Evaluation of Erythrocyte Iron Incorporation in Beijing Prepubertal Children Using a Single Stable Isotope Tracer Method

作     者：ZHANG Yu LI Ya Jie REN Tong Xiang LIU Xiao Bing YANG Li Chen PAO Jian Hua WANG Jurr YANG Xiao Guang ZHANG Yu;LI Ya Jie;REN Tong Xiang;LIU Xiao Bing;YANG Li Chen;PIAO Jian Hua;WANG Jun;YANG Xiao Guang

作者机构：Key Laboratory of Trace Element NutritionMOHChinese Center for Disease Control and PreventionBeijing 100050China Department of Preventive MedicineChangzhi Medical CollegeChangzhi 046000ShanxiChina National Institute of MetrologyBeijing 100029China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2020年第33卷第6期

页      面：414-420页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100403[医学-营养与食品卫生学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China grant number 81330066 

主　　题：Stable isotope tracer technique Iron Erythrocyte incorporation rate Beijing prepubertal children MC-ICP-MS 

摘      要：Objective To analyze the rate of erythrocyte iron incorporation and provided guidance for the iron nutrition for prepubertal *** Fifty-seven prepubertal children of Beijing were involved in this study and each subject was orally administered 3 mg of 57 Fe twice daily to obtain a total of 30 mg 57 Fe after a 5-d period. The stable isotope ratios in RBCs were determined in 14 th day, 28 th day, 60 th day, and 90 th day. The erythrocyte incorporation rate in children was calculated using the stable isotope ratios, blood volume and body iron *** The percentage of erythrocyte 57 Fe incorporation increased starting 14 th day, reached a peak at 60 d(boys: 19.67% ± 0.56%, girls: 21.33% ± 0.59%) and then decreased. The erythrocyte incorporation rates of 57 Fe obtained for girls in 60 th day was significantly higher than those obtained for boys(P 0.0001).Conclusions The oral administration of 57 Fe to children can be used to obtain erythrocyte iron incorporation within 90 d. Prepubertal girls should begin to increase the intake of iron and further studies should pay more attention to the iron status in prepubertal children.