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烟碱对胶原诱导小鼠关节炎的作用

现代免疫学 2011年第4期31卷 325-330页

作者：杨懿铭李春燕杨洁任亚娜谢如锋范华骅华东师范大学生命科学学院生物医学系(上海市血液中心联合培养) 上海200062 上海市血液中心血液工程研究室上海200051

为观察烟碱对胶原诱导关节炎模型小鼠的作用,并初步探讨其免疫学和分子机制,建立胶原诱导关节炎模型,以PBS溶液喂饲模型小鼠为对照,采用半定量评分系统和病理切片评价关节炎模型小鼠对照组和烟碱实验组的病情进展。并采用流式细胞术分... 详细信息

为观察烟碱对胶原诱导关节炎模型小鼠的作用,并初步探讨其免疫学和分子机制,建立胶原诱导关节炎模型,以PBS溶液喂饲模型小鼠为对照,采用半定量评分系统和病理切片评价关节炎模型小鼠对照组和烟碱实验组的病情进展。并采用流式细胞术分别测定对照组和烟碱实验组小鼠脾脏CD4+细胞表型;RT-PCR方法检测对照组和烟碱实验组脾细胞Th1/Th17相关细胞因子IFN-γ、IL-17A、IL-21、IL-22,以及促炎症因子IL-6,抑炎症因子IL-10 mRNA的表达变化。流式CBA法检测模型小鼠血浆TNF-α含量。结果,采用烟碱喂饲关节炎模型小鼠能够有效减缓关节炎病症进展,减轻模型小鼠关节炎症状。病理切片显示对照组小鼠患处充血、水肿及中等量炎症细胞浸润;而相应烟碱实验组小鼠病理症状较轻。相比对照组,烟碱实验组Th17细胞比例明显降低(7.63%vs 12.53%);且烟碱实验组IL-17A、IFN-γmRNA比值低于对照组,具有显著性差异,P<0.05。烟碱干预能有效降低实验小鼠IL-6、IL-21 mRNA含量,P<0.05。另外,烟碱实验组小鼠血浆TNF-α含量明显低于对照组(10.82±2.22)pg/ml和(30.14±4.12)pg/ml,两者具有显著性差异,P<0.01。提示,烟碱干预能够有效减缓关节炎小鼠病症进展,减轻小鼠关节炎症状;这一效应是通过降低Th17细胞比例、降低炎症因子IL-17A/IFN-γ比例,减少IL-6、IL-21、TNF-α等多因素共同参与的过程。

关键词：胶原诱导关节炎乙酰胆碱能受体 Th17

Using the concept of ecological groundwater level to evaluate shallow groundwater resources in hyperarid desert regions

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Journal of Arid Land 2012年第4期4卷 378-389页

作者： Qi feng JiaZhong PENG JianGuo li HaiYang XI Jianhua SI Alashan Desert Eco-hydrology Experimental Research Station Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of SciencesLanzhou 730000China department of geography Shaanxi Normal UniversityXi’an 710062China Gansu Hydrology and Water Resources Engineering Center Lanzhou 730000China

This paper, based on the analysis and calculation of the groundwater resources in an arid region from 1980 to 2001, put forward the concept of ecological groundwater level threshold for either salinity control or the determination of ecological warning. The surveys suggest that soil moisture and soil salinity are the most important environmental factors in determining the distribution and changes in vegetation. The groundwater level threshold of ecological warning can be determined by using a network of groundwater depth observation sites that monitor the environmental moisture gradient as reflected by plant physiological characteristics. According to long-term field observations within the Ejin oases, the groundwater level threshold for salinity control varied between 0.5 m and 1.5 m, and the ecological warning threshold varied between 3.5 m and 4.0 m. The quantity of groundwater re- sources （renewable water resources, ecological water resources, and exploitable water resources） in arid areas can be calculated from regional groundwater level information, without localized hydrogeological data. The concept of groundwater level threshold of ecological warning was established according to water development and water re- sources supply, and available groundwater resources were calculated. The concept not only enriches and broadens the content of groundwater studies, but also helps in predicting the prospects for water resources development.

关键词： evaluation water resources Ejin oasis ecological groundwater level groundwater level threshold of ecologicalwarning

严重少弱精子症患者的辅助生育结局和安全性分析

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国际泌尿系统杂志 2024年第2期44卷 289-293页

作者：刘杨青王可欣丁孝芹高松占冯浩娄华李真嘉若琳杨险峰郑州大学第三附属医院男性科郑州450052 郑州大学第三附属医院生殖医学中心郑州450052

目的探讨严重少弱精子症患者的辅助生育结局及安全性。方法选取2015年9月至2019年12月在本院接受卵胞质内单精子注射(ICSI)治疗的严重少弱精子症患者(严重少弱精组,183例)和接受经皮附睾精子抽吸术(PESA)取精的梗阻性无精子症患者(对照... 详细信息

目的探讨严重少弱精子症患者的辅助生育结局及安全性。方法选取2015年9月至2019年12月在本院接受卵胞质内单精子注射(ICSI)治疗的严重少弱精子症患者(严重少弱精组,183例)和接受经皮附睾精子抽吸术(PESA)取精的梗阻性无精子症患者(对照组,183例)的临床资料,比较两组的正常受精率、正常卵裂率、可利用胚胎率、优胚率、女方妊娠结局、新生儿结局及出生缺陷。结果严重少弱精组的植入率、妊娠率、可利用胚胎率均低于对照组,差异均有统计学意义(均P0.05)。严重少弱精组的临床妊娠114例,分娩104例,而对照组的临床妊娠132例,分娩118例。两组的流产率、异位妊娠率、双胎率等指标比较方面,差异均无统计学意义(均P>0.05)。严重少弱精组患者中,单胎分娩76例,活产数为76例;双胎分娩28例,活产数为56例。对照组患者中,单胎分娩83例,活产数为83例;双胎分娩35例,活产数为70例。在单胎、双胎分娩周期中,两组的自然分娩率、早产率、低出生体重儿、性别比(男/女)方面等指标比较,差异均无统计学意义(均P>0.05)。严重少弱精组患者的1例新生儿存在左外耳廓凹陷;对照组无出生缺陷新生儿,差异无统计学意义(P>0.05)。结论相比于梗阻性无精子症者,严重少弱精子症者在新鲜胚胎移植中的可利用胚胎率、植入率、妊娠率偏低,但两组患者妊娠后和新生儿的情况无差异,到出生阶段是安全的。

关键词：弱精子症无精子症不育,男(雄)性妊娠结局先天畸形

Quasi-periodic Oscillation Analysis for the BL Lacertae Object 1823+568

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Research in Astronomy and Astrophysics 2022年第5期22卷 158-164页

作者： huai-Zhen li Quan-Gui Gao Long-hua Qin Ting-feng Yi Qi-Rui Chen Physics department Yuxi Normal UniversityYuxi 653100China department of Physics Yunnan Normal UniversityKunming 650092China

We studied the optical band periodic variability of 1823+568 using the Jurkevich method,the Lomb-Scargle periodogram and the REDFIT38 software,and found evidence of quasi-periodic *** unprecedented variability with period P=283^(+17)_(-13) days was identified by three different analysis *** quasi-periodic variability most likely results from nonballistic helical jet motion driven by the orbital motion in a binary black hole *** the light-travel time effect,the real physical period is P_(d)=67.1 ***,we estimated that the primary black hole mass is M■1.92×10^(9) M_(⊙)to 3.43×10^(9) M_(⊙).

关键词： blazars(1823+568)-relativisticjets-non-thermalsources

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铁死亡调控肝纤维化中的作用机制研究进展

药学学报 2021年第11期56卷 2916-2922页

作者：陈浩李小枫王华安徽医科大学第一附属医院药剂科安徽合肥230022 国家中医药管理局中药化学三级实验室安徽合肥230022 安徽医科大学药学院安徽合肥230032 安徽医科大学炎症免疫性疾病安徽省实验室安徽合肥230032 安徽医科大学第一附属医院肿瘤内科安徽合肥230022

肝纤维化是多种慢性肝病发展为肝硬化和肝癌所必须经历的共同病理过程。肝纤维化在发生、发展过程中受到多种细胞因子以及信号通路的调控。近年来,大量研究表明铁死亡(ferroptosis)与肝纤维化密切相关,与正常肝脏相比,发生纤维化的肝脏... 详细信息

肝纤维化是多种慢性肝病发展为肝硬化和肝癌所必须经历的共同病理过程。肝纤维化在发生、发展过程中受到多种细胞因子以及信号通路的调控。近年来,大量研究表明铁死亡(ferroptosis)与肝纤维化密切相关,与正常肝脏相比,发生纤维化的肝脏内铁离子水平和脂质过氧化程度显著增加。因此,铁死亡可能是肝纤维化疾病诊断、预防和治疗的潜在靶标。本文就近年来关于铁死亡在肝纤维化中的作用进行综述,以期为肝纤维化的治疗提供新的思路。

关键词：铁死亡肝星状细胞肝纤维化铁离子脂质过氧化

Nucleic acids analysis

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Science china Chemistry 2021年第2期64卷 171-203页

作者： Yongxi Zhao Xiaolei Zuo Qian li feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian huang Yanyi huang Guoliang Ke hua Kuang Fan li Jiang li Min li Na li Zhenyu lin Dingbin liu Juewen liu libing liu Xiaoguo liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang Fei Wang Jianbin Wang lihua Wang Shu Wang lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-feng Yuan Quan Yuan Chao Zhang Zhi Zhu Chaoyong Yang Xiao-Bing Zhang huanghao Yang Weihong Tan Chunhai Fan Institute of Analytical Chemistry and Instrument for life Science The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Cancer Metastasis Alert and Prevention Center Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and BiodetectionSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Faculty of Materials Science and Chemistry Engineering Research Center of Nano-Geomaterials of Ministry of EducationChina University of GeosciencesWuhan 430074China College of Chemistry and Molecular Engineering Biomedical Pioneering Innovation Center(BIOPIC)Beijing Advanced Innovation Center for Genomics(ICG)Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Bioimaging Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced

Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic *** the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological *** this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided.

关键词： nucleic acids analysis signal amplification DNA nanotechnology aptamer biosensing

心肌缺血左室心肌组织速度和二维应变的对比研究

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新疆医科大学学报 2010年第2期33卷 205-207页

作者：陈晓峰李华新疆医科大学附属中医医院心脏超声诊断科新疆乌鲁木齐830000

目的应用二维应变技术分别测量左室心肌缺血时的心肌运动速度(Vel)和二维应变(Str),并对比两种技术相关指标在病理状态下的变化趋势。方法18例缺血性心肌病左室射血分数降低患者[EF<50%,(36±11)%]及20例正常对照志愿者[EF≥50%,(63±17... 详细信息

目的应用二维应变技术分别测量左室心肌缺血时的心肌运动速度(Vel)和二维应变(Str),并对比两种技术相关指标在病理状态下的变化趋势。方法18例缺血性心肌病左室射血分数降低患者[EF<50%,(36±11)%]及20例正常对照志愿者[EF≥50%,(63±17)%]纳入本研究,应用斑点追踪技术二维应变(STE)分析软件分别测量左室长轴方向各室壁的左室收缩期心肌运动速度(S-Vel)、舒张期心肌运动速度(D-Vel)、收缩期应变(S-str)、舒张期应变(D-str),并对两组测量结果进行对比分析。结果心肌缺血组左室各游离壁各指标包括收缩期峰值速度(S-Vel)、舒张期峰值速度(D-Vel)、收缩期峰值应变(S-str)、舒张期峰值应变(D-str)均较正常对照组降低(P<0.01);正常对照组左室侧壁的S-str和D-str较左室前壁高(P<0.01)。结论应用二维应变显像技术测定心肌的运动速度和形变有望成为评价心肌疾病的非创性新手段,并可能有助于对心脏疾病过程中病理生理过程变化的理解。

关键词：组织速度应变心肌缺血

Efficacy of a Chinese herbal formula on hepatitis B e antigenpositive chronic hepatitis B patients

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World Journal of Gastroenterology 2020年第30期26卷 4501-4522页

作者： Yu-feng Xing Chun-Shan Wei Tian-Ran Zhou Dan-Ping huang Wei-Chao Zhong Bin Chen hua Jin Xiao-Yu Hu Zhi-Yun Yang Qing He Kai-Ping Jiang Jun-Min Jiang Zhen-Bin Hu Xin Deng Fan Yang feng-Yi li Gang Zhao li-Chun Wang Yu-Qiang Mi Zuo-Jiong Gong Peng Guo Jian-hua Wu Wei-Qun Shi Hong-Zhi Yang Da-Qiao Zhou Guang-Dong Tong department of Hepatology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina department of Hepatology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina department of Integrated Traditional and Western Medicine on liver Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China department of Infectious Disease The Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610032Sichuan ProvinceChina department of Integrated Traditional and Western Medicine on liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China The First department of Hepatology Shenzhen No.3 People’s HospitalShenzhen 518100Guangdong ProvinceChina department of Hepatology Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina department of Hepatology Guangdong Hospital of Traditional Chinese MedicineGuangzhou 510006Guangdong ProvinceChina department of Hepatology The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530012Guangxi ProvinceChina department of Hepatology Ruikang HospitalGuangxi University of Chinese MedicineNanning 530012Guangxi ProvinceChina Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430060Hubei ProvinceChina Treatment and Research Center of Infectious Disease 302 Military Hospital of ChinaBeijing 100039China department of Hepatology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201204China Center of Infectious Disease Huaxi HospitalSichuan UniversityChengdu 610044Sichuan ProvinceChina department of Infectious Disease Tianjin Infectious Disease HospitalTianjin 300192China department of Infectious Disease Hubei People’s HospitalWuhan 430060Hubei ProvinceChina department of Hepatology Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing 100080China C

BACKGROUND No guideline recommends antiviral therapy for hepatitis B e antigen(HBeAg)-positive chronic hepatitis B patients with persistently normal alanine aminotransferase levels and a high hepatitis B virus(HBV)DNA viral *** To evaluate the feasibility and safety of a Chinese herbal formula as a therapeutic option for chronic HBV *** In total,395 patients(30–65 years old)with confirmed HBeAg-positive chronic hepatitis B infection and persistently normal alanine aminotransferase were randomized to receive either Chinese herbal formula or placebo for 96 *** to evaluate therapeutic efficacy included:(1)HBV DNA levels decreased to less than 4 log10 IU/mL at weeks 48 and 96;and(2)HBeAg clearance and seroconversion rates at weeks 48 and *** HBV DNA levels≤4 log10 IU/mL were 10.05%at week 48 and 18.59%at week 96 in the treatment *** HBeAg clearance and conversion rates were 8.54%and 8.04%at week 48 and 16.08%and 14.57%at week 96,***,HBV DNA levels≤4 log10 IU/mL were 2.55%and 2.55%at weeks 48 and 96,respectively,and the HBeAg clearance rates were 3.06%and 5.61%at weeks 48 and 96,respectively,in the control *** quantitative hepatitis B surface antigen and HBeAg levels at baseline and changes during the treatment period as well as the alanine aminotransferase elevation at weeks 12 and 24 were strong predictors of HBeAg *** High rates of HBV DNA reduction,HBeAg clearance and seroconversion could be achieved with Chinese herbal formula treatments,and the treatments were relatively safe for HBeAg-positive chronic hepatitis B-infected patients with persistently normal alanine *** ability of the compound to modulate host immune function probably contributed to this effect.

关键词： Chronic hepatitis B Chinese Herbal Formula treatment Hepatitis B e antigen clearance Hepatitis B e antigen seroconversion Hepatitis B virus DNA reduction Clinical trial

Uncoupling Protein 4 Overexpression Promotes Proliferation and Inhibits Apoptosis And Differentiation of Preadipocytes

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Uncoupling Protein 4 Overexpression Promotes Proliferation a...