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EGFR-mutant non-small cell lung cancer patients harboring CDK4 amplification show favorable response to afatinib:Two case reports

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Chinese Medical Journal 2024年第12期137卷 1465-1467页

作者： Shuting Zhan Bo Cheng Xiwen liu Jianfu li Ge Bai Qi Cai Huiting Wang Yang Xiang Chunyan li Jianxing He wenhua liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical University&Guangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China National Center for Respiratory Medicine State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseasesGuangzhou Institute of Respiratory Health&The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Southern Medical University GuangzhouGuangdong 510120China Department of Respiratory and Critical Care Medicine The Tenth Affiliated Hospital of Southern Medical UniversityDongguanGuangdong 523108China

To the editor:Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)show significant efficacy in patients with advanced-stage non-small cell lung cancer(NSCLC)with sensitive EGFR mutations and significantly prolong the survival of these ***,drug resistance emerges in most *** studies indicated that cyclin-dependent kinase 4/6(CDK4/6)gene amplification was one of the resistance mechanisms of the EGFR-TKI osimertinib,weakening its *** options for EGFR-mutant NSCLC patients with CDK4 amplification are limited to add CDK4 inhibitors.

关键词： CDK4 NSCLC EGFR

A Special Issue on Stem Cell Research

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Cell Research 2007年第1期17卷 1-2页

作者： Dangsheng Deputy editor-in- chief li Gang Pei PDH editor-in-chief Deputy editor-in-chief Cell Research editor-in-chief Cell Research

Stem cells possess the remarkable ability of extensive self-renewal and differentiation into specific celllineages,and they play essential roles in development and adult tissue *** to their criticalimportance in normal physiology and the promise for use in regenerative medicine to treat a variety ofdiseases,stem cells have attracted extensive research interest in recent *** China’s premium in-ternational journal with a broad scope in cell and molecular biology,Cell Research has witnessed moreand more submissions on stem cell ***,along with the traditional strengths of the journal inmolecular immunology,cancer biology,and plant molecular physiology,stem cell research has graduallyand naturally evolved into a new growth point of Cell *** the growing interest of bothour readers and authors in this exciting and expanding field,we are pleased to present this Special Issueon Stem Cell Research.

关键词： Cell A Special Issue on Stem Cell Research

Object Helps U-Net Based Change Detectors

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 548-550页

作者： Lan Yan Qiang li Kenli li College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Dear editor,This letter focuses on leveraging the object information in images to improve the performance of the U-Net based change *** detection is fundamental to many computer vision *** existing solutions based on ... 详细信息

关键词： Net computer networks

Autonomous Recommendation of Fault Detection Algorithms for Spacecraft

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 273-275页

作者： Wenbo li Baoling Ning the National Key Laboratory of Science and Technology on Space Intelligent Control Beijing Institute of Control EngineeringBeijing 100094China the School of Data Science and Technology Heilongjiang UniversityHarbin 150001China

Dear editor, This letter deals with the problem of algorithm recommendation for online fault detection of spacecraft. By transforming the time series data into distributions and introducing a distribution-aware measure, a principal method is designed for quantifying the detectabilities of fault detection algorithms over special datasets.

关键词： fault introducing letter

RMPC-Based Visual Servoing for Trajectory Tracking of Quadrotor UAVs With Visibility Constraints

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 2027-2029页

作者： Qifan Yang Huiping li School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072China

Dear editor,This letter deals with the tracking problem of quadrotors subject to external disturbances and visibility constraints by designing a robust model predictive control(RMPC) scheme. According to the imagebase... 详细信息

关键词： Visual image visibility

Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-toK base editing in rice plants

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aBIOTECH 2024年第2期5卷 127-139页

作者： Yucai li Shaoya li Chenfei li Chen Zhang Lei Yan Jingying li Yubing He Yan Guo Lanqin Xia Institute of Crop Sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Hainan Yazhou Bay Seed Laboratory/National Nanfan Research Institute(Sanya) CAASSanya 572024China

Engineering of a new type of plant base editor for simultaneous adenine transition and transversion within the editing window will greatly expand the scope and potential of base editing in directed evolution and crop ***,we isolated a rice endogenous hypoxanthine excision protein,N-methylpurine DNA glycosylase(OsMPG),and engineered two plant A-to-K(K=G or T)base editors,rAKBE01 and rAKBE02,for simultaneous adenine transition and transversion base editing in rice by fusing OsMPG or its mutant mOsMPG to a plant adenine transition base editor,*** further coupled either OsMPG or mOsMPG with a transactivation factor VP64 to generate rAKBE03 and rAKBE04,*** these four rAKBEs,at five endogenous loci in rice protoplasts,indicated that rAKBE03 and rAKBE04 enabled higher levels of A-to-G base transitions when compared to ABE8e and ***,whereas rAKBE01 only enabled A-to-C/T editing at one endogenous locus,in comparison with rAKBE02 and rAKBE03,rAKBE04 could significantly improve the A-to-C/T base transversion efficiencies by up to 6.57-and 1.75-fold in the rice protoplasts,***,although no stable lines with A-to-C transversion were induced by rAKBE01 and rAKBE04,rAKBE04 could enable simultaneous A-to-G and A-to-T transition and transversion base editing,at all the five target loci,with the efficiencies of A-to-G transition and A-to-T transversion editing ranging from 70.97 to 92.31%and 1.67 to 4.84%in rice stable lines,***,these rAKBEs enable different portfolios of editing products and,thus,now expands the potential of base editing in diverse application scenario for crop improvement.

关键词： Rice(Oryza sativa L) Rice N-methylpurine DNA glycosylase(OsMPG) A-to-K base editor(AKBE) Transactivation module VP64

Implementation of a particle-in-cell method for the energy solver in 3D spherical geodynamic modeling

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Earth and Planetary Physics 2024年第3期8卷 549-563页

作者： Hao Dong ZeBin Cao liJun liu YanChong li SanZhong li liMing Dai XinYu li Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Laboratory of Submarine Geosciences and Prospecting TechniquesMinistry of Education and College of Marine GeosciencesOcean University of ChinaQingdao 266100China State Key Laboratory of lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Laboratory for Marine Geology Laoshan LaboratoryQingdao 266237China Department of Earth Science&Environmental Change University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Laboratory of Seismology and Physics of Earth’s Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China

The thermal evolution of the Earth’s interior and its dynamic effects are the focus of Earth ***,the commonly adopted grid-based temperature solver is usually prone to numerical oscillations,especially in the presence of sharp thermal gradients,such as when modeling subducting slabs and rising *** phenomenon prohibits the correct representation of thermal evolution and may cause incorrect implications of geodynamic *** examining several approaches for removing these numerical oscillations,we show that the Lagrangian method provides an ideal way to solve this *** this study,we propose a particle-in-cell method as a strategy for improving the solution to the energy equation and demonstrate its effectiveness in both one-dimensional and three-dimensional thermal problems,as well as in a global spherical simulation with data *** have implemented this method in the open-source finite-element code CitcomS,which features a spherical coordinate system,distributed memory parallel computing,and data assimilation algorithms.

关键词： numerical oscillation overshooting and undershooting particle-in-cell method three-dimensional spherical geodynamic modeling energy solver finite element method

Distributed Predefined-Time Control for Cooperative Tracking of Multiple Quadrotor UAVs

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2179-2181页

作者： Kewei Xia Xinyi li Kaidan li Yao Zou Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijing 100081China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China the School of Automation Beijing Institute of TechnologyBeijing 100081China the School of Intelligence Science and Technology University of Science and Technology BeijingBeijing 100083China the Key Laboratory of Intelligent Bionic Unmanned Systems Ministry of EducationUniversity of Science and Technology BeijingBeijing 100083China

Dear editor,This letter addresses the predefined-time control for cooperative tracking of multiple quadrotor unmanned aerial vehicles(UAVs)under a directed communication network.A predefined-time distributed estimator... 详细信息

关键词： acceleration letter estimator

3D Localization for Multiple AUVs in Anchor-Free Environments by Exploring the Use of Depth Information

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1051-1053页

作者： Yichen li Wenbin Yu Xinping Guan the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai Jiao Tong UniversityShanghai 200240China

Dear editor,This letter investigates the cooperative localization problem for multiple autonomous underwater vehicles(AUVs)in underwater anchor-free environments,where AUV localization errors grow without bound due to the accumulated errors in inertial measurements(termed accumulated errors hereafter)and the lack of anchors(with known positions).

关键词： AUVs underwater hereafter