Predicted essential proteins of Plasmodium falciparum for potential drug targets

作     者：Qing-Feng He Li Deng Qin-Ying Xu Zheng Shao 

作者机构：Department of ParasitologyGuangdong Medical College 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第5期

页      面：352-354页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Science and Technology Innovation Fund of Guangdong Medical College(No.STIF 201107) 

主　　题：Plasmodium falciparum Essential proteins Database of essential genes Druggability Potential drug targets 

摘      要：Objective:To identify novel drug targets for treatment of Plasmodium ***: Local *** were used to find the proteins non-homologous to human essential proteins as novel drug *** domains of novel drug targets were identified by InterPro and Pfam.3D structures of potential drug targets were predicated by the SWISS-MODEL workspace. Ligands and ligand-binding sites of the proteins were searched by ***:Three essential proteins were identified that might be considered as potential drug ***37254.1 belonged to 1-deoxy-D-xylulose 5-phosphate reductoisomerase,CAD50499.1 belonged to chorismale synthase,CAD51220.1 belonged to FAD binging 3 family,but the function of CAD51220.1 was *** 3D structures,ligands and ligand-binding sites of AAM37254.1 and CAD50499.1 were successfully ***:Two of these potential drug targets are key enzymes in 2-C-methyl-d-erythritol 4-phosphate pathway and shikimate pathway, which are absent in humans,so these two essential proteins are good potential drug *** function and 3D structures of CAD50499.1 is still unknown,it still need further study.