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Towards Task-Free Privacy-Preserving Data Collection

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China Communications 2022年第7期19卷 310-323页

作者： Zhibo Wang Wei Yuan Xiaoyi Pang jingxin li Huajie Shao School of Cyber Science and Engineering Wuhan University430072 China School of Cyber Science and Technology Zhejiang University310027 China State Key Laboratory of Integrated Services Networks Xidian University710071 China Department of Computer Science College of William and MaryWilliamsburgVA23186 USA

With the rapid developments of Internet of Things(IoT)and proliferation of embedded devices,large volume of personal data are collected,which however,might carry massive private information about attributes that users do not want to *** privacy-preserving methods have been proposed to prevent privacy leakage by perturbing raw data or extracting task-oriented features at local ***,they would suffer from significant privacy leakage and accuracy drop when applied to other tasks as they are designed and optimized for predefined *** this paper,we propose a novel task-free privacy-preserving data collection method via adversarial representation learning,called TF-ARL,to protect private attributes specified by users while maintaining data utility for unknown downstream *** this end,we first propose a privacy adversarial learning mechanism(PAL)to protect private attributes by optimizing the feature extractor to maximize the adversary’s prediction uncertainty on private attributes,and then design a conditional decoding mechanism(ConDec)to maintain data utility for downstream tasks by minimizing the conditional reconstruction error from the sanitized *** the joint learning of PAL and ConDec,we can learn a privacy-aware feature extractor where the sanitized features maintain the discriminative information except *** experimental results on real-world datasets demonstrate the effectiveness of TF-ARL.

关键词： IoT privacy protection data collection adversarial learning deep learning

Systematic characterization of small RNAs associated with *** Argonautes

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Science China(life Sciences) 2023年第6期66卷 1303-1322页

作者： Lei liu Xiaolin Wang Wenfang Zhao Qiqi li jingxin li He Chen Ge Shan Department of Laboratory Medicine The First Affiliated Hospital of USTCthe CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei230027China Information Materials and Intelligent Sensing Laboratory of Anhui Province Anhui UniversityHefei230601China Department of Pulmonary and Critical Care Medicine Regional Medical Center for National Institute of Respiratory DiseasesSir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China

Argonaute proteins generally play regulatory roles by forming complexes with the corresponding small RNAs(s RNAs).An expanded Argonaute family with 20 potentially functional members has been identified in Caenorhabditis *** s RNAs in *** are mi RNAs,small interfering RNAs including 22G-RNAs and 26G-RNAs,and 21U-RNAs,which are *** pi *** studies have only covered some of these Argonautes for their s RNA partners,and thus,a systematic study is needed to reveal the comprehensive regulatory networks formed by *** Argonautes and their associated s *** obtained in situ knockin(KI)strains of all *** Argonautes with fusion tags by CRISPR/Cas9 *** immunoprecipitation against these endogenously expressed Argonautes and high-throughput sequencing acquired the s RNA profiles of individual *** s RNA partners for each Argonaute were then *** found that there were 10Argonautes enriched mi RNAs,17 Argonautes bound to 22G-RNAs,8 Argonautes bound to 26G-RNAs,and 1 Argonaute PRG-1bound to pi *** 22G-RNAs were bound by four Argonautes HRDE-1,WAGO-4,CSR-1,and *** found that all four Argonautes played a role in transgenerational epigenetic *** roles of the corresponding Argonaute-s RNA complex in managing levels of long transcripts and interspecies regulation were also *** this study,we portrayed the s RNAs bound to each functional Argonaute in *** analyses together with experimental investigations provided perceptions in the overall view of the regulatory network formed by *** Argonautes and s *** s RNA profiles bound to individual Argonautes reported here will be valuable resources for further studies.

关键词： Argonaute miRNA 22G-RNAs 26G-RNAs piRNA uridylation transgenerational inheritance interspecies

Characteristics of air pollution events over Hotan Prefecture at the southwestern edge of Taklimakan Desert, China

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Journal of Arid Land 2018年第5期10卷 686-700页

作者： li jingxin WANG Shigong CHU Jinhua WANG Jiaxin li Xu YUE Man SHANG Kezheng State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Beijing 100081 China Sichuan Key Laboratory of Plateau Atmosphere and Environment College of Atmospheric Sciences Chengdu University of Information Technology Chengdu 610225 China Gansu Key Laboratory of Arid Climate Change and Reducing Disaster College of Atmospheric Sciences Lanzhou University Lanzhou 730000 China Chongqing Meteorological Bureau Chongqing 401147 China

Hotan Prefecture is located at the southwestern edge of Taklimakan Desert, the world＇s largest shifting sand desert, of China. The desert is one of the main sources for frequent sand-dust weather events which strongly affect the air quality of Hotan Prefecture. Although this region is characterized by the highest annual mean PMlo concentration values that are routinely recorded by environmental monitoring stations across China, both this phenomenon and its underlying causes have not been adequately addressed in previous researches. Reliable pollutant PM_10 data are currently retrieved using a tapered element oscillating microbalance （TEOM） 1400a, a direct real-time monitor, while additional concentration values including for PM_2.5, sulfur dioxide （SO_2）, nitrogen dioxide （NO_2）, carbon monoxide （CO） and ozone （O_3） have been collected in recent years by the Hotan Environmental Monitoring Station. Based on these data, this paper presents a comparison of the influences of different kinds of sand-dust weather events on PM_10 （or PM_2.5） as well as the concentrations of other gaseous pollutants in Hotan Prefecture. It is revealed that the highest monthly average PM_10 concentrations are observed in the spring because of the frequent occurrence of three distinct kinds of sand-dust weather events at this time, including dust storms, blowing dust and floating dust. The floating dust makes the most significant contribution to PM_10 （or PM_2.5） concentration in this region, a result that differs from eastern Chinese cities where the heaviest PM_10 pollution occurs usually in winter and air pollution results from the excess emission of local anthropogenic pollutants. It is also shown that PM_10 concentration varies within wpical dust storms. PM_10 concentrations vary among 20 dust storm events within Hotan Prefecture, and the hourly mean concentrations tend to sharply increase initially then slowly decreasing over time. Data collected from cities in eastern China show the op

关键词： PM10 (or PM2.5) concentration sand-dust weather events gaseous pollutants air pollution Taklimakan Desert

Attention-based neural network for end-to-end music separation

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CAAI Transactions on Intelligence Technology 2023年第2期8卷 355-363页

作者： Jing Wang Hanyue liu Haorong Ying Chuhan Qiu jingxin li Muhammad Shahid Anwar Beijing Institute of Technology BeijingChina Communication University of China BeijingChina China Electronics Standardization Institute BeijingChina Gachon University SeongnamSouth Korea

The end-to-end separation algorithm with superior performance in the field of speech separation has not been effectively used in music ***,since music signals are often dual channel data with a high sampling rate,how to model longsequence data and make rational use of the relevant information between channels is also an urgent problem to be *** order to solve the above problems,the performance of the end-to-end music separation algorithm is enhanced by improving the network *** main contributions include the following:(1)A more reasonable densely connected U-Net is designed to capture the long-term characteristics of music,such as main melody,tone and so on.(2)On this basis,the multi-head attention and dualpath transformer are introduced in the separation *** attention units are applied recursively on the feature map of each layer of the network,enabling the network to perform long-sequence *** results show that after the introduction of the channel attention,the performance of the proposed algorithm has a stable improvement compared with the baseline *** the MUSDB18 dataset,the average score of the separated audio exceeds that of the current best-performing music separation algorithm based on the time-frequency domain(T-F domain).

关键词： channel attention densely connected network end-to-end music separation

Thermal conductivity and bending strength of SiC composites reinforced by pitch-based carbon fibers

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Journal of Advanced Ceramics 2022年第2期11卷 247-262页

作者： liyang CAO Yongsheng liU Yunhai ZHANG Yejie CAO jingxin li Jie CHEN Lu ZHANG Zheng QI Science and Technology on Thermostructural Composites Materials Laboratory Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Space Physics Laboratory Beijing 100076China

In this work,pitch-based carbon fibers were utilized to reinforce silicon carbide(SiC)composites via reaction melting infiltration(RMI)method by controlling the reaction temperature and resin carbon *** conductivities and bending strengths of composites obtained under different preparation conditions were characterized by various analytical *** showed the formation of SiC whiskers(SiC_(w))during RMI process according to vapor–solid(VS)***_(w) played an important role in toughening the C_(pf)/SiC composites due to crack bridging,crack deflection,and SiC_(w) *** in reaction temperature during RMI process led to an initial increase in thermal conductivity along in-plane and thickness directions of composites,followed by a *** reaction temperature of 1600℃,thermal conductivities along the in-plane and thickness directions were estimated to be 203.00 and 39.59 W/(m×K),*** these conditions,bending strength was recorded as 186.15±3.95 *** in resin carbon content before RMI process led to the generation of more SiC *** conductivities along in-plane and thickness directions remained stable with desirable values of 175.79 and 38.86 W/(m×K),*** comparison,optimal bending strength improved to 244.62±3.07 *** sum,these findings look promising for future application of pitch-based carbon fibers for reinforcement of SiC ceramic composites.

关键词： pitch-based carbon fiber continuous carbon fiber reinforced silicon carbide matrix composites(C/SiC) thermal conductivity bending strength

Comparison of dust emissions, transport, and deposition between the Taklimakan Desert and Gobi Desert from 2007 to 2011

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Science China Earth Sciences 2017年第7期60卷 1338-1355页

作者： CHEN SiYu HUANG JianPing li jingxin JIA Rui JIANG NanXuan KANG liTai MA XiaoJun XIE TingTing Lanzhou University College of Atmospheric Sciences Chinese Academy of Meteorological Sciences Institute of Climate System (Polar Meteorology) State Key Laboratory of Severe Weather

The Taklimakan Desert(TD) and Gobi Desert(GD) are two of the most important dust sources in East Asia, and have important impact on energy budgets, ecosystems and water cycles at regional and even global scales. To investigate the contribution of the TD and the GD to dust concentrations in East Asia as a whole, dust emissions, transport, and deposition over the TD and the GD in different seasons from 2007 to 2011 were systematically compared, based on the Weather Research and Forecasting model coupled with Chemistry(WRF-Chem). Dust emissions, uplift, and long-range transport related to these two dust source regions were markedly different due to differences in topography, elevation, thermal conditions, and atmospheric circulation. Specifically,the topography of the GD is relatively flat, and at a high elevation, and the area is under the influence of two jet streams at high altitudes, resulting in high wind speeds in the upper atmosphere. Deep convective mixing enables the descending branch of jet streams to continuously transport momentum downward to the mid-troposphere, leading to enhanced wind speeds in the lower troposphere over the GD which favors the vertical uplift of the GD dust particles. Therefore, the GD dust was very likely to be transported under the effect of strong westerly jets, and thus played the most important role in contributing to dust concentrations in East Asia. Approximately 35% and 31% of dust emitted from the GD transported to remote areas in East Asia in spring and summer, respectively. The TD has the highest dust emission capabilities in East Asia, with emissions of about 70.54 Tg yr.1 in spring, accounting for 42% of the total dust emissions in East Asia. However, the TD is located in the Tarim Basin and surrounded by mountains on three sides. Furthermore, the dominant surface wind direction is eastward and the average wind speed at high altitudes is relatively small over the TD. As a result, the TD dust particles are not easily transpo

关键词： East Asian dust WRF-Chem model Taklimakan Desert Dust Gobi Desert Dust Dust emissions Dust transport Dust deposition

Single-Exosome Profiling Identifies ITGB3+and ITGAM+Exosome Subpopulations as Promising Early Diagnostic Biomarkers and Therapeutic Targets for Colorectal Cancer

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Research 2023年第3期6卷 491-505页

作者： Wei Guo Yanling Cai Xianming liu Yuge Ji Cuiyu Zhang liyan Wang Wenting liao Yuefei liu Nan Cui Jinsheng Xiang Zesong li Di Wu jingxin li Department of Physiology School of Basic Medical SciencesDepartment of Colorectal SurgeryQilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong250012China Guangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors Department of UrologyThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's Hospital(Shenzhen Institute of Translational Medicine)Shenzhen518035China Shenzhen Key Laboratory of Genitourinary Tumor Department of UrologyThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's Hospital(Shenzhen Institute of Translational Medicine)Shenzhen518035China Department of Gastrointestinal Surgery Shenzhen People’s HospitalThe Second Clinical Medical College of Jinan UniversityThe First Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdong518020China Center for Experimental Nuclear Medicine and Electron Microscope School of Basic Medical SciencesShandong UniversityJinanShandong250012China Shenzhen SecreTech Co. Ltd.ShenzhenChina Vesicode AB Nobelsvag 16SolnaSweden

Tumor metastasis is a hallmark of colorectal cancer(CRC),in which exosome plays a crucial role with its function in intercellular *** exosomes were collected from healthy control(HC)donors,localized primary CRC and liver-metastatic CRC *** performed proximity barcoding assay(PBA)for single-exosome analysis,which enabled us to identify the alteration in exosome subpopulations associated with CRC *** in vitro and in vivo experiments,the biological impact of these subpopulations on cancer proliferation,migration,invasion,and metastasis was *** potential application of exosomes as diagnostic biomarkers was evaluated in 2 independent validation cohorts by *** distinct exosome subpopulations were *** found 2 distinctly abundant subpopulations:one ITGB3-positive and the other *** ITGB3-positive cluster is rich in liver-metastatic CRC,compared to both HC group and primary CRC *** the contrary,ITGAM-positive exosomes show a large-scale increase in plasma of HC group,compared to both primary CRC and metastatic CRC ***,both discovery cohort and validation cohort verified ITGB3+exosomes as potential diagnostic ***3+exosomes promote proliferation,migration,and invasion capability of *** contrast,ITGAM+exosomes suppress CRC ***,we also provide evidence that one of the sources of ITGAM+exosomes is ***3+exosomes and ITGAM+exosomes are proven 2 potential diagnostic,prognostic,and therapeutic biomarkers for management of CRC.

关键词： invasion metastasis Exosome

Molecular Epidemiological Characteristics of Gastroenteritis Outbreaks Caused by Norovirus GII.4 Sydney[P31]Strains—China,October 2016–December 2020

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China CDC weekly 2021年第53期3卷 1127-1132,I0001页

作者： Xi Zhu Yaqing He Xingyan Wei Xiangyu Kong Qing Zhang jingxin li Miao Jin Zhaojun Duan Key Laboratory of Medical Virology and Viral Diseases Ministry of Health of the People’s Republic of ChinaBeijingChinaNational Institute for Viral Disease Control and PreventionChina CDCBeijingChina Shenzhen Center for Disease Control and Prevention ShenzhenGuangdongChina.

Introduction:Human noroviruses are the leading cause of acute viral gastroenteritis(AGE)worldwide in all age ***.4 strains have been the predominant genotype circulating globally over the last 2 decades and since ***.4 Sydney viruses have emerged and caused the majority of AGE outbreaks ***:Data from norovirus outbreaks from the laboratory-based surveillance of norovirus outbreaks in China(CaliciNet China)between October 2016–December 2020 were ***:During October 2016–December 2020,1,954 norovirus outbreaks were reported,and positive fecal samples from 1,352(69.19%)outbreaks were ***.4 Sydney[P31]viruses accounted for 2.1%(October 2016–August 2017),5.5%(September 2017–August 2018),3.3%(September 2018–August 2018),26.6%(September 2019–August 2020),and and 1.1%(September 2020–December 2020)of GII outbreaks,*** to reference strains of GII.4 Sydney[P31]from 2012 to 2013,7 amino acid mutations in epitopes[A(297,372 and 373),B(333),E(414),and H(309 and 310)]and 1 in human histo-blood group antigens binding site at site II 372 were found by analyzing 9 GII.4 Sydney[P31]complete genomic ***:This report identified the genomic variation of GII.4 Sydney[P31]from CaliciNet *** surveillance with prompt genotyping and genetic analysis is necessary to monitor the emergence of novel GII.4 variants.

关键词： Sydney GII prompt

Enhancement of physicochemical properties and baking quality of broken rice flour through superheated steam

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Grain & Oil Science and Technology 2024年第4期7卷 229-236页

作者： Zixiu Zhang jingxin li Xishuang Wang Xinzhu Wu Jialin Wang Xiaolin Zhang Han Ding Ju Qiu Ruge Cao State Key Laboratory of Food Nutrition and Safety College of Food Science and EngineeringTianjin University of Science and TechnologyTianjin 300457China School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological University21 Nanyang LinkSingapore 637371Singapore Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100083China

This study investigated the effects of superheated steam(SS)treatment at different temperatures(120℃,150℃,180℃)on the physicochemical properties of broken rice flour and the quality of broken rice *** treatment at 120℃ significantly enhanced the moisture content of broken rice flour(Plity of broken rice cakes,especially at 150℃ and 180℃.This study presents a method for improving the quality of broken rice flour and rice cakes using superheated steam treatment,addressing challenges related to poor flour characteristics and suboptimal cake *** findings offer technical and theoretical support for enhancing rice cake production,contributing to the comprehensive utilization of rice resources.

关键词： Broken rice Rice flour Physicochemical properties Broken rice cake Baking quality Textural properties