *** based on bilayer crystalline films with solution-processed silver electrodes show comparable performance to devices with transferred gold *** addition to that,OFETs with SMR fabricated silver electrodes show lower contact resistance than the ones with evaporated silver ***,the temperature under which SMR electrodes annealed is relatively low(60℃),making this approach applicable to varies of organic semiconductors,such as spin-coated polymer films,vacuum evaporated films,2D and even monolayer crystalline ***,OFETs with sub-micrometer channel width and 25μm channel length are realized which might find practical application in the ultra-small pixel mini/micro-LEDs.

关键词： solution processed electrodes top contact organic crystalline thin films organic field-effect transistors

Pressure-stabilized hexagonal perovskite-related isolated tetrahedral anion silicate La_(6)Sr_(3)Si_(6)O_(24)

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Chinese Chemical Letters 2023年第5期34卷 548-552页

作者： jie Feng Lei Zhao Wenda Zhang Cheng li Congling Yin Xiaojun Kuang Guangxi Key Laboratory of Optic and Electronic Materials and Devices MOE Key Laboratory of New Processing Technology for Nonferrous Metals and MaterialsCollege of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004China Neutron Scattering Division Oka Ridge National LaboratoryOak Ridge 37831United States Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin 541004China

The discovery of new perovskite compounds under high pressure mainly focuses on the ABO_(3)compositions and the compositions highly deviated from ABO_(3)are less *** we demonstrate that the La_(6)Sr_(3)Si_(6)O_(24)silicate composition can be stabilized as a hexagonal perovskite-related structure with isolated tetrahedra anions under high pressure of 6 *** compound adopts 9-layer shifted hexagonal perovskite-like structure with both B-cation and oxygen deficiencies and contains pseudo-cubic(c)(La/Sr)O_(2)layers and hexagonal(h)(La/Sr)O_(3)layers stacked according to(c hh)_(3)*** structure features both B-cation vacancy ordering between the two consecutive hexagonal layers and oxygen vacancy ordering in c-(La/Sr)O_(2)layers,resulting in isolated tetrahedral Si O_(4)anions and ionic conduction *** work demonstrates the practicability of accessing new perovskite-related functional materials from the compositions highly deviated from ABO_(3)under high pressure.

关键词： High pressure Hexagonal perovskite Isolated tetrahedral anion Silicate Ionic conductors

Promoting di-isobutene selectivity over ZnO/ZrO_(2)-SO_(4) in isobutene oligomerization

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Chinese Journal of Chemical Engineering 2021年第10期34卷 165-171页

作者： Jiyuan li Mifen Cui Zhuxiu Zhang Xian Chen qing liu Zhaoyang Fei Jihai Tang Xu Qiao State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM) Nanjing 210009China

Isooctane attracts great interest in recent years because of its promising potential as friendlyenvironmental gasoline,which is obtained by dimerization of isobutene with a hydrogenation ***,a solid acid catalyst sulfated zirconia modified by ZnO was *** oligomerization of isobutene had been investigated over ZrO_(2)-SO_(4) and ZnO(X)/ZrO_(2)-SO_(4) catalyst in order to find efficient catalysts for the production of isobutene *** presence of ZnO obviously enhanced the dimerization of isobutene and ZnO(X)/ZrO_(2)-SO_(4) exhibited the highest di-isobutene yield of 60%.Kinetic studies showed the higher trimerization-to-dimerization activation energy ratios of ZnO(X)/ZrO_(2)-SO_(4) than those of ZrO_(2)-SO_(4) from 353 to 393 *** addition,reaction rate of dimerization was higher than trimerization over ZnO(X)/ZrO_(2)-SO_(4).The high L/B ratio manifested the capability to enhance the selectivity of C8 in isobutene ***,ZnO(X)/ZrO_(2)-SO_(4) exhibited stable conversion for the dimerization of isobutene.

关键词： Sulfated zirconia Zinc oxide Isobutene Selectivity Chemical reaction Catalysis

Hydrothermal Synthesis and Characterization of Perovskite Oxide AgTaO_3

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Chemical Research in Chinese Universities 2012年第5期28卷 760-763页

作者： HE li-jie ZHANG Dong FENG Shou-hua ZOU Bo CHEN Gang Yingkou University Zone Yingkou 115000P.R.China State Key Laboratory of Superhard Materials College of Physics State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012P.R.China

The perovskite-type AgTaO3 crystals were prepared by mild hydrothermal method and determined by powder X-ray diffraction. Rietveld refinement indicates that AgTaO3 crystallized in an orthorhombic system with the space group Pcmn. The lattice parameters are a=5.5822（1） nm, b=7.8522（2） nm and c=5.5347（1） nm, with α=β=γ= 90.0o. The compound was characterized by scanning electron microscopy（SEM）, X-ray photoelectron spectroscopy （XPS）, high resolution transmission electron microscopy（HR-TEM） and UV-Vis diffuse reflectance spectrometry （UV-Vis DRS）. The photocatalytic activity of AgTaO3 powder was evaluated by the degradation of Congo red under UV-light irradiation. The result shows that the titled compound has a high photocatalytic activity at room temperature and potential application in photocatalysis.

关键词： Hydrothermal synthesis Perovskite structure Photocatalytic activity

Lanthanide Complexes with Acetylacetonate and 5,10,15,20-Tetra[para-|(4-chlorobenzoyloxy) phenyl]porphyrin

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Chemical Research in Chinese Universities 2000年第3期16卷 259-262页

作者： ZHAO Zhi-xin li Xiang-qing WANG Xing-qiao liU Guo-fa Department of Chemistry Jilin UniversityChangchun 130023P.R.China

The lanthanide complexes of acetylacetonate and 5,10,15,20-tetra[para-(chlorobenzoyloxy)phenyl]porphyrin having a general formula Ln[(cbop)4p]acac (where Ln = Tb, Ho, Er, Tm;cbop = (4-chlorobenzoyloxy)phenyl;Hacac = a... 详细信息

关键词： Lanthanide complexes Porphyrin Acetylacetone

Changes of regulatory T cells and FoxP3 gene expression in the aging process and its relationship with lung tumors in humans and mice

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Chinese Medical Journal 2012年第11期125卷 2004-2011页

作者： PAN Xu-dong MAO Yan-qing ZHU li-jing li jie XIE Yan WANG ling ZHANG Guang-bo Special Requirement Ward First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Clinical Immunology Laboratory First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background Immunosuppressive regulatory T cells （Tregs） participate in tumor immune evasion and the number and suppressive function of Tregs change with the aging process, but it is not clear whether such change leads to a higher incidence of tumors in the elderly. To this end, we designed experiments to explore the changes of Tregs and the functional gene Forkhead box P3 （FoxP3） in the aging process and its relationship with lung tumors in humans and mice. Methods The percentage of CD4＋CD25＋CD127lowTregs and expression of FoxP3 mRNA were analyzed using flow cytometry （FCM） and real-time fluorescence-based quantitative polymerase chain reaction （FQ-PCR）. Markers were analyzed in the peripheral blood （PB） of 65 elderly patients （age 〉-65 years） with primary non-small cell lung cancer （NSCLC）, 20 younger patients （aged 〈55 years） with NSCLC, 30 elderly healthy individuals and 30 young healthy individuals. Furthermore, we set up the Lewis lung cancer model with C57BL/6 female mice. Thirty-six mice were divided into a young healthy group, a middle-aged healthy group, tumor group, and an elderly tumor group. The percentage an elderly healthy group, a young tumor group, a middle-aged of CD4＋CD25＋FoxP3＋ Tregs and the expression level of FoxP3 mRNA in splenocytes were determined in the six groups. Results The percentage of peripheral CD4＋CD25＋CD127low Tregs and the expression of FoxP3 mRNA were significantly increased in elderly patients with NSCLC comparing with the other groups and in elderly healthy individuals compared with young healthy individuals. Further analysis showed that the percentage of CD4＋CD25＋CD127lowTregs and the expression of FoxP3 mRNA were closely associated with tumor node metastasis （TNM） staging in elderly patients with NSCLC. In the mouse model, the percentage of CD4＋CD25＋FoxP3＋ Tregs and the expression of FoxP3 mRNA in splenocytes of the tumor groups were significantly higher than in the healthy groups, with the highest expression in the elderly tu

关键词： aging regulatory Tcells CD127 FoxP3 immunosenescence, lung tumor

An axion-like scalar field environment effect on binary black hole merger

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Research in Astronomy and Astrophysics 2018年第6期18卷 35-48页

作者： qing Yang li-Wei Ji Bin Hu Zhou-Jian Cao Rong-Gen Cai Department of Astronomy Beijing Normal University Beijing 100875 China CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190 China School of Physical Sciences University of Chinese Academy of Sciences Beijing 100049 China

The environment, such as an accretion disk, could modify the signal of the gravitational wave from astrophysical black hole binaries. In this article, we model the matter field around intermediatemass binary black holes by means of an axion-like scalar field and investigate their joint evolution. In detail, we consider equal mass binary black holes surrounded by a shell of axion-like scalar field both in spherically symmetric and non-spherically symmetric cases, and with different strengths of the scalar field. Our result shows that the environmental scalar field could essentially modify the dynamics. Firstly,in the spherically symmetric case, with increase of the scalar field strength, the number of circular orbits for the binary black hole is reduced. This means that the scalar field could significantly accelerate the merger process. Secondly, once the scalar field strength exceeds a certain critical value, the scalar field could collapse into a third black hole with its mass being larger than that of the binary. Consequently,the new black hole that collapses from the environmental scalar field could accrete the binary promptly and the binary collides head-on with each other. In this process, there is almost no quadrupole signal produced, and, consequently, the gravitational wave is greatly suppressed. Thirdly, when the scalar field strength is relatively smaller than the critical value, the black hole orbit could develop eccentricity through accretion of the scalar field. Fourthly, during the initial stage of the inspiral, the gravitational attractive force from the axion-like scalar field could induce a sudden turn in the binary orbits, hence resulting in a transient wiggle in the gravitational waveform. Finally, in the non-spherical case, the scalar field could gravitationally attract the binary moving toward the center of mass for the scalar field and slow down the merger process.

关键词： stars: black holes gravitational waves methods: numerical

Unplanned J-valve implantation during open heart surgery for severe valvular annulus and ventricle calcification

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Journal of Geriatric Cardiology 2022年第12期19卷 1003-1006页

作者： Tian-Ge LUO Bo li jie HAN Hai-Bo ZHANG Cardiac Valve Centre Department of Cardiac SurgeryBeijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijingChina Department of Cardiac Surgery People’s Hospital of Liaoning ProvinceShenyangChina

Aortic annulus calcification(AC)and mitral AC are common in patients with cardiac valvular disease.[1]Procedures to resect or debride aortic AC and mitral AC may lead to cerebral emboli,heart failure,arrhythmia,coronary artery lesions,and even ventricular rupture.[2]Therefore,it is often a challenge for surgeons to choose an appropriate surgical strategy for patients with severe valvular AC.[3,4]A sutureless valve is a good choice,doing away with the need to take time to remove the AC,but many countries do not have this *** aortic valve implantation(TAVI)and transcatheter mitral valve replacement(TMVR)have developed rapidly during recent years.

关键词： mitral implantation calcification