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基于稀疏A^(*)与人工势场算法的EOSID路径规划

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现代计算机 2024年第5期30卷 56-60,76页

作者：杨军利李阿丹程颖李立坤中国民用航空飞行学院飞行技术学院广汉618300 中国东方航空武汉有限责任公司武汉430000 中国商用飞机有限责任公司上海200000

为提升起飞一发失效应急程序(EOSID)的制作效率,根据飞机性能限制和民航相关规章要求,提出了基于数字高程模型(DEM)的稀疏A和人工势场算法的ESOID全局路径规划方法,并进行了实例验证。结果表明,应用该方法可提升规划算法的局部避障能力... 详细信息

为提升起飞一发失效应急程序(EOSID)的制作效率,根据飞机性能限制和民航相关规章要求,提出了基于数字高程模型(DEM)的稀疏A和人工势场算法的ESOID全局路径规划方法,并进行了实例验证。结果表明,应用该方法可提升规划算法的局部避障能力及鲁棒性,生成的起飞一发失效三维路径与传统人工方法相近,为EOSID路径的自动规划提供了一种可行方法。

关键词： EOSID 路径规划稀疏A^(*) 人工势场法

低能量激光对机械压力作用下牙周膜成纤维细胞成骨分化作用的研究

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中国激光医学杂志 2024年第4期33卷 181-186,237,238页

作者：柳强刘亚辉李利坤郭建茹唐山职业技术学院附属医院口腔牙周科唐山市063004 唐山职业技术学院附属医院检验科唐山市063004 唐山职业技术学院附属医院病理科唐山市063004

目的探究低能量激光(low-level laser,LLL)对机械压力作用下人牙周膜成纤维细胞(human periodontal ligament fibroblasts,hPDLFs)成骨分化的作用。方法研究对象为体外培养hPDLFs,将细胞分为空白组、模型组和干预组,其中空白组细胞不给... 详细信息

目的探究低能量激光(low-level laser,LLL)对机械压力作用下人牙周膜成纤维细胞(human periodontal ligament fibroblasts,hPDLFs)成骨分化的作用。方法研究对象为体外培养hPDLFs,将细胞分为空白组、模型组和干预组,其中空白组细胞不给予机械压力或LLL干预;模型组细胞给予2 g/cm^(2)的机械静压力干预;干预组细胞给予机械压力后再行LLL干预。LLL激光照射波长为810 nm,光纤直径400μm,频率2.46 Hz,功率100 mW,光斑面积9.6 cm^(2),功率密度10 mW/cm^(2),能量密度值为3.75 J/cm^(2),干预24 h后,qPCR检测细胞成骨基因Runt相关转录因子2(Runt-related transcription factor 2,Runx2)、骨钙素(osteocalcin,OCN)、骨形态发生蛋白2(bone morphogenetic protein 2,BMP2)的mRNA水平,碱性磷酸酶(alkaline phosphatase,ALP)及茜素红(alizarin red,ARS)染色检测细胞成骨分化情况,Western blotting检测细胞BMP2蛋白及Smad1/5/9蛋白磷酸化水平。结果分离培养的hPDLFs表达波形丝蛋白及细胞角蛋白,符合hPDLFs特征。模型组和干预组细胞Runx2、OCN、BMP2的mRNA水平、ALP及ARS染色面积、BMP2蛋白及Smad1/5/9蛋白磷酸化水平显著高于空白组(P<0.05)。此外,干预组上述指标水平均显著高于模型组(P<0.05)。进一步对干预组细胞给予BMP/smad通路抑制剂LDN-193189处理,发现LDN-193189干预显著减少了细胞ALP及ARS染色面积(P<0.05)。结论LLL能够通过BMP2/Smad1/5/9通路促进机械压力作用下hPDLFs成骨分化。

关键词：低能量激光机械压力牙周膜成纤维细胞成骨分化

Research on ozone formation sensitivity based on observational methods:Development history,methodology,and application and prospects in China

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Journal of Environmental Sciences 2024年第4期138卷 543-560页

作者： Wanghui Chu Hong li Yuanyuan Ji Xin Zhang likun Xue Jian Gao Cong An State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Environment Research Institute Shandong UniversityQingdao 266237China

Observation-based method for O_(3)formation sensitivity research is an important tool to analyze the causes of ground-level O_(3)pollution,which has broad application potentials in determining the O_(3)pollution formation mechanism and developing prevention and control *** paper outlined the development history of research on O_(3)formation sensitivity based on observational methods,described the principle and applicability of the methodology,summarized the relative application results in China and provided recommendations on the prevention and control of O_(3)pollution in China based on relevant study results,and finally pointed out the shortcomings and future development prospects in this field in *** overview study showed that the O_(3)formation sensitivity in some urban areas in China in recent years presented a gradual shifting tendency from the VOC-limited regime to the transition regime or the NO_(x)-limited regime due to the implementation of the O_(3)precursors emission reduction policies;O_(3)pollution control strategies and precursor control countermeasures should be formulated based on local conditions and the dynamic control capability of O_(3)pollution control measures should be *** are still some current deficiencies in the study field in ***,it is recommended that a stereoscopic monitoring network for atmospheric photochemical components should be further constructed and improved;the atmospheric chemical mechanisms should be vigorously developed,and standardized methods for determining the O_(3)formation sensitivity should be established in China in the near future.

关键词： Observation-based method Ozone formation sensitivity Ozone pollution prevention and control VOCs NO_(x) OBM

Interfacial built-in electric field and crosslinking pathways enabling WS_(2)/Ti_(3)C_(2)T_(x) heterojunction with robust sodium storage at low temperature

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Journal of Energy Chemistry 2024年第2期89卷 635-645,I0014页

作者： Jiabao li Shaocong Tang Jingjing Hao Quan Yuan Tianyi Wang likun Pan Jinliang li Shenbo Yang Chengyin Wang College of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuChina Shanghai Key Laboratory of Magnetic Resonance School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsGuangdong Provincial Key Laboratory of Nanophotonic ManipulationDepartment of PhysicsJinan UniversityGuangzhou 510632GuangdongChina Hongzhiwei Technology(Shanghai)CO.LTD Shanghai 200241China

Developing efficient energy storage for sodium-ion batteries(SIBs)by creating high-performance heterojunctions and understanding their interfacial interaction at the atomic/molecular level holds promise but is also ***,sluggish reaction kinetics at low temperatures restrict the operation of SIBs in cold ***,cross-linking nanoarchitectonics of WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,featuring built-in electric field(BIEF),have been developed,employing as a model to reveal the positive effect of heterojunction design and BIEF for modifying the reaction kinetics and electrochemical ***,the theoretical analysis manifests the discrepancy in work functions leads to the electronic flow from the electron-rich Ti_(3)C_(2)T_(x) to layered WS_(2),spontaneously forming the BIEF and“ion reservoir”at the heterogeneous ***,the generation of cross-linking pathways further promotes the transportation of electrons/ions,which guarantees rapid diffusion kinetics and excellent structure ***,superior sodium storage performance is obtained for the WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,with only 0.2%decay per cycle at 5.0 A g^(-1)(25℃)up to 1000 cycles and a high capacity of 293.5 mA h g^(-1)(0.1A g^(-1)after 100 cycles)even at-20℃.Importantly,the spontaneously formed BIEF,accompanied by“ion reservoir”,in heterojunction provides deep understandings of the correlation between structure fabricated and performance obtained.

关键词： WS_(2)/Ti_(3)C_(2)T_(x)heterojunction Built-in electric field Ion reservoir Reaction kinetics Sodium storage performance at low temperature

Comprehensive understanding on sources of high levels of fine particulate nitro-aromatic compounds at a coastal rural area in northern China

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Journal of Environmental Sciences 2024年第1期135卷 483-494页

作者： Yueru Jiang Xinfeng Wang Min li Yiheng liang Zhiyi liu Jing Chen Tianyi Guan Jiangshan Mu Yujiao Zhu He Meng Yang Zhou Lan Yao likun Xue Wenxing Wang Environment Research Institute Shandong UniversityQingdao 266237China Department of Environmental Systems Science Swiss Federal Institute of Technology ZurichZurich 8092Switzerland Department of Water Resources and Drinking Water Swiss Federal Institute of Aquatic Science and TechnologyDuebendorf 8600Switzerland Qingdao Eco-Environment Monitoring Center of Shandong Province Qingdao 266003China College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100China School of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200234China

Nitro-aromatic compounds(NACs)are among the major components of brown carbon(BrC)in the atmosphere,causing negative impacts on regional climate,air quality,and ecological *** to the extensive origins,it is still a challenge to figure out the contributions and originating regions for different sources of atmospheric ***,field observations on fine particulate NACs were conducted at a coastal rural area in Qingdao,China in the winter of 2018 and *** mean total concentrations of fine particulate nitro-aromatic compounds were 125.0±89.5 and 27.7±21.1 ng/m^(3)in the winter of 2018 and 2019,*** the measured eleven NACs,nitrophenols and nitrocatechols were the most abundant *** characteristics and correlation analysis showed that humidity and anthropogenic primary emissions had significant influences on the NAC *** this study,two tracing methods of the improved spatial concentration weighted trajectory(SCWT)model and the receptor model of positive matrix factorization(PMF)were combined to comprehensively understand the origins of NACs in fine particles at coastal *** major sources were identified,including coal combustion,biomass burning,vehicle exhaust,and secondary ***,coal combustion was responsible for about half of the observed nitro-aromatic compounds,followed by biomass burning(~30%).The results by SCWT demonstrated that the coal combustion dominated NACs mainly originated from the Shandong peninsula and the areas to the north and southwest,while those dominated by biomass burning primarily came from local Qingdao and the areas to the west.

关键词： Nitro-aromatic compounds Fine particles Source apportionment Originating region Combustion activities

QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study

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Signal Transduction and Targeted Therapy 2024年第2期9卷 797-806页

作者： Yan Huang Yunpeng Yang Yuanyuan Zhao Hongyun Zhao Ningning Zhou Yaxiong Zhang likun Chen Ting Zhou Gang Chen Ting Wu Lu Lu Shilin Xue Xiaoyan Kang li Zhang Wenfeng Fang Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineNo.651 Dongfeng East RoadGuangzhouGuangdong 510060China Department of Medicine Qilu Pharmaceutical Co.Ltd.JinanChina

First-line chemoimmunotherapy(with or without bevacizumab)has improved outcomes in advanced non-small cell lung cancer(NSCLC).Here,this open-label,multi-cohort phase II study(NCT05329025)was done to investigate the safety and efficacy of QL1706(a single bifunctional MabPair product against PD-1 and CTLA-4)and chemotherapy with or without bevacizumab in this *** were enrolled into five different cohorts based on genotype(cohorts 1-4,epidermal growth factor receptor[EGFR]wild-type;cohort 5,EGFR-mutant and progressed on EGFR-tyrosine kinase inhibitors[TKIs]).Between June 11,2021 and December 29,2021,91 patients were *** frequent treatment-related adverse events(TRAEs)included decreased appetite(60[65.9%]),anemia(60[65.9%]),infusion-related reactions(48[52.7%]),and pruritus(44[48.4%]).Grade≥3 TRAEs occurred in 30(33.0%)***-seven(45%)patients with wild-type EGFR achieved partial response(PR)(objective response rate[ORR]=45%)and had a median progression-free survival(mPFS)of 6.8 months(95%CI:5.2-9.7).For 31 patients harboring mutated EGFR,17(54.8%)achieved PR(ORR=54.8%),with an mPFS of 8.5 months(95%CI:5.72-not evaluable).Overall,QL1706 plus chemotherapy,regardless of having bevacizumab,was generally tolerable and had promising antitumor activity for EGFR wild-type advanced NSCLC in first-line ***,QL1706 plus chemotherapy and bevacizumab showed favorable antitumor activity for patients who had EGFR mutated NSCLC but failed in TKI therapy,demonstrating a potential for treating this population.

关键词： bevacizumab chemotherapy phase

Shenyang Ice and Snow Festival:Quick Before It Melts!

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China Today 2004年第12期53卷 70-71页

作者： li likun

THE Shenyang Ice and Snow Festival has been makingits name as awinter holiday destination for the past seven years, having learned much from its sister city's international Sapporo Snow Festival. The 2005 Sheny ang Ice and Snow Festival runs from January 15 to 21 at Shenyang Qipan Mountain International Scenery and Tourism Development Zone, China's biggest ski resort.

关键词：沈阳市冰雪节冰雕滑雪旅游胜地

Novel anti-androgen receptor signaling agents:Understanding the mechanisms of resistance

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Asian Journal of Urology 2014年第1期1卷 30-39页

作者： Styliani Karanika Theodoros Karantanos Jianhua Yin likun li Timothy C.Thompson Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Epidemiology Second Military Medical UniversityShanghaiChina

Prostate cancer remains an intractable threat to the lives of men *** deaths from prostate cancer(PCa)in the United States have declined in recent years,in other parts of the world Pca mortality is *** introduction of 2nd generation antiandrogen receptor agents into the therapeutic armamentarium for metastatic castrationresistant prostate cancer(mCRPC)has resulted in modestly increased survival advantages as demonstrated by initial clinical ***,analysis of the molecular pathways affected by these agents may lead to new insight into mechanisms of resistance that drive mCRPC,including proliferation and survival signaling pathways that are derepressed by maximum repression of androgen *** therapies that involve anti-AR signaling agents together with agents that target these pathways establish a paradigm for the development of more effective treatment of *** this review,we briefly summarize the current clinical trial literature with regard to novel anti-AR signaling agents such as abiraterone acetate and *** discuss observational data that point to mechanisms of resistance that emerged from these *** further present and discuss recent experimental studies that address the mechanisms of resistance to these ***,we discuss novel and rational therapeutic approaches,including combination therapy,for patients with mCRPC.

关键词： Prostate cancer Castration-resistant prostate cancer Anti-androgen receptor agents Combination therapies

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Let There Be light

China Today 2008年第4期57卷 70-75页

作者： GAO YAN li likun

THE express train of the Chinese economy can only keep going when its fuel tank is full. like any part of the world, China depends heavily on electricity. In China’s case its power supply comes primarily from coal-burning power stations. With a tremendous trove of the flammable black rock, Shanxi Province in north China is traditionally the locomotive of the nation’s power industry. During an inspection of the province in July 2005, President Hu Jintao commented: "As a major coal producer, Shanxi should take advantage of its

关键词：中国经济发展能源管理电力系统