检索结果-南通市图书馆

基于UPLC-MS/MS测定比格犬血浆中炒酸枣仁提取物9种成分及其药代动力学研究

在线全文

学校读者我要写书评

暂无评论

中国中药杂志 2024年第9期49卷 2501-2511页

作者：夏可欣于歆吴思玚赵丽凤王玉艳康琛袁征李鹰飞中国中医科学院中药研究所北京100700 山东中医药大学中医学院山东济南250301

该研究建立了一种简便、快速、灵敏的超高效液相色谱-串联质谱法(UPLC-MS/MS),能够同时测定给药炒酸枣仁提取物后比格犬血浆中木兰花碱、乌药碱、维采宁Ⅱ、异斯皮诺素、斯皮诺素、当药黄素、N-去甲基荷叶碱、6'''-阿魏酰斯皮诺素和酸... 详细信息

该研究建立了一种简便、快速、灵敏的超高效液相色谱-串联质谱法(UPLC-MS/MS),能够同时测定给药炒酸枣仁提取物后比格犬血浆中木兰花碱、乌药碱、维采宁Ⅱ、异斯皮诺素、斯皮诺素、当药黄素、N-去甲基荷叶碱、6'''-阿魏酰斯皮诺素和酸枣仁皂苷B的含量。采用Waters HSS-T3 C_(18)色谱柱(2.1 mm×100 mm,1.8μm),流动相为甲醇-水(含0.01%甲酸),梯度洗脱,9种成分和2种内标于8 min内完全分离;质谱检测在电喷雾离子源正、负离子切换模式下,采用多反应监测模式进行检测。分析方法经特异性、选择性、线性范围、准确度、精密度、回收率、基质效应和稳定性验证,可满足犬灌胃炒酸枣仁提取物后的药代动力学的研究要求。结果显示,比格犬单次灌胃给药后,木兰花碱、乌药碱、维采宁Ⅱ、异斯皮诺素、斯皮诺素、6'''-阿魏酰斯皮诺素和酸枣仁皂苷B的T_(max)为2.40~3.20 h,t1/2为2.08~6.79 h,其中木兰花碱和斯皮诺素的暴露量相对较高,C_(max)分别为76.7、31.5 ng·mL^(-1),AUC_(0-∞)分别为581、315 ng·h·mL^(-1);其余5种暴露较弱的化合物的C_(max)为0.81~13.0 ng·mL^(-1),AUC_(0-∞)为6.00~106 ng·h·mL^(-1)。该研究为炒酸枣仁后续相关药理研究提供了参考依据。

关键词：炒酸枣仁比格犬药代动力学 UPLC-MS/MS

Synthesis and Crystal Structure of Chiral 4-Hydroxy-4-butyrolactam Fused Aziridine

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2008年第2期27卷 133-136页

作者： WANG Jian-Ping WANG Jian-Ge FU Yong-Ju li ying-fei Department of Chemistry Luoyang Normal University Luoyang 471022 China Chemical Engineering ＆ Pharmaceutics College Henan University of Science and Technology Luoyang 471003 China

A novel compound of chiral 4-hydroxy-4-butyrolactam fused aziridine was synthesized via tandem nucleophilic displacement reaction under mild condition. Its structure was determined by IR, 1H NMR, elemental analysis and X-ray diffraction. The crystal of the new compound is of orthorhombic, space group P212121 with a = 6.4246（6）, b = 13.5081（13）, c = 18.6399（18） A, Mr = 278.39, Z = 4, V = 1617.6（3）A^3, Dc = 1.143 g/cm^3, p（MoKa） = 0.075 mm^-1, F（000） = 608, the final R = 0.0297 and wR = 0.0679.

关键词： butyrolactam aziridine asymmetric synthesis crystal structure

Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance li-ion battery

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第7期43卷 2994-3006页

作者： ying li Yi-Han Zhao Lu-Lu Zhao Peng-fei Wang ying Xie Ting-Feng Yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries(liBs)due to its high theoretical specific ***,its serious volume expansion problem during alloying/dealloying of li~+limits its practical *** this work,C-Sb composite was constructed as anode material of liBs by electrospinning route for the first time,Sb was introduced into the polyacrylonitrile-based hard carbon and coal tar pitch-based soft carbon composite amorphous carbon fiber with a diameter of 300-600 nm,which realized high cycling *** C-Sb-2(the mass ratio of polyacrylonitrile to Sb source is 1:2)electrode displayed charge capacities of 1098.5,930.3,841.7,753.5,643.9 and 545.8 mAh·g^(-1)at 0.1,0.2,0.3,0.5,1 and 2 A·g^(-1),*** when the current density returned to 0.1 A·g^(-1),the charge capacity was 939.3 mAh·g^(-1),revealing good stability and *** introduction of Sb into the amorphous carbon improved its conductivity and addressed the volume expansion issue of high specific capacity Sb during charge/***-situ XRD analysis confirmed the high reversibility of the C-Sb-2 during charging and *** functional theory(DFT)calculations revealed the gradual enhancement of the interface interaction between Sb_(x)li_(y) and amorphous carbon(AMC)with increasing lithium content,contributing to the anchoring of alloy nanoparticles on the AMC surface and buffering the volume change of the ***,the gradual lithiation of Sb facilitated the electron transfer from Sb_(x)li_(y) to *** findings hold promise for designing lithium storage materials with exceptional performance,highlighting the potential of C-Sb composites as anode materials for efficient next-generation lithium storage.

关键词： li-ion battery Metallic Sb Carbon Electrospinning Cycling stability

Wideband spectrum sensing using step-sampling based on the multipath nyquist folding receiver

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第1期31卷 523-536页

作者： Kai-lun Tian Kai-li Jiang Sen Cao Jian Gao ying Xiong Bin Tang Xu-ying Zhang Yan-fei li University of Electronic Science and Technology of China Chengdu611731China China Electronics Technology Group Corporation 29th Research Institute Chengdu610036China

Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical *** Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spectrum sensing,which is subject to the complexity of processing the modulated *** this case,a multipath NYFR architecture with a step-sampling rate for the different paths is *** different numbers of digital channels for each path are designed based on the Chinese remainder theorem(CRT).Then,the detectable frequency range is divided into multiple frequency grids,and the Nyquist zone(NZ) of the input can be obtained by sensing these ***,high-precision parameter estimation is performed by utilizing the NYFR *** with the existing methods,the scheme proposed in this paper overcomes the challenge of NZ estimation,information damage,many computations,low accuracy,and high false alarm *** simulation experiments verify the effectiveness of the proposed architecture in this paper.

关键词： Wideband spectrum sensing Sub-Nyquist sampling Step-sampling Nyquist folding receiver(NYFR) Multisignal processing

Homoclinic Solutions for a Class of Perturbed Fractional Hamiltonian Systems with Subquadratic Conditions

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第5期40卷 1177-1196页

作者： ying LUO fei GUO Yan liU School of Mathematics Tianjin UniversityTianjin 300354P.R.China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin300354P.R.China

In this paper,we consider the following perturbed fractional Hamiltonian systems{tD_(∞)^(α)(_(-∞)D_(t)^(α)u(t))+L(t)u(t)=■_(u)W(t,u(t))+■(u)G(t,u(t)),t∈R,u∈H^(α)(R,R^(N)),whereα∈(1/2,1],L∈C(R,R^(N×N))is symmetric and not necessarily required to be positive definite,W∈C1(R×R^(N,R))is locally subquadratic and locally even near the origin,and perturbed term G∈C1(R×R^(N,R))maybe has no parity in *** the perturbed method improved by the authors,a sequence of nontrivial homo clinic solutions is obtained,which generalizes previous results.

关键词： Perturbed fractional Hamiltonian systems subquadratic condition perturbed method homoclinic solutions multiplicity

Self-assembly of perovskite nanocrystals:From driving forces to applications

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第1期88卷 561-578,I0013页

作者： Yi li fei Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Self-assembly of metal halide perovskite nanocrystals(NCs)into superlattices can exhibit unique collective properties,which have significant application values in the display,detector,and solar cell *** review discusses the driving forces behind the self-assembly process of perovskite NCs,and the commonly used self-assembly methods and different self-assembly structures are ***,we summarize the collective optoelectronic properties and application areas of perovskite superlattice ***,we conclude with an outlook on the potential issues and future challenges in developing perovskite NCs.

关键词： Self-assembly Metal halide perovskite Nanocrystals Driving forces

Recent progress in hair follicle stem cell markers and their regulatory roles

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第2期16卷 126-136页

作者： Yi-Zhan Xing Hai-ying Guo fei Xiang Yu-Hong li Department of Cell Biology Army Medical UniversityChongqing 400038China Institute of Burn Research Southwest HospitalArmy Medical UniversityChongqing 400038China

Hair follicle stem cells(HFSCs)in the bulge are a multipotent adult stem cell *** can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound *** increasing number of biomarkers have been used to isolate,label,and trace HFSCs in recent *** more detailed data from single-cell transcriptomics technology,we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.

关键词： Hair follicle stem cells Bulge Secondary hair germ Marker Single-cell RNA-sequencing

Anti-inflammatory Therapy Progress in Major Adverse Cardiac Events after PCI:Chinese and Western Medicine

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2023年第7期29卷 655-664页

作者： REN Xue-yu li ying-fei liu Hui-qing liN Hui liN Qian WU Yang WAN Jie LU Jin-jin liU Jing CUI Xiao-yun Graduate School of Beijing University of Chinese Medicine Beijing100029China Department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Department of Cardiology Dong Fang HospitalBeijing University of Chinese MedicineBeijing100078China

Acute coronary syndrome(ACS)is one of the leading causes of death in cardiovascular *** coronary intervention(PCI)is an important method for the treatment of coronary heart disease(CHD),and it has greatly reduced the mortality of ACS patients since its ***,a series of new problems may occur after PCI,such as in-stent restenosis,no-reflow phenomenon,in-stent neoatherosclerosis,late stent thrombosis,myocardial ischemia-reperfusion injury,and malignant ventricular arrhythmias,which result in the occurrence of major adverse cardiac events(MACE)that seriously reduce the postoperative benefit for *** inflammatory response is a key mechanism of MACE after ***,examining effective anti-inflammatory therapies after PCI in patients with ACS is a current research focus to reduce the incidence of *** pharmacological mechanism and clinical efficacy of routine Western medicine treatment for the anti-inflammatory treatment of CHD have been *** Chinese medicine(CM)preparations have been widely used in the treatment of *** and clinical studies showed that effectiveness of the combination of CM and Western medicine treatments in reducing incidence of MACE after PCI was better than Western medicine treatment *** current paper reviewed the potential mechanism of the inflammatory response and occurrence of MACE after PCI in patients with ACS and the research progress of combined Chinese and Western medicine treatments in reducing incidence of *** results provide a theoretical basis for further research and clinical treatment.

关键词： inflammatory response percutaneous coronary intervention major adverse cardiac events anti-inflammatory therapy Chinese medicine

Harmonic Transfer Function Based Single-input Single-output Impedance Modeling of LCC-HVDC Systems

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1327-1332页

作者： Yang Wang fei Xia ying Wang Xianyong Xiao College of Electrical Engineering Sichuan UniversityChengdu 610065China

This study presents a harmonic transfer function(HTF)based single-input single-output(SISO)impedance modeling *** method converts an HTF from phase domain to sequence domain and then transforms it into an SISO impedance while preserving the frequency coupling information of different sequences and different *** of this method to a line-commutated converter based high-voltage direct current(LCC-HVDC)system are *** results demonstrate the accuracy of the derived SISO impedance,and a truncation-order selection is *** case study shows that the proposed method facilitates simpler impedance measurements and associated stability analysis.

关键词： line-commutated converter based high-voltage direct current(LCC-HVDC) harmonic transfer function(HTF) single-input single-output(SISO)impedance frequency coupling