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Analysis of GC×GC fingerprints from medicinal materials using a novel contour detection algorithm:A case of Curcuma wenyujin

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Journal of Pharmaceutical Analysis 2024年第4期14卷 542-551页

作者： Xinyue Yang Yingyu Sima Xuhuai Luo yaping li Min He Department of Pharmaceutical Engineering School of Chemical EngineeringXiangtan UniversityXiangtanHunan411105China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha410082China Department of Quality Control Xiangtan Central HospitalXiangtanHunan411100China

This study introduces an innovative contour detection algorithm,PeakCET,designed for rapid and efficient analysis of natural product image fingerprints using comprehensive two-dimensional gas chromatogram(GC×GC).This method innovatively combines contour edge tracking with affinity propagation(AP)clustering for peak detection in GC×GC fingerprints,the first in this *** edge tracking signif-icantly reduces false positives caused by“burr”signals,while AP clustering enhances detection accuracy in the face of false *** efficacy of this approach is demonstrated using three medicinal products derived from Curcuma *** not only performs contour detection but also employs inter-group peak matching and peak-volume percentage calculations to assess the compositional similarities and differences among various ***,this algorithm compares the GC×GC fingerprints of Radix/Rhizoma Curcumae Wenyujin with those of products from different botanical *** findings reveal that genetic and geographical factors influence the accumulation of secondary metabolites in various plant *** sample exhibits unique characteristic components alongside common ones,and vari-ations in content may influence their therapeutic *** research establishes a foundational data-set for the quality assessment of Curcuma products and paves the way for the application of computer vision techniques in two-dimensional(2D)fingerprint analysis of GC×GC data.

关键词： GC×GC Image fingerprints Contour detection Clustering of mass spectra Curcuma products

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Current Status and Perspectives of Dual-Atom Catalysts Towards Sustainable Energy Utilization

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Nano-Micro Letters 2024年第7期16卷 402-440页

作者： Yizhe li Yajie li Hao Sun liyao Gao Xiangrong Jin yaping li Zhi LV lijun Xu Wen liu Xiaoming Sun State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science EngineeringCollege of ChemistryBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China Xinjiang Coal Mine Mechanical and Electrical Engineering Technology Research Center Xinjiang Institute of EngineeringUrumqi 830023Xinjiang Uygur Autonomous RegionPeople’s Republic of China

The exploration of sustainable energy utilization requires the imple-mentation of advanced electrochemical devices for efficient energy conversion and storage,which are enabled by the usage of cost-effective,high-performance ***,heterogeneous atomically dispersed catalysts are considered as potential candidates for a wide range of *** to conventional cata-lysts,atomically dispersed metal atoms in carbon-based catalysts have more unsatu-rated coordination sites,quantum size effect,and strong metal-support interactions,resulting in exceptional catalytic *** these,dual-atomic catalysts(DACs)have attracted extensive attention due to the additional synergistic effect between two adja-cent metal *** have the advantages of full active site exposure,high selectiv-ity,theoretical 100%atom utilization,and the ability to break the scaling relationship of adsorption free energy on active *** this review,we summarize recent research advancement of DACs,which includes(1)the comprehensive understanding of the synergy between atomic pairs;(2)the synthesis of DACs;(3)characterization meth-ods,especially aberration-corrected scanning transmission electron microscopy and synchrotron spectroscopy;and(4)electrochemical energy-related *** last part focuses on great potential for the electrochemical catalysis of energy-related small molecules,such as oxygen reduction reaction,CO_(2) reduction reaction,hydrogen evolution reaction,and N_(2) reduction *** future research challenges and opportunities are also raised in prospective section.

关键词： Dual-atom catalysts Synergetic effect Electrocatalysis Oxygen reduction reaction CO_(2)reduction reaction Hydrogen evolution reaction N2 reduction reaction

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In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

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Nano-Micro Letters 2024年第1期16卷 341-359页

作者： Jiawei Kang yaping li Yating Qin Zhongming Huang Yifan Wu Long Sun Cong Wang Wei Wang Gang Feng Yiying Qi Department of Orthopaedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou City 310009Zhejiang ProvincePeople’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215ZhejiangPeople’s Republic of China The Affiliated Nanhua Hospital Orthopedic Research CentreHengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanPeople’s Republic of China Department of Radiology Jining No.1 People’s HospitalJining Medical UniversityJining 272000ShandongPeople’s Republic of China

The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage *** multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense ***,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their *** hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural *** resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and *** vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,*** vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral *** biomaterial delivery approach represents a significant toward improved osteochondral repair.

关键词： Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a

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Expression and clinical significance of pattern recognition receptor-associated genes in hand, foot and mouth disease

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 173-183,I0001-I0003页

作者： Muqi Wang Huiling Deng Yuan Chen Yikai Wang Yufeng Zhang Chenrui liu Meng Zhang Ting li Shuangsuo Dang yaping li Department of Infectious Diseases The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Pediatrics Xi'an Central HospitalXi'an 710004China Department of Infectious Diseases Xi'an Children's HospitalXi'an 710003China

Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated ***:We conducted a comparative analysis of PRR-associated gene expression in human peripheral blood mononuclear cells(PBMCs)infected with enterovirus 71(EV-A71)which were derived from patients with HFMD of different severities and at different stages.A total of 30 PRR-associated genes were identified as significantly upregulated both over time and across different EV-A71 ***,EliSA was employed to quantify the expression of the six most prominent genes among these 30 identified genes,specifically,BST2,IRF7,IFI16,TRIM21,MX1,and ***:Compared with those at the recovery stage,the expression levels of BST2(P=0.027),IFI16(P=0.016),MX1(P=0.046)and DDX58(P=0.008)in the acute stage of infection were significantly upregulated,while no significant difference in the expression levels of IRF7(P=0.495)and TRIM21(P=0.071)was found between different stages of the *** expression levels of BST2,IRF7,IFI16 and MX1 were significantly higher in children infected with single pathogen than those infected with mixed pathogens,and BST2,IRF7,IFI16 and MX1 expression levels were significantly lower in coxsackie B virus(COXB)positive patients than the negative *** levels of one or more of BST2,IRF7,IFI16,TRIM21,MX1 and DDX58 genes were correlated with PCT levels,various white blood cell counts,and serum antibody levels that reflect disease course of *** aminotransferase was correlated with BST2,MX1 and DDX58 expression ***:PRR-associated genes likely initiate the immune response in patients at the acute stage of HFMD.

关键词： Pattern recognition receptors(PRRs) Hand,foot,and mouth disease(HFMD) Immune Enterovirus 71(EV-A71)

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Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3218-3231页

作者： Wen Zhang Yihui Zhai Ying Cai Xiang Gong Yunxuan Jiang Rong Rong Chao Zheng Binyu Zhu Helen He Zhu Hao Wang yaping li Pengcheng Zhang China State Institute of Pharmaceutical Industry Shanghai 201203China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Biomedical Engineering&State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Yantai Institute of Materia Medica Shandong 264000China State Key Laboratory of Oncogenes and Related Genes Renji-Med-X Stem Cell Research CenterDepartment of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127China University of Chinese Academy of Sciences Beijing 100049China

Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with triple-negative breast cancer(TNBC).Here,we create a LCL161-loaded macrophage membrane decorated nanoparticle(LMN)for immunotherapy of MHC-I-deficient *** on the macrophage membrane helps LMNs recognize CD47-expressing cancer cells for targeted delivery of LCL161,which induces the release of high mobility group protein 1 and proinflammatory cytokines from cancer *** released cytokines and high mobility group protein 1 activate antitumor immunity by increasing the intratumoral density of the phagocytic macrophage subtype by 15 times and elevating the intratumoral concentration of CTL lymphotoxin by 4.6 *** also block CD47-mediated phagocytosis *** inhibit the growth of MHC-I-deficient TNBC tumors,as well as those resistant to combined therapy of anti-PDL1 antibody and albumin-bound paclitaxel,and prolong the survival of animals,during which process CTLs also play important *** macrophage membrane-decorated nanoparticle presents a generalizable platform for increasing macrophagemediated antitumor immunity for effective immunotherapy of MHC-I-deficient cancers.

关键词： MHC-I deficiency Macrophage CD47 Immunotherapy Triple-negative breast cancer Phagocytosis Immune checkpoint Innate immunity

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基于Stacking集成学习的剩余使用寿命预测

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计算机集成制造系统 2024年第7期30卷 2464-2473页

作者：韩腾飞李亚平南京林业大学经济管理学院江苏南京210037

剩余使用寿命(RUL)预测对于设备维护策略的制定有着关键作用。面对可变环境和多样的操作条件,单一寿命预测模型的性能波动较大,泛化能力弱。针对这一问题,提出一种融合多个相异模型的Stacking集成模型,纠正单一模型的预测误差。首先,对... 详细信息

剩余使用寿命(RUL)预测对于设备维护策略的制定有着关键作用。面对可变环境和多样的操作条件,单一寿命预测模型的性能波动较大,泛化能力弱。针对这一问题,提出一种融合多个相异模型的Stacking集成模型,纠正单一模型的预测误差。首先,对状态监测数据进行滑动时间窗口处理,获得具有时间序列信息的性能退化数据;然后,以提高模型的准确性和多样性为目标,确定基学习器的种类;最后,将梯度提升决策树(GBDT)作为元学习器,整合基学习器的预测结果,输出最终结果。基于NASA C-MAPSS数据集,对提出的集成模型进行验证,结果表明:Stacking集成模型的预测精度显著高于基学习器,与其他传统预测模型相比,也具有明显优势。

关键词： Stacking集成模型剩余寿命预测滑动时间窗口集成学习

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代谢综合征与阿尔茨海默病的相关性及机制研究进展

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中国全科医学 2024年第3期27卷 268-272页

作者：李雅萍李霞上海交通大学医学院附属精神卫生中心老年科上海市200000

近期研究发现代谢综合征(MetS)患者有认知功能下降甚至向痴呆进展的趋势,而阿尔茨海默病(AD)是痴呆最重要的分型。本文回顾总结既往研究中MetS导致的认知功能障碍与AD发病的相关性,指出有较多证据支持MetS作为整体及其组分中的高血压、... 详细信息

近期研究发现代谢综合征(MetS)患者有认知功能下降甚至向痴呆进展的趋势,而阿尔茨海默病(AD)是痴呆最重要的分型。本文回顾总结既往研究中MetS导致的认知功能障碍与AD发病的相关性,指出有较多证据支持MetS作为整体及其组分中的高血压、高血糖是AD的危险因素,而胰岛素抵抗、神经慢性炎症、脂肪因子紊乱等在发病过程中起到重要作用,因尚缺乏可有效延缓或逆转AD病理进展的治疗方案,期待以相对可治MetS为干预靶标,为早期防治AD综合策略的制订提供科学证据。

关键词：代谢综合征阿尔茨海默病高血糖症认知功能障碍胰岛素抵抗高血压肥胖腹部血脂异常

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考虑时空不确定性的风电出力场景生成方法

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电力自动化设备 2024年第7期44卷 101-107页

作者：孙锴张大海李亚平严嘉豪北京交通大学电气工程学院北京100044 中国电力科学研究院有限公司(南京) 江苏南京210003

为准确描述风电出力的不确定性及时空相关性,提出一种考虑时空不确定性的风电出力场景生成方法。将生成对抗网络作为风电出力的场景生成模型,将卷积神经网络作为模型生成器与判别器以实现时间特征的提取,采用特征工程方式实现不同风电... 详细信息

为准确描述风电出力的不确定性及时空相关性,提出一种考虑时空不确定性的风电出力场景生成方法。将生成对抗网络作为风电出力的场景生成模型,将卷积神经网络作为模型生成器与判别器以实现时间特征的提取,采用特征工程方式实现不同风电场间出力空间相关性的量化;通过格拉姆角场方式进行特征变换,并合理设置网络结构及参数进行网络训练,得到生成器输入与输出场景间的映射关系。采用实测数据对所提方法的有效性进行对比验证,实验结果表明所提方法具有较强的风电出力不确定性表示能力。

关键词：场景生成时空特性特征工程不确定性生成对抗网络

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考虑灵活资源及模数驱动方法的电力系统调度方法综述

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高电压技术 2024年第1期50卷 42-54页

作者：张大海孙锴史一茹李立新李亚平贠韫韵北京交通大学电气工程学院北京100044 中国电力科学研究院有限公司南京210003

可再生能源及负荷种类的增多给电力系统运行带来更大不确定性,也给电力系统经济调度带来挑战。深入分析总结灵活资源特性并对不确定性的准确建模是评估电力系统灵活性和实现经济调度的基础。基于模型或数据驱动的调度建模方法面临诸多挑... 详细信息

可再生能源及负荷种类的增多给电力系统运行带来更大不确定性,也给电力系统经济调度带来挑战。深入分析总结灵活资源特性并对不确定性的准确建模是评估电力系统灵活性和实现经济调度的基础。基于模型或数据驱动的调度建模方法面临诸多挑战,将模型与数据驱动方式相结合,并充分发挥二者优势是电力系统优化调度的发展方向。该文从灵活资源分类及特性、系统灵活性评估方法及优化调度的模型与数据驱动建模3个方面进行了归纳整理。首先,从电网侧、供应侧及需求侧3个方面介绍了系统中的灵活资源,并总结了其调节特性。其次,介绍了权重分配、数理统计及包络区间3种常用电力系统灵活性评价指标,并总结了不同方法的适用性。然后,总结了模型驱动或数据驱动的应用现状及其各自优缺点,并对模型数据交互驱动的研究现状进行了概述。最后,对考虑灵活资源的电力系统调度方案研究进行了展望。

关键词：灵活资源评价指标模型驱动数据驱动优化调度

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基于生成对抗模仿学习的综合能源系统能量优化调度

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高电压技术 2024年第8期50卷 3535-3544,I0019-I0022页

作者：史一茹张大海李立新李亚平贠韫韵孙锴北京交通大学电气工程学院北京100044 中国电力科学研究院有限公司北京100192

近年来,基于深度强化学习的综合能源系统(integrated energy system,IES)优化调度已取得阶段性进展。然而,随着IES系统结构、规模、技术等层面的持续发展,传统深度强化学习训练时间漫长和设计复杂度高等弊端逐渐显露。为此,提出一种面向... 详细信息

近年来,基于深度强化学习的综合能源系统(integrated energy system,IES)优化调度已取得阶段性进展。然而,随着IES系统结构、规模、技术等层面的持续发展,传统深度强化学习训练时间漫长和设计复杂度高等弊端逐渐显露。为此,提出一种面向IES能量优化调度的生成对抗模仿学习方法。首先,IES智能体通过模仿具备高奖励回馈的专家调度策略自适应学习动作探索过程,避免盲目探索造成的时间与算力浪费。其次,基于生成对抗理论,增设判别器网络辨别生成策略与专家策略之间的差异,以此作为内部奖励函数辅助神经网络参数更新,避免人工设置奖励的主观偏好和经验限制对IES调度结果的影响。最后,电-热耦合系统算例分析结果表明:训练过程中所提方法的收敛速度较传统深度强化学习算法提升了52%,收敛效果提升了10%,同时使IES智能体获得了接近专家调度经验的决策能力;在线应用时无需依赖对外界环境的准确预测和精确建模,即可实现快速实时决策。

关键词：综合能源系统优化调度强化学习模仿学习生成对抗网络

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