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Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-Yuan Wu Si-Wei Chi liu-Jian Ouyang Xiao-Qin Xu Jing-Nan Chen Bing-Han Jin Rahim Ullah Xue-lian Zhou Ke Huang Guan-ping Dong Zhe-Ming li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu Wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large nu... 详细信息

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(lidated in populations with a large number of healthy *** This study collected venous blood and anthropometric data from a total of 13,287 healthy children aged 3 months to 18 years who underwent routine physical examinations in the Department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 4276 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(Plic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(Plishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases

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Ladder Time Stepwise Inertia Coordinated Control Method of Multiple Wind Farms to Suppress System Frequency Secondary Drop

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Energy Engineering 2024年第8期121卷 2293-2311页

作者： He li Xianchao liu Jidong li Yuchen Qiu Tongliao PowerSupply Company State Grid East Inner Mongolia Electric Power CompanyTongliao028000China Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology Northeast Electric Power UniversityJilin132012China

Currently,both regulated and deregulated power trading exist in China’s power system,which has caused imbalanced funds in the electricity *** this paper,a simulation analysis of the electricity market with wind energy resources is conducted,and the calculation methods of unbalanced funds are investigated *** detail,the calculation formulas of unbalanced funds are illustrated based on their definition,and a two-track electricity market clearing model is ***,the concept of the dual-track system is explained,and the specific calculation formulas of various types of unbalanced funds are ***,considering the renewable energy consumption,the market clearing model based on DC power flow is constructed and solved;by combining fitting methods of mid-and long-term curves,the unbalanced funds are calculated based on clearing results and formulas.

关键词： Wind power stepwise inertial frequency control secondary drop

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Short-term effects of low-level PM2.5,PM10,O3,and tropical meteorological conditions on emergency department visits for respiratory diseases in Haikou,China

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 317-328,I0010,I0011页

作者： Jichao Peng Jun Chen Xinxin Wu Jin Qian Nan li Yang Yi Yue Huang Juncai Lu Wenxing Zhang Zhengyu li Zhao li Min li Xiaoran liu School of Public Health Hainan Medical UniversityHaikou 571199China Danzhou People's Hospital Danzhou 571799China The Second Affiliated Hospital of Hainan Medical University Haikou 570105China The First Affiliated Hospital of Hainan Medical University Haikou 570102China Emergency and Trauma College Hainan Medical UniversityKey Laboratory of Emergency and Trauma of Ministry of EducationHaikou 571199China Hainan General Hospital Affiliated to Hainan Medical University Haikou 570311China

Objective:To assess the correlation between atmospheric pollutants,meteorological factors,and emergency department visits for respiratory diseases in Haikou ***:Daily data on atmospheric pollutants,meteorological factors,and emergency department visits for respiratory diseases in Haikou City from 2018 to 2021 were *** Spearman rank correlation test was used to analyze the correlation,and a distributed lag non-linear model was employed to analyze the health effects and lag impacts of environmental *** analyses were conducted based on sex and ***:According to the criteria of International Classification of Diseases(ICD-10:J00-J99),a total of 221913 cases were included,accounting for 21.3%of the total emergency department visits in Haikou *** every 1℃increase in temperature,the risk of emergency department visits increased by 1.029%(95%CI 1.016%-1.042%).Relative humidity greater than 80%reduced the risk of visits,while higher atmospheric pressure(>1010 hpa)also decreased the likelihood of daily emergency department *** concentrations of PM2.5(30-50μg/m^(3)),PM10(>60μg/m^(3)),and O_(3)(75-125μg/m^(3))were associated with increased *** temperatures(>25℃)have a greater impact on females and children aged 0-14 years,while males are more sensitive to low atmospheric *** aged 65 and above exhibited increased sensitivity to O_(3)concentration,and the effects of PM2.5,PM10,and O_(3)are more pronounced in individuals over 14 years ***:Short-term exposure to high temperatures,particulate matter pollutants(PM_(2.5)and PM_(10)),and ozone(O_(3))is associated with increased emergency department visits for respiratory diseases.

关键词： Distributed lag nonlinear model Meteorological factors Air pollution Emergency department visits Respiratory diseases

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递增负荷训练诱导的动情周期抑制大鼠甲状腺超微结构与功能变化的研究

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体育科学 2005年第10期25卷 59-63页

作者：王人卫檀志宗李国平黄雅君张洪海高晓磷上海体育学院上海200438 上海运动健康研究中心上海200030 国家体育总局运动医学研究所北京100061 国家体育总局体育科学研究所北京100061

目的:探讨递增负荷训练诱导的动情周期抑制的大鼠甲状腺超微结构与功能的变化,进一步阐明运动性月经失调的发生机制。将35只成熟、健康的雌性2月龄大鼠随机分为:对照组(C)、递增负荷训练7周组(Ta其中有7只为恢复1周Tar组)、5周组(Tb)、... 详细信息

目的:探讨递增负荷训练诱导的动情周期抑制的大鼠甲状腺超微结构与功能的变化,进一步阐明运动性月经失调的发生机制。将35只成熟、健康的雌性2月龄大鼠随机分为:对照组(C)、递增负荷训练7周组(Ta其中有7只为恢复1周Tar组)、5周组(Tb)、3周组(Tc)。结果:随运动负荷递增,大鼠阴道中底层细胞数量逐周增加,第7周最高;Ta、Tb组大鼠甲状腺腺泡上皮细胞胞浆内粗面内质网扩张,出现较多的分泌大泡和合成泡及变性坏死的细胞;恢复1周后,粗面内质网异常扩张,有较多的溶酶体;Ta、Tar组大鼠血清TSH浓度较C组有高度显著性差异(P<0.01);Ta组大鼠训练前3周饮食量最高,3周后随训练强度增大饮食量下降;训练前后Ta组大鼠体重增幅明显低于C组(P<0.05)。结论:7周训练诱导了大鼠动情周期抑制和甲状腺功能的减退。提示,甲状腺功能减退是AMI发生机制之一。

关键词：递增负荷训练动情周期超微结构甲状腺功能鼠动物实验

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Adjuvant Therapy for Hepatocellular Carcinoma After Curative Treatment:Several Unanswered Questions

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 525-533页

作者： Le li Zhen-Zhen li li-Xin Pan Jia-Yong Su Shan Huang liang Ma Jian-Hong Zhong Hepatobiliary Surgery Department Guangxi Medical University Cancer HospitalNanningGuangxiChina Guangxi Academy of Medical Sciences Emergency DepartmentThe People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxiChina Pathology Department Guangxi Medical University Cancer HospitalNanningGuangxiChina Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanningGuangxiChina Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor NanningGuangxiChina

Most patients with hepatocellular carcinoma(HCC)have a poor *** and local ablation are the main curative treatments for ***,the recurrence rate after hepatectomy or ablation is up to 70%,which seriously affects patient *** adjuvant therapies have been explored to reduce postoperative ***,although a variety of adjuvant therapies have been shown to reduce the recurrence rate and improve overall survival,a standard consensus of national HCC guidelines for adjuvant treatment is ***,there are significant differences in the recommendations for adjuvant therapy for HCC between the Eastern and Western guidelines.A variety of adjuvant treatment methods,such as antiviral therapy,transarterial chemoembolization or traditional Chinese medicine,are recommended by the Chinese HCC ***,Western guidelines make few recommendations other than antiviral *** immune checkpoint inhibitors are recommended only in the recently updated American Association for the Study of liver Diseases *** review summarized the existing adjuvant therapy options after curative hepatectomy or ablation and discusses several important dilemmas of adjuvant treatments.

关键词： Hepatocellular carcinoma Adjuvant therapy Curative hepatectomy Recurrence Overall survival Immune checkpoint inhibitor

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Salt-assisted vapor-liquid-solid growth of high-quality ultrathin nickel oxide flakes for artificial synapses in image recognition applications

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Nano Research 2024年第5期17卷 4622-4630页

作者： Hui Zhang Zongjie Shen Alei li lin Wang Qinan Wang Yunfei li Yunlei Zhong Juntong Zhu Yong Zhang Mengjiao Han Dan Tian Chun Zhao lixing Kang Qingwen li School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China Division of Advanced Materials Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China College of Energy Soochow Institute for Energy and Materials Innovationsand Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215123China Songshan Lake Materials Laboratory Dongguan 523808China School of Advanced Technology Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing Forestry UniversityNanjing 210037China

Transition metal oxides have attracted intense interest owing to their abundant physical and chemical *** controlled preparation of large-area,high-quality two-dimensional crystals is essential for revealing their inherent properties and realizing high-performance ***,fabricating two-dimensional(2D)transition metal oxides using a general approach still presents substantial ***,we successfully achieve highly crystalline nickel oxide(NiO)flakes with a thickness as thin as 3.3 nm through the salt-assisted vapor-liquid-solid(VLS)growth method,which demonstrated exceptional stability under ambient *** explore the great potential of the NiO crystal in this work,an artificial synapse based on the NiO-flake resistive switching(RS)layer is ***-term and long-term synaptic behaviors are obtained with external *** artificial synaptic performance provides the foundation of the neuromorphic application,including handwriting number recognition based on artificial neuron network(ANN)and the virtually unsupervised learning capability based on generative adversarial network(GAN).This pioneering work not only paves new paths for the synthesis of 2D oxides in the future but also demonstrates the substantial potential of oxides in the field of neuromorphic computing.

关键词： nickel oxide(NiO)flakes vapor-liquid-solid(VLS)growth memristor synapse generative adversarial network(GAN)

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A grouping strategy for reinforcement learning-based collective yawcontrol of wind farms

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 1-5页

作者： Chao li Luoqin liu Xiyun Lu Department of Modern Mechanics University of Science and Technology of ChinaHefei 230027China

Reinforcement learning(RL)algorithms are expected to become the next generation of wind farm control ***,as wind farms continue to grow in size,the computational complexity of collective wind farm control will exponentially increase with the growth of action and state spaces,limiting its potential in practical *** this Letter,we employ a RL-based wind farm control approach with multi-agent deep deterministic policy gradient to optimize the yaw manoeuvre of grouped wind turbines in wind *** reduce the computational complexity,the turbines in the wind farm are grouped according to the strength of the wake ***,to improve the control efficiency,each subgroup is treated as a whole and controlled by a single *** results show that the proposed method can not only increase the power production of the wind farm but also significantly improve the control efficiency.

关键词： Reinforcement learning Wake steering Wind-farm flow control Production maximization

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不同施肥处理烤烟氮磷钾吸收分配规律研究

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中国烟草学报 2012年第1期18卷 53-57,63页

作者：张翔毛家伟黄元炯李国平李文勋桂炎伟陈启龙河南省农科院植物营养与资源环境研究所郑州450002 河南省烟草公司郑州450007 临颖县烟草分公司河南临颖462600

为研究不同施肥处理条件下烤烟氮磷钾吸收积累规律,进行了田间随机排列试验,结果表明,有机无机配施处理烤烟氮、磷、钾积累量分别为130.64 kg/hm2、27.35 kg/hm2、230.03 kg/hm2,单施有机肥分别为67.25 kg/hm2、14.31 kg/hm2、114.7 kg/... 详细信息

为研究不同施肥处理条件下烤烟氮磷钾吸收积累规律,进行了田间随机排列试验,结果表明,有机无机配施处理烤烟氮、磷、钾积累量分别为130.64 kg/hm2、27.35 kg/hm2、230.03 kg/hm2,单施有机肥分别为67.25 kg/hm2、14.31 kg/hm2、114.7 kg/hm2,不施肥处理分别为40.08 kg/hm2、10.14 kg/hm2、82.46 kg/hm2。不同施肥处理烟株氮磷钾积累强度均在移栽后60-75d达到最高值。烟株氮、磷、钾在根、茎、叶器官分配顺序:叶>茎>根,叶的积累量大于茎、根积累量之和。每生产100kg干烟叶,不施肥处理氮、磷、钾需要量分别为2.63 kg、0.65 kg、5.31kg,单施有机肥处理分别为3.16 kg、0.67 kg、5.14kg,有机无机肥配施处理分别为4.26 kg、0.89 kg、6.65kg。

关键词：烤烟氮磷钾吸收分配

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三种辐照方式对黑松花粉萌发和花粉管生长的影响

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核农学报 2008年第4期22卷 432-434,409,F0003页

作者：李国平杨鹭生陈素英黄志明胡文英莆田学院环境与生命科学系福建莆田351100

研究了低能氮离子束、紫外线与γ射线辐照对黑松花粉萌发和花粉管生长的影响。结果表明,低能氮离子注入对黑松花粉的损伤效应与γ射线和紫外线照射的不同,主要表现在氮离子束剂量-萌发率效应曲线呈"马鞍型"和氮离子束注入诱发花粉管顶... 详细信息

研究了低能氮离子束、紫外线与γ射线辐照对黑松花粉萌发和花粉管生长的影响。结果表明,低能氮离子注入对黑松花粉的损伤效应与γ射线和紫外线照射的不同,主要表现在氮离子束剂量-萌发率效应曲线呈"马鞍型"和氮离子束注入诱发花粉管顶端肿胀,这说明低能离子束的作用机制可能与γ射线和紫外线的不同。认为花粉是研究离子注入生物学效应机制的理想模式系统。

关键词：黑松花粉花粉管离子注入 γ射线辐照紫外线辐照

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Highly robust zinc metal anode directed by organic–inorganic synergistic interfaces for wearable aqueous zinc battery

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SmartMat 2024年第1期5卷 135-146页

作者： Xixi Zhang Chuanlin li Guangmeng Qu Chenggang Wang Shunshun Zhao Tongkai Wang Na li Xiaojuan li Xijin Xu School of Physics and Technology University of JinanJinanChina School of Chemistry and Chemical Engineering Shandong UniversityJinanChina State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology of MaterialsBeijing University of Chemical TechnologyBeijingChina

Flexible aqueous zinc batteries(FAZBs)with high safety and environmental friendliness are promising smart power sources for smart wearable ***,the bare zinc anode usually suffers from damnable dendrite growth and rampant side reaction on the surface,greatly impeding practical applications in ***,a composite polymer interface layer is artificially self‐assembled on the surface of the zinc anode by graft‐modified fluorinated monomer(polyacrylic acid‐2‐(Trifluoromethyl)propenoic acid,PAA‐TFPA),on which an organic–inorganic hybrid(PAA‐Zn/ZnF2)solid electrolyte interface(SEI)with excellent ionic conductivity is formed by interacting with Zn2+.Both the pouch cell and fiber zinc anode exhibit excellent plating/stripping reversibility after protecting by this organic–inorganic SEI,which can be stably cycled more than 3000 h in symmetric Zn||Zn cells or 550 h in fiber Zn||Zn ***,this interface layer preserves zinc anode with excellent mechanical durability under various mechanical deformation(stably working for another 1200 h after bending 100 h).The corresponding PAA‐Zn/ZnF2@Zn||MnO2 full cell displays an ultra‐long life span(79%capacity retention after 3000 cycles)and mechanical robustness(85%of the initial capacity for another 3000 cycles after bending 100 times).More importantly,the as‐assembled cells can easily power smart wearable devices to monitor the user's health condition.

关键词： hybrid SEI mechanical durability wearable zinc battery zinc anode

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