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Three-dimensionally ordered macroporous cross-linked polystyrene incorporating functional group via hydrophilic spacer arm

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Chinese Chemical Letters 2010年第12期21卷 1493-1496页

作者： li Xia yuan Xiao mei Wang Xu Zhang Pan Ge liu Wei Dong Yan Institute of Polymer Science and Engineering Hebei University of Technology Tianjin 300130 China

A versatile and effective method for incorporating functional groups on the pore wall of three-dimensionally ordered macroporous cross-linked polystyrene（3DOM CLPS） by hydrophilic spacer arm has been *** 3DOM CLPS with pore size 865 nm was prepared by sacrifice template *** hydrophilic spacer arm（polyethylene glycol,molecular weight is 600） was grafted to the 3DOM CLPS via nucleophilic substitution *** other side of active hydroxyl can be further converted into a lot of other functional *** this report,the chelating ligand 2-mercaptobenzothiazole（MBZ） group was introduced on the end of the PGE chain to evidence the versatile functionalization *** functionalized ordered macroporous materials were characterized by FT-IR,element analyzer,*** results reveal that the pores were successfully bonded with 2-mercaptobenzothiazole groups via hydrophilic spacer arms and the original morphology of ordered macroporous materials were remained after *** MBZ group density is 0.052 mmol/m^*** functionalized 3DOM CLPS are expected to application as heavy metal ions adsorbent.

关键词： Three-dimensionally ordered macroporous polymer Functionalization Hydrophilic space arm Heterocyclic functional group

Effects of Zishen Yutai Pills on in vitro Fertilization-Embryo Transfer Outcomes in Patients with Diminished Ovarian Reserve:A Prospective,Open-Labeled,Randomized and Controlled Study

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Chinese Journal of Integrative Medicine 2023年第4期29卷 291-298页

作者： li Xiu-fang WANG Zhong-qing XU Hai-yan liU Hong SHENG Yan XU Jin li yuan-mei liAN Fang The First Clinical College Shandong University of Traditional Chinese MedicineJinan 250014China Center for Reproductive Medicine Shandong UniversityJinan 250021China Medical College of Optometry and Ophthalmology Shandong University of Traditional Chinese MedicineJinan 250014China Department of Traditional Chinese Medicine Jinan Golden Time Health Nursing HospitalJinan 250000China Reproductive and Genetic Center of Integrated Traditional and Western Medicine Affiliated Hospital of Shandong University of Traditional ChineseJinan 250011China Medicine

Objective:To explore the effects of Zishen Yutai Pills(ZYPs)on the quality of oocytes and embryos,as well as pregnancy outcomes in patients with diminished ovarian reserve(DOR)receiving in vitro fertilizationembryo transfer(IVF-ET).The possible mechanisms,involving the regulation of bone morphogenetic protein 15(BMP15)and growth differentiation factor 9(GDF9),were also ***:A total of 120 patients with DOR who underwent their IVF-ET cycle were randomly allocated to 2 groups in a 1:1 *** patients in the treatment group(60 cases)received ZYPs from the mid-luteal phase of the former menstrual cycle by using gonadotropin-releasing hormone(Gn RH)antagonist *** patients in the control group(60 cases)received the same protocol but without *** primary outcomes were the number of oocytes retrieved and high-quality *** outcomes included other oocyte or embryo indices as well as pregnancy *** events were assessed by comparison of the incidence of ectopic pregnancy,pregnancy complications,pregnancy loss,and preterm *** of BMP15 and GDF9 in the follicle fluids(FF)were also quantified with enzymelinked immunosorbent ***:Compared with the control group,the numbers of oocytes retrieved and high-quality embryos were significantly increased in the ZYPs group(both Plinical pregnancy rates,live birth rates,and pregnancy loss rates(all P>0.05).The administration of ZYPs did not increase the incidence of adverse *** expressions of BMP15 and GDF9 in the ZYPs group were significantly up-regulated compared with the control group(both P<0.05).Conclus

关键词： Zishen Yutai Pills diminished ovarian reserve in vitro fertilization-embryo transfer oocytes embryos

Geographical range evolution of the genus Polypedates(Anura:Rhacophoridae)from the Oligocene to present

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Zoological Research 2021年第1期42卷 116-123页

作者： li-mei yuan Xi-ling Deng De-Chun Jiang Sebastian Klaus Nikolai LOrlov Kong Yang Jia-Tang li Institute of Qinghai-Tibetan Plateau Southwest Minzu UniversityChengduSichuan 610041China CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengduSichuan 610041China Department of Ecology and Evolution J.W.Goethe-UniversitätFrankfurt/M.Hessen 60438Germany Zoological Institute Russian Academy of SciencesSt.Petersburg 199034Russia Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesNay Pyi Taw 05282Myanmar CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China University of Chinese Academy of Sciences BeijingChina

DEAR EDITOR,Currently,the genus Polypedates comprises 26 species distributed in South,Southeast,and East *** of their relatively low dispersal capability and intolerance to seawater,this genus is ideal for the study of terrestrial range evolution that extends into the island archipelagos of southeastern *** this study,based on data compiled for Polypedates from previous studies and partial mitochondrial and nuclear genes collected in this study,we performed systematic biogeographical *** confirmed a Sundaland origin for the extant genus and showed northward dispersal into mainland Southeast Asia and Asia,which coincided with the timing of paleoclimatic change from the Oligocene to Middle *** fluctuations had a profound impact on species diversification within the genus ***,the Red River did not mediate species exchange between Southeast Asia and mainland Asia until the end of the Miocene,with the sudden onset of northward dispersal in several clades independently at that ***,the lineage of widespread insular *** strongly supports the hypothesis of terrestrial connection between island archipelagos of Southeast Asia during the Mid-Pleistocene paleoclimate *** biogeographical analysis also supports the recent introduction of *** to the Philippines and Ryukyus,as previously suggested.

关键词： mainland northward evolution

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基于滤子混合协同进化算法的无功优化

控制与决策 2017年第9期32卷 1701-1706页

作者：张宏立李远梅新疆大学电气工程学院乌鲁木齐830047

混合整数非线性规划问题存在于大量工程和管理中,针对此问题提出一种滤子混合协同进化算法.利用滤子技术代替罚函数处理约束条件,采用混合编码和由差分进化算法与遗传算法异构的种群协同解决混合整数变量问题,引入基于平均熵和Logistic... 详细信息

混合整数非线性规划问题存在于大量工程和管理中,针对此问题提出一种滤子混合协同进化算法.利用滤子技术代替罚函数处理约束条件,采用混合编码和由差分进化算法与遗传算法异构的种群协同解决混合整数变量问题,引入基于平均熵和Logistic混沌初始化增加算法鲁棒性,利用自适应缩放因子和精英交流学习策略构成策略协同,与种群协同耦合,以提高算法搜索能力.以IEEE30节点测试系统进行无功优化为例,仿真结果表明所提出的算法具有全局搜索能力和有效性.

关键词：混合整数非线性规划滤子技术协同进化差分进化算法无功优化

Silencing Pinl Suppresses the Expression and Bioactivity of MMP-9 through NF-KB in Colorectal Carcinoma SW480 Cells

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Clinical oncology and cancer researeh 2010年第1期7卷 12-17页

作者： li-yuan QIN mei-ning li Wen-juan REN Dong ZHANG Jian-lin ZHANG Yue-hong ZHANG Niu-liang CHENG Department of Biochemistry and MolecularBiology Shanxi Medical University Taiyuan030001. Shanxi Province. China.

OBJECTIVE To examine the effect of Pin1 on the expression and bioactivity of MMP-9 through NF-kB in human colorectal carcinoma SW480 cells. METHODS The eukaryotic expression vector of RNA interfering （shRNA） with the Pin1 gene （pGenesil-1-PIN1） was constructed in our previous experiments and was confirmed through sequencing. Cell motility was tested through the wound healing assay and the Boyden chamber assay. The protein levels and bioactivity of MMP-9 were tested by Western blotting and gelatin zymography in SW480 cells after transfection with pGenesil-l-PIN1 （SW480/ p-shRNA）. The DNA-binding activity of NF-kB in cells transfected with pGenesil-1-PIN1 was analyzed by the electrophoretic mobility shift assay （EMSA）. In addition, to determine whether NF-kB has direct interaction with the MMP-9 promoter derived from the genomic DNA of SW480 cells transfected with pGenesil- 1-PIN1, oligonucleotides containing a putative NF-kB binding site were synthesized and EMSAs were performed. RESULTS The results of the Boyden chamber assay showed that cell motility was reduced from 90.2 ± 6.5 per field （x 10 objective） to 49.6± 7.2 per field （P 〈 0.05, Student＇s t-test） for SW480 cells transfected with pGenesil-1-PIN1 （SW480/p-shRNA）. Western blotting detected low protein levels of Pin1 and MMP-9 in SW480/ p-shRNA cells. The relative protein levels of Pin1 were 0.49 ± 0.07 in SW480/p-shRNA compared with 0.94 ± 0.09 in SW480/p-Con, and MMP-9 were 0.45 ± 0.07 in SW480/p-shRNA, 0.83 ± 0.07 in SW480/p-Con （P 〈 0.05）. The results of gelatin zymography showed that silencing Pin1 markedly reduced the bioactivity of MMP-9 in SW480 cells. EMSA results revealed low DNA-binding activity of NF-kB in SW480/p-shRNA cells compared to SW480/ p-Con cells, and that NF-kB bound directly to the oligonucleotides which contained putative NF-kB binding sites in the MMP-9 promoter derived from the genomic DNA of SW480/p-shRNA cells. CONCLUSION Inhibited Pin1 expression may contribute to the suppressive

关键词： colorectal cancer Pin1 RNAi MMP-9 NF-kB.

Twin dilivery of a 46,XY gonadal dysgenetic woman following vitrified oocytes donation

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Chinese Medical Journal 2011年第7期124卷 1109-1110页

作者： GAO Shan-shan SHENG Yan li yuan li mei YANG Hui-jun CHEN Zi-jiang Shandong Provincial Key Laboratory of Reproductive Medicine Center for Reproductive Medicine Provincial Hospital Affiliated to Shandong University Jinan Shandong 250012 China

A 46,XY gonadal dysgenetic woman gave birth to two healthy girls following vitrified oocytes donation. The loss of SRY gene was considered as the cause of this patient. Although similar cases have been reported about pregnancies of 46,XY pure gonadal dysgenetic women, successful delivery from vitrified oocytes has been hardly reported yet. Oocytes vitrification technique provides a beneficial way by saving superfluous oocytes from the pregnancy patients to these women who need.

关键词： gonadal dysgenesis oocyte vitrification," SRY deletion

UPPER TRIASSIC SPORO-POLLEN ASSEMBLAGES FROM MOSUOHE RIVER VALLEY OF BAODING, SICHUAN

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古生物学报 1991年第3期 353-358页

作者： Shang Yu-ke (Nanjing Institute of Geology and Palaeontology, Academia Sinica) li yuan-mei(Petroleum Institute of Yunnan-Guizhou-Guangxi, Ministry of Oil Industry, Kunming)

In 1972, after frequent investigations on lithology, sedimentology and palaeontology (especially on palaeobotany), the Upper Triassic coal series (formerly the "Lalaqing Coal Series") in the Baoding area, southwestern Sichuan was previously divided by No. 1 Regional Geological Survey Team of Yunnan Province into two formations in ascending order as the Daqiaodi Formation, and the Daqing Formation (consisting of the Lower and Upper Members).

关键词： SICHUAN UPPER TRIASSIC SPORO-POLLEN ASSEMBLAGES FROM MOSUOHE RIVER VALLEY OF BAODING

全球史视野下的翻译史研究——关系梳理与参考借鉴

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上海翻译 2019年第4期 66-70,F0003页

作者：袁丽梅上海大学

当前翻译史研究存在研究对象集中、理论视角单一等问题。本文认为翻译史研究作为涉及史学与翻译学的交叉学科,应积极尝试借鉴史学理论与方法以推动译史研究。本文以近年来在中外史学界勃兴的全球史为例,从译史个案研究的资料扩充和对译... 详细信息

当前翻译史研究存在研究对象集中、理论视角单一等问题。本文认为翻译史研究作为涉及史学与翻译学的交叉学科,应积极尝试借鉴史学理论与方法以推动译史研究。本文以近年来在中外史学界勃兴的全球史为例,从译史个案研究的资料扩充和对译史书写的启示两方面探讨全球史视野对翻译史研究的参考价值,继而讨论进一步拓展、丰富译史研究的视角、方法,推动译史研究与其他学科领域的融合,以及在此基础上推进翻译史研究与翻译理论自身的发展。

关键词：翻译史全球史个案研究译史书写

通过“レポ—ト”探讨日语课堂教学方法之改革

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内蒙古民族大学学报（社会科学版） 2008年第6期34卷 105-106页

作者：袁丽梅长春工程学院外语系吉林长春130000

在日本大学学日语常遇到的一个写作内容,那就是"レポ—ト"。本文通过对日本教师"レポ—ト"教学方法的分析,探讨了我国日语课堂教学法的改革。

关键词：レポ—ト启发式探讨式分组式学生为主体