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Biomedical and Environmental Sciences 2020年第6期33卷 414-420页

作者： ZHANG Yu li ya jie REN Tong Xiang liU Xiao Bing yaNG li Chen PAO Jian Hua WANG Jurr yaNG Xiao Guang Key Laboratory of Trace Element Nutrition MOHChinese Center for Disease Control and PreventionBeijing 100050China Department of Preventive Medicine Changzhi Medical CollegeChangzhi 046000ShanxiChina National Institute of Metrology Beijing 100029China

Objective To analyze the rate of erythrocyte iron incorporation and provided guidance for the iron nutrition for prepubertal *** Fifty-seven prepubertal children of Beijing were involved in this study and each subject was orally administered 3 mg of 57 Fe twice daily to obtain a total of 30 mg 57 Fe after a 5-d period. The stable isotope ratios in RBCs were determined in 14 th day, 28 th day, 60 th day, and 90 th day. The erythrocyte incorporation rate in children was calculated using the stable isotope ratios, blood volume and body iron *** The percentage of erythrocyte 57 Fe incorporation increased starting 14 th day, reached a peak at 60 d(boys: 19.67% ± 0.56%, girls: 21.33% ± 0.59%) and then decreased. The erythrocyte incorporation rates of 57 Fe obtained for girls in 60 th day was significantly higher than those obtained for boys(P < 0.0001).Conclusions The oral administration of 57 Fe to children can be used to obtain erythrocyte iron incorporation within 90 d. Prepubertal girls should begin to increase the intake of iron and further studies should pay more attention to the iron status in prepubertal children.

关键词： Stable isotope tracer technique Iron Erythrocyte incorporation rate Beijing prepubertal children MC-ICP-MS

Effect of recombinant human endostatin on endometriosis in mice

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Chinese Medical Journal 2007年第14期120卷 1241-1246页

作者： JIANG Hong-qing li ya-li ZOU jie Department of Obstetrics and Gynecology General Hospital of the People＇s Liberation Army Beijing 100853 China

Background Direct and indirect evidences have suggested that angiogenesis is a prerequisite for the development of endometriosis. Aiming at offering experimental evidences for anti-angiogenesis therapy, we transplanted the eutopic endometrium from patient with endometriosis into the severe combined immunodeficiency disease （SCID） mice, to evaluate the effect of the endostatin on the growth and angiogenesis of the established endometriosis lesions in SCID mice model. Methods Eutopic endometrium of women with endometriosis was transplanted into the SCID mice. The mice were randomized into treatment （n= 10） and control groups （n=10）. Two weeks after the implantation of endometrium fragment, the treatment group was injected with recombinant human endostatin YH-16 into the peritoneal cavity （2 mg·kg^-1·d^-1）, whereas the control group received equivalent volume of PBS （200 μl/d）. The volume of endometriotic lesions in SCID mice was measured every three days, and all the treatment lasted for 14 days. Immunohistochemistry was used to determine microvessel density （MVD） and the expression of VEGF. The results were analyzed by t test and X^2 test to value the treating effect. Results Compared with the control group, growth of endometriosis lesion was reduced in the mice treated with YH-16. Statistically significant differences in the volume and weight of the ectopic lesions were observed between the treatment and the control groups （P〈0.05）. Microscopical examination showed that after being treated with YH-16, the volume of the endometrial tissues decreased, the glands depauperated, and the glandular epithelium partially degenerated. Necrotic debris was observed in the endometrial stroma. MVD and expression of VEGF in the treatment group were significantly lower than those in the control group （P〈0.05）.Conclusions Recombinant human endostatin affects the maintenance and growth of endometriotic tissues by inhibiting angiogenesis and reducing the expression of VEGF in ec

关键词： endometriosis recombinant human endostatin animal model

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Biomedical and Environmental Sciences 2021年第4期34卷 324-329页

作者： liU Xiao Bing WANG Jun li ya jie TAN Hong Xing liU yan yan YU Wei ZHANG Yu yaNG li Chen PIAO Jian Hua liU Xiao li yaNG Xiao Guang Shenzhen Center for Chronic Disease Control Shenzhen 518020GuangdongChina Key Laboratory of Trace Element Nutrition of National Health Commission National Institute of Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Changzhi Medical College Changzhi 047500ShanxiChina

Iodine is an essential component of thyroid hormones’biosynthesis and is crucial for normal growth and healthy development[1].If the amount of dietary iodine intake cannot match the long-term requirement,regardless of whether it is excessively low or high,it can cause various thyroid dysfunctions,including hyperthyroidism,hypothyroidism,and autoimmune thyroid diseases[2].

关键词： intake diseases dietary

Zinc Absorption from Representative Diet in a Chinese Elderly Population Using Stable Isotope Technique

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Biomedical and Environmental Sciences 2017年第6期30卷 391-397页

作者： li ya jie li Min liU Xiao Bing REN Tong Xiang li Wei Dong yaNG Chun WU Meng yaNG lin li MA Yu Xia WANG Jun PIAO Jian Hua yaNG li Chen yaNG Xiao Guang Key Laboratory of Trace Element Nutrition National Health and Family Planning Commission of China Department of Trace Element Nutrition National Institute for Nutrition and Health Chinese Center for Disease Control and Prevention Beijing 100050 China National Institute of Metrology Beijing 100029 China Department of Nutrition and Food Hygiene Capital University of Medical Sciences Beijing 100069 China HeBei Medical University Shijiazhuang 050017 Hebei China

Objective To determine the dietary zinc absorption in a Chinese elderly population and provide the basic data for the setting of zinc （Zn） recommended nutrient intakes （RNI） for Chinese elderly people. Methods A total of 24 elderly people were recruited for this study and were administered oral doses of 3 mg 67Zn and 1.2 mg dysprosium on the fourth day. The primary macronutrients, energy, and phytic acid in the representative diet were examined based on the Chinese National Standard Methods. Fecal samples were collected during the experimenta and dysprosium content. period and analyzed for zinc content, 67Zn isotope ratio, Results The mean （± SD） zinc intake from the representative Chinese diet was 10.6 ± 1.5 mg/d. The phytic acid-to-zinc molar ratio in the diet was 6.4. The absorption rate of 67Zn was 27.9% ±9.2%. The RNI of zinc, which were calculated by the absorption rate in elderly men and women, were 10.4 and 9.2 mg/d, respectively. Conclusion This study got the dietary Zn absorption in a Chinese elderly population. We found that Zn absorption was higher in elderly men than in elderly women. The current RNI in elderly female is lower than our finding, which indicates that more attention is needed regarding elderly females＇ zinc status and health.

关键词： Zinc absorption Chinese elderly people Stable isotope technique

A Comparative Analysis of Chemical Properties and Factors Impacting Spring Sea Fog over the Northwestern South China Sea

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Journal of Tropical Meteorology 2022年第3期28卷 297-307页

作者： HAN li-guo XU Feng XU Jian-jun li ya-jie CHAI Bo-yu LÜJing-jing College of Ocean and Meteorology/South China Sea Institute of Marine Meteorology(SIMM) Guangdong Ocean UniversityZhanjiangGuangdong 524088 China CMA-GDOU Joint Laboratory for Marine Meteorology Guangdong Ocean UniversityZhanjiangGuangdong 524088 China Key Laboratory of Climate Resources and Environment in Continental Shelf Sea and Deep Sea of Department of Education of Guangdong ProvinceGuangdong Ocean UniversityZhanjiangGuangdong 524088 China Shenzhen Institute of Guangdong Ocean University ShenzhenGuangdong 518120 China Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration Nanjing University of Information Science and TechnologyNanjing 210044 China

In the present study,we analyzed the chemical properties and factors impacting the sea fog water during two sea fog events over the northwestern South China Sea in March 2017,and compared our results with those of other *** sea fog water during these two events were highly acidic and their average pH was below 3,which was related to the high initial acidifying potential and large amounts of NOand SOnot involved in the neutralization *** dominant cations in the sea fog water were Naand *** primary anions in the sea fog water over the South China Sea were Cland NO,while that over the North Pacific Ocean was mainly SO,and ratios of the three fog water ions near the Donghai Island were *** in the sea fog water during the two events were mainly derived from marine aerosols,while the difference was that the first low-level sea fog airflow trajectory passed over Hainan ***,the proportion of K+in the first sea fog was much higher than that in sea water and the *** was the key to fog water nucleation,which made ion concentration in the sea fog water during the second event higher than that during the first.A decrease in average diameter during the first sea fog formation led to an ion concentration increase,while the average diameter of sea fog water during the second event was lower than that during the first,which corresponded with a moderate ion concentration increase.

关键词： northwestern South China Sea sea surface fog chemical properties impact factors

基于离散事件触发通信机制的非均匀传输网络化控制系统故障调节与通信满意协同设计

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吉林大学学报（工学版） 2018年第1期48卷 245-258页

作者：李炜李亚洁兰州理工大学电气工程与信息工程学院兰州730050 中国石油兰州石化公司自动化研究院兰州730060

基于离散事件触发通信机制(DETCS),考虑执行器饱和约束,研究了网络化控制系统(NCS)同时满足多项约束目标的主动容错与网络通信间的协同设计问题。首先,通过在传统的NCS中引入事件发生器,提出并构建了DETCS下NCS主动容错的架构与设计理念... 详细信息

基于离散事件触发通信机制(DETCS),考虑执行器饱和约束,研究了网络化控制系统(NCS)同时满足多项约束目标的主动容错与网络通信间的协同设计问题。首先,通过在传统的NCS中引入事件发生器,提出并构建了DETCS下NCS主动容错的架构与设计理念,即基于系统中物理采样器采样周期的驱动来设计状态和故障观测器,基于网络通信约束触发的事件驱动来设计反馈控制。其次,建立了集网络属性、执行器饱和约束、故障估计、扰动信息、故障调节与反馈控制为一体的非均匀传输闭环故障系统模型。接着,给出了满足H∞性能的状态和时变故障估计的广义观测器的求解方法,并以此为基础给出了非均匀传输故障调节与网络通信间的满意协同设计方法。最后,通过采用四容水箱基准实例验证了理论结果的正确性与实用性。

关键词：通信技术时变故障调节非均匀传输满意主动容错控制执行器饱和协同设计

网络化控制系统α/H_∞容错控制与网络通讯的协同设计

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吉林大学学报（工学版） 2016年第6期46卷 2010-2020页

作者：李亚洁李炜兰州理工大学电气工程与信息工程学院兰州730050 中国石油兰州石化分公司自动化研究院兰州730060

在离散事件触发通讯机制下,针对执行器失效故障及饱和约束,研究了网络化控制系统具有α-安全度的鲁棒H_∞容错设计问题。首先,基于离散事件触发通讯机制(DETCS)将闭环故障网络控制系统(NCS)建立成一种具有状态时延且含事件触发条件的模... 详细信息

在离散事件触发通讯机制下,针对执行器失效故障及饱和约束,研究了网络化控制系统具有α-安全度的鲁棒H_∞容错设计问题。首先,基于离散事件触发通讯机制(DETCS)将闭环故障网络控制系统(NCS)建立成一种具有状态时延且含事件触发条件的模型。其次,基于Lyapunov稳定性理论和文中给出的与安全度相关的3个新定义,推证出了使闭环故障NCS具有扰动抑制性能的时滞/事件共同依赖的具有α-安全度的不变集充分条件,并提出了一种关于容错控制与网络通讯的协同设计方法。最后,仿真验证了该方法的可行性,即在系统设计中兼顾了系统的控制质量和网络的服务质量。

关键词：自动控制技术协同设计事件触发控制安全度执行器饱和相容性分析

自适应事件触发通信机制下机理解析与数据驱动融合的ICPS双重安全控制

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控制与决策 2024年第1期39卷 206-218页

作者：赵莉李炜李亚洁兰州理工大学电气工程与信息工程学院兰州730050 陇东学院电气工程学院甘肃庆阳745000

针对存在拒绝服务(DoS)攻击与执行器故障的工业信息物理融合系统(ICPS),将机理解析与数据驱动方法相结合,在新型自适应事件触发通信机制下,研究双重安全控制问题.首先,设计自适应事件触发机制,能够触发参数随系统行为动态自适应变化,节... 详细信息

针对存在拒绝服务(DoS)攻击与执行器故障的工业信息物理融合系统(ICPS),将机理解析与数据驱动方法相结合,在新型自适应事件触发通信机制下,研究双重安全控制问题.首先,设计自适应事件触发机制,能够触发参数随系统行为动态自适应变化,节约更多网络通信资源;其次,基于系统最大允许时延建立攻击检测机制,可以有效区分大、小能量DoS攻击;再次,基于极限学习机算法(ELM)建立时序预测模型,用于大能量DoS攻击时重构修正控制量,以主动容侵攻击的影响,并给出与小能量攻击时机理解析的弹性被动容侵来提升系统对攻击的防御能力;然后,借助T-S模糊理论、时滞系统理论、新型Bessel-Legendre不等式等,推证得到系统鲁棒观测器及双重安全控制器的解析求解方法,使双重安全控制与通讯性能得到折衷协同提升;最后,通过实例仿真验证所提出方法的有效性.

关键词：工业信息物理融合系统(ICPS) 双重安全控制 DoS攻击主被动容侵数据驱动机理解析

Measurement of linewidth enhancement factor of SOA using fiber Sagnac Ring

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Optoelectronics Letters 2006年第2期2卷 142-144页

作者： GAO Hua-li WU Chong-qing li ya-jie NI Dong School of Science Beijing Jiaotong University Beijing 100044 China

Semiconductor optical amplifiers (SOA) are optical amplifying devices and key parts in optical switches and optical *** are largely used in communication *** enhancement factor is an important parameter for SOA.A method is proposed to measure the linewidth enhancement factor with Sagnac *** phase modulation (XPM) and cross gain modulation (XGM) coexist in *** quantitative relation of linewidth enhancement factor to XGM and the interference extinction ratio is *** experimental results indicate that the value of linewidth enhancement factor changes from 5.13 to 6.24 when the electric current varies from 130 mA to 240 mA.

关键词：光学纤维线宽半导体光学放大器 SOA 光学开关

数据驱动与机理解析方法融合的ICPS自适应综合安全控制

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控制与决策 2024年第9期39卷 3079-3089页

作者：李炜陈婧婧李亚洁兰州理工大学电气工程与信息工程学院兰州730050 甘肃省工业过程先进控制重点实验室兰州730050

针对一类隐蔽虚假数据注入(FDI)和执行器故障共存的工业信息物理融合系统(ICPS),将数据驱动与机理解析方法有机结合,研究综合安全控制与通讯协同设计问题.首先,设计一种服从指数型自适应律的离散事件触发通讯机制(ADETCS),并构建可同时... 详细信息

针对一类隐蔽虚假数据注入(FDI)和执行器故障共存的工业信息物理融合系统(ICPS),将数据驱动与机理解析方法有机结合,研究综合安全控制与通讯协同设计问题.首先,设计一种服从指数型自适应律的离散事件触发通讯机制(ADETCS),并构建可同时抵御网络FDI攻击和物理部件故障的自适应ICPS框架;然后,基于数据驱动技术,通过优选和优化建立FDI攻击的预测模型PSO-CatBoost,对攻击进行准确重构和补偿;接着,借助于增广型Lyapunov-Krasovskii泛函、改进仿射Bessel-Legendre不等式等少保守性技术,推导出鲁棒观测器和综合安全控制器的求解方法;最后,通过四容水箱实例验证所提出方法的有效性.实验结果表明:将数据驱动的隐蔽FDI重构补偿与机理解析的补偿误差抑制深度融合,主被动协同有效容侵了网络攻击,结合对故障的主动容错,并在ADETCS下随系统行为变化自适应调整触发参数,可显著提升ICPS的双重安全防御能力,节约更多的网络资源.

关键词：工业信息物理系统隐蔽FDI攻击自适应触发机制数据驱动机理解析综合安全控制