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Thoracic spine infection caused by Pseudomonas fluorescens:A case report and review of literature

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World Journal of Clinical Cases 2024年第12期12卷 2099-2108页

作者： liang li Bao-Hua Zhang Jin-Feng Cao li-Jin Zhang ling-ling Guo Department of Traditional Chinese Medicine Zibo Central HospitalZibo 255000Shandong ProvinceChina Department of Pathology Zibo Central HospitalZibo 255000Shandong ProvinceChina Department of Medical Imaging Zibo Central HospitalZibo 255000Shandong ProvinceChina

BACKGROUND The clinical incidence of spinal infection is gradually increasing,and its onset is insidious,easily leading to missed diagnosis and misdiagnosis,which may lead to serious complications such as nervous system dysfunction,spinal instability and/or deformity,and cause a huge burden on society and families.Early identification of the causative agent and precision medicine will greatly reduce the suffering of patients.At present,the main pathogenic bacteria that cause spinal infection are Staphylococcus aureus,Streptococcus,Pneumococcus,Escherichia coli,and Klebsiella.There are no reports of spinal infection caused by Pseudomonas fluorescens.CASE SUMMARY We report a 32-year-old female patient with spinal infection.She presented with flank pain,initially thought to be bone metastases or bone tuberculosis,and had a family background of tumors.Her clinical features and changes in imaging and laboratory tests led to the suspicion of thoracic spine infection.Histopathology of the lesion showed inflammation,tissue culture of the lesion was negative several times,and the possible pathogen-Pseudomonas fluorescens was found after gene sequencing of the lesion.The patient recovered completely after a full course of antibiotic treatment.CONCLUSION This report increases the range of pathogens involved in spinal infections,highlights the unique advantages of gene sequencing technology in difficult-todiagnose diseases,and validates conservative treatment with a full course of antibiotics for spinal infections without complications.

关键词： Thoracic spine infection Pseudomonas fluorescens Spinal infection Case report

Realization of flexible in-memory computing in a van der Waals ferroelectric heterostructure tri-gate transistor

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Nano Research 2024年第3期17卷 1886-1892页

作者： Xinzhu Gao Quan Chen Qinggang Qin liang li Meizhuang liu Derek Hao Junjie li Jingbo li Zhongchang Wang Zuxin Chen School of Semiconductor Science and Technology South China Normal UniversityFoshan 528225China Guangdong Provincial Key Laboratory of Chip and Integration Technology Guangzhou 510631China Institute of Solid State Physics Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230601China School of Science STEM CollegeRMIT UniversityMelbourne 3000Australia CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Technical Institute of Physics&ChemistryChinese Academy of SciencesUrumqi 830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China College of Optical Science and Engineering Zhejiang UniversityHangzhou 310027China International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga s/nBraga 4715-330Portugal

Combining logical function and memory characteristics of transistors is an ideal strategy for enhancing computational efficiency of transistor devices.Here,we rationally design a tri-gate two-dimensional(2D)ferroelectric van der Waals heterostructures device based on copper indium thiophosphate(CuInP_(2)S_(6))and few layers tungsten disulfide(WS_(2)),and demonstrate its multi-functional applications in multi-valued state of data,non-volatile storage,and logic operation.By co-regulating the input signals across the tri-gate,we show that the device can switch functions flexibly at a low supply voltage of 6 V,giving rise to an ultra-high current switching ratio of 107 and a low subthreshold swing of 53.9 mV/dec.These findings offer perspectives in designing smart 2D devices with excellent functions based on ferroelectric van der Waals heterostructures.

关键词： two-dimensional(2D)ferroelectric heterostructure tri-gate polymorphic regulation in-memory computing

Mechanism of Mingjing Granules in Treating Wet Age-Related Macular Degeneration Based on Network Pharmacology and Experimental Verification

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 22-32页

作者： Xiao-Yu li li-Na liang Wei-Jun Zhang Yun Gao Qiang Chen Eye Function Laboratory Eye HospitalChina Academy of Chinese Medical SciencesBeijingChina China Evidence-Based Medicine Center for Traditional Chinese Medicine BeijingChina Center for East-West Medicine UCLA David Geffen School of MedicineLos AngelesCAUSA

Objective:To analyze the potential mechanism of Mingjing granules in the treatment of wet age-related macular degeneration(wAMD)based on the research methods of network pharmacology and molecular docking approach and to provide a new reference for the currently limited treatment of wAMD.Materials and Methods:We searched TCMSP,GeneCards,OMIM,PharmGkb,TTD,and DrugBank database to screen the main active ingredients of Mingjing granules and their therapeutic targets of wAMD.The network of active components and targets was constructed using Cytoscape3.6.1 software,which was also used for the topological analysis of target genes.The network of Protein-Protein Interactions(PPI)was mapped using the String platform.We also used R language to do the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway for additional analysis.Molecular docking studies were finished by Chemoffice,Autodock,and Pymol.Finally,the efficacy of the Mingjing granules was examined in animal experiments,in which we used enzyme-linked immunosorbent assay to the contents of vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)levels in peripheral blood.Results:Active compounds,including quercetin,lignocaine,and kaempferol,were found.PPI network analysis showed that tumor necrosis factor(TNF),MMP-9,epidermal growth factor(EGF),prostaglandin-endoperoxide synthase 2(PTGS2),and caspase-3(CASP3)were related to both Mingjing granules and wAMD.GO and KEGG pathway analysis showed that these targets were mainly involving lipids and atherosclerosis,TNF,and interleukin-17(IL-17)signaling pathways.Docking studies suggested that quercetin and luteolin can fit in the binding pocket of four target proteins(CASP3,EGF,PTGS2,and TNF).In the vivo experiment,the Mingjing granules were found to be effective on the expression of VEGF and MMP-9 in peripheral blood.Conclusions:This study initially reveals the multi-constituent,multi-target,and multi-pathway mechanism of action of Mingjing granules in the treatment of wAMD and impli

关键词： Experimental verification Mingjing granules molecular docking network pharmacology wet age-related macular degeneration

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Correlation analysis between lung ultrasound scores and pulmonary arterial systolic pressure in patients with acute heart failure admitted to the emergency intensive care unit

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Journal of Intensive Medicine 2024年第1期4卷 125-132页

作者： Ping Xu Basma Nasr liang li Wenbin Huang Wei liu Xuelian Wang Emergency Department Zigong Fourth People’s HospitalZigongChina Institute of Medical Big Data Zigong Academy of Artificial Intelligence and Big Data for Medical ScienceZigongChina Artificial Intelligence Key Laboratory of Sichuan Province ZigongChina Department of Cardiology First Affiliated Hospital of Dalian Medical UniversityDalianChina

Background:No convenient,inexpensive,and non-invasive screening tools exist to identify pulmonary hypertension(PH)-left heart disease(LHD)patients during the early stages of the disease course.This study investigated whether different methods of lung ultrasound(LUS)could be used for the initial investigation of PH-LHD.Methods:This was a single-center prospective observational study which was performed in the Zigong Fourth People’s Hospital.We consecutively enrolled patients with heart failure(HF)admitted to the emergency intensive care unit from January 2018 to May 2020.Transthoracic echocardiography and LUS were performed within 24 h before discharge.We used the Spearman coefficient for correlation analysis between ultrasound scores and pulmonary arterial systolic pressure(PASP).Bland-Altman plots were generated to inspect possible bias,and receiver operating characteristic(ROC)curves were calculated to assess the relationship between ultrasound scores and an intermediate and high echocardiographic probability of PH-LHD.Results:Seventy-one patients were enrolled in this study,with an overall median age of 79(interquartile range:71.5–84.0)years.Among the 71 patients,36(50.7%)cases were male,and 26(36.6%)had an intermediate and high echocardiographic probability of PH.All four LUS scores in patients with an intermediate and high probability of PH were significantly higher than in patients with a low probability of PH(Plity of PH(P<0.05).

关键词： Acute heart failure Pulmonary arterial systolic pressure Pulmonary hypertension Left heart disease Lung ultrasound

A Novel Analysis Approach of Uniform Persistence for an Epidemic Model with Quarantine and Standard Incidence Rate

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 695-707页

作者： Song-bai GUO Yu-ling XUE Xi-liang li Zuo-huan ZHENG School of Science Beijing University of Civil Engineering and ArchitectureBeijing 102616China School of Mathematics and Statistics Hainan Normal UniversityHaikou 571158China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematics and Information Science Shandong Technology and Business UniversityYantai 264005China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Inspired by the transmission characteristics of the coronavirus disease 2019(COVID-19),an epidemic model with quarantine and standard incidence rate is first developed,then a novel analysis approach is proposed for finding the ultimate lower bound of the number of infected individuals,which means that the epidemic is uniformly persistent if the control reproduction number R_(c)>1.This approach can be applied to the related biomat hem at ical models,and some existing works can be improved by using that.In addition,the infection-free equilibrium V^(0)of the model is locally asymptotically stable(LAS)if R_(c)linearly stable if R_(c)=1;while V^(0)is unstable if R_(c)>1.

关键词： uniform persistence epidemic model control reproduction number quarantine standard incidence rate

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A Novel Fracturing Fluid with High-Temperature Resistance for Ultra-Deep Reservoirs

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Fluid Dynamics & Materials Processing 2024年第5期20卷 975-987页

作者： lian liu liang li Kebo Jiao Junwei Fang Yun Luo Northwest Oilfield Branch China Petroleum&Chemical CorporationUrumqi830011China Sinopec Key Laboratory for Enhanced Recovery in Fractured and Cavernous Reservoir Urumqi830011China

Ultra-deep reservoirs play an important role at present in fossil energy exploitation.Due to the related high temperature,high pressure,and high formation fracture pressure,however,methods for oil well stimulation do not produce satisfactory results when conventional fracturing fluids with a low pumping rate are used.In response to the above problem,a fracturing fluid with a density of 1.2~1.4 g/cm^(3)was developed by using Potassium formatted,hydroxypropyl guanidine gum and zirconium crosslinking agents.The fracturing fluid was tested and its ability to maintain a viscosity of 100 mPa.s over more than 60 min was verified under a shear rate of 1701/s and at a temperature of 175℃.This fluid has good sand-carrying performances,a low viscosity after breaking the rubber,and the residue content is less than 200 mg/L.Compared with ordinary reconstruction fluid,it can increase the density by 30%~40%and reduce the wellhead pressure of 8000 m level reconstruction wells.Moreover,the new fracturing fluid can significantly mitigate safety risks.

关键词： Ultra-deep reservoir high-temperature resistance weighted fracturing fluid guanidine gum potassium formatted

Nonstoichiometric In-S group yielding efficient carrier transfer pathway in In_(2)S_(3) photoanode for solar water oxidation

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SusMat 2024年第1期4卷 154-165页

作者： Runyu Chen linxing Meng Changda Wang Weiwei Xu Yulong Huang li Song liang li School of Physical Science and Technology Jiangsu Key Laboratory of Thin FilmsCenter for Energy Conversion Materials&PhysicsSoochow UniversitySuzhouJiangsuP.R.China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhouJiangsuP.R.China National Synchrotron Radiation Laboratory CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefeiAnhuiP.R.China School of Electronic and Information Engineering Changshu Institute of TechnologyChangshuJiangsuP.R.China

The construction of high-efficiency photoanodes is essential for developing outstanding photoelectrochemical(PEC)water splitting cells.Furthermore,insufficient carrier transport capabilities and sluggish surface water oxidation kinetics limit its application.Using a solvothermal annealing strategy,we prepared a nonstoichiometric In-S(NS)group on the surface of an In_(2)S_(3) photoanode in situ and unexpectedly formed a type II transfer path of carrier,thereby reducing the interfacial recombination and promoting the bulk separation.Firstprinciples calculations and comprehensive characterizations demonstrated NS group as an excellent oxygen evolution cocatalyst(OEC)that effectively facilitated carrier transport,lowered the surface overpotential,increased the surface active site,and accelerated the surface oxygen evolution reaction kinetics by precisely altering the rate-determining steps of*to*OH and*O to*OOH.These synergistic effects remarkably enhanced the PEC performance,with a high photocurrent density of 5.02 mA cm^(−2)at 1.23 V versus reversible hydrogen electrode and a negative shift in the onset potential by 310 mV.This work provides a new strategy for the in situ preparation of high-efficiency OECs and provides ideas for constructing excellent carrier transfer and transport channels.

关键词： In_(2)S_(3) photoanode water splitting

High-precision X-ray polarimeter based on channel-cut crystals

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Nuclear Science and Techniques 2024年第3期35卷 30-39页

作者： Shang-Yu Si Zhong-liang li Wen-Hong Jia lian Xue Hong-Xin Luo Jian-Cai Xu Bai-Fei Shen lin-Gang Zhang liang-liang Ji Yu-Xin Leng Ren-Zhong Tai Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China

We report on using synthetic silicon for a high-precision X-ray polarimeter comprising a polarizer and an analyzer,each based on a monolithic channel-cut crystal used at multiple Brewster reflections with a Bragg angle very close to 45°.Experiments were performed at the BL09B bending magnet beamline of the Shanghai Synchrotron Radiation Facility using a Si(800)crystal at an X-ray energy of 12.914 keV.A polarization purity of 8.4×10^(-9)was measured.This result is encouraging,as the measured polarization purity is the best-reported value for the bending magnet source.Notably,this is the firstly systematic study on the hard X-ray polarimeter in China,which is crucial for exploring new physics,such as verifying vacuum birefringence.

关键词： X-ray polarimeter Vacuum birefringence Synchrotron radiation Channel-cut crystal

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Spectral properties and energy of weighted adjacency matrix for graphs with a degree-based edge-weight function

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Acta Mathematica Sinica,English Series 2024年

作者： Xue liang li Ning YANG Center for Combinatorics and LPMC Nankai University

Let G be a graph and di denote the degree of a vertex vi in G, and let f(x, y) be a real symmetric function. Then one can get an edge-weighted graph in such a way that for each edge vivj of G, the weight of vivj is assigned by the value f(di, dj). Hence, we have a weighted adjacency matrix Af(G) of G, in which the ij-entry is equal to f(di, dj) if vivj ∈ E(G) and 0 otherwise. This paper attempts to unify the study of spectral properties for the weighted adjacency matrix Af(G) of graphs with a degree-based edge-weight function f(x, y). Some lower and upper bounds of the largest weighted adjacency eigenvalue λ1 are given, and the corresponding extremal graphs are characterized. Bounds of the energy Ef(G) for the weighted adjacency matrix Af(G) are also obtained. By virtue of the unified method, this makes many earlier results become special cases of our results.

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